Pramlintide

July 20, 2023

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease.


Status:In Mass Production
Unit:5mg,10mg,1g/customized
Capacity: 1kg/month

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Raw Pramlintide powder (196078-30-5) video

Pramlintide Description

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease.

Pramlintide Specifications

Product NamePramlintide
Chemical Namepramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
Brand NameSymlin (Amylin).
Drug Classpeptide
CAS Number196078-30-5
InChIKeyTZIRZGBAFTZREM-MKAGXXMWSA-N
Molecular FormulaC171H267N51O53S2
Molecular Weight3949.42
Monoisotopic Mass3947.924 g/mol
Melting Point >175°C (dec.)
Biological Half-Life48 minutes
ColorWhite to Off-White Solid
Solubility Acetic Acid (Slightly), DMSO (Slightly)
Storage Temperature -20°C
ApplicationAn analogue of human amylin used in the treatment of insulin dependent diabetes.

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