Urolithin A

April 8, 2021

Urolithin A has been demonstrated to stimulate mitophagy and improve muscle health in old animals and in preclinical models of aging. Meanwhile, it also has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.


Status:In Mass Production
Unit:25kg/Drum
Capacity: 1600kg/month

 

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Urolithin A(1143-70-0)video

Urolithin A(1143-70-0)Specifications

Product NameUrolithin A powder
Chemical Name3,8-dihydroxy-6H-benzo[c]chromen-6-one;

3,8-Dihydroxy-6H-dibenzo(b,d)pyran-6-one;

3,8-Dihydroxyurolithin;

3,8-dihydroxybenzo[c]chromen-6-one;

6H-Dibenzo[b,d]pyran-6-one, 3,8-dihydroxy-;

3,8-Hydroxydibenzo-alpha-pyrone;

CAS Number1143-70-0
InChIKeyRIUPLDUFZCXCHM-UHFFFAOYSA-N
SMILESC1=CC2=C(C=C1O)C(=O)OC3=C2C=CC(=C3)O
Molecular FormulaC13H8O4
Molecular Weight228.2 g/mol
Monoisotopic Mass228.042259 g/mol
Melting point 340-345 °C
Boiling point 527.9±43.0 °C(Predicted)
Flash Point214.2ºC
Biological Half-LifeUrolithin A is present in urine up to 48 hours after pomegranate juice consumption.
ColorWhite to beige
Solubility DMSO: 20 mg/mL, clear
Storage Temperature 2-8°C
ApplicationUsed as a food supplement and anti-aging product, can be used to reduce inflammation and fight cancer;

 

Reference:

[1] Garcia-Muñoz, Cristina; Vaillant, Fabrice (2014-12-02). “Metabolic Fate of Ellagitannins: Implications for Health, and Research Perspectives for Innovative Functional Foods”. Critical Reviews in Food Science and Nutrition. 54 (12): 1584–1598. doi:10.1080/10408398.2011.644643. ISSN 1040-8398. PMID 24580560. S2CID 5387712.

[2] Ryu, D. et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nat. Med. 22, 879–888 (2016).

[3] “FDA GRAS notice GRN No. 791: urolithin A”. US Food and Drug Administration. 20 December 2018. Retrieved 25 August 2020.

[4] Singh, A.; Andreux, P.; Blanco-Bose, W.; Ryu, D.; Aebischer, P.; Auwerx, J.; Rinsch, C. (2017-07-01). “Orally administered urolithin A is safe and modulates muscle and mitochondrial biomarkers in elderly”. Innovation in Aging. 1 (suppl_1): 1223–

[5] Heilman, Jacqueline; Andreux, Pénélope; Tran, Nga; Rinsch, Chris; Blanco-Bose, William (2017). “Safety assessment of urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid”. Food and Chemical Toxicology. 108 (Pt A): 289– doi:10.1016/j.fct.2017.07.050. PMID 28757461.

 

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