Tadalafil powder (171596-29-5)

October 20, 2018

Phcoker is a professional GMP grade manufacturer of Tadalafil powder, the regularly manufacturing specification of tadalafil powder is white to off-white colour, purity>99%. Factory package size from 1KG small bag to 25KG  large drum. Packaging specifications can be adjusted according to customer requirements. Tadalafil powder is the active ingredient to produce tadalafil related drug.

Monthly production capacity: >1100KG


Other Name:Cialis, Adcirca, Alyq, Entadfi, Tadliq

 

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Tadalafil powder video

 

Properties


 

Product Name: Tadalafil powder
Chemical Name: (6R,12aR)-6-(1,3-benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methylpyrazino[1′,2′:1,6]pyrido[3,4-b]indole-1,4-dione
Brand Name: Cialis, Adcirca, Alyq, Entadfi, Tadliq
CAS Number: 171596-29-5
InChIKey: WOXKDUGGOYFFRN-IIBYNOLFSA-N
Molecular Formula: C22H19N3O4
Molecular Weight: 389.4
Monoisotopic Mass: 389.138 g/mol
Melting Point: 298-300°C
Color: White to Off-White Cyrstalline Solid Powder
Solubility : Soluble in DMSO (78 mg/ml at 25° C), methanol, water (< 1 mg/ml at 25° C), dichloromethane, and ethanol (< 1 mg/ml at 25° C)
Storage Temperature: Store at room temperature between 59°F and 86°F (15°C and 30°C). Don’t store this medication in moist or damp areas.
Tadalafil Application: tablets, pills, capsules, functional drinks,candy,coffee

Description


Tadalafil History丨Tadalafil Background

Tadalafil powder is the active ingredient of tadalafil-based medicine, it is a selective phosphodiesterase-5 inhibitor that is used in the treatment of erectile dysfunction (ED), pulmonary arterial hypertension (PAH), and benign prostatic hypertrophy. Here is timetable of tadalafil development:

August 1991: Tadalafil was discovered by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs.

In 1993: The Bothell, Washington, biotechnology company ICOS Corporation began studying compound IC351, a phosphodiesterase type 5 (PDE5) enzyme inhibitor.

In 1994:ICOS received a patent for compound IC351 (structurally unlike sildenafil and vardenafil), and Phase 1 clinical trials began in 1995. In 1997, the Phase 2 clinical studies were initiated for males experiencing ED, then progressed to the Phase 3 trials that supported the drug’s FDA approval.

In 1998: tadalafil be further develop and commercialize as a treatment for ED.

May 2002: Cinical trial testing demonstrated that Tadalafil was effective for up to 36 hours

In 2003: Tadalafil be approved by FDA

October 2011: Tadalafil approved by US FDA to treat the signs and symptoms of benign prostatic hyperplasia

By viewing the background introduction of Tadalafil, you can have a clearer understanding of the entire development history of tadalafil. As one of the best sell ED treatment drugs in the market, Tadalafil sold under different brand name and different forms include oral pill, capsule, tablet. Cialis and  Adcirca are two of the popular brand name.

Tadalafil powder as the active ingredient of tadalafil-based drugs,we can have a deeper understanding of tadalafil powder through these related products, including its benefits,side effects..etc. Let’s continue to have a look.

What Is Tadalafil丨Tadalafil Powder?

Tadalafil is a medicine used to treat erectile dysfunction (ED, also called impotence) and problems with urination caused by an enlarged prostate (benign prostatic hypertrophy or BPH). It is sometimes known by its generic name tadalafil, and sometimes known by its trade name, Cialis. There are also other brands of this medicine available, such as Adcirca, Alyq, Entadfi, Tadliq.

Tadalafil powder is the active ingredient of the tadalafil brand product. It is a white to off-white powder, manufacturered by chemical factories, China and India are the two major suppliers of Tadalafil powder. Tadalafil powder supplied with different purity standard, the best is 99.99% pure raw powder form. Tadalafil powder price in India is totally different than China. Researchers seeking tadalafil powder for research purpose or individual who resell tadalafil powder found that, although the tadalafil powder manufacturers claim the purity is >99%, but the testing result is totally different, some of them even no any effects. So it is challenge to find out the best supplier from so many tadalafil powder manufacturers.

How Does Tadalafil Work丨Mechanism Of Action Of Tadalafil

Tadalafil is a popular product in the market,individual can buy tadalafil with prescription from pharmacy or the doctor prescribes it for you. How is tadalafil work? What is the mechanism of action of tadalafil?  Tadalafil mainly acts in three directions, here they are:

Tadalafil for erectile dysfunction(ED): If you have erectile dysfunction also called sexual impotence, when sexually aroused, it operates by transiently boosting blood circulation to the penis. However, without physical stimulation to the penis, such as during sexual intercourse, tadalafil will not induce an erection.

Tadalafil for benign prostatic hyperplasia (BPH): Tadalafil Aids in alleviating symptoms associated with an enlarged prostate gland by relaxing the muscles in both the prostate and bladder. Individuals with BPH typically experience challenges with urination, including decreased flow and hesitancy at the onset of urination.

Tadalafil for pulmonary hypertension treatment: Men and wemen who experiencing symptoms of pulmonary arterial hypertension, where the smaller blood vessels in the lungs become more resistant to blood flow, find that the right ventricle of the heart must exert greater effort to adequately pump blood through the lungs. Tadalafil acts on the PDE5 enzyme within the lungs to relax blood vessels, thereby enhancing blood supply to the lungs and alleviating the heart’s workload.

It is precisely because Tadalafil works through the above 3 ways and brings great convenience to people’s lives that more and more people are buying Tadalafil for different purposes. Tadalafil related  drug sold under different brand name for different purpose, like tadalafil 5mg, tadalafil 20mg tablet for oral, people can choose to buy the form of Tadalafil that suits them according to their needs. But tadalafil price is different from place to place, be sure buy it from the best tadalafil suppliers!

What Are The Benefits You Can Get From Tadalafil丨Tadalafil Benefits

One of the most well-known benefits of tadalafil is as a treatment for male erectile dysfunction(ED). While this is the common benefits of tadalafil, tadalafil have some other good benefits for men and wemen, here are the primary 8 benefits of tadalafil in 2024:

Tadalafil for Erectile Dysfunction(ED): Tadalafil is popular sell for sexual function problem treatment, in combination with sexual stimulation, tadalafil works by increasing blood flow to the penis to help a man get and keep an erection. This type of Tadalafil drug is usually available on the market in different dosage strengths, from small dosage 2.5mg to large dosage 20mg.

Tadalafil for enlarged prostate: Research show that tadalafil helps to treat and prevent enlargement of the prostate, although tadalafil is not the first line treatment for prostate conditions, but it helps to relieve symptoms of BPH.

Tadalafil for heart performance improvement: Among the remarkable health advantages associated with tadalafil is its capacity to enhance heart function. Research indicates that use tadalafil can alleviate symptoms of pulmonary arterial hypertension and enhance physical endurance in individuals suffering from chronic heart failure. Notably, a study revealed that individuals who took 20mg doses of tadalafil for six months experienced enhanced blood circulation and increased oxygen delivery to their hearts.

Tadalafil for blood pressure control: Another benefits of tadalafil use is it helps reduce blood pressure. Studies show that a lot of patients have reported tadalafil can reduce systolic blood pressure by 4-5 mmHg over a 24-hour period.

Tadalafil is safe to use: as a prescription drug, tadalafil has quite mild side effects. Research datas show that taking daily dosage of tadalafil 2.5mg or 5mg means having a constant working concentraton in your body, instead of the peaks and troughs you get with occasional dosing, this help to reduces the irritating side effects of tadalafil.

Tadalafil for longevity: Studies in 2020 found another useful benefits of tadalafil. The study showed that Tadalafil has a positive effect on vascular endothelial cell regeneration by increasing the amount of endothelial progenitor cells and CXCR4 expression which is linked to the cGMP cellular messenger system resulting in improved repair of vascular damage. So it mean tadalafil can help to improve the repair and recovery of the lining of blood vessel walls thus improving cardiovascular health and longevity.

Tadalafil for antidepressant use: One of the most exciting health benefits of tadalafil is its potential for fight depression. There are research results indicate that tadalafil is effective in treating depression in men by boosting serotonin levels in the brain, which helps lift mood and fight off feelings of sadness and despair.

Tadalafil for self-confidence building: Erectile dysfunction is a problem faced by more and more men, and their self-confidence is severely affected by this problem.Tadalafil is a medication which comes under the class of selective PDE 5 inhibitors, it works quickly and effectively to help men with ED get and maintain an erection.Thereby helping men increase their self-confidence and improve their happiness in life.

What Are The Benefits Of Buying Tadalafil Powder

Tadalafil powder as the active ingredient of tadalafil related medicines, what are the benefits to buy tadalafil powder than tadalafil oral capsule/tablet/pill…? According to market research data provided by phcoker (polypeptide) company, here are the top 3 benefits of buying tadalafil powder.

Tadalafil powder price is cheaper: According to the tadalafil price research from Walmart, indicate that one bottle of 60 capsules of tadalafil pill which contain 10mg of each capsule, tadalafil price per capsule is from US$12.99-US$39.99. Tadalafil pure powder price is from US$0.4-US$0.55 per gram. It can be seen from this that, for people who seeking tadalafil powder for research or so, tadalafil powder cost almost negligible.

Tadalafil powder is easier to buy: Tadalafil is a prescription drug and can only be obtained from pharmacies or hospitals with a doctor’s prescription. On the contrary, you can buy Tadalafil powder very easily from online. Specially from China or India where is the largest market of tadalafil powder manufacturers locate. But tadalafil powder buyers complain it is too difficult to find a good manufacturer of tadalafil pure raw powder.

Tadalafil powder with wider range of use: Compare to tadalafil tablet/pill/capsule,tadalafil powder has wider range of use. So what can tadalafil powder be used for?

1. Tadalafil powder for oral tablet/pill/capsule: Oral tablet, pill and capsule are the traditional use method of tadalafil powder. According to formulation, the manufacturers mix tadalafil powder with other supplement ingredient together to make it into oral pill, tablet or capsule. For different purpose, the dosage of each pill may from 2.5mg-20mg and so on.

2. Tadalafil powder for functional drink: According to the customers comment data provided by Phcoker(polypeptide) company, tadalafil powder can be used to make functional drink. For example, mix with honey, juice…

3. Tadalafil powder for candy: According to the Tadalafil recipe, Tadalafil powder is mixed with candy-making materials to make candies of various shapes, including hard candies and soft candies. According to Phcoker(polypeptide) company’s market research, the process of making Tadalafil gummies is more complicated and more difficult. This type of Tadalafil candy is rich in color, easy to carry, and is very popular on the market.

4. Tadalafil powder for gum: Another common use of Tadalafil powder is making chewing gum. This kind of Tadalafil chewing gum are very popular in the Korean market. They can be carried in purses, pockets and other places every day. The packaging is high-end and very popular among customers.

As an indispensable part of life, tadalafil has a very wide market demand. If you want to know more about the benefits of Tadalafil powder, please feel free to contact us.

Where To Buy Tadalafil Powder丨Tadalafil Powder Manufacturers

Since Tadalafil powder has so many benefits as above mentioned, where can we buy Tadalafil powder and how to choose the best tadalafil powder supplier among the many Tadalafil powder manufacturers in the market?

Tadalafil powder buy in India: India is the largest market for generic drugs, not only tadalafil powder, but you can buy sildenafil powder in India with very cheap price also.

Tadalafil powder buy amazon: There are suppliers sell tadalafil powder in Amazon. But most of them are suppliers of tadalafil oral form, such as tadalafil pill, tablet, capsule. Because it is a third-party platform, the price of tadalafil in Amazon may more expensive.

Tadalafil powder buy in China: In addition to India, China is another large source of Tadalafil powder. Due to the special nature of Tadalafil, the real Tadalafil powder factories are hidden, so if you want to find the best Tadalafil powder manufacturer, you need to conduct multiple comparisons. From price to quality, shipping, service…

Good Tadalafil powder manufacturers have strict requirements for the production environment and quality management system of Tadalafil powder. They can not only provide professional test reports(Certificate of Analysis, HPLC, MS), but even professional third-party laboratory test reports. A good Tadalafil powder manufacturer can not only guarantee the quality of the sample, but the quality of each batch must be the same as the sample.

What Are The Potential Side Effects Of Tadalafil

Like most medications, tadalafil has several common side effects associated with its use. However, none of them are serious, daily-life activities altering, or life-threatening. In fact, most of them will resolve on their own and will not require medical intervention. The common side effects of Tadalafil include, but are not limited to:

Stuffy nose

Headaches

Dyspepsia

Stomach ache

Flushing; warmth and redness of the skin

Tinnitus; persistent ringing sound in the ear

Hearing problems

Blurry vision

Loss of vision

Priapism

The last side effect is relatively more serious and refers to a prolonged and painful erection that has lasted, usually more than four hours. In such situations, it is recommended to seek medical help immediately as it is a more serious, albeit rare, side effect of Tadalafil consumption.

Since October of 2007, FDA requires all PDE5 inhibitor drugs containers to include a warning label that lets the users know that these medications have the potential to cause temporary yet sudden hearing loss. This decision by the FDA was the result of several complaints of hearing loss in patients using Tadalafil or similar drugs that were registered with the FDA, requiring them to properly analyze the issue. FDA research found hearing loss to be a serious side effect of TAdalafil that they believe all patients should be made aware of, in clear terms, so they can make an informed decision.

Vision loss was yet another frequent complaint associated with Tadalafil use and when FDA looked into these complaints, it was found that this side effect was mostly occurring in patients already suffering from an eye pathology, namely non-arteritic anterior ischemic optic neuropathy or NAION. Since there was no direct cause and effect found by the FDA, there is no warning label related to vision loss on Tadalafil powder or other PDE5 inhibitors packing labels.

Who Should Not Use Tadalafil?

Tadalafil  has various benefits and uses but it is specifically designed for the male gender, especially those over the age of 18 years. The medication should not be taken by women and children as they may be at higher risk of developing several of the common side effects and complications associated with Tadalafil use. The following populations should not take Tadalafil or tadalfil-relate drugs, or consult with their doctor before starting any medication belonging to the PDE5 inhibitors drug class:

People with a history of surgical intervention within the last three months

People with a history of cardiac events in the last three months to six months

People with hypertension and hyperlipidemia

People with renal diseases

People with retinitis pigmentosa

People with hemophilia or similar blood disorders

People with multiple myeloma, or leukemia

People with stomach ulcers

People with a history of stroke or with increased risk of suffering a stroke

These people aren’t allowed to take Tadalafil because their current medications can interact with the drug, resulting in life-threatening complications. In some cases, these patients’ bodies may be more susceptible to the relatively common and non-serious side effects of the drug but the intensity of complications may be higher than usual.

Common Drug Interactions With Tadalafil

Certain medications should not be taken together as they can interact with each resulting in either decreased effect of both, the increased effect of both, or amplification of negative effects of both medications.  Tadalafil is one such medication that should not be taken along with the following medications.

Antacids: These medications interact with Tadalafil such that they result in decreased efficiency of the latter drug, although the exact mechanism is yet not understood. However, it is important to warn patients about the possible interaction between these two medications, especially as the former drug is a common household medication.

PDE5 Inhibitors: Consumption of drugs with a similar mechanism of action as Tadalafil can result in a significant increase in blood flow and a life-threatening decrease in blood pressure. Mixing two different PDE5 inhibitors or taking a double dose of the same drug can result in complications rather than extra benefits.

Alcohol: Taking Tadalafil powder with alcohol cannot cause any specific complications but it can result in a huge increase in the intensity of the side effects. They may be common in occurrence but when intensified, can become intolerable and may require medical help.

Nitrates: These medications are used for cardiac purposes and their main function is to increase blood flow through blood vessels by having a vasodilatory effect on them. This mechanism of action is similar to that of Tadalafil, hence the combination of the two drugs results in an exaggeration of the negative effects of both drugs.

Anti Hypertensives: The reason for this is the same as that of nitrates. Anti hypertensives and Taladafil both work on reducing blood pressure by vasodilating vessels, which if taken together, would result in extremely low blood pressure that could result in mortality, if left untreated.

CYP3A4 Inducers: CYP3A4 is the enzyme responsible for the excretion of the Tadalafil compound from the body after it has served its purpose. However, a medication that increases the effects of this enzyme would consequently result in increased excretion of Tadalafil, even before it has been able to fulfill its purpose. This renders the latter inefficient and useless.

CYP3A4 Inhibitors: Any drug that inhibits the action of the CYP3A4 enzyme would result in decreased excretion of Tadalafil which would leave it in the human system longer than necessary. This prolonged effect is unnecessary and has the potential to be quite dangerous overall, which is why the combination of these two should be avoided at all costs.

Guanylate Cyclase Stimulators: These medications target the vasculature of the lungs, aiming to reduce the pressure of the blood flowing through it. However, that is also one of the beneficial effects and uses of Tadalafil. Taking these two together could result in extremely low pulmonary blood pressure, which can be fatal if not aptly and timely treated.

Tadalafil Further Research Information

Tadalafil, Vardenafil, Sildenafil, Flibanserin are 4 of the popular sex enhancement medicine in the market, they are all available in the market in different forms, include tablet,pill,capsule,drink,candy and so on. So what are the difference between them? Which one is good for you?

Tadalafil Vs Sildenafil: Tadalafil and Sildenafil have emerged among the most effective and commonly prescribed oral medications for effectively treating erectile dysfunction (ED). Both Sildenafil and Tadalafil work by blocking certain chemicals in the body, which helps increase blood flow to the penis, aiding in erections.However, there are noteworthy differences between these ED treatment options:

Tadalafil goes by the brand name Cialis, while Sildenafil is sold widely under the brand name Viagra.

Tadalafil elicits a much longer duration of action, lasting up to 36 hours, with effects that can persist from 24-36 hours after a dose. Time to onset is faster with Sildenafil, producing effects within 30-60 minutes on average.

Both tadalafil and sildenafil have similar systemic side effects, but Sildenafil is more prone to temporary visual changes like blurred vision or blue-tinted vision

Tadalafil is similarly effective as sildenafil in the treatment of ED. In comparison studies, tadalafil is preferred to sildenafil (50/100mg) by men with ED, possibly because of its longer duration of action. Of the phosphodiesterase inhibitors, tadalafil may displace sildenafil as the drug of choice among men with ED.

Tadalafil Vs Vardenafil: Studies show that both Tadalafil and Vardenafil are effective for treating ED. However, individual responses to each medication may vary.

Tadalafil sold under brand name of Cialis, often referred to as “the weekend pill”, up to 36 hours of effectiveness. While Vardenafil known by the brand name of Levitra, and typically lasts for around 5-6 hours.

The side effects of Tadalafil and vardenafil are generally mild, but there are differences. Common side effects include headaches, flushing, and nasal congestion. However, back pain and muscle aches are more common in Tadalafil users. While Vardenafil might cause some visual disturbances.

Tadalafil dosage common seen are 2.5mg,5mg,10mg and 20mg, while Vardenafil is usually available in 5mg,10mg and 20mg.

Tadalafil and Vardenafil both cost-effective drug as generic versions.

Tadalafil Vs Flibanserin: Tadalafil and Flibanserin both are well-known sex enhancement drug, but they are no the same thing.

Tadalafil (Cialis) is used to treat erectile dysfunction (ED, impotence; inability to get or keep an erection), and the symptoms of benign prostatic hyperplasia (BPH; an enlarged prostate). While Flibanserin is a medication that treats hypoactive sexual desire disorder.

Tadalafil sold under the brand  name of Cialis and widely used in men, while Flibanserin known with the brand name of Addyi, and usually use for women. Both of Tadalafil and Flibanserin can be taken as oral.

 

Manufacturers/Factory


As demand for Tadalafil for sex enhancement continues to increase, demand for tadalafil on the market exceeds supply. Under such circumstances, many people turn to purchasing tadalafil powder from the online tadalafil powder sources. This tadalafil powder can be purchased through some laboratories, medical institutions and tadalafil powder factories. These tadalafil powder suppliers must have strict GMP production conditions, conduct strict testing of their products and issue test reports (such as COA, HPLC, etc.). Please be careful before purchasing tadalafil powder from online tadalafil powder suppliers. Phcoker is one the best tadalafil powder GMP manufacturers worth to check.

 

Where to buy


Researchers found that many tadalafil powder  manufacturers supply tadalafil powder online. If you want to buy the tadalafil powder  online, you have come at the right place!

Phcoker as a tadalafil powder GMP manufacturer, is the best place where you can buy tadalafil powder  with compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy tadalafil powder, you may curious:

What Are The Advantages If Buy Tadalafil Powder  From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Tadalafil Powder Online?

  • Visit professional tadalafil powder supplier Phcoker.com, choose the tadalafil powder you want to buy.
  • Leave your contact and message on Phcoker.com website, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy tadalafil powder.

Does Phcoker.com Support The Free Sample Of Tadalafil Powder?

Yes, as one of the best manufacturer of tadalafil powder, Phcoker.com provide free sample of tadalafil powder to customers who want to testing it. Please check the details with the customer service.

Can I Buy Tadalafil Pure Powder Form From Phcoker.com?

YES! Tadalafil powder is active ingredient of tadalafil relate drug production. Phcoker provide tadalafil powder with purity >99.9%.

Can I Buy Discount Tadalafil Powder From Phcoker.com?

YES! Phcoker produce high quality Tadalafil powder in term and keep tadalafil powder in stock. You can buy high quality tadalafil powder in bulk. During promotion sale, you can buy tadalafil powder with lower price. You can keep touch with the customer manager and they will update the latest bulk tadalafil powder  price for you in time.

 

FAQ


What is the brand name of Tadalafil powder?

Cialis and Adcirca is the brand name of Tadalafil.

How long does Tadalafil powder last?

Generally speaking, the effects of Tadalafil usually last about an hour after taking it, but since everyone’s physical condition is different, their response to the drug will also be different.

Is Tadalafil safe?

Tadalafil is generally considered a safe medication, but this is not recommended if you are taking specific medications that may interact with Tadalafil.

What effects does Tadalafil have on men?

Tadalafil is commonly used to treat men with erectile dysfunction

Tadalafil is used to treat men with erectile dysfunction. It belongs to the class of drugs that are phosphodiesterase 5 (PDE5) inhibitors. These medications prevent phosphodiesterase type 5 from working too quickly.

Will using Tadalafil increase testosterone levels?

Studies have shown that the use of Tadalafil powder inhibits the mRNA and protein expression of aromatase, resulting in an increase in testosterone levels in the supernatant.

When is Tadalafil most effective?

If treating erectile dysfunction, take it at least 30 minutes before you want to have sex. If you are treating prostatic hypertrophy, you can take it in the morning or evening, but it is best to take it at the same time every day.

What should I pay attention to when using Tadalafil?

Please do not eat grapefruit or grapefruit juice while you are taking Tadalafil, as this may affect the amount of drug absorbed into your body. In addition, please do not take other medications at the same time unless this has been discussed with your doctor.

How will your body react after using Tadalafil?

Tadalafil mainly acts on the PDE5 enzyme in the lung area, causing blood vessels to relax, which can increase the blood supply to the lungs and reduce the workload of the heart.

How will I feel after using Tadalafil?

The most common side effects of using Tadalafil are: headache, indigestion, back pain, muscle aches, flushing, and stuffy or runny nose. But these side effects usually go away after a few hours.

Does Tadalafil affect the kidneys?

Tadalafil has a positive effect on renal blood flow and blood pressure. Some studies have concluded that both high and low doses of Tadalafil can prevent chronic kidney disease.

 

Referenced Citations


[1]”Tadalafil Use During Pregnancy”. Drugs.com. 14 March 2019. Archived from the original on 1 December 2020. Retrieved 20 August 2020.

[2]”FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)”. nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[3] “Cialis 10mg film-coated tablets – Summary of Product Characteristics (SmPC)”. (emc). 26 April 2017. Archived from the original on 1 December 2020. Retrieved 20 August 2020.

[4] “Adcirca- tadalafil tablet”. DailyMed. 23 June 2022. Archived from the original on 6 March 2023. Retrieved 10 April 2023.

[5] “Tadalafil Monograph for Professionals”. Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 20 September 2020. Retrieved 8 April 2019.

[6]Revill J (2 February 2003). “Drugs giant says its new pill will pack more punch than rival Viagra”. The Observer. Archived from the original on 3 April 2007. Retrieved 6 April 2007.

[7]”FDA approves Cialis to treat benign prostatic hyperplasia”. U.S. Food and Drug Administration (FDA). 6 October 2011. Archived from the original on 18 January 2017.

[8]McCarthy S (5 March 2005). “First they tried to play it safe; Ads for erectile dysfunction drug Cialis bared all – including a scary potential side effect. It was risky but it has paid off”. The Globe and Mail. p. B4. Archived from the original on 14 December 2019. Retrieved 12 June 2017.

[9]Parker-Pope T (28 August 2009). “The Cost of Treating Erectile Dysfunction”. The New York Times. Archived from the original on 10 September 2015. Retrieved 20 December 2016.

[10] “Tadalafil powder & Intermediate”. cmoapi.com. Archived from the original on 9 November 2021. Retrieved 7 September 2021.

[11] “FDA Announces Revisions to Labels for Cialis, Levitra and Viagra”. U.S. Food and Drug Administration (FDA). 18 October 2007. Archived from the original on 22 October 2016. Retrieved 28 September 2009.

[12] Lemma GL, Desta Z, Jones DR, Gorski JC, Hall SD (February 2003). “Droperidol is predominantly metabolized by human CYP3A enzymes”. Clinical Pharmacology & Therapeutics. 73 (2): P16. doi:10.1016/s0009-9236(03)90413-9. ISSN 0009-9236. S2CID 71353631.

[13]Kaye K. Gaines. “Tadalafil (Cialis) and Vardenafil (Levitra) Recently Approved Drugs for Erectile Dysfunction”. Medscape. Archived from the original on 14 July 2016. Retrieved 30 September 2016.

[14] “Ppsynvi (macitentan and tadalafil) Becomes the First and Only Health Canada-Approved Once Daily Fixed Dose Combination Treatment for Patients with Pulmonary Arterial Hypertension (PAH)”. Johnson & Johnson (Press release). Archived from the original on 26 November 2021. Retrieved 26 November 2021.

[15]Hatzimouratidis K (August 2014). “A review of the use of tadalafil in the treatment of benign prostatic hyperplasia in men with and without erectile dysfunction”. Therapeutic Advances in Urology. 6 (4). SAGE Publications: 135–147. doi:10.1177/1756287214531639. PMC 4054509. PMID 25083163.

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


1.Miao Tang

Department of Pharmacy, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China

2.Tomohiro Nishimura

Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo, 105-8512, Japan

3.Ekkehard Grünig MD

Thoraxklinik at Heidelberg University Hospital and Translational Lung Research Center, German Center for Lung Research, Heidelberg, Germany

4.Jane Sun Zhang MD

Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois

5.Dhruvanshi Gol

Department of Pharmaceutical Quality Assurance, B.K. Mody Government Pharmacy College, Polytechnic campus, Near Aji dam, Rajkot, 360003, Gujarat, India


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