Retatrutide

March 2, 2024

Phcoker is a professional GMP manufacturer of Retatrutide that provide both form of Retatrutide powder and Retatrutide finished lyophilized powder in vial.  The regularly manufacturing specification include Retatrutide 5mg, Retatrutide 10mg, Retatrutide 15mg. Larger dosage and contract manufacturing service is available.

Monthly production capacity: >1,000,000 vials


Other Name:LY-3437943

 

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Properties


Sequence: YA1QGTFTSDYSIL2LDKK4AQA1AFIEYLLEGGPSSGAPPPS3
Molecular Formula: C223H343F3N46O70
Molecular Weight: 4845.444g/mol
PubChem CID: 474492335
CAS Number: 2381089-83-2
Synonyms: LY3437943

Description


If you’re considering trying one of the newer weight management medications, you’re not alone. Glucagon-like peptide-1 (GLP-1) agonists are currently the most popular weight management medications. The GLP-1 market size is estimated at $11.87 billion in 2023 and is expected to reach $12.55 billion by 2028. The demand for these newer medications is growing rapidly, which is leading to shortages and the development of new medications.

Besides, your healthcare dollars are valuable, and it’s important to make informed decisions about how to spend them. Before choosing which medication to invest in, it might be helpful to learn more about one of the newest weight management medications, Retatrutide peptide.

Structure of Retatrutide

Structure Retatrutide

Retatrutide Peptide: The “Godzilla” of weight loss medication

Obesity is a treatable, chronic disease whose biological basis is complex. Researchers are currently in the field of rapidly expanding treatments to provide potentially highly effective treatment options for obese patients.

Retatrutide Peptide weight loss medication

Retatrutide peptide is a new and promising treatment for obesity, developed by Eli Lilly. Known for its potent weight loss effects, it is currently under investigation in clinical trials and has garnered significant attention in the medical community. This injectable drug is also known as GGG tri-agonist, GLP-1/GIP/glucagon tri-agonist, or LY3437943.

Retatrutide belongs to the GLP-1 family along with weight loss drugs such as Semaglutide and Tirzepatide. However, there are differences between these three products. Semaglutide targets only a hunger-controlling hormone called GLP-1, while Tirzepatide targets both GLP-1 and GIP. Retatrutide takes weight loss to the next level by targeting three hunger-regulating hormones: GIP, GLP-1, and glucagon receptors.

Researchers who specialize in weight loss peptides has been great interest in Retatrutide. To do more in-depth research, they purchased Retatrutide powder from the retatrutide powder manufacturers online, mainly focusing on the effects, benefits, and comparison of Retatrutide with Semaglutide and Tirzepatide. As a more advanced weight loss peptide, Retatrutide is undoubtedly more expensive than Semaglutide and Tirzepatide. Although it will be cheaper to buy Retatrutide online, it is important to choose a reliable supplier.

Exploring Retatrutide: Eli Lilly’s Latest Breakthrough in Obesity Treatment

Core Registration Studies

Since Retatrutide was launched, it has been sought after by many weight loss people and scientific researchers. People even buy Retatrutide to conduct more in-depth research to better understand the amazing effects of Retatrutide. The primary studies for retatrutide are:

  • TRIUMPH-1: Randomized, double-blind, placebo-controlled trial to study efficacy and safety in obese or overweight participants without type 2 diabetes, including those with OSA and OA
  • TRIUMPH-2: Randomized, double-blind, placebo-controlled trial to study efficacy and safety in obese or overweight patients with type 2 diabetes, including those with OSA
  • TRIUMPH-3: Randomized, double-blind, placebo-controlled trial designed to investigate class II (BMI ≥ 35 kg/m 2 and < 40 kg/m 2 ) or class III (BMI ≥ 40 kg/m 2 ) participants Efficacy and Safetym 2) Obesity and Established Cardiovascular Disease
  • TRIUMPH-4: Randomized, double-blind, placebo-controlled trial to study efficacy and safety in obese or overweight OA participants

The Clinical Results Of Retatrutide

Phase II trial

The latest results from the phase II trial (NCT04881760) showed that after 48 weeks, the percentage change in body weight was -8.7%, -17.1%, – 22.8% and -24.2%. Additionally, the study found that 60% of participants lost more than 15% of their body weight. From a safety perspective, the most common side effects are of a gastrointestinal nature. Therefore, the safety profile of retarglutide is the same as that of other incretin-based treatments.

Phase III trial

A Phase III trial (TRIUMPH-3; NCT05882045) began in May to evaluate the effects of retarglutide in patients with established cardiovascular disease and those with severe obesity. The trial is expected to end in November 2025.

How does Retatrutide work?

(1)What are receptor agonists?

Receptors are protein entities that decorate the outside of our cells and are conduits for signals from outside the cell. After binding, these substances send messages to our specific cells, stimulating the relevant organs to respond.

An agonist is a compound, either a drug or a chemical, that binds to a cell receptor and produces a specific response. It can be either naturally occurring or synthetic. The most typical examples of natural agonists are hormones and neurotransmitters.

(2)Retatrutide’s mechanism of action:

Different receptor agonists play different roles in our bodies, depending on the cell receptor they bind to. As mentioned previously, Retatrutide stimulates glucagon, GLP-1, and GIP receptor agonists. Understanding agonists is the first step in understanding how Retartrutide works. Here’s what each does in our bodies and why they help with weight loss:

Retatrutide’s mechanism of action

GLP-1 (glucagon-like peptide-1):

The intestinal peptide hormone glucagon-like peptide-1 (GLP-1) is obtained by our bodies from the food we eat. This hormone has many uses, but its main role is to control food intake and hunger. When we eat a meal or snack, blood sugar rises, which prompts the release of GLP-1, which prompts the pancreas to secrete insulin.

Insulin is an important hormone produced by our bodies and is key in releasing the glucose we take in from our diet into our cells. Cells rely on glucose as their main energy source, which highlights the important role of insulin. Lack of enough insulin prevents glucose from entering cells, which not only blocks nutrient absorption but also causes blood sugar to rise, leading to weight gain.

GLP-1 promotes insulin secretion from the pancreas while reducing glucose release from the liver. In addition to regulating blood sugar, GLP-1 also intentionally reduces gastric emptying, thereby prolonging digestion. This means you’ll feel full faster after a meal. Additionally, GLP-1 affects the brain’s hunger center, which can lead to a decrease in appetite. These two parts of GLP-1 interact to quell hunger. This effect is similar to appetite suppressants such as phentermine, which are commonly used for weight loss.

GIP (glucose-dependent insulinotropic polypeptide):

Glucose-dependent insulinotropic polypeptide (GIP) belongs to the incretin hormone family, like GLP-1. Therefore, these two peptide hormones behave in very similar ways. This hormone is produced in the small intestine after a meal and resides on pancreatic beta cells, effectively initiating the release of insulin. This feature helps control blood sugar after meals. However, the GIP’s residence time in our system is very short, about 7 minutes. GIP agonist drugs like Mounjaro work by maintaining GIP levels in the blood to prolong its presence. This hormone causes the stomach to slowly empty while reducing appetite.This is why the stomach is one of the best places to inject Tirzepatide for weight loss.

Glucagon receptor:

Glucagon is another vital hormone that plays an important role in regulating blood sugar levels. It comes from the pancreas, similar to GLP-1 and GIP, but it comes from a specific type of cell called alpha cells. Glucagon works in the exact opposite way to the above hormones. When blood sugar levels drop due to factors such as fasting or sleep, glucagon begins converting glycogen (retained sugar) into glucose. This provides our bodies with easily available fuel. Although insulin and glucagon perform different tasks, they work together to maintain optimal blood sugar levels. Insulin directs sugar into glycogen, while glucagon directs sugar into glycogen.

(3)How does glucagon help with weight loss?

Our system stores excess glucose from dietary intake as fat and glycogen. When we don’t consume carbohydrates (such as during sleep, a low-calorie diet, or intermittent fasting), glucagon begins working to control glucose production. Once glycogen stores are depleted, glucagon switches to breaking down fat stores, converting them into energy.

Retatrutide Weight Loss Drug Unveiled: Transforming Treatment for Diabetes and Obesity and Fatty Liver

(1)Retatrutide for Treatment of Type 2 Diabetes

Retatrutide has also shown promise in reducing glycated hemoglobin levels, which is important for managing diabetes and preventing its complications. Its effects on heart health are still being studied, but research suggests that it might improve heart rate and blood pressure.

In phase 2 trials, retatrutide has been found to significantly lower levels of glycated hemoglobin (HbA1c). Hemoglobin is a protein in the blood that carries oxygen, but when it combines with sugar, it forms glycated hemoglobin. High levels of this type of hemoglobin are usually due to consistently high blood sugar levels, which are characteristic of diabetes. Monitoring HbA1c levels is important for managing diabetes because keeping them low not only helps control blood sugar effectively but also reduces the risk of long-term complications like heart disease, nerve damage, kidney problems, and eye issues.

(2)Retatrutide for Treatment of Obesity

What sets retatrutide apart is its innovative mechanism of action, targeting three distinct receptors in the brain. Unlike existing weight loss jab, retatrutide goes a step further by turbocharging calorie burning while simultaneously inducing a sense of fullness. The results of a trial presented at the European Congress on Obesity in Venice were nothing short of remarkable – participants experienced an average weight loss of one-quarter of their body weight after nearly a year. Experts have hailed Retatrutide powder as the most effective anti-obesity treatment to date, earning it the nickname “Godzilla” among weight loss jabs.

Manufactured by American pharmaceutical firm Eli Lilly, retatrutide could soon become an option for patients on the NHS, pending further long-term studies. In a trial involving 338 obese adults, those administered with retatrutide witnessed unprecedented weight loss outcomes. Over 48 weeks, participants lost an average of 24% of their body weight, equivalent to more than four stone each. Notably, retatrutide demonstrated greater efficacy in women, with a weight loss of 28.5% compared to 21.2% in men. In stark contrast, the placebo group experienced a mere 2% reduction in body weight.

These are the highest results ever seen with an anti-obesity drug. This is encouraging news for many people who have effectively given up trying to lose weight.

Retatrutide for Treatment

(3)Retatrutide for Treatment of fatty liver Disease

Retatrutide powder has been a significant topic at the American Diabetes Association’s (ADA) Scientific Sessions, highlighting its potential as a breakthrough treatment for obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). According to research, more than 33 million people in the United States have type 2 diabetes. Among them, 5%-7% of people suffer from clinically significant liver disease.

Hepatologists at Virginia Commonwealth University say that more than 85 percent of obese participants with fatty liver disease in clinical trials of the experimental drug Retatrutide had their liver fat reduced to the point where they were no longer diagnosed as fatty liver disease.

Fatty liver disease is a common but reversible condition linked to obesity, alcoholism, and type 2 diabetes. In this condition, fat builds up in your liver, making it harder for your liver to complete its normal functions of:

  • Removing toxins from your blood
  • Digesting food
  • Storing energy

Notably, participants in the Phase 2 Clinical Trials of retatrutide also reported healthy changes in their hemoglobin A1c (a measure of diabetes control), blood pressure, and LDL (unhealthy) cholesterol as they lost weight.

(4)Retatrutide for Treatment of Heart Heath

Although the direct impact of retatrutide on heart health in humans hasn’t been studied, research has been conducted.

Supporting this idea is the fact that several incretin agonists like semaglutide and liraglutide have been linked to improvements in heart health among people with diabetes. Because of this, these peptides are now being studied for potential direct use in treating heart disease. Retatrutide is expected to yield even better outcomes due to its broader impact on glucagon levels. However, the exact effects will need further investigation through detailed clinical and benchtop trials. These findings suggest that retatrutide and similar molecules could be beneficial for repairing the cardiovascular system and preventing heart disease in the first place.

Retatrutide powder, with its impressive clinical trial results and comprehensive approach to metabolic health, represents a significant advancement in the treatment of obesity and related conditions. The involvement of reliable manufacturers like Phcoker ensures that the medication is produced to high standards, contributing to its potential success as a groundbreaking therapy.

Retatrutide vs Tirzepatide vs Semaglutide: Which Peptide Offers Better Long-Term Benefits?

Semaglutide, Tirzepatide and Retatrutide, as the three giants in the weight loss world, are deeply loved by people and are often compared together. So what are the differences and similarities among them? Why Retatrutide is more expensive than Semaglutide and Tirzepatide?

They are three prominent medications used for weight loss and management of type 2 diabetes. Each of these drugs has unique properties and mechanisms of action, contributing to their effectiveness and cost.

(1)Semaglutide
  • Brand Names: Ozempic, Wegovy
  • Mechanism of Action: GLP-1 receptor agonist
  • Average Weight Loss: ~15% (34 pounds after 68 weeks)
  • Uses: Primarily for type 2 diabetes and chronic weight management
  • Administration: Once weekly injection

Semaglutide works by mimicking the glucagon-like peptide-1 (GLP-1) hormone, which regulates appetite and food intake. It helps to slow gastric emptying and increase feelings of fullness, leading to reduced calorie intake.

(2)Tirzepatide
  • Brand Name: Mounjaro
  • Mechanism of Action: Dual GIP and GLP-1 receptor agonist
  • Average Weight Loss: 22.5% after 72 weeks
  • Uses: Primarily for type 2 diabetes and chronic weight management
  • Administration: Once weekly injection

Tirzepatide combines the effects of glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonism, enhancing insulin secretion, and providing a stronger impact on weight loss and glycemic control compared to GLP-1 agonists alone.

(3)Retatrutide
  • Status: Experimental, Phase 3 trials ongoing
  • Mechanism of Action: Triple receptor agonist (GLP-1, GIP, and Glucagon receptors)
  • Average Weight Loss: 24% (58 pounds after 48 weeks)
  • Uses: Potentially for weight loss and type 2 diabetes
  • Administration: Expected to be a once-weekly injection

Retatrutide is designed to target three receptors simultaneously, which could offer superior efficacy in weight reduction and metabolic control. The combination of GLP-1, GIP, and glucagon receptor agonism provides a comprehensive approach to appetite regulation, glucose metabolism, and energy expenditure.

Comparisons and Key Differences

(1)Efficacy and Weight Loss
  • Semaglutide: Effective with significant weight loss but comparatively less than the other two.
  • Tirzepatide: Superior weight loss effects due to dual receptor agonism.
  • Retatrutide: Preliminary data shows it could be the most effective, with faster and more substantial weight loss than both Semaglutide and Tirzepatide.
(2)Mechanisms of Action
Mechanisms of Action at Receptors
MEDICATION GLP-1R GIPR GLUCAGON-R
Semaglutide +    
Tirzepatide + +  
Retatrutide + + +
(3)Clinical Trial Durations and Outcomes
  • Semaglutide: 68 weeks for 15% weight loss.
  • Tirzepatide: 72 weeks for 22.5% weight loss.
  • Retatrutide: 48 weeks for 24% weight loss, with potential for greater long-term results.
(4)Costs and Availability
  • Semaglutide and Tirzepatide: Widely available, with established pricing.
  • Retatrutide: Currently more expensive due to its experimental status and the promise of superior efficacy. Pricing is expected to reflect its advanced mechanism and potential benefits.

Why Retatrutide is More Expensive?

Retatrutide’s higher cost can be attributed to several factors:

  • Advanced Mechanism: Its triple receptor targeting mechanism represents a novel and potentially more effective approach to weight loss and diabetes management.
  • Development Stage: Being in the experimental phase, the costs associated with ongoing research, development, and clinical trials contribute to higher prices.
  • Potential Benefits: Early clinical trial data suggests superior weight loss and metabolic outcomes, making it a premium option in the market.

Conclusion

Retatrutide, developed by Eli Lilly and produced by manufacturers like Phcoker, is positioned as a premium treatment option due to its advanced technology and extensive research and development. Although the initial cost may be high, its long-term health benefits and potential savings on treatments for obesity-related complications justify the expense.

For many patients, the question of affordability is a key consideration. Phcoker is aware of these concerns and has taken steps to address them aimed at reducing the out-of-pocket Retatrutide cost for eligible individuals. These programs are designed to make treatment more accessible to a broader audience, ensuring that its price does not become a barrier to access.

Understanding Retatrutide Side Effects: What Patients Need to Know

Retatrutide peptide is a synthetic peptide, primarily available in the form of raw powder and finished vials. Supplier Phcoker Despite its high efficacy, Retatrutide has shown strong weight loss benefits, but its potential side effects must also be considered . Retatrutide also carries some risks of adverse reactions.

(1)Gastrointestinal Issues:
  • Nausea: Common, especially during the initial phases of treatment.
  • Vomiting: Often occurs alongside nausea.
  • Diarrhea: Gastrointestinal disturbances can lead to diarrhea in some patients.
  • Constipation: Alternatively, some patients might experience constipation.
  • Abdominal Pain: Discomfort or pain in the abdomen has been reported.
(2)Appetite and Digestive Changes:
  • Decreased Appetite: Intended as a therapeutic effect but can sometimes be excessive.
  • Indigestion: Some patients may experience indigestion or heartburn.

When using Retatrutide, patients should be aware of these potential side effects and promptly inform your healthcare professional. Consulting with Phcoker can help in understanding these effects and managing the treatment effectively.

Is Retatrutide Peptide Safe?

The safety of retatrutide peptide, like any medication, depends on a thorough evaluation of its benefits and risks based on clinical trial data and post-market surveillance.

(1)Safety Profile Considerations
  • Short-term Safety: Initial trials suggest retatrutide is generally well-tolerated, with manageable side effects similar to other incretin-based therapies.
  • Long-term Safety: The long-term effects, particularly concerning potential risks like cancer or severe metabolic disturbances, are still being studied.
  • Comparison with Other Therapies: Retatrutide’s safety profile is being compared with existing treatments like semaglutide and tirzepatide to establish relative safety.
(2)Monitoring and Management
  • Regular Check-ups: Patients should have regular follow-ups to monitor for side effects, particularly those related to the pancreas, gallbladder, and thyroid.
  • Blood Tests: Periodic blood tests to monitor kidney function, blood glucose levels, and other metabolic parameters.
  • Dose Adjustments: Based on tolerance and side effect profile, doses may need adjustment.

Retatrutide appears to be relatively safe based on current clinical trial data, with a side effect profile similar to other incretin-based therapies. However, as with any new medication, it is essential to continue monitoring its safety through ongoing and future studies. Patients considering retatrutide should do so under the guidance of a healthcare provider, with regular monitoring to promptly address any adverse effects. The completion of Phase 3 trials and post-market surveillance will provide a more comprehensive understanding of its safety profile.

Retatrutide Dose For Weight Loss

Studies suggest that retatrutide is one of the most effective weight loss medications based on incretins. In human phase 2 trials, retatrutide significantly reduced body weight. Participants given the highest dose lost around 20 pounds in 12 weeks, and others lost inches from their waist in 6 months. Weight loss with retatrutide varied with the dose over 48 weeks, with higher doses leading to more weight loss.

In a study reported in the New England Journal of Medicine, the amount of weight lost with retatrutide varied depending on the dose over the 48-week trial period. Those who received the lowest dose lost 8.7% of their total body weight, while those on the highest dose lost more than 24%. Similar findings were also reported in a JAMA article.

Retatrutide Availability: Where to Buy Retatrutide Safely

Understanding Retatrutide availability is crucial for patients looking to integrate this effective treatment into their health regimen. As Retatrutide gains recognition for its impactful results in weight management and diabetes care, it is vital to know where and how to purchase this innovative peptide.

Retatrutide is an innovative and highly effective treatment for obesity and diabetes, currently in the advanced stages of clinical trials. Phcoker.com provides a reliable source for purchasing high-quality Retatrutide in various forms to meet research and therapeutic needs. As it awaits FDA approval, its promising results continue to attract attention and hope for many patients.

Phcoker.com supplies high-quality Retatrutide raw powder and lyophilized powder in vial form. They provide contract customization to meet specific needs, with common vial specifications including 5mg, 10mg, and 15mg per vial. For more information or to place an order, you can contact Phcoker.com anytime.

Phcoker.com – Supporting You on Your Weight Loss Journey

Everyone’s reasons for wanting to lose weight are different. That’s why Phcoker offers you a range of options for achieving a healthy weight. From convenient at-home tests for weight-related health conditions like diabetes to online weight loss prescriptions, Phcoker is here for you.

Retatrutide Peptide weight loss

The development of powerful experimental drugs like Retatrutide can make your weight loss journey more successful, but it can also make it more confusing when trying to choose the right medication for you. You know your body, budget, and lifestyle best. At Phcoker, we know you’re the expert, so we put you first when guiding you on your weight loss journey.

 

Manufacturers/Factory


Retatrutide, as a triple receptor agonist, shows a powerful weight loss effect, which is very beneficial for obese patients who have no obvious effect on Tirzepatide and Semaglutide.

Despite this, research on Retatrutide still has a long way to go. For researchers looking for high-quality Retatrutide powder, Phcoker.com is the right place for you. As a reputable peptide manufacturer, Phcoker provides not only Retatrutide raw powder, but also Retatrutide finished vials for research use.

 

Where to buy


Many people who want to use Retatrutide cannot afford it, while others may not be fat enough to get a prescription. Both of these issues are likely to lead to huge demand for over-the-counter (OTC) Retatrutide alternatives that are easier to obtain and less expensive to use. Where to buy affordable Retatrutide powder. Phcoker.com will one of the supplier you don’t want to miss.

What Are The Advantages If Buy Retatrutide From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Retatrutide Online?

Visit professional Retatrutide supplier Phcoker, choose the Retatrutide you want to buy.

Leave your contact and message on Phcoker.com website, then submit to Phcoker.com.

The customer service will reply you in 12 hours once received your message, then talk in details about buy Retatrutide.

Does Phcoker.com Support The Free Sample Of Retatrutide Powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.

Can I Appoint The Retatrutide Colour When Buy Retatrutide?

YES! Phcoker as peptide manufacturer, provide colour customization of Retatrutide, easy to help you to build your Retatrutide peptide brand.

Can I Appoint The Products Standard When Buy Retatrutide From Phcoker.com?

YES! As one of the best Retatrutide manufacturer, Phcoker not only provide the standard specification of Retatrutide in 5mg, 10mg, but support standard customization. Provide the best support to build your own Retatrutide brand.

Can I Buy Retatrutide In Pure Powder Form From Phcoker.com?

YES! Retatrutide powder is the base that use for Retatrutide lyophilized powder manufacture. Phcoker provide Retatrutide in both of pure powder form and semi-finished vial form.

Can I Buy Discount Retatrutide Powder From Phcoker.com?

YES! Our factory produce high quality Retatrutide powder in term and keep Retatrutide powder in stock. You can buy high quality Retatrutide powder in bulk. During promotion sale, you can buy Retatrutide peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk Retatrutide price for you in time.

 

FAQ


What Is Retatrutide?

Retatrutide is an experimental medication for treating type 2 diabetes and obesity. It is an injection administered once weekly, just like Ozempic and Wegovy.

What is Eli Lilly’s latest weight-loss peptide?

Retatrutide peptide. Retatrutide peptide is the latest powerful weight loss drug launched by Eli Lilly and Company. Its weight loss effect even exceeds that of Tirzepatide, and it can help obese patients lose an average of 24% of their weight.

What is Retatrutide peptide?

Reattrutide is a triple receptor agonist – GIP, GLP-1 and glucagon receptors. Currently awaiting FDA approval. Can significantly promote weight loss in obese patients.

If It Is a Diabetes Drug, How Can Retatrutide Help with Weight Loss?

It is not unusual for diabetes medications to be prescribed for weight loss. Retatrutide is a gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon receptor agonist. Whereas Ozempic has a single mechanism of action as a GLP-1 agonist, retatrutide has three. That means retatrutide may be even more effective than Mounjaro, which only has two mechanisms of action: a GLP-1 agonist and a glucose-dependent insulinotropic polypeptide (GIP).

Why is Retatrutide undergoing clinical studies?

The purpose of the study of the Retatrutide peptide is to evaluate its efficacy and safety in patients with obesity and established cardiovascular disease. As far as the current experimental results are concerned, Retatrutide shows a more significant effect than its control group. It can be said to be an upgraded version of Retatrutide and Tirzepatide.

What are GGG tri-agonists?

Retatrutide, also known as GGG tri-agonist, is so named because it acts as an agonist on three receptors: GIP, GLP-1 and glucagon receptors.

What is the difference between Retatrutide and Tirzepatide?

As a triple receptor agonist, Retatrutide is more potent than Tirzepatide.

① Comparison of action mechanisms:

Retatrutide achieves its intended weight loss effects primarily by targeting three hunger-regulating hormones: GIP, GLP-1, and glucagon receptors.

Tirzepatide suppresses appetite through GLP-1 and GIP, thereby promoting weight loss.

②Comparison of weight loss effects:

Retatrutide – According to relevant clinical trials, Retatrutide can help obese patients lose approximately 24% of their weight within 48 weeks. Compared with other weight loss drugs, Retatrutide can achieve more powerful effects.

Tirzepatide – Studies have shown that at the lowest dose, it can lead to 5% weight loss, and at the highest dose, it can reduce 22% at 72 weeks

Is Retatrutide FDA-Approved for Weight Loss Management?

No, it is not. It is currently in Stage 3 of clinical trials, so your healthcare provider can not yet prescribe it. Although not yet approved, its developer, Eli Lilly, claims it will treat obesity, diabetes, and fatty liver disease by helping patients lose weight, reduce blood sugar levels, and lower fatty acids in their liver.

Is there a brand name for Retatrutide?

Since Retatrutide is still under research and has not been approved by the FDA, it does not have a trade name. The current official name is still Retatrutide.

What are the benefits of Retatrutide?

① Promote weight loss by acting on GIP, GLP-1 and glucagon receptors;

②Effectively manage type 2 diabetes;

③Prevent fatty liver disease related to metabolic dysfunction.

Is Retatrutide powder really effective at promoting weight loss?

YES! ! !

Retatrutide boosted average weight loss by 24% at 48 weeks, according to interim results. Not only Retatrutide raw powder but also Retatrutide finished powder.

Does Retatrutide have any side effects?

YES.

The side effects of Retatrutide are generally consistent with other weight loss drugs, mainly gastrointestinal side effects, and may be accompanied by nausea, vomiting, diarrhea, constipation and other adverse reactions during use. However, these reactions will gradually disappear with time of use.

Would you jump from Semaglutide to Retatrutide after Retatrutide is approved?

Some patients said they would not because it was too expensive.

Some patients said they would switch to it because current research shows that its weight loss effect is indeed better than other weight loss drugs.

The remaining people are still hesitant, worried that this powerful weight loss drug will cause harm to the body.

Can I get a prescription for Retatrutide?

It should be noted that Retatrutide is currently an investigational drug under investigation. This means that no prescription can be given to you at this time.

 

Referenced Citations


[1]Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators.”Tirzepatide Once Weekly for the Treatment of Obesity.”N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4.PMID: 35658024

[2]Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators.”Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.”N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25.PMID: 34170647

[3]Rosenstock J, Wysham C, Frías JP, Kaneko S, Lee CJ, Fernández Landó L, Mao H, Cui X, Karanikas CA, Thieu VT.”Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial.”Lancet. 2021 Jul 10;398(10295):143-155. doi: 10.1016/S0140-6736(21)01324-6. Epub 2021 Jun 27.PMID: 34186022

[4]Syed YY.”Tirzepatide: First Approval.”Drugs. 2022 Jul;82(11):1213-1220. doi: 10.1007/s40265-022-01746-8.PMID: 35830001

[5]Karagiannis T, Avgerinos I, Liakos A, Del Prato S, Matthews DR, Tsapas A, Bekiari E.”Management of type 2 diabetes with the dual GIP/GLP-1 receptor agonist tirzepatide: a systematic review and meta-analysis.”Diabetologia. 2022 Aug;65(8):1251-1261. doi: 10.1007/s00125-022-05715-4. Epub 2022 May 17.PMID: 35579691

[6]Thomas MK, Nikooienejad A, Bray R, Cui X, Wilson J, Duffin K, Milicevic Z, Haupt A, Robins DA.”Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes.”J Clin Endocrinol Metab. 2021 Jan 23;106(2):388-396. doi: 10.1210/clinem/dgaa863.PMID: 33236115

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Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


1.Prof W Timothy Garvey MD

UAB Diabetes Research Center, University of Alabama at Birmingham, Birmingham, AL, USA

2.Sidar Copur

Department of Medicine, Koc University School of Medicine, Istanbul 34010, Turkey

3.Lyse Bordier

Hôpital Bégin, service d’endocrinologie, Saint-Mandé, France

4.Hikmat Permana

Division of Endocrinology and Metabolic Disorders, Department of Internal Medicine, Padjadjaran University, Bandung, West Java, 45363, Indonesia

5.Akira Mima

Corresponding author. Department of Nephrology, Osaka Medical and Pharmaceutical University, Osaka, 569-8686, Japan.


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