Cagrilintide

January 29, 2024

Phcoker is a professional Cagrilintide GMP manufacturer that provide both form of Cagrilintide powder and Cagrilintide finished lyophilized powder in vial.  The regularly manufacturing specification include Cagrilintide 5mg, Cagrilintide 10mg, Cagrilintide 15mg. Larger dosage and contract manufacturing service is available.

Monthly production capacity:>1,000,000 vials

 

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Properties


Sequence: {Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH2
Molecular Formula: C194H312N54O59S2
Molecular Weight: 4409 g/mol
PubChem CID: 167312356
CAS Number: 1415456-99-3
Synonyms: GLXC-26801,1415456-99-3

 

Description


Cagrilintide peptide is a long-acting amylin analog used to treat obesity. Acts as a non-selective amylin receptor (AMYR) and alcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide can significantly reduce food intake, resulting in weight loss. Cagrilintide has shown strong potential in studying obesity. Studies have shown that the combination of Cagrilintide and Semaglutide has a more powerful therapeutic effect. The combination of Cagrilintide and Semaglutide is commonly sold under the brand name CagriSema. Cagrilintide powder and Semaglutide powder are two of the active ingredient of CagriSema.

What is Cagrilintide?

Cagrilintide[1][3] is a synthetic peptide in clinical development by Novo Nordisk. It is currently in clinical phase III for the treatment of obesity.

As a long-acting amylin analog, Cagrilintide is currently being tested alone and in combination with Semaglutide for the treatment of obesity and type 2 diabetes. Amylin is a 37-amino-acid peptide produced primarily in pancreatic beta cells and co-secreted with insulin. It has a very important impact on appetite, blood sugar control and gastric emptying[5][7]. Especially for the treatment of diabetes and obesity, amylin is worth studying.

Amylin can control blood sugar through multiple mechanisms, such as slowing gastric emptying, reducing food intake, etc. Amylin and insulin may complement each other to regulate nutrient levels. Amylin is deficient in type 1 diabetes and relatively deficient in type 2 diabetes, which requires insulin. Glucagon and amylin have similar properties, but amylin, unlike GLP-1, does not have an insulin-secreting effect.

Semaglutide approved by FDA for weight loss use with the brand name of  Wegovy, other brand name include the oral form Rybelsus and injection form Ozempic.Unlike Semaglutide, Cagrilintide not FDA approval yet, it still in clinical phase III. The researchers who are interested in Cagrilintide or individiual interested in trying different weight loss products, they start to buy Cagrilintide injection or Cagrilintide powder to do deeply research. Research on Cagrilintide mainly focuses on its effects, mechanism of action,side effects…etc. Before buying from a supplier who claiming to be the manufacturer of Cagrilintide, be sure to check the legality and the quality.

Cagrilintide structure

Cagrilintide structure 1

Cagrilintide for weight loss

Cagrilintide sold in the market with different dosage, Cagrilintide 5mg, Cagrilintide 10mg, Cagrilintide 15mg are the common seen specification among of them. How is the power of Cagrilintide for weight loss? Is Cagrilintide more powerful than Semaglutide or Tirzepaitde? Let’s have a look.

Cagrilintide is a long-acting analogue of amylin produced by our bodies. This hormone is produced in the pancreas and is secreted in response to eating. The hormone is also thought to act on parts of the brain associated with food cravings and liking, and thus has potential effects on emotional eating and food likes and dislikes. It slows the gastrointestinal response to food intake and suppresses glucagon after eating. It can be injected once a week[2][4].

The results of the study found that placebo reduced weight by 3% at all doses, while Cagrilintide’s weight loss ranged from 6% to 10.8%; compared with Liraglutide, those receiving a weekly dose of 4.5 mg had a more significant weight reduction effect. Notably, those in the Cagrilintide-treated group were still losing weight at the end of the trial. It is easy to get more information about Cagrilintide peptide from reddit or wiki, people like to share their experience about Cagrilintide use.

Cagrilintide powder as the active ingredient of Cagrilintide-based weight loss drug, the price will be cheaper than buy Cagrilintide injection.

What is Cagrilintide and Semaglutide combination therapy? /What is CagriSema?

The main benefit of Cagrilintide powder is the treatment of obesity and type 2 diabetes. Studies have shown that the combination therapy of Cagrilintide and Semaglutide has a more significant therapeutic effect on obesity and type 2 diabetes.This combination drug combines 2.4mg Cagrilintide with 2.4mg Semaglutide.

Cagrilintide/Semaglutide, sold under the trade name CagriSema[10][11][12], is a combination of Cagrilintide, a dual amylin and calcitonin receptor agonist, and Semaglutide, a GLP-1 agonist. The drug is being tested as a treatment for type 2 diabetes and obesity via a weekly injection. Preliminary findings suggest CagriSema results in greater weight loss than either drug alone. There was also a more significant improvement in HbA1c compared to Cagrilintide alone. In a phase II trial, CagriSema reduced body weight by an average of 15.6% after 32 weeks, achieving a comparable efficacy to Tirzepatide.

Individual use Semaglutide as weight management drug, like to use the CagriSema as they think it will be more powerful.

CagriSema for Type 2 diabetes

CagriSema is a combination drug developed by Novo Nordisk. Results from a recent Phase 2 clinical trial suggest CagriSema is a once-weekly injection for long-term treatment of type 2 diabetes[6][9].

This trial recruited 92 adults and randomly assigned them to three groups to receive treatment with Semaglutide, Cagrilintide and CagriSema respectively. Participants’ A1C, weight and time were measured before starting treatment and 32 weeks after treatment.

The results of the study showed that subjects treated with CagriSema experienced a 2.2% decrease in A1C, an average weight loss of 16%, and a 43% increase in time frame. The following are the experimental results:

Measure CagriSema Semaglutide Cagrilinitide
Number of participants 31 31 31
Average decrease in A1C 2.2% 1.8% 0.9%
Percentage of participants with an A1C ≤ 6.5% 75% 48% 17%
Average decrease in body weight 15.6% 5.1% 8.1%
Average increase in time in range 43% 43.6% 14.8%

Experimental results show that, as a combined drug of Semaglutide and Cagrilinitide, CagriSema has a more significant effect in the treatment of type 2 diabetes.

Researchers seeking Cagrilintide for weight loss study found that it is difficult to buy legal Cagrilintide with a reasonable price. As one of the newest weight loss drug, compare with Semaglutide and  Tirzepatide, Cagrilintide always sell at a expensive price. So they prefer to buy Cagrilintide powder from the peptide manufacturers. Buy Cagrilintide powder is more cost-efficient than Cagrilintide injection, no matter small dosage 5mg or large dosage 10mg, 15mg. It is important to buy from the legal manufacturer of Cagrilintide.

CagriSema treats obesity/CagriSema for weight loss

An international team including the National Institute for Health and Care’s Leicester Biomedical Research Center studied the combination of Semaglutide and Cagrilinitide (CagriSema) and found that CagriSema led to significant weight loss and improved blood sugar control in users.

The results of the study showed that patients taking the new combination CagriSema lost an average of 15.6% of their weight within 32 weeks of use, achieving a weight loss effect comparable to that of Tirzepatide, while patients taking Semaglutide alone lost only 5% of their weight during the same period[8][15].

The experiment mainly compares the participants’ weight and HbA1c at the end with the data at the beginning. Experimenters said that compared with Semaglutid and Cagrilinitide alone, this new combination CagriSema can reduce weight more significantly and is well tolerated.

What side effects does cagrilinitide cause?

Cagrilinitide is a weight loss peptide, mainly available in raw powder and finished vials. Supplier phcoker.com. Despite its high efficiency, Cagrilinitide injection also has certain side effects[13][14].

Cagrilinitide peptides are similar to other weight loss peptides in that the most common side effects are gastrointestinal side effects and administration site reactions, including:

Nausea

Vomit

Constipate

Diarrhea

Researchers said that most of the side effects caused by Cagrilinitide are mild or toxic. If serious symptoms occur after use, please stop using it immediately and go to the doctor.

Is Cagrilinitide powder available?

Cagrilinitide, a new long-acting weight loss drug from Novo Nordisk, is currently awaiting approval from the U.S. Food and Drug Administration, and more clinical trials are underway to tap into more benefits. The therapeutic effects brought about by the combination of Cagrilinitide and semaglutide are widely discussed in the market, and as a drug with comparable effects to Tirzepatide, this opens up a large market.

More and more suppliers are trying to produce Cagrilinitide powder. Cagrilinitide powder is now also available online. But researchers are also concerned about the quality of Cagrilinitide powder offered by online peptide suppliers. To confirm the quality of Cagrilinitide powder, you can first purchase Cagrilinitide freeze-dried powder at a favorable price for testing. As a peptide factory, phcoker.com can provide you with Cagrilinitide peptide products at factory prices.

How to store Cagrilinitide peptide?

Regardless of whether you purchase Cagrilinitide powder or lyophilized powder vials, Cagrilinitide peptides should be stored in a sealed, light-proof and dry environment at -20°C. And after opening, you should use your dosage as soon as possible to ensure the effectiveness of Cagrilinitide.

Cagrilinitide for sale | Cagrilinitide suppliers

Cagrilinitide is a long-acting amylin analog that shows great promise for the treatment of obesity and type 2 diabetes. And the combined treatment method with Semaglutide makes its effect equivalent to that of Tirzepatide, which has attracted widespread attention from the market. Further research is needed to fully understand and exploit its therapeutic potential. Researchers interested in experimenting with Cagrilinitide want to make sure they are sourcing this material from a reliable supplier. If you want to buy Cagrilinitide online, it is important to exercise caution and make sure you are getting the peptide from a reputable and trustworthy manufacturer. phcoker.com is a highly reliable manufacturer of pharmaceutical grade peptides.

 

Manufacturers/Factory


Cagrilinitide peptide is a newly prominent long-acting weight loss drug. As an amylin analog, Cagrilinitide, like the GLP-1 series of weight loss drugs, has a certain therapeutic effect on obesity and type 2 diabetes. If you are looking for professional and top-quality Peptide Cagrilinitide manufacturers or factories, this is the right place for you.

The combination treatment of Cagrilinitide and semaglutide showed a therapeutic effect comparable to that of Tirzepatide. Whether it is weight loss or the treatment of type 2 diabetes, CagriSema has shown a more significant therapeutic effect than any drug alone and is expected to become an alternative treatment to Tirzepatide.

As the best Cagrilinitide Peptide Manufacturer, phcoker.com offers the peptide Cagrilinitide not only in powder form but also in customized standard easy-to-use vial form.

You can buy Cagrilinitide at the best prices and the best quality peptides from this professional peptide manufacturer.

 

Where to buy


Do you want to buy the best Cagrilintide peptide from the best Cagrilintide suppliers in the market? You’ve come to the right place!

Phcoker.com, as a peptide factory, is the best place for you to buy Cagrilintide at competitive prices from small to large batches. Click and get in touch and you will get all the details. Before buying Cagrilintide, you may be curious:

What Are The Advantages If Buy Cagrilintide From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Cagrilintide Online?

  • Visit professional Cagrilintide supplier Phcoker.com, choose the Cagrilintideyou want to buy.
  • Leave your contact and message on Phcoker.com website, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy Cagrilintide.

Does Phcoker.com Support The Free Sample Of Cagrilintide Powder?

It depends, different products with different policy, please check it with the customer service. Most of products can be accepted for sample.

Can I Appoint The Cagrilintide Colour When Buy Cagrilintide?

YES! Phcoker as peptide GMP manufacturer, provide colour customization of Cagrilintide, easy to help you to build your Cagrilintide peptide brand.

Can I Appoint The Products Standard When Buy Cagrilintide From Phcoker.com?

YES! As one of the best Cagrilintide GMP manufacturer, Phcoker not only provide the standard specification of Cagrilintide in 5mg, 10mg, but support standard customization. Provide the best support to build your own Cagrilintide brand.

Can I Buy Cagrilintide  In Pure Powder Form From Phcoker.com?

YES! Cagrilintide powder is the base that use for Cagrilintide lyophilized powder manufacturing. Phcoker provide Cagrilintide in both of pure powder form and lyophilized powder in vial form.

Can I Buy Discount Cagrilintide  Powder From Phcoker.com?

YES! Phcoker produce high quality Cagrilintide powder in term and keep Cagrilintide powder in stock. You can buy high quality Cagrilintide powder in bulk. During promotion sale, you can buy Cagrilintide peptide with lower price. You can keep touch with the customer manager and they will update the latest bulk semaglutide price for you in time.

 

FAQ


What is Cagrilintide used for?

Cagrilintide is an amylin analogue that is currently being developed in combination with the GLP-1 receptor agonist Semaglutide to help overweight or obese people achieve sustained weight loss. This combination drug also has significant potential in the treatment of type 2 diabetes. Therapeutic effect.

Who developed Cagrilintide?

Cagrilintide is a weight loss peptide clinically developed by Novo Nordisk and is currently in Phase III clinical stage for the treatment of obesity.

How does cagrilintide work?

Cagrilintide is a long-acting amylin analog that works primarily by targeting calcitonin receptors and receptor activity-modifying proteins 1, 2, and 3 (RAMP1-3).

What is the trade name for Cagrilintide?

The combination of Cagrilintide and semaglutide, sold under the brand name CagriSema, treats obesity and type 2 diabetes via a weekly injection.

Does Cagrilintide have side effects?

Like other weight loss peptides, Cagrilintide can also cause gastrointestinal side effects, including nausea and diarrhea.

Is Cagrilintide safe?

Trial participants experienced only some gastrointestinal side effects and no grade 2 or 3 hypoglycemia. These results indicate that Cagrilintide is safe.

What is the prescription for Cagrilintide?

The dosage of weight loss drugs is usually based on the target fat mass to be reduced. It is usually recommended to use Cagrilintide in combination with 2.4 mg of Semaglutide, but this also needs to be adjusted according to customer needs. For specific dosage, you need to consult a professional doctor.

What is the mechanism of action of CagriSema?

CagriSema is a combination drug of Semaglutide and Cagrilintide. This means it can promote weight loss by mimicking the effects of amylin, which creates a feeling of fullness.

What are the results of CagriSema’s Phase 2 trial?

CagriSema’s phase II trial results show that this combination therapy can reduce body weight by 15.6% at 32 weeks after use.

Is CagriSema safe?

In Phase II trials, CagriSema was found to be safe and well-tolerated.

 

Referenced Citations


[1] Larsen, Anna T.; Sonne, Nina; Mohamed, Khaled Elhady; Bredtoft, Emma-Marie; Andersen, Frederik; Karsdal, Morten A.; Henriksen, Kim (1 June 2022). “823-P: The Long-Acting Dual Amylin and Calcitonin Receptor Agonist KBP Has Increased Efficacy on Weight Loss and Glucose Control Compared with Cagrilintide in Obese and Diabetic Rats“. Diabetes. 71 (Supplement_1). doi:10.2337/db22-823-P. S2CID 249259033.

[2] Lau, David C W; Erichsen, Lars; Francisco, Ann Marie; Satylganova, Altynai; le Roux, Carel W; McGowan, Barbara; Pedersen, Sue D; Pietiläinen, Kirsi H; Rubino, Domenica; Batterham, Rachel L (December 2021). “Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial“. The Lancet. 398 (10317): 2160–2172. doi:10.1016/S0140-6736(21)01751-7. PMID 34798060. S2CID 244169045

[3]Kruse, Thomas; Hansen, Jakob Lerche; Dahl, Kirsten; Schäffer, Lauge; Sensfuss, Ulrich; Poulsen, Christian; Schlein, Morten; Hansen, Ann Maria Kruse; Jeppesen, Claus Bekker; Dornonville de la Cour, Charlotta; Clausen, Trine Ryberg; Johansson, Eva; Fulle, Simone; Skyggebjerg, Rikke Bjerring; Raun, Kirsten (12 August 2021). “Development of Cagrilintide, a Long-Acting Amylin Analogue“. Journal of Medicinal Chemistry. 64 (15): 11183–11194. doi:10.1021/acs.jmedchem.1c00565. ISSN 0022-2623. PMID 34288673. S2CID 236175929

[4]Frias, Juan P; Deenadayalan, Srikanth; Erichsen, Lars; Knop, Filip K; Lingvay, Ildiko; Macura, Stanislava; Mathieu, Chantal; Pedersen, Sue D; Davies, Melanie (August 2023). “Efficacy and safety of co-administered once-weekly cagrilintide 2·4 mg with once-weekly semaglutide 2·4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial”. The Lancet. 402 (10403): 720–730. doi:10.1016/S0140-6736(23)01163-7. PMID 37364590. S2CID 259237278

[5] D’Ascanio, Antonella M.; Mullally, Jamie A.; Frishman, William H. (8 March 2023). “Cagrilintide: A Long-Acting Amylin Analog for the Treatment of Obesity”. Cardiology in Review. Publish Ahead of Print. doi:10.1097/CRD.0000000000000513. PMID 36883831. S2CID 257404657

[6] Larsen, A. T.; Mohamed, K. E.; Sonne, N.; Bredtoft, E.; Andersen, F.; Karsdal, MA; Henriksen, K. (1 December 2022). “Does receptor balance matter? – Comparing the efficacies of the dual amylin and calcitonin receptor agonists cagrilintide and KBP-336 on metabolic parameters in preclinical models“. Biomedicine & Pharmacotherapy. 156: 113842. doi:10.1016/j.biopha.2022.113842. ISSN 0753-3322. PMID 36242844. S2CID 252881350

[7] Enebo, Lone B; Berthelsen, Kasper K; Kankam, Martin; Lund, Michael T; Rubino, Domenica M; Satylganova, Altynai; Lau, David C W (May 2021). “Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2·4 mg for weight management: a randomised, controlled, phase 1b trial“. The Lancet. 397 (10286): 1736–1748. doi:10.1016/S0140-6736(21)00845-X. PMID 33894838. S2CID 233354744

[8] Idris, Iskandar (July 2023). “Coadministration of the long‐acting amylin analog cagrilintide plus semaglutide ( CagriSema ), resulted in significantly greater weight loss, along with improved measures of glucose control, in a short phase 2 trial of patients with type 2 diabetes“. Diabetes, Obesity and Metabolism Now. 1 (7). doi:10.1002/doi2.68. ISSN 2688-8939

[9] Holst, Jens Juul; Jepsen, Sara Lind; Modvig, Ida (April 2022). “GLP-1 – Incretin and pleiotropic hormone with pharmacotherapy potential. Increasing secretion of endogenous GLP-1 for diabetes and obesity therapy“. Current Opinion in Pharmacology. 63: 102189. doi:10.1016/j.coph.2022.102189. PMID 3523167

[10] “CTG Labs – NCBI“. clinicaltrials.gov. Retrieved 5 December 2023.

[11] Jeon, Eonju; Lee, Ki Young; Kim, Kyoung-Kon (1 June 2023). “Approved Anti-Obesity Medications in 2022 KSSO Guidelines and the Promise of Phase 3 Clinical Trials: Anti-Obesity Drugs in the Sky and on the Horizon“. Journal of Obesity & Metabolic Syndrome. 32 (2): 106– doi:10.7570/jomes23032. ISSN 2508-7576. PMC 10327684. PMID 37349257

[12] I Lingvay et al.Obesity management as a primary treatment goal for type 2 diabetes: time to reframe the conversation.Lancet (2022)

[13] DCW Lau et al.Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial

[14] DS Mathiesen et al.Long-acting amylin analogues for the management of obesity.Curr Opin Endocrinol Diabetes Obes

[15] T Battelino et al.Continuous glucose monitoring and metrics for clinical trials: an international consensus statement. Lancet Diabetes Endocrinol

 

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

Scientific Journal paper Author:


1. Clifford J. Bailey

Life and Health Sciences, Aston University, Birmingham, B4 7ET, UK

2. Sara Becerril

Metabolic Research Laboratory, Department of Endocrinology & Nutrition, Clínica Universidad de Navarra, University of Navarra, IdiSNA, CIBEROBN, 31008 Pamplona, Spain

3. Domenica M Rubino MD

Washington Center for Weight Management, Arlington, VA, USA

4. Domenica Rubino MD

National Institute of Health Research, UCLH Biomedical Research Centre, London, UK

 


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