Raw Synephrine powder (97-07-5) video
Raw Synephrine powder (97-07-5)
Raw Synephrine powder is a naturally occurring chemical that has been sought after by athletes and those looking to lose weight due to its effects on the body’s energy production. However, this compound can also act as an antioxidant and anti-inflammatory agent and may have other important health benefits.
Raw Synephrine powder is a biogenic amine.It is found at high levels in the peels of citrus plants, like bitter orange or Seville orange (Citrus aurantium). Extracts from fruits or peels of these plants have been used in traditional Chinese medicine to treat stomach problems and allergies for hundreds of years.
Raw Synephrine powder (97-07-5) Specifications
|Product Name||Raw Synephrine powder|
|Chemical Name||Synephrine; Oxedrine; P-Synephrine;; Parasympatol; Sympaethamine|
|Drug Class||Fat lost|
|Molecular Weight||167.208 g/mol|
|Monoisotopic Mass||167.095 g/mol|
|Melting Point||162 to 164 °C|
|Boiling Point||295.79°C (rough estimate)|
|Biological Half-Life||No date available|
|Color||White to off-white powder|
|Solubility||No date available|
|Application||Arguably the most effective fat burning ingredients|
Raw Synephrine powder (97-07-5) Description
Synephrine, also referred to as, p-synephrine, is naturally occurring alkaloid. The major component of adrenergic agonists is p-synephrine, and it has been documented in pharmacopoeia from Northern Europe and a Germany.It is present in approved drug products as neo-synephrine, its m-substituted analog. p-synephrine and m-synephrine are known for their longer acting adrenergic effects compared to norepinephrine. It can be used in clinical treatments of bronchial asthma, hypotension, collapse, shock, and orthostatic hypotension; to improve metabolism; and in treatments of digestive problems such as indigestion, swelling of the liver, phlegm, and ptosis.
In foreign countries, raw synephrine powder has been sought after by athletes and those looking to lose weight due to its effects on the body’s energy. Synephrine is utilized for the treatment of obesity by increasing calorie consumption and fat oxidation, as well as mitigating mild depression caused by obesity. However, this compound can also act as an antioxidant and anti-inflammatory agent and may have other important health benefits.
Raw Synephrine powder is a biogenic amine. It is found at high levels in the peels of citrus plants, like bitter orange or Seville orange (Citrus aurantium). Extracts from fruits or peels of these plants have been used in traditional Chinese medicine to treat stomach problems and allergies for hundreds of years. At present, p-synephrine is widely used in the pharmaceutical, food, beverage, and other industries.
Synephrine powder (97-07-5) Mechanism of Action
Cardiovascular effects of ligands are associated with adrenergic receptor binding. In general, when ligands bind to α-adrenergic receptors, vasoconstriction occurs, and when binding to β1-adrenergic receptors, cardiovascular contractility and increased heart rate result. Studies show that synephrine powder binds to β3-adrenergic receptors, resulting in an increase in the body’s ability to break down fats. Binding to β3-adrenergic receptors does not influence heart rate or blood pressure. Again, because synephrine exhibits little or no binding to α1-, α2-, β1-, and β2-adrenergic receptors and does not appear to exert indirect adrenergic effects, cardiovascular effects, such as an increase in heart rate and blood pressure, are not experienced at commonly used doses, unlike a number of other phenylethylamine and phenylpropanolamine derivatives. Small structural changes result in large differences in adrenergic receptor binding and subsequently the ability to produce cardiovascular effects.
Synephrine also enhances the body’s utilization of carbohydrates by producing more energy in the form of ATP.49–52 It facilitates cellular uptake of glucose in muscle cells, as well as glycogenolysis, gluconeogenesis, glycolysis, and oxygen uptake. The involvement of both calcium ion and cAMP with adrenergic receptors has been demonstrated to be involved in these biochemical processes, indicating the involvement of multiple mechanisms.
Beside, the use of Synephrine powder will inhibit the activation of NF-kB. This substance is key in causing inflammatory ailments such as asthma. The use of Synephrine has also been found to affect the action of the eotaxin-1 hormone largely. This prevents the movement of eosinophil to an area that is inflamed.
Although not well proved through experiments, the use of Synephrine powder has been found to inhibit the action of acetylcholinesterase. This chemical is known to cause Alzheimer’s disease.
Application of Synephrine powder (97-07-5)
▪ Improving exercise performance
▪ Treating Diabetes
▪ Help to weight loss
▪ Reducing nervousness before surgery
▪ Treating fungal skin infections such as ringworm, athlete’s foot, and jock itch.
▪ Improve Mood and Energy Levels
Recommended Synephrine powder (97-07-5) Dosage
Standard doses of Synephrine powder are 50-100mg each day and 30-40 minutes before workout. And, it is best taken first thing in the morning or 15 – 30 minutes before exercise. Synephrine powder should be taken with water before exercise.
Benefits of Synephrine powder (97-07-5)
♦ A study (DB-RCT) of 12 men showed that synephrine powder taken 45 minutes before exercise increased the number of repetitions and maximum weight load when performing squats compared to placebo.
♦ Early research suggests that drinking tea made from the leaves of Indian snakeroot and the fruit of bitter orange for 4 months appears to decrease blood sugar levels in people with diabetes.
♦ A combination of synephrine, caffeine, and St. John’s wort might help for weight reduction when used with a low calorie diet and exercise.
♦ A study (DB-RCT) of 10 subjects given 50 mg of synephrine showed that the subjects burned 65 calories more than participants given placebo in the first 75 minutes after taking the supplement.
♦ Research suggests that taking bitter orange two hours before surgery reduces nervousness.
♦ Bitter orange oil, which contains synephrine in addition to other active ingredients, in one study of 60 patients, improved fungal skin infections of the (feet, body/skin, or groin) in 2 to 3 weeks in over 80% of participants.
♦ Mice with classic signs of depression, including sleep problems and changes in eating habits, do worse in response to stressful events, like being forced to swim, than healthy mice do. One study showed that mice fed synephrine powderwere able to swim longer, indicating higher energy and mood levels
♦ One laboratory study showed that synephrine powder prevented the growth of some bacteria including E. coli, which can cause food poisoning, as well as Staphylococcus aureus, which can cause skin infections.
♦ A study performed using guinea pigs showed that synephrine reduced spasms of the smooth muscle in the trachea, a symptom that is associated with coughing. Synephrine also reduced asthma symptoms that occurred when the animals were given histamines.
♦ In mice with lung injury, synephrine reduced the number of inflammatory cells and inflammatory cytokines TNF-alpha and IL-6, while increasing the anti-inflammatory IL-10.