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Raw Pramlintide powder (196078-30-5)

Pramlintide powder (196078-30-5) is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains……

Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month



Raw Pramlintide powder (196078-30-5) video


Raw Pramlintide powder (196078-30-5) Description

Pramlintide powder (196078-30-5) is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Raw Pramlintide powder inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, Pramlintide powder (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease.


Raw Pramlintide powder (196078-30-5) Specifications

Product Name Pramlintide powder
Chemical Name pramlintide acetate;pramlintide acetate hydrate;Tripo-aMylin Acetate Hydrate;Pramlintide Acetate, Amylin Rat;AC-137 Acetate Hydrate, SyMlin Acetate Hydrate;25-L-Proline-28-L-proline-29-L-proline-aMylin (huMan) Acetate Hydrate;AMYLIN (HUMAN), 25-L-PROLINE-28-L-PROLINE-29-L-PROLINE-, ACETATE (SALT), HYDRATE
Sequence Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-I le-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2(Cys2&Cys7 bridge)
Brand Name Symlin (Amylin).
Drug Class peptide
CAS Number 196078-30-5
Molecular Formula C171H267N51O53S2
Molecular Weight 3949.42
Monoisotopic Mass 3947.924 g/mol
Melting Point  >175°C (dec.)
Biological Half-Life 48 minutes
Color White to Off-White Solid
Solubility  Acetic Acid (Slightly), DMSO (Slightly)
Storage Temperature  -20°C
Application An analogue of human amylin used in the treatment of insulin dependent diabetes.



This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.



 photo COA 196078-30-5 Pramlintide Acetate Phcoker_zpsnbkjtelc.jpg

References & product citations

7 Important Secrets about Pramlintide Use, Do you know?



  1. Younk, L. M., Mikeladze, M., & Davis, S. N. (2011). Pramlintide and the treatment of diabetes: a review of the data since its introduction. Expert opinion on pharmacotherapy12(9), 1439-1451.
  2. Herrmann, K., Frias, J. P., Edelman, S. V., Lutz, K., Shan, K., Chen, S., … & Kolterman, O. G. (2013). Pramlintide Improved Measures of Glycemic Control and Body Weight in Patients With Type I Diabetes Mellitus Undergoing Continuous Subcutaneous Insulin Infusion Therapy. Postgraduate medicine125(3), 136-144.
  3. Herrmann, K., Brunell, S. C., Li, Y., Zhou, M., & Maggs, D. G. (2016). Impact of disease duration on the effects of pramlintide in type 1 diabetes: a post hoc analysis of three clinical trials. Advances in therapy33(5), 848-861.