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Orlistat (96829-58-2)

Orlistat is in a class of medications called lipase inhibitors that works by blocking absorption of 25% of the fat in a meal and is …..

Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1470kg/month


Orlistat (96829-58-2) video

Orlistat (96829-58-2) Description

Orlistat is in a class of medications called lipase inhibitors that works by blocking absorption of 25% of the fat in a meal and is used for weight loss in overweight adults, 18 years and older, when used along with a reduced-calorie and low-fat diet. Orlistat is a drug designed to treat obesity. Its primary function is preventing the absorption of fats from the human diet, thereby reducing caloric intake. Orlistat works by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested. Prescription orlistat is used in overweight people who may also have high blood pressure, diabetes, high cholesterol, or heart disease. The effectiveness of orlistat in promoting weight loss is definite but modest. Pooled data from clinical trials suggest that people given orlistat in addition to lifestyle modifications, such as diet and exercise, lose about 2–3 kilograms (4.4–6.6 lb) more than those not taking the drug over the course of a year.Orlistat also modestly reduces blood pressure and appears to prevent the onset of type 2 diabetes, whether from the weight loss itself or other effects. It reduces the incidence of diabetes type II in people who are obese around the same amount that lifestyle changes do.


Orlistat (96829-58-2) Specifications

Product Name Orlistat
Chemical Name Tetrahydrolipstatin, 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate
Brand Name Alli, Xenical
Drug Class lipase inhibitors
CAS Number 96829-58-2
Molecular Formula C29H53NO5
Molecular Weight 495.745 g/mol
Monoisotopic Mass 495.392 g/mol
Melting Point  <50 °C
Freezing Point No date available
Biological Half-Life Based on limited data, the half-life of the absorbed orlistat is in the range of 1 to 2 hours.
Color White powder
Solubility  DMSO: 19 mg/mL
Storage Temperature  storage temp. 2-8°C
Application Use to treat obesity.



References & product citations

Orlistat for weight loss: How can it take away fat fast?



  1. Fat digestion and absorption, edited by Armand B. Christophe, Stephanie R. De Vriese, Stephanie DeVriese, page 426- 437.
  2. Progress in Obesity Research: 9, edited by Geraldo Madeiros-Neto, Alfredo Halpern, Claude Bouchard, page 1046.
  3. Obesity and Weight Management in Primary Care-By Colin Waine, Nick Bosanquet, page 68-71.


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