Tirzepatide

March 2, 2024

Phcoker is a professional GMP grade manufacturer of Tirzepatide, that provide both form of raw Tirzepatide powder and freeze-dried Tirzepatide powder vial.  The regularly manufacturing specification including but not limited to Tirzepatide 5mg, Tirzepatide 10mg, Tirzepatide 15mg. Larger dosage and custom-made manufacturing service is available.

Monthly production capacity: >1,000,000 vials

Other Name:LY3298176,Mounjaro,Zepbound,GTPL11429,P1206

 

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Properties


 

Sequence: YXEGTFTSDYSIXLDKIAQKAFVQWLIAGGPSSGAPPPS
Molecular Formula: C225H348N48O68
Molecular Weight: 4813g/mol
PubChem CID: 156588324
CAS Number: 2023788-19-2
Synonyms: LY3298176, Mounjaro,Zepbound,GTPL11429,P1206

Description


Tirzepatide is a glucose-dependent insulinotropic polypeptide (GIP) receptor and glucagon-like peptide-1 (GLP-1) dual receptor agonist. The drug is currently approved by the FDA under the brand name of Mounjaro for the treatment of type 2 diabetes. According Tirzepatide research result and the current clinical trial results, the participants in the experiment showed a substantial weight loss. Participants who used the highest dose of Tirzepatide 15mg lost an average of 15.7% of their weight, which is a major milestone in the history of weight loss drugs.

Currently, the forms of Tirzepatide on the market mainly include: raw Tirzepatide powder, lyophilized powder(freeze-dried Tirzepatide powder) in vial, pre-mixed Tirzepatide solution(injection), and oral tablets. This article mainly discusses the two forms of raw Tirzepatide powder and lyophilized Tirzepatide powder in vial, as well as the relationship and difference between these two forms and other forms of Tirzepatide.

Understanding Raw Tirzepatide Powder

Raw Tirzepatide powder is the powdered form of the active pharmaceutical ingredient (API) used in Mounjaro or other Tirzepatide related drug. It requires professional production technology to make various Tirzepatide related finished products from raw Tirzepatide powder. The appearance of raw tirzepatide powder is white, CAS number is 2023788-19-2. Usually package with pharmaceutical grade seal bag or seal bottle, the professional manufacturer of raw tirzepatide powder, can also provide split packaging services for buyers, such as split package 1 gram raw tirzepatide into 100mg x 10 small bottles. That is much convenience for research use.

The raw tirzepatide powder storage is similar to freeze-drited tirzepatide powder in vial form, stable at 2-8°C, but should be kept at -20°C for long term storage, preferably desiccated,away from the light. So it is better to pay attention the transportation method and transportation time.  Raw Tirzepatide powder shelf life is stable under the correct storage condition. So many researchers seeking raw Tirzepatide raw for research purpose.

One of the most important criteria for measuring raw Tirzepatide powder is purity(HPLC), but the test method also affects the test results. Professional labs or manufacturers of raw tirzepatide powder must have professional testing equipments and technology, and be able to provide information of professional testing methods, then the researchers who buying the raw tirzepatide powder can refer to and use. The documents usually include Certificate of Analysis, HPLC,MS…

Importance Of Raw Tirzepatide Powder Quality In Pharmaceutical Manufacturing

The quality of raw Tirzepatide powder plays a pivotal role in pharmaceutical manufacturing processes. As the foundational material for producing Tirzepatide related medications, the purity, consistency, and stability of the powder significantly influence the final product’s efficacy, safety, and shelf life. Ensuring the high quality of raw Tirzepatide powder is imperative to meet regulatory standards, maintain product integrity, and uphold patient safety. Any compromise in the quality of raw material could potentially lead to variations in drug potency, undesirable side effects, or even jeopardize the overall effectiveness of the medication. Therefore, pharmaceutical manufacturers must prioritize stringent quality control measures throughout the procurement, handling, and processing of raw Tirzepatide powder to safeguard the quality and reliability of the final pharmaceutical product.

Process Of Manufacturing Tirzepatide From Raw Powder

The process of manufacturing Tirzepatide from raw powder involves specialized techniques to produce freeze-dried powder in vials. Initially, the raw Tirzepatide powder is carefully measured and prepared under strict quality control measures to ensure its purity and potency.

Once the powder is ready, it undergoes a process known as lyophilization or freeze-drying. In this process, the powder is frozen at very low temperatures and then subjected to a vacuum environment, causing the water content to sublimate directly from solid to gas without passing through a liquid phase. This gentle drying method helps preserve the structural integrity and bioactivity of the Tirzepatide molecules.

After freeze-drying, the Tirzepatide powder is filled into vials under sterile conditions. The vials are sealed to maintain the integrity of the powder and protect it from contamination.

Throughout the entire manufacturing process, adherence to Good Manufacturing Practices (GMP) is essential to ensure the safety, efficacy, and regulatory compliance of the final Tirzepatide product.

Please note that if you do not have the corresponding production technology and meet the prescribed production conditions, or have no experience at all, please do not try it easily, as it is a very dangerous behavior.

Understanding Lyophilized Tirzepatide Powder In Vial Form

As mentioned above, Lyophilized Tirzepatide powder in vial form is produce from raw tirzepatide powder. This specialized form of Tirzepatide, achieved through lyophilization or freeze-drying, offers several advantages.

Firstly, it enhances the stability of the drug by removing water content, thereby reducing the risk of degradation and increasing shelf life.

Secondly, lyophilized Tirzepatide powder in vial form provides convenience in storage, transportation, and reconstitution, making it suitable for healthcare settings.

Understanding the characteristics and handling requirements of lyophilized Tirzepatide powder in vial is essential for ensuring its efficacy and safety in clinical use. Proper storage, reconstitution techniques, and adherence to recommended administration protocols are critical aspects of utilizing this pharmaceutical form effectively.

Common Dosages Of Lyophilized Tirzepatide Powder In Vial Form In The Weight Loss Market

As researchers or people who want to use tirzepatide for weight management increase their demand for Tirzepatide, the labs and manufacturers supply various specifications of lyophilized tirzepatide powder in vial form, also written as freeze-dried tirzepatide powder. Which including but not limited to 5mg, 10mg, 15mg, even larger dosage. One of the most common dosage is Tirzepatide 10 mg.

One of the reasons why Tirzepatide 10mg is widely accepted is that it is easier to calculate. One of the difficulties people encounter when reconstituting Tirzepatide is not knowing how to calculate the ratio of antibacterial water to Tirzepatide. Compared with other specifications, Tirzepatide 10mg is easier to calculate.

If you still don’t know how to calculate the Tirzepatide dosage, a simpler way is to use the Tirzepatide dosage calculator. Just select the Tirzepatide specification you purchased, the specification of the syringe you use, and the dosage you want to use. The calculator will show you which scale you need to push the syringe to.

Another reason that Tirzepatide 10mg is popular is the price. Tirzepatide 10mg price is competitive than Tirzepatide 5mg small dosage and cheaper than Tirzepatide 15 or more dosage. If you are interested in buying Tirzepatide with a limited budget, Tirzepatide 10mg is a good choice.

Beside Tirzepatide 10mg,  other specifications of course are popular also. Especially the large dosage like Tirzepatide 30mg. Tirzepatide buyers choose to buy different specification according to their purpose. If you are plan to reconstitute or resell Tirzepatide, then large specificiation is more competitive. For Tirzepatide manufacturers, one of the important factor to reduce produce cost of Tirzepatide is quantity.

How To Reconstitute Tirzepatide Lyophilized Powder?

Due to the surge in demand for Tirzepatide in the market, the production and supply pressure of Tirzepatide continues to increase. Therefore many people turn to buy Tirzepatide powder online for restructuring. However it is important to buy Tirzepatide powder from the regular peptide manufacturers. Many peptide companies, scientific research institutions etc. provide Tirzepatide powder, to ensure the quality, the Tirzepatide suppliers must have a strict production environment, professional technology and equipments, and be able to provide corresponding professional test reports such as Coa, HPLC etc.

After buy Tirzepatide powder, how to reconstitute Tirzepatide powder step by step?

Step 1: Restructure the environment

When you reconstruct Tirzepatide, you need to find a clean and well-lit space to ensure that Tirzepatide does not become contaminated.

Step 2: Preparation before refactoring

You need to prepare things you may need for reconstitution, such as Tirzepatide powder, bacteriostatic water, syringes, vial adapters, etc.

Step 3: Wash your hands

Before refactoring, you need to wash your hands thoroughly with soap or hand sanitizer and running water to avoid the introduction of bacteria or other contaminants.

Step 4: Reconstitute Tirzepatide Powder

Please follow the steps below to carry out the reconstitution process of Tirzepatide powder:

  • Check whether the Tirzepatidevial is damaged or contaminated. Do not use it if there is any discoloration of the powder as mentioned above.
  • Remove the protective cover of the vial and disinfect it with alcohol cotton
  • Inject bacteriostatic water
  • Gently rotate the vial to fully blend the Tirzepatidepowder and bacteriostaticwater
  • Check whether there are particles or agglomerates in the solution to ensure complete dissolution

Step 5: Take out the solution

Invert the vial and draw out the required dose of Tirzepatide solution. And check whether there are air bubbles in the syringe. If there are air bubbles, tap the syringe to remove the air bubbles.

Step 6: Administration

Administer the Tirzepatide solution in the syringe at the correct injection site as directed.

You can find many instructional videos for homemade injections on social platforms such as TikTok and YouTube. The above operation methods are for reference only. The Tirzepatide lyophilized powder used comes from the professional peptide manufacturer. Please do not try it if you do not know any about Tirzepatide reconstruction or no experience about Tirzepatide, it will be risk for your health.

Whether it is raw Tirzepatide powder or freeze-dried tirzepatide powder, their benefits, uses, side effects, etc. are all reflected through the properties of Tirzepatide. Aspects of Tirzepatide are discussed in more detail below.

Tirzepatide Background

The development and production of Tirzepatide has been a long process. The following are some of the main timelines:

①Eli Lilly and Company first applied for a patent for using tirzepatide to control blood sugar in early 2016. The patent was published later that same year.

②After passing Phase III clinical trials, Eli Lilly and Company applied for FDA approval in October 2021 and obtained a priority review voucher.

③Tirzepatide was approved for the treatment of diabetes in the following regions and dates:

– May 2022: United States

– September 2022: European Union

– November 2022: Canada

– December 2022: Australia

④In November 2023, the FDA approved tirzepatide for weight loss under the brand name Zepbound.

⑤In April 2024, the Drug Shortages Database of the U.S. Food and Drug Administration indicated that by the second quarter of 2024, there would be shortages in the supply of most doses of Zepbound(Tirzepatide brand name) and the corresponding diabetes medication Mounjaro(Tirzepatide brand name).

The above are the key events in the development of Tirzepatide. Currently, Tirzepatide peptide has been proven to be a safe and effective drug for weight loss and type 2 diabetes treatment, and has also shown many benefits on metabolism. When using it, in addition to consulting a professional healthcare provider based on your specific situation and needs, it is also important to find a regular and reliable peptide manufacturer to purchase Tirzepatide.

What Is Tirzepatide Peptide丨Definition of Tirzepatide

Tirzepatide is a weight loss drug injected once a week for weight management. The drug, developed by Eli Lilly and Company, is currently approved by the FDA to treat type 2 diabetes. Tirzepatide sold under the brand names of Mounjaro and Zepbound. Tirzepatide used along with diet and exercise, via subcutaneous injection with incremental dosage adjustments, to help improve blood sugar (glucose) in adults with type 2 diabetes mellitus.

As a dual receptor agonist of GLP-1 and GIP, Tirzepatide not only stimulates insulin secretion and release, but also has a certain inhibitory effect on glucagon. Through the dual effects of GLP-1 and GIP, Tirzepatide can effectively suppress appetite, reduce food intake, and prolong the feeling of satiety, thereby promoting weight loss.

The dual effects of Tirzepatide can not only effectively reduce weight, but this innovative method makes full use of the advantages of these two hormones to solve many problems such as metabolism, and also makes it an effective treatment for type 2 diabetes. a promising treatment option.

The Structure of Tirzepatide

The Structure Tirzepatide

Tirzepatide Mechanism of Action

If want to know how is Tirzepatide help weight management, here let’s have a look of the mechanism of action of Tirzepatide. As a synthetic peptide, Tirzepatide works mainly by targeting two receptor agonists, GLP-1 and GIP.

Tirzepatide research studies have shown that Tirzepatide has greater affinity for GIP receptors than for GLP-1 receptors. And compared to a single GLP-1 receptor agonist, the dual receptor agonist effect of Tirzepatide  has been shown to reduce hyperglycemia to a greater extent and reduce the user’s appetite to a greater extent.

According to signaling reports, Tirzepatide will mimic the action of natural GIP on the GIP handle; however, for GLP-1 receptors, Tirzepatide is more likely to favor the production of cAMP, rather than recruiting β-arrestin, which binds to sugar. , a messenger related to the regulation of glycogen and lipid metabolism.

Although the exact mechanism of action of Tirzepatide has not been fully elucidated, current research shows that Tirzepatide’s dual receptor agonist effect on GLP-1 and GIP increases insulin secretion and can effectively treat obesity and type 2 diabetes.

Tirzepatide Mechanism

What Are The Positive Effects Of Tirzepatide Benefits Of Tirzepatide

As a biological peptide drug, Tirzepatide is popular in the market because of the benefits it brings to people. It is a well-known drug for treating diabetes and an effective weight loss drug. Here are the primary benefits of Tirzepatide:

  • Promote weight loss. Studies have shown that Tirzepatidepeptide activates human GIP and GLP-1 receptors. GIP and GLP-1 receptors are two receptors crucial to regulating appetite in the human brain. Tirzepatide has been shown to reduce food intake, suppress appetite and regulate fat utilization. Numerous clinical studies have shown that patients taking Tirzepatide lost 15.7% (34.4 pounds or 15.6 kilograms) of body weight, making it a potential option for those seeking effective weight management.
  • Increases satiety. Tirzepatideslows the passage of food through the body, reduces the desire to eat, and enhances the body’s feeling of fullness, making it easier to stick to a healthy diet and maintain weight loss.
  • Control and stabilize blood sugar levels. Type 2 diabetes is a chronic progressive disease and the most common form of diabetes. This disease causes the body’s own inability to release insulin, resulting in high levels of glucose in the blood. Tirzepatidecan regulate the release and use of insulin by regulating GLP-1 and GIP, thereby keeping glycated hemoglobin (HbA1c) at a healthy level.
  • Treat type 2 diabetes. Tirzepatidepeptide has been approved by the FDA for the treatment of type 2 diabetes and can effectively help patients control blood sugar. Regulates blood sugar levels mainly by increasing the secretion of insulin.
  • Treat obesity-related diseases. Obesity can lead to physical diseases such as high blood pressure, hyperglycemia, hyperlipidemia, and even heart disease. Tirzepatidecan effectively reduce the occurrence and development of these diseases while protecting the cardiovascular system by promoting weight loss.
  • Convenient. Unlike other drugs that must be taken every day, Tirzepatideonly needs to be injected once a week, which greatly helps patients save a lot of time in their daily lives and makes taking the drug more convenient.
  • Flexible dosing.Tirzepatidecan be administered flexibly. It can be used alone or in combination with other diabetes medications. This flexible dosing method allows patients to modify the dosage according to their needs, thereby achieving better therapeutic effects.
  • Treat obese with type 1 diabetes: The latest research shows that Tirzepatide may help obese type 1 diabetes also. Researchers reported that Tirzepatide led to an average weight loss of 18.5% (>46 pounds) in patients with type 1 diabetes over one year and improved glycemic control.

In addition, researchers continue to study the potential benefits of Tirzepatide powder. Potential benefits of Tirzepatide are as follows:

  • Protect heart
  • Reduce inflammation
  • Treat alcohol addiction

These Tirzepatide research are ongoing to explore Tirzepatide’s broader benefits beyond obesity and type 2 diabetes. The powerful effects shown by Tirzepatide peptide have made it widely popular in the market.

As the market demand for Tirzepatide continues to increase, Tirzepatide suppliers continue to emerge like mushrooms after rain. How to identify the quality of Tirzepatide and buy quality-guaranteed Tirzepatide at a reasonable price has become a big problem.

Tirzepatide Side Effects And Safety

Tirzepatide has been approved by relevant regulatory agencies for weight management, such as the U.S. Food and Drug Administration (FDA), European Medicines Agency (OMA), etc.The approval of these agencies indicates that Tirzepatide has undergone rigorous testing and evaluation to determine Its safety, quality and effectiveness.

As a prescription drug, Tirzepatide is in great demand. When purchasing, please make sure your purchasing channel is reliable and trustworthy.In addition, you should be aware of some possible side effects of using Tirzepatide before purchasing.

The most common side effects of Tirzepatide are gastrointestinal adverse reactions, such as nausea, vomiting, diarrhea, etc. These symptoms are usually not serious and will disappear over time. If serious adverse reactions occur after use, please stop taking the drug promptly and seek help from a healthcare provider.

How To Store Tirzepatide Peptide?

According to the Tirzepatide storage information, raw tirzepatide powder and tirzepatide lyophilized powder storage method is similar.

Normal temperature (not higher than 30℃)

Tirzepatide can be stored at room temperature for up to 21 days. Please ensure that the temperature does not exceed 30°C and avoid exposure to light.

Refrigerated (2℃-8℃)

It should be noted that the temperature of Tirzepatide needs to be kept between 2-8°C when refrigerated. It cannot be frozen and stored, as this will decompose the medicinal properties of Tirzepatide.

Please take good care of your Tirzepatide so that it can achieve the desired results.

Research on Tirzepatide is still ongoing. Let’s take a look at more useful information about Tirzepatide continuously.

Tirzepatide Emerges As New Star in Kidney Protection In Type 2 Diabetes Treatment

Chronic kidney disease is a common complication of type 2 diabetes and can lead to kidney failure in severe cases. Results of a meta-study show that any dose of Tirzepatide reduces proteinuria levels in patients with type 2 diabetes without affecting kidney function.

The experiment will conduct an observational study on patients with type 2 diabetes who received Tirzepatide and a control group who received placebo and Semaglutide. It mainly measured the urinary albumin-creatinine ratio (UACR) and glomerular filtration rate between the Tirzepatide experimental group and the control group. (eGFR) for comparison. The results of the study showed that compared with the control group, the UACR in the Tirzepatide group was reduced by approximately 27%, but had no significant effect on eGFR levels. This shows that Tirzepatide has more obvious benefits for kidney protection.

All in all, Tirzepatide’s dual agonistic effect on GIP and GLP-1 can not only promote weight loss and control blood sugar, but also protect the kidneys, which is very important for the treatment and care of type 2 diabetes. In order to more fully understand and confirm the protective effect of Tirzepatide on the kidneys, a large number of clinical trials are still needed.

Latest Research On Tirzepatide: Tirzepatide May Relieve Obstructive Sleep Apnea

Eli Lilly and Company announced the latest study of Tirzepatide on April 17, 2024: According to the results of two Phase 3 trials, for adults with moderate or severe obstructive sleep apnea and obesity, Tirzepatide one year after taking 10mg or 15mg, the severity of sleep apnea symptoms decreased. Patients experienced a median reduction in apnea-hypopnea index (API) of up to 63% after injection.

Obstructive sleep apnea causes a decrease in blood oxygen saturation, which can lead to serious complications, including high blood pressure, heart disease, stroke, heart failure, atrial fibrillation, and type 2 diabetes. This index, which measures the number of times per hour a person’s breaths show limited or complete obstruction of airflow, is the primary tool for assessing the severity of OSA and the effectiveness of treatment.

The SURMOUNT-OSA Study 1 evaluated the effectiveness of Tirzepatide in patients not using a CPAP machine. The Lilly drug was associated with a mean reduction from baseline of 27.4 events per hour, compared to 4.8 for placebo. In addition, the researchers also said that Tirzepatide was able to reduce body weight by an average of 18.1%, compared with 1.3% for placebo.

Patients receiving CPAP in the SURMOUNT-OSA Study 2 experienced an average of 30.4 fewer events per hour compared with 6.0 fewer events per hour for placebo. Meanwhile, average weight loss in Tirzepatide was 20.1%, compared with 2.3% in placebo.

Jeff Emmick, MD, said: “With more than 20 million people suffering from severe OSA, and 85% of OSA cases going undiagnosed, it is important to address this need head-on. Although there are medications to treat excessive sleepiness associated with OSA, Tirzepatide has the potential to become a target.” The first medical treatment for the underlying disease.

This latest research on Tirzepatide peptide provides a new research direction for OSA treatment.

Tirzepatide Vs Semaglutide: All The Things You Need To Know

Tirzepatide and Semaglutide are two drugs currently on the market for weight management and treatment of type 2 diabetes. It is becoming more and more common to use drugs to lose weight, so what are the similarities and differences between Tirzepatide and Semaglutide? Here let’s have a detailed view.

Tirzepatide Vs Semaglutide: Similarities

Tirzepatide and Semaglutide both belong to the GLP-1 series of weight loss drugs and have a huge effect on weight loss and the treatment and management of type 2 diabetes. And the side effects caused by using these two drugs are generally the same. The main side effect is adverse intestinal reactions.

Tirzepatide Vs Semaglutide: Which Is Better?

Tirzepatide is an agonist of two receptors: glucagon-like peptide (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which means that Tirzepatide may also provide additional effects on weight loss and achieve better results. The amount of weight loss effect.

Semaglutide is a glucagon-like peptide (GLP-1) receptor agonist. When eating, it promotes the release of GLP-1 hormone and produces insulin. At the same time, it can also send satiety signals to the brain, thereby reducing food intake and achieving weight loss.

The latest research results show that Tirzepatide has a stronger effect than Semaglutide. However, everyone’s response to drugs is different. For example, although Tirzepatide is more effective, some people cannot bear the side effects of Tirzepatide, but have good tolerance to Semaglutide. Don’t blindly choose in pursuit of results. It is best to buy the one that suits you.

Tirzepatide Vs Semaglutide: Both Of Them Promote Weight Loss?

As the study continued, researchers found that Tirzepatide led to greater weight loss than Semaglutide. The research on Tirzepatide and Semaglutide have shown significant weight loss with weekly doses of 5 mg, 10 mg and 15 mg of Tirzepatide. Although Tirzepatide cost is more expensive than Semaglutide, it is more effective and better value.

Of note, the doses of Tirzepatide and Semaglutide used in these studies were different. The dosage of Tirzepatide in these experiments was higher, which may have had a certain impact on the results of the experiments. In addition, these studies only compared patients with type 2 diabetes, and the effects of weight loss on obese patients without type 2 diabetes have not been clearly compared.

Other Weight Loss Drug That Help To Appetite Control

Tirzepatide and semaglutide work for weight loss primarily by suppressing appetite. When it comes to managing weight loss, a multifaceted approach often yields the best results. In addition to diet and exercise, certain ingredients have been identified for their potential to aid in appetite control. Beside Tirzepatide and Semaglutide, among these are Retatrutide,CagriSema,Sibutramine HCL, Lorcaserin HCL.

Retatrutide

Retatrutide, known as LY-3437943, is an experimental drug for obesity developed by American pharmaceutical company Eli Lilly and Company. It is a triple hormone receptor agonist of GLP-1, GIP, and GCGR receptors. Retatrutide work through activates the GIP, GLP-1 and glucagon receptors that are involved with controlling hunger and satiety, allowing people to feel fuller after eating for longer. It has been shown to achieve a more than 17.5% mean weight reduction in adults without diabetes but with obesity or preobesity (overweight) during a phase 2 trial.The drug is a peptide with amino acid sequence YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3.

Like Tirzepatide and Semaglutide, Retatrutide has different form in the market. The raw Retatrutide powder and lyophilized Retatrutide powder in vial are the common seen among of them. Lyophilized Retatrutide powder in vial for sale with small dosage from 5mg to large dosage 10mg, 15mg or more. Besides, researchers seeking Retatrutide for research found that some supplier provide pre-mix Retatrutide injection solution also, although they cannot judge the quality of the Retatrutide injection solution from the surface.

CagriSema

CagriSema is the brand name of mixture peptide of Cagrilintide and Semaglutide. So it mean CagriSema is a combination of cagrilintide, a dual amylin and calcitonin receptor agonist, and semaglutide, a GLP-1 agonist. CagriSema is being tested in type 2 diabetes and obesity. Preliminary trial results found a greater weight loss compared to either medication alone. CagriSema studies show that HbA1c was significantly improved compared to cagrilintide alone and non-significantly better than semaglutide alone. A future trial sponsored by Novo Nordisk is comparing tirzepatide and CagriSema head-to-head.

As of 2023, CagriSema is in a Phase III trial. CagriSema is anticipated to compete directly with Zepbound (a brand name of Tirzepatide) once it reaches the market. This is undoubtedly exciting news for those who are concerned about the weight loss market.

Sibutramin HCL

When it comes to appetite suppressants, we have to mention Sibutramin HCL.

Sibutramine HCL, commonly known as sibutramine,its CAS number is 84485-00-7. It is a medication used for weight loss management. Sibutramine operates by suppressing appetite through its action as a serotonin-norepinephrine reuptake inhibitor (SNRI). By inhibiting the reuptake of these neurotransmitters, sibutramine increases their levels in the synaptic cleft, leading to enhanced feelings of fullness and satisfaction after eating. This mechanism helps individuals consume fewer calories, thereby aiding in weight loss.

Sibutramine can be found in the market mainly include two forms: raw sibutramine powder and Sibutramine weight loss pill. Raw sibutramine HCL powder is a white to off-white powder, it is the active ingredient of sibutramine oral pill. Raw sibutramine powder used to be easily buy from the market, but with changes in market regulation, it is difficult to buy real sibutramine powder now. Therefore, many weight loss product suppliers pay more attention to peptide-based weight loss products, such as Tirzepatide and Semaglutide. Compared with Sibutramine, peptide weight loss products have higher safety and minimal side effects.

Sibutramine was withdrawn from the market in the USA and European Union due to it increases adverse events in patients with cardiovascular diseases. But non‐prescription weight loss pills containing raw sibutramine powder can be still easily purchased over the Internet. However, it’s important to note that sibutramine is associated with potential side effects and risks, and its use should always be supervised by a healthcare professional.

Lorcaserin HCL

Lorcaserin HCl is a 5-hydroxytryptamine (5-HT2C) agonist with a chemical formula of (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride hemihydrate. The oral form of Locaserin is available as a blue, film-coated 10-mg round, biconvex tablet that is debossed with an “A” on one side and a “10” on the other.

Lorcaserin reduces food intake, possibly via suppressing appetite and increasing satiety, but the exact mechanism of action is unknown. It is a selective serotonin 2c(5-HT2c) receptor agonist, and it is thought that this specificity will make serotonin-related valvulopathy unlikely.

On February 13, 2020 FDA requested that the manufacturer of Belviq and Belviq XR (active ingredient is raw lorcaserin powder) voluntarily withdraw the weight-loss drug from the U.S. market because a safety clinical trial shows an increased occurrence of cancer.

Tirzepatide For Sale丨Where To Buy Tirzepatide?

Tirzepatide’s role as a dual receptor agonist of GLP-1 and GIP brings a potential breakthrough in the treatment of obesity and type 2 diabetes. The demand for Tirzepatide is also increasing in the market. But because the drug is only covered for people with type 2 diabetes, its price prevents some patients who need it to lose weight from getting Tirzepatide.

Therefore individual and researchers who looking for buy Tirzepatide, they turn to purchase from online suppliers. There are multiple advantages of purchase Tirzepatide online: no prescription required, cheap Tirzepatide cost,fast shipping,multiple forms (raw Tirzepatide powder, free-ze dried powder,injection solution)etc. There are also certain risks involved. Because it is impossible to judge the quality of a product from its appearance. Therefore, it is a big challenge to find a Tirzepatide supplier with quality assurance. It is meaningless to simply compare Tirzepatide prices only, as price is directly proportional to quality.

 

Manufacturers/Factory


Tirzepatide is a new FDA-approved drug for weight management in type 2 diabetes. Due to its dual receptor agonist properties, which also provide weight loss benefits, Tirzepatide may also be used off-label to treat obesity. Tirzepatide exerts its effects by acting on GIP and GLP-1 receptors. The dual effects of GLP-1 and GIP can attack the secretion and release of insulin while inhibiting glucagon. The synergistic effect of the two can effectively improve blood sugar management and promote weight loss.

Phcoker is peptide manufacturer specialized in Tirzepatide supply. The Tirzepatide supplied by Phcoker inlcude raw Tirzepatide powder and lyophilized powder in vial form.  Raw Tirzepatide powder as the active ingredient of Tirzepatide related drug, one of the biggest advantages is competitive price than free-ze dried powder form. The buyers of raw Tirzepatide powder usually are researchers who professional with the use of it. Beside raw Tirzepatide powder, Phcoker provide custom-made production of lyophilized powder form of Tirzepatide, the regular specification are 5mg,10mg and larger dosage, for special dosage requirements, custom-made service is available. If you are researchers,clinic,brand owner, Phcoker is a good choice for you.

 

Where to buy


Would you like to buy the best Tirzepatide peptide from the professional Tirzepatide suppliers in the market? You have come at the right place!

Phcoker as a peptide factory, is the best place where you can buy Tirzepatide in compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy Tirzepatide, you may curious:

What Are The Advantages If Buy Tirzepatide From Phcoker?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Tirzepatide Online?

  • Visit professional Tirzepatidesupplier Phcoker.com, choose the Tirzepatide you want to buy.
  • Leave your contact and message on Phcoker.com website, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy Tirzepatide.

Does Phcoker Provide Sample Of Tirzepatide?

Yes, please check it with our customer service.

Can I Appoint The Tirzepatide Cap Colour When Buy Tirzepatide Lyophilized Powder In Vial?

YES! Phcoker as peptide manufacturer, provide cap colour customization of Tirzepatide, easy to help you to build your Tirzepatide peptide brand.

Can I Appoint The Products Dosage When Buy Tirzepatide From Phcoker.com?

YES! As one of the best Tirzepatide manufacturers, Phcoker not only provide the standard specification of Tirzepatide in 5mg, 10mg, but support dosage customization. Provide the best support to build your own Tirzepatide brand.

Can I Buy Tirzepatide In Pure Raw Powder Form From Phcoker.com?

YES! Raw Tirzepatide powder is the base that use for Tirzepatide lyophilized powder manufacture. Phcoker provide Tirzepatide in both of pure raw powder form and semi-finished vial form.

Can I Buy Discount Tirzepatide From Phcoker.com?

YES! Our factory produce high quality raw Tirzepatide powder in term and keep Tirzepatide in stock. You can buy high quality raw Tirzepatide powder in bulk. During promotion sale, you can buy Tirzepatide peptide by lower price. You can keep totouch with our customer manager and they will update the latest bulk Tirzepatide price for you in time.

 

FAQ


What is Tirzepatide?

Tirzepatide is a dual GIP and GLP-1 receptor agonist with great therapeutic effect on type 2 diabetes and obesity. It is one of the most popular GLP-1 series drugs currently on the market.

Can Tirzepatide lyophilized powder be mixed with other medications?

NO. Tirzepatidecannot be mixed with any other drugs and should be administered separately to avoid conflicting properties.

What are the ingredients of Mounjaro?

The active pharmaceutical ingredient of Mounjaro is raw Tirzepatide powder.

What should I do if I miss a dose of Tirzepatide?

If you miss a dose of Tirzepatide, you need to take the missed dose as soon as you remember (this is provided that this is within 4 days of the missed dose). If more than four days have passed since your last dose, you should skip the missed dose and continue on your regular dosing schedule. You cannot inject 2 times within 3 days! ! !

How should the reconstructed Tirzepatide be stored?

Reconstituted Tirzepatide should be refrigerated at 2-8°C (36-46°F) and preferably used within 8 hours to ensure efficacy.

When will Tirzepatide peptide be available/approved?

Tirzepatide will be approved for marketing in the United States in May 2022; approved for marketing in the European Union in September 2022; and will be approved for medical use in Canada and Australia in November and December 2022.

How should Tirzepatide be used correctly?

Tirzepatide should be administered as a weekly injection according to the instructions for use, with or without food. Injection sites should be rotated between the thigh, abdomen, and upper arm.

What is compounded Tirzepatide?

Compunded Tirzepatide is a single peptide that targets human GIP and GLP-1 (two naturally occurring incretin hormones) receptors. By activating these receptors, the compound Tirzepatide can help obese patients achieve significant weight loss and improve their overall health.

What is the dosage of Tirzepatide?

According to research, the dosage of Tirzepatide for weight loss should start at 2.5mg. Thereafter, increase the dose by 2.5 mg every four weeks until the target doses of 5 mg, 10 mg and 15 mg are reached.

This dosage is for reference only, please consult your healthcare provider for specific dosage.

Is Tirzepatide a fast track to weight loss?

Tirzepatide is nearing FDA approval to treat obesity in adults. Obesity drugs appear to be improving. A new FDA-approved drug is being “fast tracked” and has been shown to help users lose more than a fifth of their body weight.

 

Referenced Citations


[1]”Australian prescription medicine decision summaries: Mounjaro“. Therapeutic Goods Administration. Archived from the original on 5 February 2023. Retrieved 28 February 2023.

[2]”Mounjaro tirzepatide 15 mg/0.5 mL solution for injection pre-filled pen (379334)“. Therapeutic Goods Administration. Archived from the original on 3 January 2023. Retrieved 28 February 2023.

[3]”Public Summary: Mounjaro tirzepatide 15 mg/0.5 mL solution for injection pre-filled pen“. Therapeutic Goods Administration. Retrieved 28 February 2023

[4]”Notice: Multiple Additions to the Prescription Drug List (PDL) [2023-03-08]“. Health Canada. 8 March 2023. Archived from the original on 22 March 2023. Retrieved 21 March 2023.

[5] “Summary Basis of Decision – Mounjaro“. Health Canada. 17 March 2023. Archived from the original on 25 April 2023. Retrieved 24 April 2023.

[6]Thomas MK, Nikooienejad A, Bray R, Cui X, Wilson J, Duffin K, et al. (January 2021). “Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes“. The Journal of Clinical Endocrinology and Metabolism. 106 (2): 388–396. doi:10.1210/clinem/dgaa863. PMC 7823251. PMID 33236115

[7] “FDA Approves Novel, Dual-Targeted Treatment for Type 2 Diabetes“. U.S. Food and Drug Administration (FDA) (Press release). 13 May 2022. Archived from the original on 13 May 2022. Retrieved 13 May 2022. Public Domain This article incorporates text from this source, which is in the public domain.

[8]New Drug Therapy Approvals 2022 (PDF). U.S. Food and Drug Administration (FDA) (Report). January 2024. Archived from the original on 14 January 2024. Retrieved 14 January 2024. Public Domain This article incorporates text from this source, which is in the public domain.

[9]Min T, Bain SC (January 2021). “The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials“. Diabetes Therapy. 12 (1): 143–157. doi:10.1007/s13300-020-00981-0. PMC 7843845. PMID 33325008

[10]Kolata G (8 November 2023). “F.D.A. Approves New Obesity Drug Tirzepatide That Will Compete With Wegovy“. The New York Times. Archived from the original on 9 November 2023. Retrieved 9 November 2023.

[11]Frias JP, Nauck MA, Van J, Benson C, Bray R, Cui X, et al. (June 2020). “Efficacy and tolerability of tirzepatide, a dual glucose-dependent insulinotropic peptide and glucagon-like peptide-1 receptor agonist in patients with type 2 diabetes: A 12-week, randomized, double-blind, placebo-controlled study to evaluate different dos“. Diabetes, Obesity & Metabolism. 22 (6): 938–946. doi:10.1111/dom.13979. PMC 7318331. PMID 31984598

[12]Dahl D, Onishi Y, Norwood P, Huh R, Bray R, Patel H, et al. (February 2022). “Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial“. JAMA. 327 (6): 534–545. doi:10.1001/jama.2022.0078. PMC 8826179. PMID 35133415

[13]Frias JP, Nauck MA, Van J, Kutner ME, Cui X, Benson C, et al. (November 2018). “Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor agonist, in patients with type 2 diabetes: a randomised, placebo-controlled and active comparator-controlled phase 2 trial“. The Lancet. 392 (10160): 2180–2193. doi:10.1016/S0140-6736(18)32260-8. PMID 30293770

[14]Willard FS, Douros JD, Gabe MB, Showalter AD, Wainscott DB, Suter TM, et al. (September 2020). “Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist“. JCI Insight. 5 (17). doi:10.1172/jci.insight.140532. PMC 7526454. PMID 32730231

[15] Østergaard S, Paulsson JF, Kofoed J, Zosel F, Olsen J, Jeppesen CB, et al. (October 2021). “The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs“. Scientific Reports. 11 (1): 21179. Bibcode:2021NatSR..1121179O. doi:10.1038/s41598-021-00654-3. PMC 8551270. PMID 34707178.

 

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


 

  1. Giovanni Pacini

Independent Researcher, Padova, Italy

  1. Kazuhiko Kido

PharmD, BCCP, BCPS, Clinical Associate Professor, Department of Clinical Pharmacy, West Virginia University School of Pharmacy

  1. Jessica W. Skelley

PharmD, BCACP, Professor, Department of Pharmacy Practice, McWhorter School of Pharmacy, Samford University, Birmingham, AL

  1. Qi Liu

Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei, PR China

  1. Stephen J. Nicholls MBBS, PhD

Victorian Heart Institute, Monash University, VIC, Melbourne, Australia

 


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