April 1, 2021

CAD-31 also shows positive effects in preventing certain toxic events in neurodegenerative diseases related to old age.

Status: In Mass Production
Unit: 50kg/Drum
Capacity: 1600kg/month





Product Name CAD031 powder
Synonym CAD-031; CAD 031; CAD-31; CAD 31; CAD31;
Chemical Name Acetic acid, 2,2,2-trifluoro-, (2E)-1-(2,4-dimethylphenyl)-2-[[3-(trifluoromethoxy)phenyl]methylene]hydrazide
CAS Number 2071209-49-7
Molecular Formula C18H14F6N2O2
Molecular Weight 404.312
Boiling point  386.8±52.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
Biological Half-Life N/A
Color N/A
Solubility  Soluble in DMSO
Storage Temperature  -20°C 12 Months; 4°C 6 Months
Application As a drug candidate for Alzheimer’s disease (AD)


What is CAD031 powder?

CAD031, also known as CAD31, is a new type of brain penetrant, a J147 derivative and a drug candidate for Alzheimer’s disease (AD). It has higher neurogenic activity in human neural precursor cells (NPC) than J147; and has effective neuroprotective properties in six different neuronal cell assays, which can mimic the toxicity observed in the old brain . In addition, CAD-31 is permeable and may be very safe. It has important effects on synapse formation and AD energy metabolism pathway. CAD-31 also shows positive effects in preventing certain toxic events in neurodegenerative diseases related to old age.

The experiment found that CAD031 also stimulated the division of NPC in the subventricular area of old APPswe/PS1E9 mice; rescued primary cortical neurons from oxidation, and effectively reduced oxidative stress with an EC50 of 20 nM; in an in vitro ischemia model When the EC50 is 47 nM, it can also prevent the loss of energy metabolism, leading to neuronal cell death; targeting fatty acid metabolism and inflammation, showing therapeutic efficacy on cognitive and physiological parameters in AD mouse models.


How does CAD031 powder work?

Studies showed that CAD031 targets acetyl-CoA and fatty acid metabolism via the AMPK/ACC1 pathway. Importantly, CAD031 extended the median lifespan of SAMP8 mice by about 30%. These data show that specific alterations in mitochondrial composition and metabolism highly correlate with aging, supporting the use AD drug candidates that limit physiological aging in the brain.


CAD031 powder benefits

sCAD031 is an Alzheimer’s disease (AD) drug candidate for AD;

sCAD031 is broadly neuroprotective

sCAD031 has an excellent pharmacological and safety profile

sCAD031 reverses some aspects of cognitive dysfunction in old transgenic AD mice

sCAD031 can reduce inflammation, target lipid metabolism, and is a marker for increasing neurogenesis and synapses;



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