Urolithin A（1143-70-0）video
Urolithin A（1143-70-0）Specifications
| Product Name | Urolithin A powder |
| Chemical Name | 3,8-dihydroxy-6H-benzo[c]chromen-6-one; 3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one; 3,8-Dihydroxyurolithin; 3,8-dihydroxybenzo[c]chromen-6-one; 6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy-; 3,8-Hydroxydibenzo-alpha-pyrone; |
| CAS Number | 1143-70-0 |
| InChIKey | RIUPLDUFZCXCHM-UHFFFAOYSA-N |
| SMILES | C1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O |
| Molecular Formula | C13H8O4 |
| Molecular Weight | 228.2 g/mol |
| Monoisotopic Mass | 228.042259 g/mol |
| Melting point | 340-345 °C |
| Boiling point | 527.9±43.0 °C(Predicted) |
| Flash Point | 214.2ºC |
| Biological Half-Life | Urolithin A is present in urine up to 48 hours after pomegranate juice consumption. |
| Color | White to beige |
| Solubility | DMSO: 20 mg/mL, clear |
| Storage Temperature | 2-8°C |
| Application | Used as a food supplement and anti-aging product, can be used to reduce inflammation and fight cancer; |
Reference:
[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). “Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods”. Critical Reviews in Food Science and Nutrition. 54 (12): 1584–1598. doi:10.1080/10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.
[2] Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016).
[3] “FDA GRAS notice GRN No. 791: urolithin A”. US Food and Drug Administration. 20 December 2018. Retrieved 25 August 2020.
[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). “Orally administered urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly”. Innovation in Aging. 1 (suppl_1): 1223–
[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). “Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid”. Food and Chemical Toxicology. 108 (Pt A): 289– doi:10.1016/j.fct.2017.07.050. PMID 28757461.
