Raw Caffeic acid phenethyl ester powder (104594-70-9) video
Raw Caffeic acid phenethyl ester powder (104594-70-9) Specifications
|Product Name||Raw Caffeic acid phenethyl ester powder|
|Chemical Name||Raw Caffeic acid phenethyl ester powder; |
Phenylethyl caffeate; Phenethyl caffeate; Caffeic acid 2-phenylethyl ester; β-Phenylethyl caffeate;
|Brand Name||No data for available|
|Drug Class||Tyrosine Kinase Inhibitors, Inhibitors|
|Molecular Weight||284.311 g/mol|
|Monoisotopic Mass||284.31 g·mol−1|
|Melting Point||125-126ºC (dec.)|
|Boiling point||498.6±45.0 °C at 760 mmHg|
|Biological Half-Life||No Data Available|
|Solubility||Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.|
|Storage Temperature||Store at 0°C|
|Raw Caffeic acid phenethyl ester powder Application||Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.|
Raw Caffeic acid phenethyl ester powder (104594-70-9) Description
Raw Caffeic acid phenethyl ester powder is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, Raw Caffeic acid phenethyl ester powder (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).
Caffeic acid phenethyl ester has been reported to have anti-carcinogenic, anti-inflammatory, and immunomodulatory properties. CAPE also inhibits HIV-1 integrase. The anti-inflammatory characteristics have been thought to be due to suppression of the lipoxygenase pathway of arachidonic acid metabolism by CAPE. Studies have also demonstrated CAPE to be a specific and potent inhibitor of activation of nuclear transcription factor NF kappa B, which is a protein complex that controls the transcription of DNA. Caffeic Acid Phenethylester is an inhibitor of ODC and Tyrosine Kinase
Caffeic acid phenethyl ester powder (104594-70-9) Mechanism of Action
Caffeic acid phenethyl ester is a constituent of the propolis of honeybee hives, it blocks NF-κB activation induced by phorbol ester, ceramide, okadaic acid, and hydrogen peroxide by preventing the translocation of the p65 subunit of NF-κB to the nucleus. In a series of tumor cell lines, Caffeic acid phenethyl ester shows promising antiproliferative activity with EC50 of 1.76, 3.16, 13.7, and 44.0 μM against murine colon 26-L5, murine B16-BL6 melanoma, human HT-1080 fibrosarcoma and human lung A549 adenocarcinoma cell lines, respectively. Caffeic acid phenethyl ester, as a potent antioxidant, exerts its anti-apoptotic effect in cerebellar granule cells by blocking ROS formation and inhibiting caspase activity. Moreover, Caffeic acid phenethyl ester attenuates the pro-inflammatory phenotype of LPS-stimulated HSCs, and LPS-induced sensitization of HSCs to fibrogenic cytokines by inhibiting NF-κB signaling.
In vivo, Caffeic acid phenethyl ester (10 mg/kg, i.p.) inhibits the growth and angiogenesis of primary tumors in C57BL/6 and BALB/c mice inoculated with Lewis lung carcinoma, colon carcinoma, and melanoma cells. Caffeic acid phenethyl ester (5, 10, 20 mg/kg) also shows immunomodulatory effects in vivo by decreasing thymus weight and/or cellularity of thymus and spleen.
Application of Caffeic acid phenethyl ester powder (104594-70-9)
▪ NFkB blocker
Benefits of Caffeic acid phenethyl ester powder (104594-70-9)
Phenethyl caffeate is a compound found in propolis, a mixture produced by bees. Caffeic acid phenethyl ester (CAPE) could be effective in the prevention and treatment of inflammatory diseases including rheumatoid arthritis, systemic lupus erythematosus and psoriasis, various cancers and diseases comprising tumor formation, cataracts, and other diseases that result from oxidative stress. Furthermore, CAPE can be used to treat an HIV infection when combined in a pharmaceutical composition with a substance that inhibits HIV replication. It also can be used to anti-atherosclerotic, antioxidative, cardioprotective, anti-obesity and antimitogenic.