Plecanatide

July 20, 2023

Plecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is an agonist of guanylate cyclase-C, it increases intestinal transit and fluid through a buildup of cGMP.
Plecanatide should not be used in children less than six years of age, and should be avoided in patients six years to 18 years of age.


Status:In Mass Production
Unit:5mg,10mg,1g/customized
Capacity: 1kg/month

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Raw Plecanatide Acetate powder (467426-54-6) video

Plecanatide Description

Plecanatide is a drug approved in January 2017 by the FDA for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation. It is an agonist of guanylate cyclase-C, it increases intestinal transit and fluid through a buildup of cGMP.

Plecanatide should not be used in children less than six years of age, and should be avoided in patients six years to 18 years of age.

Plecanatide Specifications

Product NamePlecanatide
Chemical NameL-Leucine,L-asparaginyl-L-α-aspartyl-L-α-glutamyl-L-cysteinyl-L-αglutamyl-L-leucyl-L-cysteinyl-L-valyl-L-asparaginyl-L-valyl-L-alanyl-L-cysteinyl-L-threonylglycyl-Lcysteinyl-, cyclic (4→12),(7→15)-bis(disulfide);Plecanatide Impurtiy; SP-304;
Brand NameTrulance
Drug ClassPeptide
CAS Number467426-54-6
InChIKeyNSPHQWLKCGGCQR-DLJDZFDSSA-N
Molecular FormulaC65H104N18O26S4
Molecular Weight1681.887
Monoisotopic Mass1680.625 g/mol
Melting Point N/A
Biological Half-Lifehalf-life (t½) cannot be calculated due to negligible systemic absorbance
Colorwhite to off-white
Solubility Water Solubility:0.165 mg/mL
Storage Temperature −20°C
ApplicationUsed for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation.

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