Phosphatidylserine (51446-62-9)

March 9, 2020

Phosphatidylserine is an aminophospholipid and amino acid derivative which is produced naturally within the…….


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Phosphatidylserine (51446-62-9) video

Phosphatidylserine Specifications

Product NamePhosphatidylserine
Chemical NamePhosphatidyl-L-serine;1,2-Dioctadecanoyl-sn-glycero-3-phosphoserine;Ptd-L-Ser;PS;
Brand NameN/A
Drug ClassN/A
CAS Number51446-62-9
Molecular FormulaC42H82NO10P
Molecular Weight792.1 g/mol
Monoisotopic Mass791.567635 g/mol
Boiling point 816.3±75.0 °C(Predicted)
Freezing PointN/A
Biological Half-LifeN/A
Colorlight yellow powder
Solubility soluble in Chloroform, Toluene; insoluble in Ethanol,

Methanol, Water


Storage Temperature store at -20 °C
Applicationuses in dietary supplements

in functional drinks

in infant formula milk


Phosphatidylserine Overview

Phosphatidylserine is an aminophospholipid and amino acid derivative which is produced naturally within the body. In fact, it’s a phospholipid which makes up a sizable portion of the human brain. It should be noted, however, that while the body can produce PS on its own, most of it comes from our food. Unfortunately, the modern diet often doesn’t contain enough PS. Unless you consistently have a large helping of Atlantic mackerel, chicken heart, soy lecithin, bovine brain, and Atlantic herring, chances are you’re going to need to get your PS from a supplement. PS also acts as a signaling agent for apoptosis, which is a standard process of cell death that is necessary for an organism to grow and develop. Thanks to clinical trials conducted in Italy, word of its effectiveness at memory enhancement quickly spread to the rest of the world, leading to its current state as a much sought after nootropic.


What is Phosphatidylserine?

Phosphatidylserine ( Ptd-L-Ser or PS), is a phospholipid nutrient found in fish, green leafy vegetables, soybeans and rice, and is essential for the normal functioning of neuronal cell membranes and activates Protein kinase C (PKC) which has been shown to be involved in memory function. In apoptosis, phosphatidyl serine is transferred to the outer leaflet of the plasma membrane. This is part of the process by which the cell is targeted for phagocytosis. PS has been shown to slow cognitive decline in animal models. PS has been investigated in a small number of double-blind placebo trials and has been shown to increase memory performance in the elderly. Because of the potentail cognitive benefits of phosphatidylserine, the substance is sold as a dietary supplement to people who believe they can benefit from an increased intake.

The dietary supplement was originally processed from bovine sources however Prion disease scares in the 1990s outlawed this process, and a soy-based alternative was adopted.

Phosphatidylserine Powder, Organic Phosphatidylserine are synthesized in the body of serine compounds, Italy, Scandinavia and other European countries are widely used phosphatidylserine supplements to treat dementia caused by old age and normal memory loss in elderly.

Due to its strong lipophilicity, it can quickly pass the blood-brain barrier and enter the brain after absorption, playing the role of soothing vascular smooth muscle cells and increasing the blood supply to the brain.

Phosphatidylserine is most commonly used for improving mental function, especially in the elderly.


Phosphatidylserine benefits

Phosphatidylserine is found naturally in certain foods and is also sold in dietary supplement form. Phosphatidylserine supplements are touted as a natural remedy for a variety of health conditions, including:

Attention deficit-hyperactivity disorder (ADHD)

Alzheimer’s disease



Multiple sclerosis


Phosphatidylserine has effect on scavenging free radicals, anti-oxidation.

Phosphatidylserine has function of prevention and treatment of cardiovascular and cerebrovascular diseases.

In addition, phosphatidylserine supplements are purported to preserve memory, promote healthy sleep, improve mood, and enhance exercise performance.

How does Phosphatidylserine work?

Phosphatidylserine is an important chemical with widespread functions in the body. It is part of the cell structure and is key in the maintenance of cellular function, especially in the brain.


Phosphatidylserine powder uses and application

Phosphatidylserine powder uses in dietary supplements to improve brain function, Prevent Alzheimer’s disease and improve memory.

Phosphatidylserine powder uses in functional drinks to ease the pressure of study and work, promote the recovery of brain fatigue and balance of emotions.

Phosphatidylserine powder uses in infant formula milk, dairy products to improve the brain cell membrane, improve intelligence; focus attention and avoid children with adhd.

Phosphatidylserine is used as a natural sebum control alcohol level of athletes to improve the training results.



  • Link between cutaneous infection, stress and depression. Jagmag T, Tirant M, Lotti T. J Biol Regul Homeost Agents. 2017 Oct-Dec;31(4):1037-1041.
  • Atp8a1 deficiency is associated with phosphatidylserine externalization in hippocampus and delayed hippocampus-dependent learning. Levano K, Punia V, Raghunath M, Debata PR, Curcio GM, Mogha A, Purkayastha S, McCloskey D, Fata J, Banerjee P. J Neurochem. 2012 Jan;120(2):302-13. doi: 10.1111/j.1471-4159.2011.07543.x. Epub 2011 Dec 2.
  • Effects of soy lecithin phosphatidic acid and phosphatidylserine complex (PAS) on the endocrine and psychological responses to mental stress.Hellhammer J, Fries E, Buss C, Engert V, Tuch A,  Rutenberg D, Hellhammer D. Stress. 2004 Jun;7(2):119-26.
  • A review of nutrients and botanicals in the integrative management of cognitive dysfunction.Kidd PM. Altern Med Rev. 1999 Jun;4(3):144-61. Review.
  • Antiphospholipid, antinuclear, Epstein-Barr and cytomegalovirus antibodies, and soluble interleukin-2 receptors in depressive patients. Maes M, Bosmans E, Suy E, Vandervorst C, Dejonckheere C, Raus J. J Affect Disord. 1991 Feb;21(2):133-40.
  • Double-blind study with phosphatidylserine (PS) in parkinsonian patients with senile dementia of Alzheimer’s type (SDAT). Fünfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger G. Prog Clin Biol Res. 1989;317:1235-46.


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