Raw Pterostilbene powder (537-42-8) video
Raw Pterostilbene powder (537-42-8)
Raw Pterostilbene powder a naturally-derived stilbenoid structurally related to resveratrol, with potential antioxidant, anti-inflammatory, pro-apoptotic, antineoplastic and cytoprotective activities. Upon administration, Raw Pterostilbene powder exerts its anti-oxidant activity by scavenging reactive oxygen species (ROS), thereby preventing oxidative stress and ROS-induced cell damage. It may also activate the nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated pathway and increase the expression of various antioxidant enzymes, such as superoxide dismutase (SOD). In addition, Raw Pterostilbene powder is able to inhibit inflammation by reducing the expression of various inflammatory mediators, such as interleukin (IL) 1beta, tumor necrosis factor alpha (TNF-a), inducible nitric oxide synthase (iNOS), cyclooxygenases (COX), and nuclear factor kappa B (NF-kB). It also inhibits or prevents the activation of many signaling pathways involved in carcinogenesis, and increases expression of various tumor suppressor genes while decreasing expression of certain tumor promoting genes. It also directly induces apoptosis in tumor cells.
Raw Pterostilbene powder (537-42-8) Specifications
|Product Name||Raw Pterostilbene powder|
|Chemical Name||Raw Pterostilbene powder;
4-(3,5-Dimethoxystyryl)phenol; (E)-4-(3,5-dimethoxystyryl)phenol; 3′,5′-Dimethoxy-4-stilbenol
|Brand Name||No data for available|
|Drug Class||No data for available|
|Molecular Weight||256.301 g/mol|
|Monoisotopic Mass||256.11 g/mol|
|Exact Mass||256.11 g/mol|
|Biological Half-Life||No data for available|
|Solubility||No data for available|
|Storage Temperature||Store at room temperature|
|Application||A naturally-derived stilbenoid structurally related to resveratrol|
Raw Pterostilbene powder (537-42-8) Description
Pterostilbene is a methylated stilbene molecule with structural similarity to resveratrol, the only difference being two methoxy groups on the pterostilbene molecule that replace hydroxy groups on the resveratrol molecule. While most of the actions of the two are comparable, pterostilbene appears to be much more well absorbed following oral ingestion and may be a more potent antioxidant and anticancer molecule.
Only one study has evaluated pterostilbene powder in humans. It found an increase in LDL-cholesterol and a trend towards lower HDL levels in people with high cholesterol levels who took 100 or 250 mg per day. It was unclear if the lower dose led to a reduction in blood pressure, but the reduction in the group who took the higher dose was potent.
Pterostilbene powder (537-42-8) Mechanism of Action
Pterostilbene fights oxidative stress by rebalancing antioxidant enzymes. It increases superoxide dismutase 1 (SOD1) and peroxiredoxin-4 (PRDX4), which bind to reactive oxygen species. Researchers have observed this effect in human eye cells, suggesting that pterostilbene may protect from oxidative damage. Beside, Pterostilbene does also activate a SIRT1 signaling pathway that protects against cellular damage. This pathway increases the expression of p53, a protein that protects the DNA and prevents mutations that could lead to cancer.
Aolthough SIRT1 may protect against some of the degeneration and damage that takes place as we grow old. However, pterostilbene is not a magic pill against aging.
Multiple studies have demonstrated that pterostilbene decreases inflammation regulated by tumor necrosis factor-alpha (TNF-alpha). Oxidative stress causes inflammation; pterostilbene may block TNF-alpha and interleukin-1b (IL-1b) by reducing reactive oxygen species.
Pterostilbene also prevents stress within a part of the cellular machinery called the endoplasmic reticulum, or ER. In one study, when cells from the lining of blood vessels were exposed to pterostilbene, their ER did not respond to inflammatory signals, and they did not become inflamed.
Pterostilbene has a huge range of potential anti-cancer mechanisms. It may protect healthy cells and selectively damage cancerous cells. In glioma (brain or spinal cancer) cells, pterostilbene decreased Bcl-2 and increased Bax; these changes increase cell “suicide” signals and cause glioma cells to die off.
Pterostilbene appears to selectively target the hippocampus region in the brain. There, it increases brain-derived neurotrophic factor (BDNF), mitogen-activated protein kinases (MAPK), and cAMP response element binding protein (CREB). These three proteins help neurons grow, multiply, and respond to their surroundings. SNRI antidepressants often target these pathways as well. Also in the hippocampus, pterostilbene increases a protein called Nrf2, which in turn increases the expression of antioxidant proteins.
The monoamine oxidases, MAOs, are enzymes that break down neurotransmitters in the brain. One of these enzymes, MAO-B, selectively breaks down dopamine; as a result, drugs that block MAO-B increase dopamine in the brain. According to a recent discovery, pterostilbene inhibits MAO-B activity and, thus, increases available dopamine.
Pterostilbene powder may prevent Alzheimer’s disease by protecting the brain from beta-amyloid (Aβ). The precise pathway is unknown, but it appears to involve PI3K and Akt, two proteins that support memory, learning, and neuron growth.
Use of Pterostilbene powder (537-42-8)
- Alzheimer’s disease
- High blood pressure
- High cholesterol
- Insulin resistance
Recommended Pterostilbene powder (537-42-8) Dosage
In humans, doses of up to 250 mg per day are considered safe. Higher doses such as these have been demonstrated to reduce blood pressure and promote some weight loss. LDL cholesterol levels increased significantly as well, but this effect was completely negated with the addition of grape seed extract.
In animals, much lower doses have had cognitive effects. Between 1 and 2 mg per kg of body weight per day reduced anxiety in mice. Using a typical dose-equivalent calculation between mice and humans, the starting dose (in mg) for a person would be their weight in kg divided by 12.3. That works out to:
4.6 mg/day for a 125 lb person
5.5 mg/day for a 150 lb person
6.5 mg/day for a 175 lb person
7.3 mg/day for a 200 lb person
If you are taking pterostilbene powder for its cognitive benefits, you may wish to start with a very low dose. However, such low-dose effects have only been observed in mice thus far, and people may very well enjoy cognitive benefits at higher doses.
Benefits of Pterostilbene powder (537-42-8)
Pterostilbene powder is an antioxidant that primarily exists, it also has chemopreventive, antiinflammatory, antidiabetic, antidyslipidemic, antiatherosclerotic and neuroprotective effects. Beside, it also have some benefits as below:
- Helps fight against cancer
- Improves cognition and prevents cell death in the brain
- Reduces Blood Sugar
- Reduces Inflammation
- Protects the Liver
- May Protect the Heart
- May Support Weight Loss
- Protects the Eyes
- May Increase Lifespan
- Lowers blood pressure