Hydroxypinacolone Retinoate (893412-73-2)

September 8, 2021

Hydroxypinacolone Retinoate is one of the most bio-available, nonprescription forms of Vitamin-A sold in cosmetics. It can be used to reduce seborrhea, dilute epidermal pigment, prevent skin aging, prevent acne, whitening spots, etc . It is mainly used for anti-aging and preventing acne recurrence.


Status:In Mass Production
Capacity: 1100kg/month


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Hydroxypinacolone Retinoate (893412-73-2) Specifications

Product NameHydroxypinacolone Retinoate
Chemical NameUNII-NJ3V2F02E1;


(2E,4E,6E,8E)-3,3-Dimethyl-2-oxobutyl 3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoate;

CAS Number893412-73-2
Molecular FormulaC26H38O3
Molecular Weight398.58
Monoisotopic Mass398.28209507
Boiling point 508.5±33.0 °C(Predicted)
Freezing PointN/A
Density0.990±0.06 g/cm3(Predicted)
ColorYellow powder or crystal
Solubility insoluble in water, and easily hydrolyzed under strong acid and alkali
Storage Temperature Store in a cool, ventilated warehouse. The storage temperature should not exceed 37 ° C. It should be stored separately from oxidants and edible chemicals, and avoid mixed storage.
ApplicationUsed as a conditioner, antioxidant, etc. in the field of personal care products;


What is Hydroxypinacolone Retinoate ?

Hydroxypinacolone Retinoate (HPR) is a unique retinoic acid derivative and the newest member of the vitamin A family of ingredients. It is a so-called retinoic acid ester, which is directly related to retinoic acid. Different from other forms of retinoids, HPR can directly act on the skin and bind to the retinoid receptors of skin cells, it can achieve the purpose of skin care without additional transformation steps.

At the same time, HPR is also one of the most bio-available, nonprescription forms of Vitamin-A sold in cosmetics and easy to formulate. Compared with other retinoid cosmetic (such as retinol, retinal, and retinyl palmitate), it is highly stable and has low irritation to the skin.

Because of its function of regulating the metabolism of epidermal cells and stratum corneum, HPR is often used to reduce seborrhea, dilute epidermal pigment, prevent skin aging, prevent acne, whitening spots, etc . At present, it is mainly used for anti-aging and preventing acne recurrence.


How does Hydroxypinacolone Retinoate work?

The binding of retinoid receptors can epigenetically enhance gene expression, which effectively turns key cellular functions on and off. When skin cell retinoid receptors are bound with retinoids, a cascade of mechanisms that benefit skin structures and functions are ‘switched on’. This can result in enhanced cell proliferation, biosynthesis of extracellular proteins and glycans, and improved cellular turnover. Stimulating these age defying processes in the skin is critical for fighting and reversing signs of ageing and overall skin balance.

As a class of chemical compounds termed retinoids, Hydroxypinacolone Retinoate can binde to retinoid receptors in cells, which stimulates skin cell proliferation, restoring thickness to skin that has become thinner over time. These processes help reduce lines and wrinkles to promote a youthful appearance, while safeguarding skin from further wrinkle development. Moreover, Hydroxypinacolone Retinoate also reduces uneven pigmentation improving brightness and luminosity and regulates cell to renew plumpness, elasticity and hydration to improve skin health, youthfulness and clarity.

Compared with other forms of vitamin A, Hydroxypinacolone retinoate is the stability and low irritation of its ingredients. Thermal stress tests have shown that it will remain stable and effective on the skin for up to 15 hours.


Hydroxypinacolone Retinoate benefits

As a high-quality ingredient in cosmetic ingredients, Hydroxypinacolone Retinoate has extraordinary benefits for the skin.

1) Anti-aging;

2) Reduce pigmentation and blemishes;

3) Improve fine lines and wrinkles;

4) Reduce sebum production, shrink pores and improve texture;

5) Increase hydration and improve skin luster;

Also, Hydroxypinacolone Retinoate is also highly recommended for addressing acne due to its ability to regulate oil production.


The Side effects of Hydroxypinacolone Retinoate

Since Hydroxypinacolone Retinoate is a new type of compound, the research on it is still ongoing, and its adverse reactions and serious side effects have not been found yet.

If have any concern before using, it would be advisable to seek the help of a doctor or dermatologist before applying it all over the skin.


Where is Hydroxypinacolone Retinoate Powder Sold?

Hydroxypinacolone Retinoate Powder wholesale trades are much more common than retail sales as it is usually purchased in bulk directly from the Hydroxypinacolone Retinoate Powder manufacturer factory. Generally, medications of such private nature are commonly bought online as it provides patients with discretion and privacy that they need. Fortunately, HPR is nonprescription forms of Vitamin-A sold in cosmetics, so, the medication is available in almost all of the local and online pharmacies.



[1]Ruth, N., and T. Mammone. “1310 Anti-aging effects of retinoid hydroxypinacolone retinoate on skin models.” Journal of Investigative Dermatology 138.5 (2018): S223.

[2]Giornale italiano di dermatologia e venereologia, 2015 Apr;150(2):143-7., Treatment of mild to moderate acne with a fixed combination of hydroxypinacolone retinoate, retinol glycospheres and papain glycospheres.

[3]Giornale Italiano di Dermatologia e Venereologia, 2016/03, Efficacy and safety of a 12-month treatment with a combination of hydroxypinacolone retinoate and retinol glycospheres as maintenance therapy in acne patients after oral isotretinoin.

[4]S Mukherjee, A Date and V Patravale, Retinoids in the treatment of skin aging: An overview of clinical efficacy and safety, Clin Interv Aging 1(4) 327-48 (2006)

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