J-147 (1146963-51-0) video
J-147 (1146963-51-0) Description
J-147 is an experimental drug with reported effects against both Alzheimer’s disease and ageing in mouse models of accelerated aging.It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.
J-147 almost ready for clinical trials in humans. Now, Salk scientists have solved the puzzle of what, exactly, J147 does. In a paper published January 7, 2018, in the journal Aging Cell, they report that the drug binds to a protein found in mitochondria, the energy-generating powerhouses of cells. In turn, they showed, it makes aging cells, mice and flies appear more youthful.
J-147 (1146963-51-0) Specifications
|Brand Name||No data available|
|Drug Class||No data available|
|Molecular Weight||350.341 g/mol|
|Monoisotopic Mass||350.124 g/mol|
|Melting Point||No data available|
|Freezing Point||No data available|
|Biological Half-Life||No data available|
|Color||White to off-white powder|
|Solubility||Water Solubility : 0.000115 mg/mL|
|J-147 Application||experimental drug with reported effects against both Alzheimer’s disease and ageing in mouse models of accelerated aging.|