+86(1360)2568149 info@phcoker.com

Nicotinamide powder (98-92-0)

Nicotinamide is an alternative form of vitamin B3. It is promoted as an anti-aging supplement because…..

 


Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month

 

Description

Nicotinamide powder (98-92-0) video

 

Nicotinamide powder (98-92-0) Specifications

Product Name Nicotinamide powder
Chemical Name ▪ nicotinamide riboside

▪ nicotinamide ribose

▪ nicotinamide-beta-riboside

▪ nicotinamide ribonucleoside

▪ N-ribosylnicotinamide

Brand Name Nicotinamide powder
Drug Class Anti-wrinkle peptide, pore minimizingpeptide peptide
CAS Number 98-92-0
InChIKey DFPAKSUCGFBDDF-UHFFFAOYSA-N
Molecular Formula C6H6N2O
Molecular Weight 122.12
Monoisotopic Mass 122.13 g/mol
Melting Point  128-131 °C(lit.)
Freezing Point N/A
Biological Half-Life N/A
Color White powder
Solubility  Soluble in water and 1000 g/L (20 ºC)
Storage Temperature  0-6°C
Application Nicotinamide cream is used as a treatment for acne. It has anti-inflammatory actions, which may benefit people with inflammatory skin conditions. Nicotinamide increases the biosynthesis of ceramides in human keratinocytes in vitro and improves the epidermal permeability barrier in vivo.

 

What is Nicotinamide?

Nicotinamide, also known as niacinamide, NAA, and nicotinic amide, is the amideof nicotinic acid (vitamin B3 / niacin). Nicotinamide is a water-soluble vitamin and is part of thevitamin B group. Nicotinic acid, also known as niacin, is converted to nicotinamide in vivo, and, though the two are identical in their vitamin functions, nicotinamide does not have the same pharmacological and toxic effects of niacin, which occur incidental to niacin’s conversion. Thus nicotinamide does not reduce cholesterol or cause flushing,although nicotinamide may be toxic to the liver at doses exceeding 3 g/day for adults. In cells, niacin is incorporated into nicotinamide adenine dinucleotide (NAD) andnicotinamide adenine dinucleotide phosphate (NADP), although the pathways for nicotinic acid amide and nicotinic acid are very similar. NAD+ and NADP+ are coenzymes in a wide variety of enzymatic oxidation-reduction reactions. Commercial production of niacin and niacinamide (several thousand tons annually) is by hydrolysis or aminolysis of 3-cyanopyridine (nicotinonitrile).

 

Nicotinamide(Niacinamide) mechanism of action

Niacinamide is a derivative of vitamin B3, is a recognized cosmetic dermatology skin anti-aging ingredients,whitening, anti-wrinkle effect of nicotinamide varieties used in hair care, can stimulate hair follicles, improve hair follicle blood blur, play a role in preventing hair loss. In addition, because nicotinamide with the expansion of blood vessels, may also be used for dark circles products

Niacinamide can be made from niacin in the body. Niacin is converted to niacinamide when it is taken in amounts greater than what is needed by the body. Niacinamide is easily dissolved in water and is well-absorbed when taken by mouth.

Niacinamide is required for the proper function of fats and sugars in the body and to maintain healthy cells.

Unlike niacin, niacinamide has no beneficial effects on fats and should not be used for treating high cholesterol or high fat levels in the blood.

 

Nicotinamide benefits

  1. Nicotinamide can prevent pathological changes of skin and diseases of alimentary canal, such as dermatitis, black tongue, vomiting and diarrhea etc.
  2. By participating in material and energy metabolism, Nicotinamide can promote the body growth.
  3. By combining with other medicines, Nicotinamide can cure catarrh and ulcer.
  4. By improving the ability of blood supply with strong expansion function of blood vessel, Nicotinamide is highly effective in curing such diseases as dermatosis, hypercholesterolemia disease and coronary heart disease.

 

Nicotinamide for skin

Nicotinamide is used in the basic cream system of cosmetics, the dosage is 2%, can achieve whitening anti-wrinkle, moisturizing, shrinking pores and

other effects.In addition, nicotinamide can also be used to treat dark circles, as it dilates blood vessels.

 

Niacinamide powder uses

Biochemical research; Nutrient composition of tissue medium; Clinical drugs for B vitamins, used for prevention and treatment of pellagra and stomatitis, glossitis and other diseases.

It is an essential nutrient for mammals.Water solubility is better than niacin, but it is easy to form complex with vitamin C and agglomerate.Dosage 30 ~ mg/kg.

Niacinamide and niacin are commonly used in most applications, and niacinamide is also produced in animals. Lack of nicotinamide can cause pellagra, so this product can prevent pellagra. Plays a role in the metabolism of protein and sugar, improving nutrition in humans and animals. It can be used as a nutritional additive in cosmetics. Also used in medicine and food, feed additives.

 

Reference:

  • Nicotinamide for skin cancer chemoprevention. Damian DL et al. Australas J Dermatol. (2017)
  • Nicotinamide for Skin-Cancer Chemoprevention. Drago F et al. N Engl J Med. (2016)
  • A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. Chen AC et al. N Engl J Med. (2015)

 

PRECAUTION AND DISCLAIMER:

This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.

 


References & product citations