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NSI-189 base (1270138-40-3)

NSI-189 base is a nootropic and neurogenic research chemical derived from nicotinamide……..

Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1460kg/month


NSI-189 base (1270138-40-3) video


NSI-189 base (1270138-40-3) Description

NSI-189 base is a nootropic and neurogenic research chemical derived from nicotinamide and pyrazine. That was derived from pyrazine and nicotinamide. Studies have shown that it stimulates neurogenesis of human hippocampus-derived neural stem cells in vivo and vitro. In healthy adult mice, NSI-189 has been shown to increase the hippocampal volume by 20% and reverse behavioral symptoms in mouse depression models, meaning at the source it could address depression. The hippocampus is responsible for spatial navigation, along with the consolidation of information from short-term memory to long-term memory.

The chemical entity stimulates new neuron growth in the hippocampus, which is an area of the brain that is believed to be contributory in conditions such as post-traumatic stress disorder (PTSD), Alzheimer’s disease, and major depressive disorder (MDD).

NSI-189 base (1270138-40-3) Specifications

Product Name NSI-189 base
Chemical Name (4-benzylpiperazin-1-yl)(2-(isopentylamino)pyridin-3-yl)methanone; UNII-YVE9U408ZL; YVE9U408ZL;
Brand Name NSI-189 base
Drug Class Inhibitors; Nootropic
CAS Number 1270138-40-3
Molecular Formula C22H30N4O
Molecular Weight 366.509 g/mol
Monoisotopic Mass 366.242 g/mol
Melting Point N/A
Biological Half-Life 17.4 – 20.5 hours
Color White
Solubility  10 mM in DMSO
Storage Temperature  Cool Dry Place
NSI-189 base Application It is used for treating other condition including post-traumatic stress disorder (PTSD), Alzheimer’s disease and age-related cognitive problems.




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Shangke Chemical is a high-tech enterprise specializing in active pharmaceutical intermediates (APIs). To control the quality during production, a large number of experienced professionals, a first-class production equipment and laboratories are the key points.

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