Semax

March 2, 2024

Phcoker is a professional Semax GMP manufacturer that provide both form of Semax powder and Semax finished lyophilized powder in vial.  The regularly manufacturing specification include Semax 5mg, Semax 10mg, Semax 15mg. Larger dosage and contract manufacturing service is available.

 Monthly production capacity: >1,000,000 vials


Other Name:Heptapeptide SEMAX (MEHFPGP), Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), СЕМь АминоКиСлот – СЕМАКС, L-methionyl-L-alpha-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline

 

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Raw Semax powder (80714-61-0) video

Properties


Sequence:Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP in single-letter form)
Molecular Formula:C37H51N9O10S
Molecular Weight:813.93g/mol
PubChem CID:122178
CAS Number:80714-61-0
Synonyms:L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L-proline, (Pro8,Gly9,Pro10)ACTH-(4-10)

Description


Semax is an experimental drug that originally developed in Russia for preventing and treating circulatory diseases. Studies have shown that it has potential benefits in boosting immune function, protecting neurons, and improving cardiovascular function. It has also been claimed to act as a “nootropic” or “cognitive enhancer.” In addition, it has shown promise in pain management and proper promotion of blood clotting. Semax is often discussed together with selank.

What Is Semax Peptide?

Semax is a synthetic derivative of adrenocorticotropin. The Ministry of Public Health and Pharmaceutical Industry of the Russian Federation approved the clinical use of Semax on March 28, 1996. It is a neuroactive peptide with endogenous regulatory properties that affect brain cell processes, helping to protect and enhance the recovery of brain function after ischemic injuries (such as cerebral stroke, closed head injury), neurodegenerative processes such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease. It is mainly used in Russia for the treatment of various diseases and is included in the list of important and essential medicines in Russia.

Semax powder is a base ingredient in many pharmacological products in the United States and is also used in clinical practice to treat a variety of neurological disorders. Healthy people who pursue extreme sports and higher physical goals like to use them to improve performance and fitness.

Semax is often referred to as a “nootropic” and has been shown to improve cognitive function and memory. Some people use it to improve their productivity and focus, while others use it to improve their learning and problem-solving skills. Beyond that, Semax has potential uses in treating a variety of brain conditions such as stroke, traumatic brain loss, and cardiovascular disease.

Given the many benefits of semax, if you plan to buy semax online or off-line, be sure to choose a reliable supplier,many peptide manufacturers provide semax for sale under various price,how to choose high-quality semax among so many semax peptide suppliers is a challenge.

What’s The Mechanism Of Semax Peptide?

Through the above review of semax, we have an overall understanding of the role of semax. So how does semax work in the body after use? Let us take a look in details.

The benefits of semax are mainly achieved through rapidly increase the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor TrkB in the hippocampus. And rapidly activates serotonergic and dopaminergic brain systems.

BDNF is one of the most active neuronutrients, and these chemicals help stimulate and control neurogenesis, the birth of new neurons in the brain.

BDNF plays a crucial role in neuroplasticity, enabling brain cells to adapt, compensate for injury, and adjust to new circumstances. By supporting the survival of existing neurons and facilitating the growth, regeneration, and formation of new neurons and synapses, BDNF contributes to the brain’s overall health and functionality.

Semax also helps reduce the breakdown of enkephalins. Enkephalins are mainly involved in reducing pain, reducing inflammation, preventing cancer cell growth and increasing immune cell activity. Not only that, they also play a role in memory, learning, emotional behavior, and pain. Maintaining normal brain function requires balanced enkephalin levels.

The popular form of semax peptide for sale in the market are spray and injection. The active ingredient of both semax nasal spray and injection all are semax powder. Please buy the suitable semax injection or oral according to your purpose reasonably.

What Are The Benefits Of Semax?

Semax is a nootropic drug is used mostly in Russia that has been studied for its potential congnitive- enhancing and neuroprotective effects. People choose to buy semax for different purposes. According to researchers’ research on semax, here are the top 3 benefits of semax you would like to know:

  1. Cognitive enhancement: Semax peptide can help to improved focus and concentration, enable individuals to perform mentally inensive tasks with greater ease efficiency.
  2. Neuroprotection and neuroregeneration: Semax acts by augmenting neural plasticity, a fundamental phenomenon that permits the brain to mold and build new neural connections throughout an individual’s life. The amplified plasticity is crucial for cognition, memory storage, and the healing process from cerebral harm. Consequently, Semax nasal spray fosters a more durable, healthier brain.
  3. Mood and emotional well-being: Semax peptide fosters the creation of neurotransmitters like serotonin and dopamine, both crucially linked to emotions of joy and satisfaction. Hence, the Semax is instrumental in bolstering mental health and emotional equilibrium.

Semax Side Effects And Safety

While most individuals tolerate Semax without any issues, it’s essential for users to stay informed about possible side effects. Some might encounter mild side effects like, headaches, or tiredness. In rare cases, some may have severe reactions such as allergies that necessitate immediate medical care. Like any supplement, the body may develop a tolerance to Semax over an extended period of use, requiring larger doses to achieve the same result. For safety, Phcoker recommends users track their response to Semax peptide and seek medical advice if they notice any discomfort or negative reactions.

Semax And Selank: Similarities, Differences, Combined Use

Semax and Selank as two popular nootropic peptides, are often discussed together. So what are the differences and similarities between them? Let’s take a look in details:

Similarities: Both Selank and Semax are melanocortins and have pleiotropic effects involved in brain health and function.

Differences: Selank by itself has traditionally been prescribed for anxiety and depression. Selank has pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant, and anti-stress medication. On the other hand, Semax is used as a therapeutic for patients with pathologies related to brain circulation dysfunction.

Combined Use: As a combination, the blend peptide of Selank and Semax has applications in improving learning processes, exploratory behavior, regeneration and development, nociceptive and inflammatory processes, accelerate nerve regeneration and improve neuromuscular performance and overall neural health.

Semax Peptide For Sale

Researchers have never stopped studying semax, mainly focusing on the role of semax in nootropics and its differences from other supplement-based nootropic products, such as Noopept, J147, etc. Due to the popularity of semax, many scientific research institutions and pharmaceutical peptide manufacturers provide semax both in raw powder form and lyophilized powder in vial form. Strong peptide manufacturers can even provide customized services for semax, including mixing semax with other peptide products(blend of semax+Selank..). If you plan to purchase semax or create your own peptide brand, you must be careful when choosing a reliable peptide supplier. Phcoker is good peptide GMP manufacturer you might interested in talking with.

 

Manufacturers/Factory


Semax peptide is a synthetic peptide that is derived from a naturally occurring substance in the body called ACTH. It is primarily used as a nootropic, or a cognitive enhancer, to improve memory and mental performance. Often people claim that Semax peptide can make them feel more focused, alert, and motivated.

Phcoker is one of the top Semax peptide manufacturers in the market, itnot only supply semax peptide in raw powder form but also supply Semax in lyophilized powder in vial form. If you are looking for the professional and top peptide Semax peptide factory and manufacturer, here is the best place.

 

Where to buy


Would you like to buy the best Semax peptide from the best Semax suppliers in the market? You have come at the right place!

Phcoker.com as a peptide factory, is the best place where you can buy Semax powder in competitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy Semax peptide, you may curious:

What Are The Advantages If Buy Semax From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Semax Online?

  • Visit professional Semax supplier Phcoker.com, choose the Semax you want to buy.
  • Leave your contact and message on Phcoker.comwebsite, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy Semax.

Does Phcoker.com Support The Free Sample Of Semax Powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.

Can I Appoint The Semax Colour When Buy Semax?

YES! Phcoker as peptide manufacturer, provide colour customization of Semax, easy to help you to build your Semax peptide brand.

Can I Appoint The Products Standard When Buy Semax From Phcoker.com?

YES! As one of the best Semax manufacturer, Phcoker not only provide the standard specification of Semax in 5mg, 10mg, but support standard customization. Provide the best support to build your own Semax brand.

Can I Buy Semax In Pure Powder Form From Phcoker.com?

YES! Semax powder is the base that use for Semax lyophilized powder manufacturing. Phcoke provide Semax in both of pure powder form and semi-finished vial form.

Can I Buy Discount Semax Powder From Phcoker.com?

YES! Our factory produce high quality Semax powder in term and keep Semax powder in stock. You can buy high quality Semax powder in bulk. During promotion sale, you can buy Semax peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk Semax price for you in time.

 

FAQ


What is Semax good for?

Semax has been found to stimulate memory and attention in rodents and humans. Evidence from animal studies revealed that Semax can augment the effects of psychostimulants on central dopamine release and also stimulates central brain-derived neurotrophic factor (BDNF) synthesis.

What are the peptides for ADHD?

Relieve ADHD symptoms with the nootropic peptide, Semax. Treat ADHD symptoms without Adderall or similar drugs. Semax peptide is a synthetic copy of the essential hormone, naturally present in the human body, called adrenocorticotropic hormone (ACTH).

Is Selank a Semax?

Selank is closely related to another nootropic drug, Semax, also developed by the Institute of Molecular Genetics in Russia. This drug is currently available in Russian and Ukrainian pharmacies.

What Forms of Semax are Available?

Semax peptide is available as nasal and subcutaneous injections.

Who should use Semax?

The Semax combination works for patients that are interested in improving mental clarity, memory, and focus and has applications in alleviating anxiety and depression.

In combination with appropriate medically supervised rehabilitation, this medication has shown therapeutic agency with individuals suffering from PTSD and/or substance dependence withdrawal. This medication should not be used by pregnant or nursing patients and individuals under the age of 18.

Referenced Citations


[1] Yatsenko KA, Glazova NY, Inozemtseva LS, Andreeva LA, Kamensky AA, Grivennikov IA, et al. (November 2013). “Heptapeptide semax attenuates the effects of chronic unpredictable stress in rats”. Doklady Biological Sciences. 453: 353–357. doi:10.1134/S0012496613060161. PMID 24385169. S2CID 9699654.

[2] Volodina MA, Sebentsova EA, Glazova NY, Levitskaya NG, Andreeva LA, Manchenko DM, et al. (March 2012). “Semax attenuates the influence of neonatalmaternal deprivation on the behavior of adolescent white rats”. Bulletin of Experimental Biology and Medicine. 152 (5): 560–563. doi:10.1007/s10517-012-1574-2. PMID 22803132. S2CID 1419653.

[3] Pae CU (January 2008). “Therapeutic possibility of “Semax” for depression”.CNS Spectrums. 13 (1): 20–21. doi:10.1017/S1092852900016102. PMID 18204410.

[4] Bertolini A (March 2012). “Drug-induced activation of the nervous control of inflammation: a novel possibility for the treatment of hypoxic damage”. European Journal of Pharmacology. 679 (1–3): 1–8. doi:10.1016/j.ejphar.2012.01.004. PMID 22293371.

[5] Kost NV, Sokolov OI, Gabaeva MV, Grivennikov IA, Andreeva LA, Miasoedov NF, Zozulia AA (2001). “Semax and selank inhibit the enkephalin-degrading enzymes from human serum”. Bioorganicheskaia Khimiia (in Russian). 27 (3): 180–183. doi:10.1023/A:1011373002885. PMID 11443939. S2CID 26029820.

[6] Lebedeva IS, Panikratova YR, Sokolov OY, Kupriyanov DA, Rumshiskaya AD, Kost NV, Myasoedov NF (September 2018). “Effects of Semax on the Default Mode Network of the Brain”. Bulletin of Experimental Biology and Medicine. 165 (5): 653–656. doi:10.1007/s10517-018-4234-3. PMID 30225715. S2CID 254292493.

[7] Kaplan AY, Kochetova AG, Nezavibathko VN, Rjasina TV, Ashmarin IP (September 1996). “Synthetic acth analogue semax displays nootropic‐like activity in humans”. Neuroscience Research Communications. 19 (2): 115–123. doi:10.1002/(SICI)1520-6769(199609)19:2<115::AID-NRC171>3.0.CO;2-B.

[8] Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN (2018). “[The efficacy of semax in the tretament of patients at different stages of ischemic stroke]”. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova. 118 (3. Vyp. 2): 61–68. doi:10.17116/jnevro20181183261-68. PMID 29798983.

[9] Kurysheva NI, Shpak AA, Ioĭleva EE, Galanter LI, Nagornova ND, Shubina NI, Shlyshalova NN (2001). “[Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmic tone]”. Vestnik Oftalmologii. 117 (4): 5–8. PMID 11569188.

[10] Ivanikov IO, Brekhova ME, Samonina GE, Myasoedov NF, Ashmarin IP (July 2002). “Therapy of peptic ulcer with semax peptide”. Bulletin of Experimental Biology and Medicine. 134 (1): 73–74. doi:10.1023/A:1020621124776. PMID 12459874. S2CID 23447014.

[11] Korneev EA, Kazakova TB (1999). “Current approaches to the analysis of the effects of stress on metabolic processes in cells of the nervous and immune systems”. Med. Immunology. 1 (1–2): 17–22.

[12] Dolotov OV, Karpenko EA, Inozemtseva LS, Seredenina TS, Levitskaya NG, Rozyczka J, et al. (October 2006). “Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus”. Brain Research. 1117 (1): 54–60. doi:10.1016/j.brainres.2006.07.108. PMID 16996037. S2CID 27592503.

[13] Eremin KO, Kudrin VS, Grivennikov IA, Miasoedov NF, Rayevsky KS (2004). “Effects of Semax on dopaminergic and serotoninergic systems of the brain”. Doklady Biological Sciences. 394 (1–6): 1–3. doi:10.1023/b:dobs.0000017114.24474.40. PMID 15088389. S2CID 12955434.

[14] Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS (December 2005). “Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents”. Neurochemical Research. 30 (12): 1493–1500. doi:10.1007/s11064-005-8826-8. PMID 16362768. S2CID 38202287.

[15] Vilenskiĭ DA, Levitskaia NG, Andreeva LA, Alfeeva LI, Kamenskiĭ AA, Miasoedov NF (June 2007). “[Effects of chronic Semax administration on exploratory activity and emotional reaction in white rats]”. Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova (in Russian). 93 (6): 661–669. PMID 17850024.

 

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


  1. Nataliya Yu. Glazova

Institute of Molecular Genetics, RAS, 2 Akademika Kurchatova square, Moscow 123182, Russia

  1. Glazova

National Research Centre “Kurchatov Institute”, Institute of Molecular Genetics, Moscow, Russian Federation

  1. Levitskaya

Lomonosov Moscow State University, Biological- Human and Animal phisiology, Moscow, Russian Federation

  1. Cristina Satriano

Dipartimento di Scienze Chimiche, Università degli Studi di Catania, Viale A. Doria 6, 95125 Catania, Italy

  1. Valeria Lanza

CNR-Istituto di Biostrutture e Bioimmagini, Via P. Gaifami 18, 95126 Catania, Italy

 


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