Nicotinamide adenine dinucleotide (53-84-9) video
Nicotinamide adenine dinucleotide (53-84-9) Specifications
|Product Name||Nicotinamide adenine dinucleotide(NAD+)|
|Chemical Name||Nadide;coenzyme I;beta-NAD;beta-NAD+;beta-Diphosphopyridine nucleotide; diphosphopyridine nucleotide;Enzopride;|
|Molecular Weight||663.4 g/mol|
|Monoisotopic Mass||663.109123 g/mol|
|Melting Point||160 °C (320 °F; 433 K)|
|Solubility||H2O: 50 mg/mL|
|Application||Health food, cosmetic, feed additive|
What is Nicotinamide adenine dinucleotide(NAD+)?
Nicotinamide adenine dinucleotide (NAD) is a cofactor that assists metabolism found in all living cells. It exists in two forms, oxidized (NAD +) and reduced (NADH).
Coenzyme NAD +, the oxidized form of NAD, was first discovered in 1906 by British biochemists Arthur Harden and William John Young. NAD + is synthesized by two metabolic pathways, which can be produced from the de novo amino acid pathway, or can be produced by recycling pre-formed components (such as nicotinamide) back to the rescue pathway of NAD +. It is an essential pyridine nucleotide and serves as an essential cofactor and substrate for many key cellular processes involving oxidative phosphorylation and ATP production, DNA repair, epigenetic regulation of gene expression, intracellular calcium signaling and Immunological function.
NAD + is the main electron acceptor molecule in biological oxidation. It accepts electrons from other molecules and is reduced. It also acts as a coenzyme of hydride transferase and a substrate that consumes NAD (+) polymerase, and forms a coenzyme redox pair with reduced β-nicotinamide adenine dinucleotide (NADH). NAD (R) is the ADP-ribose donor unit ribosylation in ADP-A. It is also a precursor to cyclic ADP-ribose (ADP-ribosyl cyclase).
As an oxidant in cell metabolism, NAD (R) also plays a role in adenosine diphosphate (ADP) -ribose transfer reactions involving a diadenylate (ADP-ribose) polymerase and several other enzymatic processes. It can preventively give NAD to prevent or reduce diabetes, cancer and other age-related diseases. Also, NAD + boosters may work synergistically with supplements such as resveratrol to help rejuvenate mitochondria and fight aging diseases.
Nicotinamide adenine dinucleotide(NAD+) benefits
As a effective oxidant, Nicotinamide adenine dinucleotide shows that some good benefits in human activities.
♦ Optimize your cellular activity,
♦ Increase your energy naturally;
♦ Improve brain function, focus and memory;
♦ Boost your metabolism;
♦ Improve sleep;
♦ Boost global sirtuin activity;
♦ Improve antioxidant efficacy;
♦ Reduce inflammation;
♦ Improved balance, mood, vision and hearing;
Nicotinamide adenine dinucleotid is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.
In addition,Nicotinamide adenine dinucleotide(NAD+) also has prevention and treatment of heart block, sinus node function and anti-fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atriove ntricular block caused by verapamil.
Nicotinamide adenine dinucleotide(NAD+) Application:
- Diagnostic reagents raw materials, scientific research experiments.
- Health food, cosmetic, feed additive
- API production
More Nicotinamide adenine dinucleotide(NAD+) research
The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer’s andParkinson disease.
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- French SW. Chronic alcohol binging injures the liver and other organs by reducing NAD⁺ levels required for sirtuin’s deacetylase activity. Exp Mol Pathol. 2016 Apr;100(2):303-6. doi: 10.1016/j.yexmp.2016.02.004. Epub 2016 Feb 16. PMID: 26896648.
- Kane AE, Sinclair DA. Sirtuins and NAD+ in the Development and Treatment of Metabolic and Cardiovascular Diseases. Circ Res. 2018 Sep 14;123(7):868-885. doi: 10.1161/CIRCRESAHA.118.312498. PMID: 30355082. PMCID: PMC6206880.