1. What is leuprorelin acetate? 
Leuprorelin acetate is a kind of peptide that is used together with other drugs to treat prostate cancer in men. However, it doesn’t cure the disease but to prevent it from spreading and help suppress the prostate cancer effect on your body. Leuprorelin is sold in the United States of American under the brand name Lupron, and it might be available in different countries under a different brand name.
A majority of the prostate cancer types depend on testosterone hormones to grow and spread in your body. However, Leuprorelin acetate powder works by suppressing the production of the testosterone hormones making it easy to slow down the growth of prostate cancer cells as well as relieve the pains or difficulties experienced by patients while urinating.
On the other hand, Lupron is used by women to treat endometriosis symptoms, commonly known as uterine fibroids. Leuprolide acetate and pregnancy is a major concern to women, don’t take this drug if you are expecting to have a baby but you can discuss that with your doctor. Lupron is an injectable drug that should be injected into the muscle every 1-6 months. Always ensure that you take the dosage from your doctor, but you can also be trained on how to inject yourself for easy dosage administration at the comfort of your home.
Leuprolide acetate buy is readily available in both online and physical pharmacies. The leuprolide acetate cost can sometimes vary depending on where you buy it. However, it’s always advisable to get the right prescription from a medical professional. Remember overdosing or misusing leuprorelin acetate can lead to severe side effects, and you should avoid taking it without undergoing a medical examination. Cancer is a severe disease, and you should not risk taking its medication casually. Talk to your doctor for more information about leuprorelin acetate powder dosage.
2. Leuprolide acetate application
Leuprolide acetate powder is a potent gonadotropin-releasing hormone receptor (GnRHR) agonist, and it has proven to be essential in different clinical applications. For instance, in the treatment of uterine fibroids, prostate cancer, central precocious puberty (a condition that leads to children attaining their puberty early than expected), and endometriosis. In all these health conditions, leuprolide can be used alone or with other drugs. This drug can also be used together with other medications to treat anemia, which results from uterine fibroids.
The leuprorelin acetate dosage should be injected into your body through the muscles. Use the U-100 insulin syringe to administer your dosage and also ensure that you use syringes provided by the manufacturer. In case you must use different syringe, then use the only 0.5-mL disposable. Remember that the leuprorelin acetate powder should be mixed as described by the manufacturer before use. Shaking the solution might not provide you with adequate mixing. Leuprolide interactions will help you in achieving your desired results but always get them from your doctor.
3. How does leuprolide acetate work?
Leuprorelin acetate mechanism of action depends on the health condition under treatment. For instance, when used for prostate cancer treatment, it lowers testosterone hormone production, which aids the growth and spread of cancer cells. Although Leuprorelin Acetate powder (74381-53-6)use doesn’t cure prostate cancer, it helps in reducing the pains and growth of the cancer cells in your body. However, the drug can be taken alone, but medics recommend that you take it together with other prostate cancer medications for better results.
Although the drug is not approved for use in women in some countries, it has proved to be effective in the treatment of endometriosis. Here, the drug works by suppressing estrogen production in your body, which is commonly known as “estrogen surge.” Here, the Leuprorelin acetate mechanism of action focuses mainly on reducing the estrogen, hormone that is responsible for your periods. When you start taking leuprorelin acetate dosage, the estrogen levels will rise for the first few weeks, after which the estrogen levels will go down. This process might temporarily stop your periods, and as a result, the endometriosis symptoms will be relieved.
Leuprorelin acetate breast cancer, on the other hand, helps in fighting the deadly disease in women. Although progesterone and estrogen are not the cause of breast cancer, they play a significant role in aiding their growth and spread. The production of these two hormones can be stopped by either a surgical procedure to remove the ovaries or a medical procedure.
Luteinizing hormone produced by the pituitary gland, triggers the production of progesterone and estrogen by the ovaries. The leuprorelin acetate use suppresses the production of the luteinizing hormone, thus reducing estrogen and progesterone levels in your body. That means the cancer cells’ growth and spread will be slowed down, making it easy for breast cancer to be controlled.
4. How to use leuprorelin acetate?
The leuprorelin acetate administration can be done in two major ways through direct injection or the powder, which is usually reconstructed with a solvent before taking the dosage. Doctors are the best people to carry our both procedures, but when you are trained, you can easily do it at home.
(1) Leuprorelin acetate injection
Leuprorelin acetate injection is a long-acting medication that is injected intramuscularly and should be administered by a medical professional. The injection is mostly given once every month or even once every 3, 4, or 6 months depending on your condition. On the other hand, leuprorelin acetate injection can sometimes be given as a long-acting suspension commonly known as (Eligard) which is injected into your muscles every 1, 3, 4, or 6 months.
After medical examination, your doctor will advise you accordingly as well as prescribe the best peptide powder dosage for you. The time your dosage cycle will take will also be determined by your doctor after examining your condition. The injections usually vary from one patient to another.
(2) Leuprorelin acetate powder reconstitution
Sometimes you might decide to use the leuprorelin powder, which is also a potent form of this potent drug that helps in fighting different health conditions, as mentioned earlier. However, the Leuprorelin acetate powder must be prepared well or reconstituted before it’s injected into your muscles. The powder need to be inspected and you are not supposed to use a contaminated syringe. When preparing the leuprorelin acetate, use the diluent provided by the drug manufacturer. Screw the white plunger into the stopper until it begins to turn, make sure that you hold the syringe upright. Now release the diluent by pushing the plunger slowly for about 8 seconds till the first topper reaches the blue line at the middle of the barrel. All this time keep the syringe upright.
Gradually mix the powder to ensure that it forms a uniform milky suspension. In case the powder particles don’t fully disappear into the solution, tap the syringe until all particles dissolve completely. Don’t take the dosage if the Leuprorelin Acetate powder (74381-53-6) has not gone into suspension completely. After the reconstruction, take your dosage quickly since the suspension settles within a very short time. Also, don’t take any suspension that has not been used within two hours after reconstruction because it has no preservatives and can be harmful to your health.
5. Leuprorelin acetate Dosage and leuprorelin acetate Administration
Leuprorelin acetate administration is only though injection, and you should always get your dosage from a medical professional for better results. As much as you suspect you have a condition that can be treated by this peptide powder, never buy and start taking it without undergoing a medical examination. Leuprolide acetate manufacturers might indicate the drug dosage on the usage instructions, but that might not work for you.
Human bodies are different, and some doses might be too high to expose you to different leuprolide acetate side effects or too low to fail to deliver the desired results. Leuprolide acetate dosages vary from one person to another, and they are also determined by the condition being treated as well as the age of the user. Leuprolide acetate is a drug that should be taken under a doctor’s guidance since it can be risky when misused or overdosed. Here are some of the different leuprolide acetate dosages for different health conditions;
Adult leuprorelin acetate dosage for Prostate cancer
Here there are different dosages which might be confusing, but your doctor will chose the right one for you. The doses are as follows;
- 1mg injection once per day
- 5mg intramuscular injection that should be taken once every month.
- You can also go for the 22.5 mg which you will take once in every three months.
- There is also 30mg injection dosage taken once in every four months.
- 45mg intramuscular injection that you will take once in every six months.
- You can also decide to go for the 65mg subcutaneous implant which is a bit flexible since you will only take the dosage once per 12 months or a year.
Adult leuprorelin acetate powder dose for Endometriosis
The recommended dosage for endometriosis patients is 3.75mg, which should be injected once per month for about six months. There’s also another option where your doctor can suggest 11.25mg, which you will be injected once every three months. Women taking leuprorelin for endometriosis should also consider going for hormone replacement therapy, which is ideal for reducing vasomotor symptoms and bone mineral density loss. However, weighing out each therapy’s benefits should also be given priority when choosing the right medical procedure.
Pediatric leuprorelin acetate dose for precocious Puberty
Precocious puberty is a condition where children develop adult characteristics early than expected. When puberty begins before the age of 8 for girls and 9 in boys, it’s considered to be precocious. The condition can be controlled by taking leuprorelin acetate dosage. However, the weight of the child will determine the right dosage for treating the disease. The dose breakdown is as follows;
- Bodyweight less than 25kg the recommended dose is 7.5mg injection once per month
- Child weighing 25 to 37.5 kg should take a dose of 11.25 once per month.
- For the children above37.5kg, the recommended dose is 15mg injection once per month.
When taking your Leuprolide powder dosages, hormonal levels should also be tested after every 1 or 2 months to ensure there is adequate pituitary gonadotropin suppression. Regular medical examination will help your doctor to monitor the treatment progress as well as tackle any developments that might occur during the therapy period.
Remember, your doctor is the right person to set Leuprorelin dosage for adults and children after examining the health condition. Sometimes you might be advised to start with low dosages, which can be adjusted with time after observing your body response. Leuprolide acetate and pregnancy is not allowed as the drug can harm the unborn baby. Women are advised not to take this peptide powder when they are expectant or when planning to get pregnant any time soon.
6. Leuprorelin acetate side effect
In many cases, when you misuse or overdose any drug, it will expose you to severe side effects; however, your body strength sometimes can determine the intensity of the effects. The same happens when you don’t follow dosage instructions while taking leuprorelin acetate. Leuprolide warnings might vary depending on various factors, such as body weight and body tolerance. Some users experience side effects even when they take leuprolide interactions low dosages while others can take high dosages and still enjoy the benefits.
There are common leuprorelin acetate side effects that can be experienced by almost every user, but they disappear with time. Advanced side effects are hazardous, and once you experience them, you should inform your doctor immediately. On the other hand, there are also rare side effects which you can rarely experience while taking leuprorelin powder. These side effects are as follows;
(1) Common leuprorelin acetate side effects
- Nausea
- Pale skin
- Pains around the injection area
- Headache
- Sweating
- Urination disorder
- Joint pains
(2) Serious leuprorelin acetate side effect
In case you experience the following side effects look for medical attention as fast as you can;
- Fainting
- Irregular or fast breathing
- Numbness or tingling of your feet or hands
- Swelling of eyelids
- Breathing difficulties
(3) Rare leuprorelin acetate side effect
There are also infrequent side effects associated with this drug. However, they are severe when they occur. Thus, you should inform your doctor immediately before it gets worse. Sometimes they occur due to overdosing, or allergy and they include;
- Excessive vaginal bleeding for female users.
- Leuprolide acetate and diabetesis also another rare side effect that you might experience. The drug is said to increase the risk of suffering from diabetes.
- Deepening of voice in women
- Heartbeat problems
Conclusion
In conclusion, leuprorelin acetate has proved to be a great drug when used correctly in the medical world. At the same time, leuprolide acetate buy is available at your nearest pharmacy, and you can also make your order on different online stores. There are many leuprolide acetate manufacturers and suppliers on the market today, but always make sure you do your research to get a quality product at a reasonable price. The leuprorelin acetate price varies from one vendor, and that’s why you need to do proper research before buying the drug. However, don’t take leuprorelin acetate breast cancer before getting the right dosage from your doctor.
References
- Song, G., Gao, H., & Yuan, Z. (2013). Effect of leuprolide acetate on ovarian function after cyclophosphamide–doxorubicin-based chemotherapy in premenopausal patients with breast cancer: results from a phase II randomized trial. Medical oncology, 30(3), 667.
- Köhler, G., Faustmann, T. A., Gerlinger, C., Seitz, C., & Mueck, A. O. (2010). A dose‐ranging study to determine the efficacy and safety of 1, 2, and 4 mg of dienogest daily for endometriosis. International Journal of Gynecology & Obstetrics, 108(1), 21-25.
- Tunn, U. W., Gruca, D., & Bacher, P. (2013). Six-month leuprorelin acetate depot formulations in advanced prostate cancer: a clinical evaluation. Clinical interventions in aging, 8, 457.
- Johnson, S. R., Nolan, R. C., Grant, M. T., Price, G. J., Siafarikas, A., Bint, L., & Choong, C. S. (2012). Sterile abscess formation associated with depot leuprorelin acetate therapy for central precocious puberty. Journal of paediatrics and child health, 48(3), E136-E139.