Raw Pramlintide powder (196078-30-5) video
Pramlintide Description
Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease.
Pramlintide Specifications
| Product Name | Pramlintide |
| Chemical Name | pramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE |
| Brand Name | Symlin (Amylin). |
| Drug Class | peptide |
| CAS Number | 196078-30-5 |
| InChIKey | TZIRZGBAFTZREM-MKAGXXMWSA-N |
| Molecular Formula | C171H267N51O53S2 |
| Molecular Weight | 3949.42 |
| Monoisotopic Mass | 3947.924 g/mol |
| Melting Point | >175°C (dec.) |
| Biological Half-Life | 48 minutes |
| Color | White to Off-White Solid |
| Solubility | Acetic Acid (Slightly), DMSO (Slightly) |
| Storage Temperature | -20°C |
| Application | An analogue of human amylin used in the treatment of insulin dependent diabetes. |
