1. What is Enfuvirtide? 
Enfuvirtide (159519-65-0) is a type of peptide that is used in the medical world to prevent human immunodeficiency virus (HIV) from infecting your healthy cells which might enhance the disease effects on your body. Enfuvirtide or T-20 is sold in different parts of the world under the brand name Fuzeon. However, depending on where you come from, you might find the enfuvirtide selling under a different brand name, but they all serve the same purpose.
Enfuvirtide powder (159519-65-0) is used together with other medications to treat HIV, which is a virus responsible for acquired immunodeficiency syndrome (AIDS). You should also note that Enfuvirtide doesn’t cure HIV, but it helps in reducing its impact and effects in your body. The people taking this product lead a good and healthy life since their cells are protected from the virus. According to studies, HIV is a virus infects white cells in your body that are responsible for fighting diseases. That’s why, in many cases, HIV/AIDS patients experience low immunity levels. However, Enfuvirtide helps in protecting your healthy cells from any damage, thus enhancing your health condition.
Enfuvirtide acetate minimizes the amount of HIV in your body, which helps in boosting your immune system. The product helps you to lower the chances of getting HIV complications such as infections that mostly attack HIV patients. As you take other HIV/AIDS medications, it’s always a good idea to accompany them with Enfuvirtide as it helps the drug to work better and improve their efficiency.
Enfuvirtide is available on different platforms but should be sold under the doctor’s prescription. Therefore, before you start taking this product, make sure you go for a medical examination, and you get the right dosage from your doctor. Enfuvirtide acetate is available online, and you can make your order from the comfort of your house or office. However, do proper research to understand the manufacturer and supplier before making your order. The enfuvirtide price can be different depending on the seller. There are many counterfeit medical substances on the market which can worsen your condition. If you are not sure about where to get the medication, talk to your doctor for further assistance.
2. Enfuvirtide mechanism of action?
As mentioned earlier, Enfuvirtide injection is a medication used in the treatment of human immunodeficiency virus (HIV). The virus doesn’t grow or replicate on its own, and therefore, it invades body cells to use their metabolism. HIV mostly attacks your immune system cells which are known as CD4 T-helper lymphocytes or white blood cells. The cells work by fighting any infection, trying to get into your body system. In the process of replication, HIV kills CD4 T-helper cells, and as a result, your body becomes weak, making it unable to fight any subsequent diseases. That means you will be infected by a majority of the diseases that you will be exposed to since your body cannot fight them.
Enfuvirtide mechanism of action ensures that your CD4 cells are protected from HIV invasion. The product binds to the protein around the virus, which helps it to attach itself to the CD4 cells. Once the enfuvirtide is attached to these proteins, it prevents HIV from fusing with your CD4 cell membrane. Note that, HIV can only replicate and increase when its genetic material gets into your CD4 cells. Thus, enfuvirtide also ensures that the virus doesn’t reproduce and grow in numbers.
This Enfuvirtide mechanism of action differs from all other anti-HIV medications on the market, which only fight the virus after it has infected your CD4 cells. Enfuvirtide HIV is, therefore, one of the most potent anti-HIV medications and can be used to fight the virus growth when it has become resistant to other drugs. However, you can still take Enfuvirtide alone or make it your first choice, and it will deliver the desired results. To date, there is no known HIV cure, but with enfuvirtide, you can be sure of lowering the amounts of the virus in your body and slow down the progression of any illness resulting from HIV/AIDS infection.
Experts recommend that you take enfuvirtide powder together with other anti-HIV medications that attack the virus in various ways. Adding the peptide powder to the existing treatment could be a great idea, especially if the infection has become resistant to the drugs. The product is said to be among the most potent anti-HIV medications, and it has been prescribed mostly to patients who have been taking other medicines without experiencing any improvement. It can also be suggested to people who have an intolerance to other anti-HIV prescriptions.
3. Enfuvirtide use in HIV
Fuzeon contains enfuvirtide powder as the active substance, which makes it an ideal prescription for fighting HIV in your body. Fuzeon belongs to a class of medications known as a fusion inhibitor. The medicinal compounds in this group like Fuzeon, block the HIV virus from fusing with CD4 cells and eventually prevent them from replicating and increasing in number. The peptide powder is used together with other anti-HIV drugs for better results. As mentioned above, enfuvirtide works by binding with the proteins which make it easy for HIV to fuse with CD4.
This action makes it impossible for the virus to get into the white blood cells and affect your immune system. In many cases, enfuvirtide acetate is prescribed to people who have been taking other medications, and the virus has developed resistant to other prescribed medications. Talk to your doctor for more information on how to effectively take this product.
4. How to use enfuvirtide powder?
Before you start taking this medication, ensure that you read the enfuvirtide manufacturer’s usage instructions in the leaflet inside the pack. The guidelines will give you more information on how to administer the product. Some Enfuvirtide suppliers will even provide you with some of the enfuvirtide side effects so that you can know when to reach out to your doctor. They also offer you with enfuvirtide warnings for you to be safe when taking the substance.
Enfuvirtide is an injection product, unlike other anti-HIV medications which are taken orally. This peptide powder has large molecules which might be crushed in your body system when taken orally and fail to deliver the desired results. For the peptide powder, make sure you get the preparation right or let your doctor do it for you. However, your doctor can train you on how to prepare the enfuvirtide powder with a solvent before administering the enfuvirtide injection.
Preparation
Follow all preparation step keenly when preparing the enfuvirtide powder. The powder should be mixed with sterile water and inspect the solution visually to ensure the solution mixes fully before administering the injection.
- Start by removing the flip-off cap from the sterile water dose for injection vile.
- Gently wipe each vial with the sterile alcohol swab then leave it for some time for the tops to air-dry.
- Use the 3ML large syringe and pull the plunger back to about 1ml mark, then inject the air into the sterile water vial slowly.
- Now insert the sterile syringe needle into the vial through the stopper center.
- Insert the syringe with the sterile water into the Fuzeon vial at an angle.
- Next inject the sterile water, and ensure it drips down slowly into the Fuzeon powder.
- Don’t shake the vial but use your fingertip to tap it for about 10 seconds for it to dissolve.
- When it starts to dissolve, put it aside to dissolve completely which can take about 45 minutes.
- When completely mixed, the solution should be colorless, clear, without any bubbles, if the solution is jelled, give it more time to dissolve before injecting yourself. Once the solution has settle and its clear you can now administer the dosage. Don’t take the dosage if you see any particles or before the solution is completely clear.
The usual dose for adults is 90ml per day which should be taken twice a day. The injection should be administered on your upper arm or upper part of your thigh. If you are giving the product to a child, your doctor will tell you the right dosage and how often to administer the injection. It’s advisable to rotate the injection areas to give them time to heal. Also, inform your doctor if you are taking any other disease medications before you start taking enfuvirtide.
5. Enfuvirtide dosage?
Enfuvirtide should be taken by any HIV/AIDS patient to enhance the immune system as it blocks the virus from fusing with CD4 cells as well as preventing them from replicating. The dosage, however, is different for children and adults. Enfuvirtide synthesis plays a vital role in fighting the HIV virus that has developed resistance to other anti-HIV medications.
- Recommended dosage
The recommended enfuvirtide adult dose for HIV is 90mg per day which should be divided into two doses. You should administer the injection though the anterior thigh, upper arm or abdomen.
Pediatric dose for 6 to 16 years old, is 2mg per kg, and the dosage should be administered twice per day. The maximum dosage for children in this age bracket is 90mg per day. For children of 17 years and above the recommended dose is 90 mg per day and should also be divided into two doses daily.
- Missed Enfuvirtide dosage?
In case you forget to take your enfuvirtide HIV dose, take it immediately, you remember. However, you can skip the dose if it’s almost time for the next dosage. Don’t use an extra dose to make up for the missed one; it could lead to severe side effects. Also, remember to get your next prescription in time before the prescription runs out entirely.
- Over Enfuvirtide dosage?
In case of any overdosing seek medical attention immediately as it can expose you to severe side effects.
When taking enfuvirtide acetate don’t inject it near your knee, elbow, navel or buttocks. Also avoid injecting the dosage into scars, moles, bruises or any skin surface that is not healthy. Taking enfuvirtide doesn’t prevent you from spreading the disease, therefore always have protected sex, avoid sharing sharp objects and your toothbrush. Observe all dosage instructions for you to enjoy maximum benefits. For more information, talk to your doctor to guide you in different ways of preventing HIV transmission.
6. What are the side effect of enfuvirtide?
Enfuvirtide HIV just like any other medication can also expose you to different side effects depending on how the medication will react with your body system. Sometimes the enfuvirtide side effects are due to overdose or misuse. However, there are some of the side effects that are common to almost all enfuvirtide users. Poor enfuvirtide storage can also lead to severe side effects. Some of the common Enfuvirtide side effects include;
- Loos of appetite, nausea, diarrhea and constipation
- Weight loss
- Pains, swelling or irritation at the injection areas
- Muscle weakness and pains
Reach out to your doctor immediately of you experience the following serious side effects;
- Swelling around your neck or throat, impotence or menstrual changes
- Symptoms of new infection such as swollen glands, wheezing or cold sores.
- Blood in your urine
- Breathing problems
The enfuvirtide side effects might differ from one person to another and therefore, don’t take any of them for granted. Inform your doctor in case the common side effects don’t disappear after some time. To be safe when taking this product, observe all dosage instructions provided by your doctor.
7. How should enfuvirtide powder be stored?
Enfuvirtide powder (159519-65-0) manufacturers always indicate how you should store the product when using it and even how to dispose it. The recommended unmixed enfuvirtide storage powder is at room temperatures about 20 to 25 degrees Celsius. However, if you are unable to store at the room temperature, you can keep it refrigerated at around 2 to 8 degrees Celsius. Also, store the sterile water at the room temperature all the time.
When you have mixed the enfuvirtide solution store it in a refrigerator at 2 to 8 degrees Celsius. Mixed enfuvirtide solution should be taken within 24 hours. Don’t use the substance after it has expired and also don’t purchase it when the kit seal is broken or missing. After using the enfuvirtide powder, follow the FDA guidelines on how you dispose the kit and unused medication.
8. More research and application on Enfuvirtide powder
When purchasing enfuvirtide powder from different suppliers, make sure you do proper research to ensure that you get a quality product that will guarantee you impressive results. Although enfuvirtide brand name Fuzeon is the common brand on the market, you can also find the product being sold under a different brand name. There are many enfuvirtide suppliers on the market, and you should always go for the best. The Enfuvirtide prices might vary from one vendor to another, don’t use it as a significant factor when choosing the right seller.
All in all, there is a need for further medical studies and research to determine other enfuvirtide uses and its application. As a regular injection product, many users have raised concerns, and further studies can help in developing enfuvirtide oral dosage. Alternatively, the substance can be developed further to be injected once or twice per month. For now, the enfuvirtide remains an injectable and potent anti-HIV medication. Feel free to talk to your doctor about enfuvirtide and gp41.
References:
- Zhu, X., Zhu, Y., Ye, S., Wang, Q., Xu, W., Su, S., … & Zhang, T. (2015). Improved pharmacological and structural properties of HIV fusion inhibitor AP3 over enfuvirtide: highlighting advantages of artificial peptide strategy. Scientific reports, 5, 13028.
- Blanco, J. L., & Martinez-Picado, J. (2012). HIV integrase inhibitors in ART-experienced patients. Current Opinion in HIV and AIDS, 7(5), 415-421.
- Chowdhury, S., & Roy, P. K. (2016). Mathematical modelling of enfuvirtide and protease inhibitors as combination therapy for HIV. International Journal of Nonlinear Sciences and Numerical Simulation, 17(6), 259-275.