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Raw NSI-189 Base powder (1270138-40-3)

Raw NSI-189 base powder is an experimental, potential antidepressant that is under investigation by Neuralstem, Inc. for the….


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1460kg/month

Description

Raw NSI-189 Base powder (1270138-40-3) video

 

Raw NSI-189 Base powder (1270138-40-3) Description

Raw NSI-189 Base powder is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine. That was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression. The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer’s disease, and major depressive disorder (MDD).

Raw NSI-189 Base powder (1270138-40-3) Specifications

Product Name Raw NSI-189 Base powder
Chemical Name (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone; UNII-YVE9U408ZL; YVE9U408ZL;
Brand Name Raw NSI-189 Base powder
Drug Class Inhibitors; Nootropic
CAS Number 1270138-40-3
InChIKey DYTOQURYRYYNOR-UHFFFAOYSA-N
Molecular Formula C22H30N4O
Molecular Weight 366.509 g/mol
Monoisotopic Mass 366.242 g/mol
Melting Point N/A
Biological Half-Life 17.4 – 20.5 hours
Color White
Solubility  10 mM in DMSO
Storage Temperature  Cool Dry Place
Raw NSI-189 Base powder Application It is used for treating other condition including post-traumatic stress disorder (PTSD), Alzheimer’s disease and age-related cognitive problems.

 

Raw NSI-189 base powder (1270138-40-3)

Raw NSI-189 Base powder is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine. That was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression. The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer’s disease, and major depressive disorder (MDD).

NSI-189 base powder (1270138-40-3) Mechanism of actions?

The mechanism of NSI-189 action is explained by its ability to stimulate the generation of new neurons in the hippocampus, however the exact target molecule is still unknown.

Benefits ofNSI-189 base powder (1270138-40-3)

  • May Improve Cognition
  • May Improve Depression
  • May Help With Stroke
  • May Help With Diabetes

Recommended NSI-189 base powder (1270138-40-3) Dosage

NSI-189 base powder have very limited research in humans and most trials have been on animal models.

That being said, a phase 1B randomized multiple dose escalation study reported that administration of 40 mg doses of NSI-189 once/day, 40 mg twice/day, and 40 mg three/day for 28 days

Side effects of NSI-189 base powder (1270138-40-3)

Intermittent peripheral neuropathy (transient loss of sensation in the hands and feet)

Increased appetite

Increased dietary preference for sugar (sweet tooth)

Fatigue/malaise

Exercise intolerance

Post-exercise headaches

Decreased motivation

Fugue states where my inner dialogue was absent

 


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