Everything about Pramlintide
|1. Rediscover Pramlintide|
|2. Who is pramlintide suitable for?|
|3. How does pramlintide work on you?|
|4. What should I do once decided to inject pramlintide?|
|5. Who Should Not Use Pramlintide?|
|6. Typical side effects from pramlintide|
Pramlintide (Symlin) is an artificial hormone that occurs in the human body naturally. The drug can lower the blood sugar levels in the body and, therefore, is used mostly by diabetes 1&2 patients alongside insulin. Typically, the Symlin hormone just like insulin is produced in the pancreas when sugar levels are high. These drugs operate in different ways to control your blood glucose. Once you take your dosage, the drug slows down the rate at which food gets absorbed from your intestine including the glucose — Pramlintide diabetes sales under the brand name Symlin and it’s not available as a generic drug.
On the other hand, the Pramlintide (196078-30-5) restricts your liver from producing more glucose, thus inhibiting glucagon action –a hormone that is produced by your pancreas and it’s responsible for stimulating the liver to produce more glucose. Taking the drug will also reduce your appetite for food making it ideal even for people who want to cut their excess body weight. In many studies conducted by various scientists, Pramlintide has proved to be effective in helping patients lower their blood sugar levels as well as help others control their body weight.
When using the drug, you don’t have to worry since it was approved for human consumption by the FDA in March 2005. However, before using Pramlintide make sure you go for a medical examination to determine if the drug is fit for you. Human bodies can be complicated especially how they react with different drugs. Don’t just buy Pramlintide over the counter and start using it without your doctor’s knowledge. Being an injectable drug, it means you need a medical professional to administer its dosage or train you how to inject yourself.
Additionally, when buying the drug make sure you get it from a trusted and experienced Pramlintide supplier. Using a counterfeit drug could be more dangerous, and that can lead to severe side effects. Talk to your doctor to help you get a high-quality Pramlintide for better results. In case you notice any severe side effects also inform your doctor immediately before the situation gets worse.
As mentioned above, this drug mostly prescribed to diabetes patients to help them control blood sugar levels in the body. The Pramlintide has proved to be effective in the treatment of diabetes for patients who their insulin is not adequate. The drug can be used together with insulin for better results. However, make sure you get the drugs prescription from your doctor to avoid experiencing severe side effects.
Studies have also revealed that Pramlintide diabetes can be useful for people who want to control their body weight. The drug reduces appetite, and by that making, the body consume the existing body fats leading to weight loss. Using this drug will mean that it will control how much you eat, which serves as the best way to watch your weight. Pramlintide is also lowers the production of glucose by your liver. However, the drug is said to have more uses, but you can confirm with your doctor or pharmacists before you start using it.
After the medical examination, your doctor can also prescribe the drug for you for any other medical reason that could be solved by Pramlintide. Sometimes the drug can be used with others such as insulin to improve its effectiveness as well as help the user attain maximum results. Make sure you involve your doctor in the whole Pramlintide dosage cycle, to avoid any severe side effects. Sometimes you might start experiencing problems immediately, you take your first dosage or even after a while, and you need medical attention once you start having any issues.
This drug is a synthetic form of the amylin hormone which is produced in your body by pancreas just like the insulin. Symlin is used in the production of this drug as the primary Pramlintide raw material. It is a human-made version of amylin, and on injection, the Pramlintide works in three ways to help in losing weight and minimize your appetite. For status, it works through brain activity. This is where it makes you feel full. Eating is brain related. You tend to eat because your mind tells you are hungry. With this drug, your brain will tell you that you are full during meal time which makes you eat less or skip meals. Ideally, excessive weight results from overeating or eating when not necessary. Cravings are the significant causes of overeating whereby you get the urge to eat something (mostly sweet things) even when you are not hungry. Symlin can help you eliminate this problem.
The other way in which Symlin works in you is by stomach activity. This is whereby on using the drug, the rate at which food moves from the stomach to the small intestine is slowed down. Digestion and food absorption takes part in the small intestine, and it is after the processes that you start feeling hungry and ready to eat again. What happens when food takes longer to get there for digestion? It will take longer for you to feel hungry thus increasing the interval between your meal time.
The third way is through liver activity. By liver activity, Symlin works by suppressing or reducing the release of glucagon by the pancreas. This is the hormone responsible for releasing sugar into the bloodstream. Glucagon helps the liver in the conversion of glycogen to glucose. In diabetic cases where there is a very high concentration of blood sugars, Symlin helps in curbing the problem by preventing the conversion of more glucose through reduced glucagon.
Use Symlin correctly because it should be prescribed for you by your doctor. Follow all directions on your prescription label. Your doctor might often adjust your dose to ensure you get the most effective results. After you begin taking your Symlin dosages, your hormone dose can change. Don’t use your medicines in larger or smaller amounts or for an extended period than advised by your medic. Remember, the Hypodermic injection should be undertaken by a professional to avoid any problems but your doctor can train you on how to inject yourself at home.
Symlin is injected beneath the skin, at an equivalent time as your hormone injection; however in a very separate dose. Don’t mix the drug with insulin in the same injection. Also, don’t self-inject your medicines if you are not sure about it because it could cause problems. Get the dosages from your doctor or after you have been trained how to use the syringes properly.
(1) What to do before using Symlin
Let your pharmacist know if you have any allergic to any medications or ingredients contained in Symlin. Check the medication guide for components before you start taking your dosages.
Inform your doctor of any prescription and nonprescription medicines that you are taking at that period. They could be a vitamin, herbal drugs or nutritional supplements. Check the WARNING notice on those medications to see if you are allowed to use them together with other medicines such as Symlin. Your physician could use the note to determine the right Pramlintide dosage right for you or so s/he can monitor you closely for any side effects.
If you are under any contraceptives, pain medications and pain killers, taken orally, you should take them at least one to two hours before using Symlin.
Notify your doctor if you are pregnant, or when you get pregnant while using the drug to avoid any complications in the future.
Read and understand the instructions and direction of use. You must read and understand and follow the medication guide. Do the research and understand how to use the drug, what to expect after use and the possible side effects of Symlin. Get all the supplies needed during medication such as needles. Get help of a professional to understand the different types of needles and which one is best for you. Read the manufacturer’s instructions and guidelines regarding the use of pen for injecting the drug. Also, make sure you understand when you need to set up a new needle and let a doctor show you how to use it.
Before administering Pramlintide injection, always look at the solution and make sure it is clear and colorless. If cloudy, thick, colored or has some solid particles, it might be expired or unsafe to use. Check the expiry date on the label and if it is not expired yet, seek help from a physician to know if it is safe for use.
Clean the area of injection. It can be anywhere on the thigh or anywhere else advised by your medic. Prepare the area by cleaning and rubbing first. The area should be at least two inches from where you plan to inject insulin.
(2) Symlin reasonable dosage
Symlin has proven to be of great benefits to those with type 1 diabetes. However, this can only be achieved if it is used reasonably and in the right amounts. There are a few ways to make Symlin work for you. The first one is by starting on a small scale. To figure out and determine the right Pramlintide dosage that works for you, you have to start low and probably increase the amount down the line. Start with using the drug at one meal per day. For example, you could start by using it at breakfast. Once you figure out the dosage at that meal and realize that there are no adverse effects, apply a similar strategy to the rest of the meals. Note that the dosage should not vary from one meal you another. You should take the same dosage regardless of what or how much you plan on eating.
The next step is to determine the ideal dosage for you. You should begin with the least which is 15 mcg if you are using a pen or 2 to 3 units if using a syringe. Use it for approximately three days and increase it by 15 mcg until you reach a therapeutic dose.
The right amount of Symlin might make your stomach sour for 15 to 30 minutes after injecting, or you may experience a low blood sugar level for a few hours. If you do not experience either of these, you need to increase your dosage. You may need to increase the dosage with prolonged use. After a long time usage like months or years, you may develop tolerance to Symlin, and you will need to take a slightly higher amount to achieve desired results.
A reasonable dosage is as follows;
15 microgram subcutaneously, injecting instantly before every major meal
-Mealtime hormone doses (including premixed insulin) ought to be reduced by five hundredths.
-Treatment ought to be magnified to next increment (30, 45, or sixty mcg) once no clinically vital nausea has occurred for a minimum of three days.
-If fundamental vomiting persists at the forty-five or sixty microgram dose level, the dose ought to be minimized to 30 micrograms.
-If the thirty microgram dose isn’t tolerated, ending ought to be thought about.
Use connected treatment in patients with kind one polygenic disorder. World Health Organization use time of day hormone medical aid and World Health Organization have not been able to accomplish desired aldohexose management despite best hormone medical aid.
Usual Adult Dose for polygenic disorder kind 2:
60 microgram subcutaneously, injecting instantly before every major meal
-Mealtime hormone doses (including premixed insulin) ought to be reduced by five hundredths.
-Treatment ought to be magnified from sixty to a hundred and twenty micrograms before every major meal once no clinically vital nausea has occurred for a minimum of three days.
-If essential vomiting persists at the hundred and twenty microgram dose, the dose ought to be minimized to sixty micrograms.
(3) After injecting Pramlintide
Take care not to let your glucose get too low. Severely low glucose (hypoglycemia) might occur at intervals three hours once your Symlin injection. If you have got severe hypoglycemia and can’t eat or drink, use an internal secretion injection. Your doctor will bring down an interior secretion emergency injection kit and show you how to effectively use it.
Also watch for signs of high glucose (hyperglycemia) like magnified thirst, magnified elimination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss.
Check your glucose fastidiously throughout times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These items will affect your aldohexose levels, and your dose desires might also include the amendment.
Use a disposable needle and syringe just the once. Follow any state or constitutional laws regarding discard used needles and syringes. Use a puncture-proof “sharps” disposal instrumentation (ask your pill pusher wherever to induce one and the way to throw it away). Keep this instrumentation out of the reach of youngsters and pets.
Never share an associate degree injection pen with another person. Sharing Pramlintide injection pens will enable illness like liver disease or HIV to pass from one person which is very dangerous.
Call your doctor if you have got severe nausea that lasts for many days. This might be an indication that your dose is just too high
Symlin is merely a part of a treatment program that conjointly includes diet, exercise, weight management, regular glucose testing, and first medical aid. Keep a daily schedule once administering your injections and testing your glucose. It’s conjointly necessary to arrange your meals and physical activity. You will not be ready to keep using Symlin if you are not following the dosage directions.
Pramlintide will slow your digestion, and it should take longer for your body to soak up any medicines you are taking orally. Avoid taking any oral medication at intervals one hour before or two hours once you’re using Symlin.
Avoid drinking alcohol. It will lower your glucose.
Your likelihood to experience severe low glucose is higher if you:
- do not follow your care provider’s directions to cut back your hormone use before meals
- use additional SYMLIN or more hormone than prescribed by your care supplier
- change your hormone dose without your doctor’s knowledge
- eat less food than your usual meal
- are sick and can’t eat
- are additional active than usual
- have a coffee glucose level before ingestion
- drink alcohol
Discontinuation Of medical aid!!!
- Persistent clinically vital nausea.
- Noncompliance with self-monitoring of blood sugar concentrations.
- Disagreement with hormone dose changes.
- Noncompliance with regular care supplier contacts or counseled clinic visits.
If you have got symptom unknowingness, then Pramlintide diabetes might not be for you. Being unable to inform if your glucose is dropping might be dangerous as a result of the magnified likelihood of hypoglycemia with Pramlintide.
If you have been diagnosed with gastroparesis, you furthermore might not be a candidate for Pramlintide because of the delayed internal organ evacuation that happens with it. Pramlintide has not been approved as safe for unborn babies or nursing moms; therefore if you’re pregnant or nursing, then Pramlintide might not be prescribed for you.
Before taking Pramlintide, your doctor should understand if you:
- Have impaired awareness of hypoglycemia
- Are pregnant, attending to become pregnant or breastfeeding
- Are allergic to metacresol
- Have or have had gastroparesis
- Are taking antidepressants or medication
Along with its required effects, Pramlintide diabetes (the active ingredient contained in Symlin) might cause some unwanted effects. Though not all of those aspect effects might occur, if they are doing occur they will want medical attention.
Check with your doctor instantly if any of the following aspect effects occur when taking Pramlintide:
- Cold sweats
- Cool pale skin
- Difficulty with swallowing
- increased hunger
- slurred speech
- Tightness within the chest
Some aspect effects of Pramlintide might occur that typically don’t want medical attention. These aspect effects might get away throughout treatment as your body adjusts to the drugs. Also, your health care skilled is all ready to tell you regarding ways in which to stop or cut back a number of these side effects. Consult with your medic if any of the following aspect effects continue or are pestering or if you have got any questions on them:
- Difficulty with moving
- Loss of craving
- Weight loss
- Less Common
- Dryness or soreness of the throat
- Voice changes
Pramlintide is associate degree amylin analog which will be used with time of day hormone within the treatment of kind one and sort two polygenic disorders. In patients with kind two polygenic diseases, Pramlintide also can be accessorial to antidiabetic monotherapy, Glucophage monotherapy, the mix of a sulfonylurea and Glucophage, or the mix of antidiabetic, Glucophage and hormone. Medical aid with Pramlintide reduces A1C by zero.2% to 0.6% and therefore the 2-hour postprandial aldohexose by three.4 to five mmol/L. Within the 1-year studies, Pramlintide medical aid minimized weight with modesty; however, in one 52-week, open-label, extension trial weight came back to baseline levels. There’s an associate degree current trial that examines the effectiveness of Pramlintide weight loss agent.
Pramlintide features a favorable safety profile and lowest contraindications. Transient nausea is the most regular adverse event. To cut back the chance of hypoglycemia, a discount of the premeal hormone by five hundredths and shut aldohexose watching is secured.
All in all, Pramlintide acetate looks like an appropriate addition if your glucose levels don’t answer hormone alone. By speed at that the abdomen empties, it helps to manage glucose levels higher than hormone by itself. Pramlintide enhances the toxicity of standard therapy against body part neoplastic cell lines harboring wild-type or mutant p53. Thus, Pramlintide could be a promising potential adjuvant therapy in body part cancer.
Keep a watch out for signs of low glucose and forever monitor levels before and once meals. Most patients on SymlinPen are glad there. Permanently consult with your doctor before you start your Pramlintide dosage or when you want to stop any medications while taking the Pramlintide.
The Pramlintide cost can vary from one manufacturer or vendor to another but always ensure that you buy Pramlintide from a reliable manufacturer. There are different drug sellers available online but be careful to avoid purchasing low quality or expired drug. Do your market research to locate the best Pramlintide sellers around you. Choose a vendor with the best prices as well as the one that makes deliveries within the shortest time possible. Your doctor could also be the best person to help you get the best drug and from the experienced vendor.
- Younk, L. M., Mikeladze, M., & Davis, S. N. (2011). Pramlintide and the treatment of diabetes: a review of the data since its introduction. Expert opinion on pharmacotherapy, 12(9), 1439-1451.
- Herrmann, K., Frias, J. P., Edelman, S. V., Lutz, K., Shan, K., Chen, S., … & Kolterman, O. G. (2013). Pramlintide Improved Measures of Glycemic Control and Body Weight in Patients With Type I Diabetes Mellitus Undergoing Continuous Subcutaneous Insulin Infusion Therapy. Postgraduate medicine, 125(3), 136-144.
- Herrmann, K., Brunell, S. C., Li, Y., Zhou, M., & Maggs, D. G. (2016). Impact of disease duration on the effects of pramlintide in type 1 diabetes: a post hoc analysis of three clinical trials. Advances in therapy, 33(5), 848-861.