Urolithin A

April 8, 2021

Urolithin A has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Meanwhile, it also has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Urolithin A(1143-70-0)Specifications

Product Name Urolithin A powder
Chemical Name 3,8-dihydroxy-6H-benzo[c]chromen-6-one;

3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo[c]chromen-6-one;

6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number 1143-70-0
InChIKey RIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILES C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Molecular Formula C13H8O4
Molecular Weight 228.2 g/mol
Monoisotopic Mass 228.042259 g/mol
Melting point 340-345 °C
Boiling point  527.9±43.0 °C(Predicted)
Flash Point 214.2ºC
Biological Half-Life Urolithin A is present in urine up to 48 hours after pomegranate juice consumption.
Color White to beige
Solubility  DMSO: 20 mg/mL, clear
Storage Temperature  2-8°C
Application Used as a food supplement and anti-aging product, can be used to reduce inflammation and fight cancer;

 

Reference:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). “Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods”. Critical Reviews in Food Science and Nutrition. 54 (12): 1584–1598. doi:10.1080/10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016).

[3] “FDA GRAS notice GRN No. 791: urolithin A”. US Food and Drug Administration. 20 December 2018. Retrieved 25 August 2020.

[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). “Orally administered urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly”. Innovation in Aging. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). “Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid”. Food and Chemical Toxicology. 108 (Pt A): 289– doi:10.1016/j.fct.2017.07.050. PMID 28757461.