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Caffeic acid phenethyl ester (104594-70-9)

Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive……..

Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1180kg/month


Caffeic acid phenethyl ester (104594-70-9) video


Caffeic acid phenethyl ester (104594-70-9) Description

Caffeic Acid Phenethyl Ester is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, caffeic acid phenethyl ester (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

It has a role as an antineoplastic agent, an anti-inflammatory agent, an immunomodulator, a metabolite, an antioxidant, a neuroprotective agent, an antiviral agent and an antibacterial agent.

Caffeic acid phenethyl ester (104594-70-9) Specifications

Product Name Caffeic acid phenethyl ester
Chemical Name Caffeic Acid Phenethyl Ester;

Phenylethyl caffeate; Phenethyl caffeate; Caffeic acid 2-phenylethyl ester; β-Phenylethyl caffeate;

2-Phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate

Brand Name No data for available
Drug Class Tyrosine Kinase Inhibitors, Inhibitors
CAS Number 104594-70-9
Molecular Formula C17H16O4
Molecular Weight 284.311 g/mol
Monoisotopic Mass 284.31 g·mol−1
Melting Point  125-126ºC (dec.)
Boiling point 498.6±45.0 °C at 760 mmHg
Biological Half-Life No Data Available
Color off-white
Solubility  Soluble in ethyl acetate at 50mg/ml. Soluble in DMSO and ethanol.
Storage Temperature  Store at 0°C
Caffeic acid phenethyl ester Application Cytotoxic agent against cancer cell lines. Inhibitor of ornithine decarboxylase and protein tyrosine kinase. Found to be a specific inhibitor of the nuclear transcription factor, NF-kB. It has also been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation.




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