1. What is Semax Peptide?
  2. Semax Application
  3. Semax Benefits
  4. How Does Semax Work?
  5. How should I use Semax?
  6. Is there any side effects when you use Semax?
  7. Should you use a Semax stack when using?
  8. What are the differences between Semax vs Selank?
  9. Where can I get Semax online?

Semax was developed in the 1980s and 90s, then later approved in Russia for treatment of stroke victims, brain damage and cognitive degeneration. The Semax peptide has been subjected to various human studies in Russia, and it has proved to possess cognitive enhancing properties.

On the other hand, there is also enough documented medical findings on how the drug can also help in reducing anxiety as well as improve the user’s mood. Semax is used as a standard nootropic, but it also has additional uses such as in enhancing brain health and in boosting the immune system among other functions. Semax benefits can only be felt when the drug is taken correctly. However, make sure you get usage guidance from your doctor for better results and experience.

1. What is Semax Peptide? Phcoker

Semax is a peptide medication that was developed in Russia in the 1980s to help in the treatment and control of disorders such as stroke. Today, Semax is listed in the Russian list of essential drugs after proving its effectiveness in treating different health conditions.

Doctors also prescribe Semax as a nootropic drug after the realization that it can also play a crucial role in improving memory performance and reduce stress. Although Russia and Ukraine have approved the usage of this drug, other countries such as the United States of America are yet to accept it despite proving to be vital in the treatment of different health conditions. However, that doesn’t block you from using peptide Semax .

Apart from the standard Semax , there also two variations available on the market, but they almost work in the same way. They include Na-Semax-Amidate and N-Acetyl. Currently, there is no extensive study that has been conducted or documented about the two Semax versions. However, from the Semax reviews, some users report that Na-Semax-Amidate is potent for enhancing focus while N-Acetyl Semax is more energizing. The Semax results might vary from one individual to another, depending on how the body responds to the dosage. You are also free to try any of the Semax versions but make sure you involve your doctor in the whole dosage process and you purchase high quality peptide semax from regular manufacturer such as phcoker.

The Semax is for sale on various online and physical stores around you where you can make your order anytime. And you will get good price if you buy semax wholesale. However, not every drug seller supplies quality products, and it is always a good idea to study the Semax suppliers before making your order. Understand how the store operates and how long it will take before you get your Semax.

It is also advisable to go for a medical checkup before you start taking this drug. Semax is a prescription drug, and therefore, your doctor should be the right person to set the correct dosage for you after examining your condition. The treatment process also needs to be monitored by a health professional for better results.

Upon buying Semax, store it away from children reach and in a fridge since it can degrade just like other peptides. For better Semax experience, ensure you adhere to all dosage instructions. Never adjust the dosage without informing your doctor.

2. Semax Application Phcoker

As mentioned earlier, Semax peptide has been essential in the medical world, especially in the treatment of different conditions. In Russia, the drug was approved after the realization that it can help in controlling circulation disorders like stroke. However, Semax studies conducted over the years have also revealed other diseases that the drug can successfully treat.

Different countries or doctors use Semax to treat various health conditions such as anxiety. Semax is applied intranasally, but only the drops differ depending on the health condition under treatment. There is also the injectable Semax form which should only be administered by a health professional. Always remember to store the drug in a refrigerator.

3.How Does Semax Work? Phcoker

Semax is a synthetic peptide derived from a naturally occurring substance called adrenocorticotropic hormone (ACTH). It is primarily used as a nootropic, which means it is believed to enhance cognitive functions such as memory, focus, and learning ability.

The exact mechanism of action of Semax is not fully understood, but it is thought to work through multiple pathways in the brain. Here are a few proposed mechanisms:

(1)Neuroprotective effects

Semax has been shown to have neuroprotective properties, which means it may help protect brain cells from damage and improve their survival. It has been found to inhibit the production of harmful substances like free radicals and inflammatory cytokines, reducing oxidative stress and inflammation in the brain.

(2)Modulation of neurotransmitters

Semax is believed to affect the levels and activities of various neurotransmitters in the brain, including dopamine, serotonin, and norepinephrine. These neurotransmitters play key roles in regulating mood, motivation, and cognitive functions. By modulating their release and uptake, Semax may enhance synaptic transmission and improve neuronal communication.

(3)Increased brain-derived neurotrophic factor (BDNF)

BDNF is a protein that promotes the growth and maintenance of neurons in the brain. Semax has been shown to increase the production and release of BDNF, which may contribute to its neuroprotective and cognitive-enhancing effects.

(4)Enhanced blood flow and oxygen supply

Semax has been found to improve cerebral blood flow and increase oxygen availability to the brain. This improved blood circulation may enhance energy metabolism and support optimal brain function.

It’s important to note that while Semax has shown promising effects in preclinical and some clinical studies, more research is needed to fully understand its mechanisms of action and determine its effectiveness and safety in various conditions. If you’re considering using Semax, it’s advisable to consult with a healthcare professional familiar with the compound to discuss potential risks and benefits.

4. How Does Semax Work? Phcoker

Semax has used in nootropic field and it has proven to be very useful in helping your brain in different ways. Since Semax was approved for pharmaceutical use in 2011, the drug has been used to treat various health conditions. When taken correctly, the drug can deliver the following benefits;

Eases ADHD Symptoms

Semax possesses effects that help in the treatment of ADHD symptoms. Medical studies show that Semax improves memory and increase neurotransmitters, which are usually low for individuals who have ADHD. Currently, Semax is an alternative treatment for children with ADHD in Russia. ADHD is a neurodevelopmental condition which can disturb dopamine levels, and Semax has proven to be instrumental in addressing the problem.

How Does Semax Work?

Prevents Oxidative Damage

Originally, Semax was designed to help heart attacks and stroke victims. Over the years, the drug has been useful in controlling and preventing oxidative degeneration. Oxidative damage happens due to oxidative stress, which is an imbalance of free radicals and antioxidants in your body. The mild oxidative stress resulting from physical exercise is also helpful in regulating tissue growth as it triggers the production of antioxidant.

However, prolonged oxidation stress caused by diseases or conditions such as stroke results in proteins damage, body cells, and DNA. According to Semax studies, the inclusion of the drug in stroke medication has had a significant impact on restoring the rate of damaged neurological functions. These effect helps stroke victims to avoid motor disorders, cerebral and focal.

Helps to reduce stress

Stress can be as a result of many conditions such as sickness, lack of sleep, or physical injury. Human bodies are different, and therefore, they also react to stress differently. For instance, some people’s body responds to stress by increasing liver enzymes production. Studies have shown that Semax for depression reduced liver enzyme production when administered to animals during medical research. On the other hand, health professionals have stated that Semax normalizes body changes that result from stress caused by physical injury.

Enhances blood circulation

The most dangerous risk factor for stroke is lack of or weak blood circulation to the brain, a condition that is known as cerebrovascular insufficiency. The use of Semax in stroke treatment has posted positive results by improving blood circulation to the brain. This drug also has an impact in preventing your heart from growing when you have high blood pressure. In turn, this protects you from developing any heart failure, even if you are under heat attack.

Increases the Brain-Derived Neurotropic Factor (BDNF)

BDNF plays a vital role in neurons survival, cognitive development, and in the plasticity of synapses. The BDNF low levels can lead to or even worsen depression and anxiety. As much as it exposes you to minimal side effects, Semax has also proved to be an excellent BDFN enhancer and an antidepressant. The drug can improve BDNF production buy up to 800%.

Through increasing BDNF production, Semax helps in controlling and easing anxiety and depression. Antidepressant medical studies have proved how high BDNF levels have a positive impact in alleviating depression. Semax stimulates limbic system receptors to produce adenosine, dopamine, serotonin, and histamine, which helps in easing symptoms associated with ADH, anxiety, and depression. The increase of all these neurotransmitters boosts motivation, thus enhancing focus and productivity.

Semax can help in relieving pains

When you are experiencing some pains, your brain will frequently release neurotransmitters known as enkephalins, which dull the pain sensation. It also changes the pain perception by minimizing the panic feelings that occur when you are in pain.

Enkephalins can only regulate body pain for some time; therefore, Semax helps by preventing its breakdown as well as increasing its production. Thus, helping to reduce pain intensity in your body for longer and that makes Semax a potent pain reliever.

Semax Improves Memory Retention

Neurotransmitters like enkephalins have an impact on perception, and when increased, they play a vital role in creating memories and regulating mood. Medical research conducted in Russia, on workers with good health, Semax enhanced their attention and memory retention. Scientific studies suggest that the promotion of proper blood circulation and oxidative protection in a human brain enhances memory.

The increase in BDNF levels in the hippocampus is also said to be vital in improving memory because the hippocampus is the brain’s center for emotion and memory. On the other hand, BDNF also helps in enhancing recall, memory, and ability to learn and retain new information. BDNF stimulates the production of Neurogenesis, which is a generation of nerve pathways in the brain that aid in improving brain function and processing.

How Does Semax Work?

5. How should I use Semax? Phcoker

Semax dosage depends on the health condition under treatment, and the dose should be set by a medical professional. The recommended Semax dosage ranges from 300mcg to 600mcg. However, the new users are advised to start with low dosages, which can be adjusted later by the doctor after monitoring your body’s response to the drug.

With drugs, no one should risk taking high dosage for a start since it might lead to severe side effects. To avoid any risk associated with this drug such as Semax hair loss it’s always a good idea to go for a medical examination before taking this peptide for whatever reason.

Semax is commonly available as a nasal spray and is administered intranasally, and you should only take 2 or 3 little drops into each nostril two or three times per day for the cycle set by your doctor. Some conditions such as when taking Semax for the recovery period after treatment, you should take 4 drops to each nasal, six times per day. For Post narcosis memory or attention disorder, the recommended dosage is 3 drops in each nasal three time a day. Semax for depression 2 to 3 drops to each nasal, three times a day is the recommended dose.

Ideally, the Semax injection dosage will depend on the health condition under treatment. However, stick to the doctor’s dosage instructions as the manufacturer recommendation might not work for you. Some users might get quality results after taking low dosages, while others will have to take higher doses to get the desired effects. That is a normal phenomenon since human body strengths differ from one individual to another.a) Semax Injection

Semax can also be administered through an injection, which can be the best dosage for users who are uncomfortable with the nasal spray. Both Semax Nasal spray and subcutaneous injection forms are used for similar purposes only that they differ in their application.

Your doctor might request you to choose one dosage form between the two. Usually, injection dosages are stronger compared to any other Semax form. So you will not have to take the injections regularly like the nasal drops which you must take two or three times per day or even more.

buTop 7 Benefits of Semax You Should Know Before Use

b) Semax injection dosage

As much as Semax injection provides an excellent alternative to the nasal dosage, always make sure you get the injections from your doctor. Different conditions call for different dosage. A medical examination will also guide your medic in setting the right dosage for you. The Semax dosage should be between 300mcg to 600mcg.

The dosage can be reduced further depending on how your body responds to the first Semax injection dosage or even adjusted upwards. In case you are not sure about injecting yourself, you can request your doctor to train you or schedule for regular visits to take your dosage. Don’t risk injecting yourself if you don’t know how to do it as it can lead to other medical complications.

6. Is there any side effects when you use Semax? Phcoker

Semax is not a popular drug in the United States of America because the FDA has not approved it since it was developed. However, there has been a lot of research and trials done in Russia which prove the Semax efficacy.

The drug has featured in various medical experiments on humans, and almost all tests report no serious Semax side effects. That makes Semax one of the safest nootropic on the market today. In Russia, Semax has been useful in the treatment of various medical conditions such as migraine headaches, stroke, and cognitive disorders.

The most surprising aspect of this drug is that it has high potency, but even when taken in high dosages, may not be toxic to your body. However, Semax has not been used by many people outside Russia until recently when Ukraine has approved its use. Your body tolerance level can also determine, the Semax results that you will get after taking the drug.

Some minor Semax side effects have been reported by some Semax users such as dry mouth, increased sweating, nausea, and drowsiness. Semax and hair loss is also another common side effect reported by some Semax users. All these side effects are rarely reported, but medics can control them. Human bodies are different, and in case you experience any other severe Semax side effects inform your doctor immediately for assistance.

7. Should you use a Semax stack when using?  aasraw

Typically, Semax delivers quality results when used alone for the treatment of various health conditions. However, just like many nootropics, you can attain the Semax maximum efficacy when you take it in a stack. Kratom, which is also another well-known nootropic on the market used as a sedative and stimulant, makes an excellent stacking with Semax. As much as Semax can relax and energize the user, taking it with Kratom enhances the desired effects.

It is advisable to consider stacking Semax with Phenylpiracetam due to the energy crush that might be caused by taking this drug with a stimulant. Phenylpiracetam is an excellent cognition-boosting nootropic but acts slowly. On the other hand, many users have reported getting significant Semax benefits when they combine it with other stimulants such as curcumin which allows a prolonged steady flow of energy in the body.

For the Semax users who have experienced increased anxiety should consider combining the drug with Ashwagandha, which serves as a relaxant. Ashwagandha is a potent Nootropic which can help in cooling down the Semax potential anxiety spikes.

All in all, Semax can be stacked with different nootropics/peptides to maximize the expected results. However, if you are not sure about which nootropic/peptide to combine with Semax, always consult with your doctor. Wrong stacking is very risky for your health as it can lead to severe side effects. And to avoid unnecessary side effects, please always buy semax from a reliable manufacturer such as phcoker.

8. What are the differences between Semax vs Selank? Phcoker

Semax and Selank are all nootropics developed in Russia, and sometimes they are used to treat similar health conditions such as adjustment disorders and anxiety. For maximum results, the two drugs can also be used together. Selank is an anxiolytic peptide which minimizes the severe effects of stress and is known for not causing any serious side effects just like Semax.

Structurally, Selank is derived from the endogenous tetrapeptide Tuftsin, which plays a vital role in your immune system. To prolong Selank effects and slow down the peptide breakdown, the manufacturers included Glyproline in its structure.

The mode of Selank action in the brain is also very unique; it serves as an anti-anxiety drug with an anti-asthenic and antidepressant supplement which enhance cognitive and memory activities. Therefore, Semax vs Selank can be debatable, but both drugs are excellent cognitive enhancers. Selank is administered intranasally, and the dosage might differ depending on the condition under medication.

The two drugs differ more in how they are used to treat different health problems. Semax is more potent in improving cognition and depression, while Selank delivers quality results when used as an anti-anxiety. However, both drugs increase BDNF levels, and sometimes they can be stacked together, as mentioned earlier. For more information about Semax vs Selank consult with a medical professional.

9. Where can I get Semax online? Phcoker

If you are in Russia, Semax is sold under a doctor’s prescription. However, in the United States of America, the drug is less regulated, although the FDA has not approved it. That means you can access it via the online nootropic stores or regular raw material manufacturer. There are many peptide semax for sale online. We always advise Semax users to be very careful and take their time to get the best peptide semax from a reliable supplier. Do your research, check the customer reviews to understand how the Semax operates before making your order. Remember, not every Semax supplier you find on the market can be trusted.

The good news is that phcoker is one of the leading Semax manufacturers in the region. You can make your order on our website and be sure to receive your product within the shortest time possible. Semax raw powder and finished vials are all available.

Author of this article:
Dr. Stans Bastiras graduated from University of California, San Diego

Author of this article:

  1. Antonio Magrì

Istituto di Biostrutture e Bioimmagini, Consiglio Nazionale delle Ricerche (CNR), Via P. Gaifami 18, 95126 Catania, Italy

  1. Y. Agapova

The Laboratory of Molecular Genetics of Hereditary Diseases, Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow 123182, Russia

  1. V. Agniullin

The Laboratory of Isotope-Labeled Physiologically Active Compounds, Department of Chemistry of Physiologically Active Compounds, Institute of Molecular Genetics RAS, 2 Kurchatov Sq., Moscow 123182, Russia

  1. N. Sollertinskaja

I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry of RAS, Russia

  1. N. Potaman

In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Phcoker has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.


[1] Dolotov, O. V., Eremin, K. O., Andreeva, L. A., Novosadova, E. V., Raevskii, K. S., Myasoedov, N. F., & Grivennikov, I. A. (2015). Semax prevents the death of tyrosine hydroxylase-positive neurons in a mixed neuroglial cell culture derived from the embryonic rat mesencephalon in a model of 6-hydroxydopamine-induced neurotoxicity. Neurochemical Journal, 9(4), 295-298.

[2] Koroleva, S. V., & Myasoedov, N. F. (2018). Semax as a Universal Drug for Therapy and Research. Biology Bulletin, 45(6), 589-600.

[3] Manchenko, D. M., Glazova, N., Levitskaia, N. G., Andreeva, L. A., Kamenskiĭ, A. A., & Miasoedov, N. F. (2010). Nootropic and analgesic effects of Semax following different routes of administration. Rossiiskii fiziologicheskii zhurnal imeni IM Sechenova, 96(10), 1014-1023.

[4]Malyshev, A. V., Razumkina, E. V., Dubynin, V. A., & Myasoedov, N. F. (2013, May). Semax corrects brain dysfunction caused by prenatal introduction of valproic acid. In Doklady Biological Sciences (Vol. 450, No. 1, p. 126). Springer Science & Business Media.

[5]Glazova NY, Manchenko DM, Volodina MA, Merchieva SA, Andreeva LA, Kudrin VS, Myasoedov NF, Levitskaya NG.”Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.”Neuropeptides. 2021 Apr;86:102114. doi: 10.1016/j.npep.2020.102114. Epub 2020 Dec 28.PMID: 33418449

[6]Dolotov OV, Karpenko EA, Seredenina TS, Inozemtseva LS, Levitskaya NG, Zolotarev YA, Kamensky AA, Grivennikov IA, Engele J, Myasoedov NF.”Semax, an analogue of adrenocorticotropin (4-10), binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain.”J Neurochem. 2006 Apr;97 Suppl 1:82-6. doi: 10.1111/j.1471-4159.2006.03658.x.PMID: 16635254

[7]Medvedeva EV, Dmitrieva VG, Limborska SA, Myasoedov NF, Dergunova LV.”Semax, an analog of ACTH(4-7), regulates expression of immune response genes during ischemic brain injury in rats.”Mol Genet Genomics. 2017 Jun;292(3):635-653. doi: 10.1007/s00438-017-1297-1. Epub 2017 Mar 2.PMID: 28255762

[8]Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F.”Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models.”ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. doi: 10.1021/acschemneuro.1c00707. Epub 2022 Jan 26.PMID: 35080861

[9]Medvedeva EV, Dmitrieva VG, Povarova OV, Limborska SA, Skvortsova VI, Myasoedov NF, Dergunova LV.”The peptide semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia: genome-wide transcriptional analysis.”BMC Genomics. 2014 Mar 24;15:228. doi: 10.1186/1471-2164-15-228.PMID: 24661604

[10]Gusev EI, Martynov MY, Kostenko EV, Petrova LV, Bobyreva SN.”[The efficacy of semax in the tretament of patients at different stages of ischemic stroke].”Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(3. Vyp. 2):61-68. doi: 10.17116/jnevro20181183261-68.PMID: 29798983

[11]Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF.”Functional Connectomic Approach to Studying Selank and Semax Effects.”Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27.PMID: 32342318

[12]Inozemtsev AN, Bokieva SB, Karpukhina OV, Gumargalieva KZ, Kamensky AA, Myasoedov NF.”Semax prevents learning and memory inhibition by heavy metals.”Dokl Biol Sci. 2016 May;468(1):112-4. doi: 10.1134/S0012496616030066. Epub 2016 Jul 14.PMID: 27411820

[13]Tsai SJ.”Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome.”Med Hypotheses. 2007;68(5):1144-6. doi: 10.1016/j.mehy.2006.07.017. Epub 2006 Sep 25.PMID: 16996699

[14]Malyshev AV, Razumkina EV, Dubynin VA, Myasoedov NF.”Semax corrects brain dysfunction caused by prenatal introduction of valproic acid.”Dokl Biol Sci. 2013 May;450:126-9. doi: 10.1134/S0012496613030046. Epub 2013 Jul 3.PMID: 23821048

[15]Eremin KO, Kudrin VS, Saransaari P, Oja SS, Grivennikov IA, Myasoedov NF, Rayevsky KS.”Semax, an ACTH(4-10) analogue with nootropic properties, activates dopaminergic and serotoninergic brain systems in rodents.”Neurochem Res. 2005 Dec;30(12):1493-500. doi: 10.1007/s11064-005-8826-8.PMID: 16362768

[16]Shevchenko KV, Nagaev IY, Andreeva LA, Shevchenko VP, Myasoedov NF.”Stability of Semax acetyl to proteolysis in various biological media.”Dokl Biol Sci. 2013 Mar;449:110-2. doi: 10.1134/S0012496613020166. Epub 2013 May 8.PMID: 23652441