Urolithin A 8-Methyl Ether

April 8, 2021

Urolithins are secondary metabolites of ellagic acid derived from ellagitannins. In humans ellagitannins are converted by the gut microflora into ellagic acid which is further transformed into urolithins A, urolithin B, urolithin C and urolithin D in the large intestines.

 


Status:In Mass Production
Unit:25kg/Drum
Capacity: 1400kg/month

 

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Urolithin A 8-Methyl Ether(35233-17-1)video

 

Urolithin A 8-Methyl Ether(35233-17-1)Specifications

Product NameUrolithin A 8-Methyl Ether powder
Chemical Name3-hydroxy-8-methoxy-6H-benzo[c]chromen-6-one;

3-hydroxy-8-methoxybenzo[c]chromen-6-one;

35233-17-1;

MLS001049096;

SMR000386929;

ChemDiv3_002724;

Urolithin A 8-Methyl Ether;

CAS Number35233-17-1
InChIKeyIGJLBTGXYKPECW-UHFFFAOYSA-N
Molecular FormulaC14H10O4
Molecular Weight242.23
Monoisotopic Mass242.057909 g/mol
Melting point 242 °C(Solv: acetic acid (64-19-7))
Boiling point 479.9±38.0 °C(Predicted)
Density 1.375±0.06 g/cm3(Predicted)
Biological Half-LifeN/A
ColorLight Beige to Very Dark Orange Solid
Solubility Acetone (Slightly, Sonicated) DMSO (Slightly, Sonicated), Methanol (Slightly)
Storage Temperature Hygroscopic, -20°C Freezer, Under inert atmosphere
ApplicationUrolithin A 8-Methyl Ether is an intermediate in the synthesis of Urolithin A (U847000), a major metabolite of Ellagitannin and exhibits anti-inflammatory and antioxidant properties.

 

Reference

[1] Espín, Juan Carlos; Larrosa, Mar; García-Conesa, María Teresa; Tomás-Barberán, Francisco (2013). “Biological Significance of Urolithins, the Gut Microbial Ellagic Acid-Derived Metabolites: The Evidence So Far”. Evidence-Based Complementary and Alternative Medicine. 2013: 270418.  doi: 1155/2013/270418.  ISSN1741-427X.  PMC 3679724.  PMID 23781257.

[2] Ryu, Dongryeol; Mouchiroud, Laurent; Andreux, Pénélope A; Katsyuba, Elena; Moullan, Norman; Nicolet-dit-Félix, Amandine A; Williams, Evan G; Jha, Pooja; Sasso, Giuseppe Lo (2016). “Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents”. Nature Medicine. 22(8): 879–888. doi:1038/nm.4132. PMID 27400265.

[3] Ishimoto, Hidekazu; Shibata, Mari; Myojin, Yuki; Ito, Hideyuki; Sugimoto, Yukio; Tai, Akihiro; Hatano, Tsutomu (2011). “In vivo anti-inflammatory and antioxidant properties of ellagitannin metabolite urolithin A”(PDF). Bioorganic & Medicinal Chemistry Letters. 21(19): 5901–5904. doi:1016/j.bmcl.2011.07.086. PMID 21843938.

[4] Kasimsetty, S. G., et al.: J. Agri. Food. Chem., 58, 2180 (2010);

[5] Bialonska, D., et al.: J. Agri. Food. Chem., 57, 10181 (2009);

 

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