+86(1360)2568149 info@phcoker.com

Raw Nonapeptide powder

Nonapeptid is an oligopeptide formed from nine amino acids. The term oligopeptide pertains to a peptide formed by a chain of……

 


Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month

 

Description

Nonapeptide powder video

 

 

What is Nonapeptide-1?

Nonapeptide-1, also called Melanostatine-5, is a propriety peptide that was originally developed for its antimicrobial activities. Animal research has revealed, however, that nonapeptide-1 can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions.Animal models suggest that nonapeptide-1 can reduce synthesis of melanin and help decrease skin pigmentation to a substantial degree.

Nonapeptide-1 is of primary research interest for its ability to reduce hyperpigmentation by inhibiting the action of tyrosinase in melanin-producing cells. The ability to regulate melanin production has potential application in a number of conditions, including photodamage of the skin.

Research also suggests that nonapeptide-1 may play a role in the central nervous system where  it may act on both dopaminergic receptors and opioid receptors to modify pain signaling as well as behavior. Studies in mice support the idea that nonapeptide-1 may have central actions that affect behavior and pain.

 

Nonapeptide-1 skin benefits

Nonapeptide-1 can prevent melanin synthesis and unwanted pigmentation by preventing activation of the tyrosinase, thus allowing for a better control over skin tone. Nonapeptide-1 is one skin whitening nonapeptide. It can be applied to various kinds of whitening or spot corrective products.

  1. Nonapeptide-1 Blocks the binding of α-MSH with its receptor MC1R on the cell membrane of melanocyte. The successive melanine producing process is stopped.
  2. A whitening agent that works on the very initial stage of skin darkening mechanism. Highly efficacious.
  3. Nonapeptide-1 Prevents further activation of tyrosinase & thus blocks melanin synthesis for better control over skin tone & brown spots.
  4. Nonapeptide-1 Prevents hyperproduction of melanin
  5. Whitening activity proven on Asian skin

 

Reference:

  1. Behavioral effects evoked by the beta globin-derived nonapeptide LVV-H6.
  2. da Cruz KR, Ianzer D, Turones LC, Reis LL, Camargo-Silva G, Mendonça MM, da Silva ES, Pedrino GR, de Castro CH, Costa EA, Xavier CH. Peptides. 2019 May;115:59-68. doi: 10.1016/j.peptides.2019.03.002. Epub 2019 Mar 16. PMID: 30890354
  3. Novel nonapeptide GLP (28-36) amide derivatives with improved hypoglycemic and body weight lowering effects. Li L, Wu L, E X, Yan W, Cai X, Han J, Sun L. Bioorg Med Chem. 2019 Apr 15;27(8):1670-1676. doi: 10.1016/j.bmc.2019.03.014. Epub 2019 Mar 7. PMID: 30878191
  1. Crystallographic structure of a complex between trypsin and a nonapeptide derived from a Bowman-Birk inhibitor found in Vigna unguiculata seeds. Fernandes JPC, Mehdad A, Valadares NF, Mourão CBF, Ventura MM, Barbosa JARG, Freitas SM. Arch Biochem Biophys. 2019 Apr 15;665:79-86. doi: 10.1016/j.abb.2019.02.013. Epub 2019 Feb 25. PMID: 30817908

 

PRECAUTION AND DISCLAIMER:

This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

 


References & product citations