CJC1295

February 27, 2019
SKU: 863288-34-0

Phcoker is a professional peptide CJC-1295 GMP manufacturer that provide both forms of CJC-1295 powder and CJC-1295 finished lyophilized powder in vial. The regularly manufacturing specification include CJC-1295 with DAC 5mg, CJC-1295 without DAC 5mg, CJC-1295 with DAC 10mg, CJC-1295 without DAC 10mg. Larger dosage and contract manufacturing service is available.

Monthly production capacity: >1,000,000 vials


Other Name:CJC-1295, CJC-1295 no DAC, CJC-1295 without DAC, CJC-1295 (DAC), CJC 1295 with DAC, CJC-1295 DAC; CJC-1295+DAC, CJC- 1295 Acetate, Mod GRF (1-29), Modified GRF 1-29, DAC:GRF, GHRH derivative;Modified GRF (1-29) with Drug Affinity Complex, CJC-1295 Drug Affinity Complex, CJC-1295 with Drug Affinity Complex Peptide, (DAC) Peptide, GRF (1-29) with Drug Affinity Complex, CJC-1295 DAC Peptide

 

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Raw CJC1295 Without DAC powder (446262-90-4) video

 

Properties


Sequence:Tyr-D-Ala-Asp-Ala-le-Phe- Th-GIn-Ser-Ty-Arg-Lys-Val-Leu-Ala-GIn-Leu-Se-Ala-Arg-Lys-Leu-Leu-GIn-Asp-lle-Leu-Ser-Arg
Molecular Formula:C152H252N44O42
Molecular Weight:3367.954 g/mol
PubChem CID:56841945
CAS Number:446262-90-4
Synonyms:CJC-1295; CJC 1295 with DAC; CJC-1295 DAC; CJC-1295 Acetate; CJC-1295+DAC; CJC-1295 NO DAC; CJC1295 with out DAC;CJC1295 No DAC acetate;CJC-1295 Acetate without DAC

Description


There are two forms of CJC-1295 include CJC-1295 with DAC and CJC-1295 without DAC. One of the key advantages of CJC-1295 is its ability to stimulate the body’s natural production of growth hormone. Research indicates that CJC-1295 can significantly increase growth hormone levels, with some studies reporting elevations of up to 200-1000%. These elevated levels of growth hormone production can persist for several days after administration, contributing to its effectiveness in promoting fat loss, muscle growth, and overall well-being. Also CJC-1295 is considered a highly effective peptide with the potential to address various health concerns associated with aging and hormonal imbalances. Here is the complete guide of CJC-1295 with DAC and without DAC you should know in 2024.

CJC-1295 Structure

CJC-1295 Structure

What Is CJC-1295 Peptide: With DAC And Without DAC

Researchers or people who trying to buy CJC-1295 will find CJC-1295 with and without DAC always appear together. So what is CJC-1295 with DAC or without DAC? CJC-1295, also known as DAC: GRF (Drug Affinity Complex: Growth Hormone-Releasing Factor), is a synthetic peptide derivative of growth hormone-releasing hormone (GHRH). If you search CJC-1295 on google, will find that there are two main forms of CJC-1295 available on the market: CJC-1295 with DAC and CJC-1295 without DAC (also known as Modified GRF 1-29).

What is CJC-1295 with DAC?

This form of CJC-1295 includes DAC (Drug Affinity Complex), which helps to prevent degradation of the peptide over time, thus prolonging its activity. CJC-1295 with DAC is a synthetic GHRH analogue composed of 30 amino acids. It stimulates growth hormone secretion and insulin-like growth factor (IGF-1) levels, leading to increased muscle mass, improved bone density, and other benefits associated with growth hormone. It is known for providing steady increases in HGH and IGF-1 levels without affecting prolactin levels, which can lead to fat loss and increased protein synthesis.

What is CJC-1295 without DAC (Modified GRF 1-29)?

This form of CJC-1295 lacks the DAC component. It is also a synthetic peptide that stimulates growth hormone production. While it doesn’t have the same prolonged activity as CJC-1295 with DAC, it is still effective in promoting growth hormone secretion. It can assist with rapid body fat reduction, faster recovery from strenuous activity, and substantial muscle gain. When used in combination with other peptides like Ipamorelin, it can produce similar increases in growth hormone secretion without certain side effects like increased appetite and cortisol levels.

Both forms of CJC-1295 have their benefits and applications depending on individual needs and preferences. CJC-1295 with DAC may be preferred for its longer-lasting effects, while CJC-1295 without DAC may be chosen for its rapid action and potential synergies when combined with other peptides. It’s essential to source these peptides from reputable manufacturers or sellers, like Phcoker to ensure quality and effectiveness.

CJC-1295: GHRH & DAC

CJC-1295, a synthetic peptide derived from growth hormone-releasing hormone (GHRH), offers enhancements over its precursor Sermorelin by extending its half-life, thus prolonging its effects. GHRH is a hormone produced in the hypothalamus, which stimulates the release of growth hormone (GH) from the pituitary gland in a pulsatile manner. This pulsatile release pattern is crucial for maintaining normal physiological levels of GH in the body.

To further enhance the half-life of CJC-1295, a Drug Affinity Complex (DAC) is added. DAC binds to a blood protein called albumin, effectively increasing the peptide’s half-life to approximately 8 days. This prolonged half-life reduces the frequency of injections required, typically to once or twice a week, compared to shorter-acting peptides like Sermorelin. While the extended half-life of CJC-1295 with DAC offers convenience in administration, maintaining constant blood levels of the peptide can lead to a sustained stimulus for GH release from the pituitary gland. However, this constant stimulation may not mimic the natural pulsatile pattern of GH secretion seen with endogenous GHRH.

The constant stimulation provided by CJC-1295 with DAC can lead to a decrease in the amplitude of GH pulses. This reduced pulse amplitude may result in decreased GH tissue stimulation over time, potentially impacting the effectiveness of the peptide in promoting muscle growth, fat loss, and other desired effects.

In summary, while CJC-1295 with DAC offers the convenience of less frequent dosing and prolonged effects, its constant stimulation of GH release may not perfectly replicate the physiological pulsatile pattern seen with natural GHRH secretion. This consideration should be weighed against its benefits when deciding on its use for therapeutic or performance-enhancing purposes. If you plan to purchase CJC-1295 do further research, this information might be help. But be careful if you are trying to buy CJC-1295 with DAC or without DAC online.

How Does CJC-1295 Work?

CJC-1295 works in the body by stimulating the anterior pituitary gland to release more growth hormone. This peptide, whether with or without DAC, binds to growth hormone-releasing hormone (GHRH) receptors, thereby triggering the secretion of growth hormone peptides by the pituitary gland. Here’s how it works:

Increased Growth Hormone Secretion: CJC-1295 encourages the pituitary gland to release more growth hormone into the bloodstream. Growth hormone plays a crucial role in various physiological processes, including muscle growth, bone density, fat metabolism, and immune function.

Stimulation of IGF-1 Levels: CJC-1295 also increases insulin-like growth factor 1 (IGF-1) levels. IGF-1 is a key mediator of the growth-promoting effects of growth hormone. It contributes to muscle growth, bone density, and other anabolic processes in the body.

Muscle Growth and Protein Synthesis: By stimulating growth hormone secretion and increasing IGF-1 levels, CJC-1295 promotes protein synthesis, leading to muscle growth and increased muscle mass. This can result in improved strength and physical performance.

Bone Density and Collagen Production: Increased levels of growth hormone and IGF-1 support bone health by enhancing bone density and stimulating collagen production. Collagen is essential for maintaining the structural integrity of bones, joints, and connective tissues.

Fat Loss: CJC-1295 aids in fat loss by promoting the breakdown of stored fat through increased metabolism and energy expenditure. This can lead to reductions in body fat and improvements in body composition.

Whether in its DAC or non-DAC form, CJC-1295 offers a range of benefits for individuals seeking to optimize their physical performance, body composition, and overall health. It can be used alone or in combination with other peptides for enhanced results. CJC-1295 is popular among fitness professionals and researchers who want to buy CJC-1295 for scientific research.

What Are Main Benefits Of CJC-1295 Peptide?

Both CJC-1295 with and without DAC offer numerous benefits, some of which overlap and some that may vary slightly. Here are top 8 benefits of CJC-1295 peptide:

Enhanced Muscle Growth

CJC 1295 may stimulate muscle growth by facilitating the breakdown of fat cells, thus providing more energy for muscle development. This can be especially beneficial for individuals aiming to gain muscle while shedding fat.

Cardiovascular System Strengthening and Increased Exercise Capacity

CJC-1295 research indicates that CJC 1295 has shown potential benefits in enhancing cardiovascular health and exercise capacity. Some CJC-1295 comments on reddit share this kinds of CJC-1295 use experience.

Accelerated Recovery from Injuries

Bio-identical hormone replacement therapy can make a significant difference in feeling better and healing from injuries faster. This treatment aids in reducing soreness and accelerating the healing process for short- or long-term musculoskeletal issues.

Boosted Cognitive Abilities

This supplement is engineered to enhance focus, thought clarity, memory recall, and overall cognitive function.

Reduced Fat Mass

Increased muscle mass not only enhances your appearance and self-confidence but also promotes fat burning even while at rest. A strengthened muscle mass elevates your resting metabolic rate, causing more calories to be burned throughout the day.

Stronger Immune System

A robust immune system is crucial for preserving good health and protecting the body from various infections, diseases, and other health conditions.

Enhanced Strength and Endurance

This can be especially advantageous for athletes and those striving to enhance their physical performance. It facilitates the breakdown of fat cells, thereby providing more energy for muscle growth and exercise.

Improved Sleep Quality

It operates by triggering the release of growth hormone from the pituitary gland, which can help regulate sleep patterns and enhance sleep quality. It also boosts melatonin production and reduces stress and anxiety levels.

Overall, CJC-1295 with and without DAC offer a range of benefits for individuals seeking to optimize their physical performance, body composition, and overall health. The choice between the two may depend on factors such as desired duration of action and individual response to treatment. After compare the CJC-1295 price, individuals will find that it is more cost-efficient to buy CJC-1295 online, but it is a challenge to find out the best peptide manufacturers of CJC-1295 powder. Especially researchers who want to make blend of CJC-1295 with other peptides like Ipamorelin, TB 500…etc. Then it require the peptide manufacturers not only provide the peptide powder of CJC-1295, Ipamorelin..etc but provide contract manufacturing service together. Phcoker is one of this kind of peptide GMP manufacturer.

CJC-1295 With DAC vs. CJC-1295 Without DAC

People who in peptide business or seeking CJC-1295 to improve body health may confuse what are the differences between CJC-1295 with DAC and CJC-1295 without DAC. Base on the research results, CJC-1295, whether with or without DAC (Drug Affinity Complex), has demonstrated effectiveness in stimulating the release of growth hormone in the body. The main difference between the two is Half-life:

CJC-1295 without DAC: This variant has a relatively short half-life, lasting approximately 30 minutes. Its half-life closely resembles that of endogenous growth hormone-releasing hormone (GHRH) found naturally in the body.

CJC-1295 with DAC: With the addition of DAC (Drug Affinity Complex), the half-life of CJC-1295 is significantly extended. It can last approximately 6-8 days due to the binding of DAC to serum albumin. This binding protects the peptide from degradation, allowing it to remain active in the body for a much longer duration compared to CJC-1295 without DAC.

These differences in half-life between the two variants impact their dosing frequency and overall efficacy in stimulating growth hormone release. CJC-1295 with DAC requires less frequent dosing due to its prolonged half-life, making it more convenient for users. So if you are interested in buying CJC-1295 but not sure which version is good for you, this information will be help.

CJC-129 Side Effects

Side effects of CJC-1295 are generally considered mild and transient, with most individuals experiencing minimal adverse reactions. However, as with any medication or peptide therapy, there is a possibility of side effects. Here are some potential side effects associated with CJC-1295:

  • Sensitivity at the injection site
  • Headache
  • Diarrhea
  • Vasodilation
  • Nausea
  • Abdominal Pain

Please note that while these side effects are possible, they are not experienced by everyone, and many individuals tolerate CJC-1295 well without any adverse reactions. Additionally, if side effects do occur, they are often mild and resolve on their own without the need for medical intervention. However, if you experience persistent or severe side effects, it’s essential to consult with a healthcare professional for further evaluation and guidance.

CJC-1295 & Ipamorelin

Blend peptide of CJC-1295+Ipamorelin is a unique peptide combination that works synergistically to potentially enhance overall vitality, promote lean muscle growth, and support an optimal sleep cycle. CJC-1295, a growth hormone releasing hormone (GHRH) analog, works in harmony with IPAMORELIN, a selective growth hormone secretagogue, to stimulate the body’s natural production of growth hormone. The combination of these two peptides can lead to a cascade of positive effects, including an improved metabolic rate, increased lean muscle mass, enhanced recovery, and better sleep patterns.

What about Ipamorelin?

Ipamorelin is a peptide hormone utilized to manage various medical conditions. It is a growth hormone-releasing peptide that spurs the body’s natural production of growth hormones. It’s frequently employed to address adult growth hormone deficiencies and aid in weight loss, energy boosting, muscle building, and overall well-being. Ipamorelin also treats conditions such as chronic fatigue syndrome, fibromyalgia, and osteoporosis. It can be administered orally or via injection and is generally well-accepted by patients.

The Synergy between CJC 1295 and Ipamorelin

When Ipamorelin and CJC-1295 are expertly combined, your body produces a stronger and more steady release of HGH. Ipamorelin releases the pulse of HGH, and the CJC-1295 releases and amplifies this pulse.

CJC 1295 and Ipamorelin function together to enhance the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). CJC 1295 promotes GH release, while Ipamorelin provokes the body to release additional GH in response to elevated GH levels in the bloodstream. Together, these two peptides can aid in promoting lean muscle mass and reducing body fat. They can also enhance skin elasticity, bone density, and sleep quality.

CJC-1295 and Ipamorelin are typically combined in therapy because they are known to work well together. CJC-1295 takes anywhere from 1-4 hours to reach peak serum in the blood, while Ipamorelin works much quicker. Ipamorelin is cleared from the body more rapidly as its half-life is about 2 hours. The combination of both peptides ensures a rapid onset with Ipamorelin and lasting effects with CJC-1295.In fact, this is the most used combination of therapeutic peptides prescribed for anti-aging.

So who is a good candidate for CJC 1295+Ipamorelin? CJC-1295 can help individuals over the age of 30 to have more energy, a faster metabolism, and stay in better shape as you age. It’s not a hormone itself, so it is a relatively safe and low-risk option when all things are considered. However, it requires a prescription and is delivered via an injection, so there are some important points to cover regarding the CJC-1295 benefits and side effects trade-offs.

CJC-1295 powder and Ipamorelin powder are the active ingredient of blend peptide of CJC-1295+Ipamorelin, researcher seeking peptides for research purpose will find that it is difficult to find the legal peptide manufacturers can provide CJC-1295 and Ipamorelin at the same time. The legal peptide manufacturers must have the technology, equipements to provide not only the fix specification peptide vials but can provide customization service of blend peptide or special standard. The peptide quality must stand inspection and with reasonable price. Phcoker is a good place to go.

CJC-1295 For Sale | CJC-1295 Supplier

The effects of CJC-1295 with or without DAC have been researched thoroughly. It is beneficial in building muscle, losing body fat, and boosting energy levels. It does all these by facilitating the production of more growth hormone for your body. CJC-1295 with or without DAC is a releasing factor for growth hormone. This substance has potential performance-enhancing effects, it is readily available, and there is reason to believe that it is being used within the bodybuilding community. Researchers interested in experimenting with CJC-1295 will want to ensure that they source this material from a reliable supplier. lf you’re looking to buying CJC-1295 online, it is essential to exercise caution and ensure that you obtain the peptide from a reputable and trustworthy manufacturer. Phcoker.com is a highly reliable manufacturer that offers pharmaceutical grade peptides.

 

Manufacturers/Factory


CJC 1295 is a very new peptide on the market, that is legally selling as a research chemical in the United States, Canada, and the UK as well as the majority of nations on earth, typically sold as lyophilized (freeze-dried) powder in amounts of 2mg/5mg/10mg per vial, without fear of legal repercussion.

Nowadays, many bodybuilder alike to buy CJC-1295 with or without DAC for sale online, to promote lean muscle growth, reduces fat, aids recovery. Or, using the therapy with Peptide CJC-1295 with DAC & CJC-1295 without DAC. Suggest each users should make an informed decision before buying Peptide CJC-1295 with DAC & CJC-1295 without DAC to avoid the risk of potential side effects, health and safety are always prioritize for all people, keep informed about the latest research developments on peptide CJC1295.

As the best CJC-1295 peptide manufacturer, Phcoker is not only supply the peptide CJC-1295 in powder form but provide the customized standard easy use vial form.

You can buy the best price CJC-1295 and best quality peptide from this professional peptide manufacturer.

 

Where to buy


Would you like to buy the best CJC-1295 peptide from the best CJC-1295 suppliers in the market? You have come at the right place!

Phcoker as a peptide factory, is the best place where you can buy CJC-1295 in compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy CJC-1295, you may curious:

What Are The Advantages If Buy CJC-1295 From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of CJC-1295 Online?

  • Visit professional CJC-1295 supplier Phcoker.com, choose the CJC-1295 you want to buy.
  • Leave your contact and message on Phcoker.com website, then submit to Phcoker.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy CJC-1295.

Does Phcoker.com Support The Free Sample Of CJC-1295 Powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.

Can I Appoint The CJC-1295 Colour When Buy CJC-1295?

YES! Phcoker as peptide manufacturer, provide colour customization of CJC-1295, easy to help you to build your CJC-1295 peptide brand.

Can I Appoint The Products Standard When Buy CJC-1295 From Phcoker.com?

YES! As one of the best CJC-1295 manufacturer, Phcoker not only provide the standard specification of CJC-1295 in 5mg, 10mg, but support standard customization. Provide the best support to build your own CJC-1295 brand.

Can I Buy CJC-1295 In Pure Powder Form From Phcoker.com?

YES! CJC-1295 powder is the base that use for CJC-1295 lyophilized powder manufacture. Phcoker provide CJC-1295 in both of pure powder form and semi-finished vial form.

Can I Buy Discount CJC-1295 Powder From Phcoker.com?

YES! Our factory produce high quality CJC-1295 powder in term and keep CJC-1295 powder in stock. You can buy high quality CJC-1295 powder in bulk. During promotion sale, you can buy CJC-1295 peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk CJC-1295 price for you in time.

FAQ


Why combin CJC-1295 and Ipamorelin?

CJC-1295 and Ipamorelin are combined in therapy because they are known to work very well together. Generally, when combined, we see a 3-5 fold increase in growth hormone release over ipamorelin alone. This will increase the benefits of your peptide therapy over using a single peptide alone.

What can I expect to see results?

While patients will notice some significant changes in the body after the first month, the full benefits are usually fully noticed after three to six months of therapy.

How long should you take CJC 1295?

The duration for which CJC 1295 should be taken depends on numerous factors, including the individual’s overall health status, the type of prescription used, and the desired outcomes. It is best to consult your Elite Anti Aging and Wellness medical provider about the optimal duration for taking CJC 1295 to maximize benefits while minimizing potential side effects. Many individuals use CJC 1295 for short-term testosterone replacement therapy, but some may choose longer treatment courses depending on their needs and circumstances.

How safe is CJC-1295?

Most importantly, studies have concluded that CJC-1295 is generally safe for most people and has shown increased growth hormone levels when taken. These studies have shown promising results, with participants experiencing increased GH levels, improved body composition, and other positive outcomes.

Does CJC-1295 really work?

CJC-1295 is an incredibly effective peptide which works by stimulating the release of your own body’s growth hormones (which drop quickly after the age of 30). Research has shown that CJC-1295 can increase growth hormone levels by 200-1000% and the elevated growth hormone production continued for up to 6 days.

How does CJC-1295 make you feel?

Ipamorelin CJC 1295 is a safe and effective peptide with very few side effects. The most common side effects are mild and include headaches, flushing, and nausea. These side effects are typically only experienced if you take high doses and will go away on their own.

What is the difference between CJC-1295 and CJC-1295 DAC?

The biggest difference between CJC DAC and CJC no DAC is that CJC with DAC has added an extra corpuscle to CJC without DAC called “Drug Affinity Complex”. And extend CJC 1295 half life from about 30 minutes to about 6 to 8 days.

Can you take CJC-1295 long term?

One study found that long-term use of CJC-1295/Ipamorelin was generally considered safe and well tolerated for adults. However, remember that every patient will react differently. Speak with your doctor about safety concerns or potential interactions with medications you are taking before using this treatment.

When should CJC 1295 Ipamorelin be taken?

It is recommended to be taken at night to maximize the body’s natural cycle of growth hormone. As a result, it stimulates the pituitary gland during REM sleep.

Why should CJC 1295 Ipamorelin be taken together?

CJC 1295 Ipamorelin should be taken together in order to maximize the amount of growth being released into your body. This creates a safe and therapeutic anti-aging benefit. Some would even call it the fountain of youth!

Referenced Citations


[1]Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. Epub 2005 Dec 13

[2]Sackmann-Sala L, Ding J, Frohman LA, Kopchick JJ. Activation of the GH/IGF-1 axis by CJC-1295, a long-acting GHRH analog, results in serum protein profile changes in normal adult subjects. Growth Horm IGF Res. 2009 Dec;19(6):471-7. doi: 10.1016/j.ghir.2009.03.001. Epub 2009 Apr 21

[3]Jump up to:a b c d e f Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA (March 2006). “Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults”. The Journal of Clinical Endocrinology and Metabolism. 91 (3): 799–805. doi:10.1210/jc.2005-1536. PMID 16352683

[4]Jetté L, Léger R, Thibaudeau K, Benquet C, Robitaille M, Pellerin I, et al. (July 2005). “Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog”. Endocrinology. 146 (7): 3052–8. doi:10.1210/en.2004-1286. PMID 15817669

[5]Jump up to:a b c Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R (December 2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse. American Journal of Physiology. Endocrinology and Metabolism. 291 (6): E1290-4. doi:10.1152/ajpendo.00201.2006. PMID 16822960

[6]Ionescu M, Frohman LA (December 2006). “Pulsatile secretion of growth hormone (GH) persists during continuous stimulation by CJC-1295, a long-acting GH-releasing hormone analog”. The Journal of Clinical Endocrinology and Metabolism. 91 (12): 4792–7. doi:10.1210/jc.2006-1702. PMID 17018654

[7]“Current Research Findings Regarding CJC-1295”. Neo Scientific. 2 June 2015. Archived from the original on 7 April 2019. Retrieved 3 August 2015. The reason why CJC1295 possesses the ability to lengthen the half-life within the active agent has to do with the scientific process known as bioconjugation. This technology, which is relatively new in nature, is defined by its ability to take a reactive group and bond it to a peptide (Aslam and Dent). This attachment causes a reaction with a nucleophilic unit; a typically partially molecule that is found within the bloodstream of an animal test subject. This reaction in turn causes a more stable bond to occur. This specific peptide has an especially high attraction to albumin, a globular protein that is soluble in water. This affinity prohibits natural degradation, which in turn increases the peptide’s half-life (Hermanson). Additionally, clinical research performed on animal test subjects has thus far shown that there have been no signs of DPP-IV degradation present when CJC-1295 was introduced (Gonzalez, US Peptide Articles)

[8]Henninge J, Pepaj M, Hullstein I, Hemmersbach P (2010). “Identification of CJC-1295, a growth-hormone-releasing peptide, in an unknown pharmaceutical preparation”. Drug Testing and Analysis. 2 (11–12): 647–50. doi:10.1002/dta.233. PMID 21204297

[9]Alba, M, Fintini, D., Sagazio, A., Lawrence, B., Castaigne, J. P., Frohman, L. A., & Salvatori,R. (2006). Once-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.American Journal of Physiology-Endocrinology and Metabolism, 291(6), E1290-E1294

[10]Van Hout, M. C., & Hearne, E. (2016). Netnography of female use of the synthetic growth hormone CJC- 1295: pulses and potions. Substance Use & Misuse, 51(), 73-84

[11]National Center for Biotechnology Information. “PubChem Compound Summary for CID 91976842, CJC1295 Without DAC” PubChem

[12]Timms M, Ganio K, Steel R.”A method for confirming CJC-1295 abuse in equine plasma samples by LC-MS/MS”Drug Test Anal. 2019 Aug;11(8):1248-1257. doi: 10.1002/dta.2599. Epub 2019 May 8.PMID: 30938069

[13]Kwok WH, Ho EN, Lau MY, Leung GN, Wong AS, Wan TS.” Doping control analysis of seven bioactive peptides in horse plasma by liquid chromatography-mass spectrometry”Anal Bioanal Chem. 2013 Mar;405(8):2595-606. doi: 10.1007/s00216-012-6697-9. Epub 2013 Jan 15.PMID: 23318763

[14]Memdouh S, Gavrilović I, Ng K, Cowan D, Abbate V.”Advances in the detection of growth hormone releasing hormone synthetic analogs” Drug Test Anal. 2021 Nov;13(11-12):1871-1887. doi: 10.1002/dta.3183. Epub 2021 Nov 7.PMID: 34665524

[15]Pineau T, Schopfer A, Grossrieder L”The study of doping market: How to produce intelligence from Internet forums”Forensic Sci Int. 2016 Nov;268:103-115. doi: 10.1016/j.forsciint.2016.09.017. Epub 2016 Sep 27. PMID: 27710891

 

Author of this article:

Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.


 

Scientific Journal paper Author:


1.Nicolas Fabresse

Pharmacologie/toxicologie, laboratoire MassSpecLab, université Versailles-Saint-Quentin-en-Yvelines, Inserm U-1173, CHU Garches, 71180 Montigny-le-Bretonneux, France

2.Lucila Sackmann-Sala

Department of Biological Sciences, Ohio University, Athens, Ohio 45701, United States

3.Jean-Claude Alvarez

Laboratoire de pharmacologie et de toxicologie, Inserm U-1173, université Versailles-Saint-Quentin-en-Yvelines, CHU Raymond-Poincaré, AP–HP, 104, boulevard Raymond-Poincaré, 92380 Garches, France

 

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