Semaglutide

March 2, 2024

Phcoker is a professional Semaglutide GMP manufacturer that provide both form of Semaglutide powder and Semaglutide finished lyophilized powder in vial.  The regularly manufacturing specification include Semaglutide 5mg, Semaglutide 10mg, Semaglutide 15mg. Larger dosage and contract manufacturing service is available.

Monthly production capacity: >1,000,000 vials


Other Name:Ozempic; Rybelsus;

 

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Properties


Sequence:His-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys(PEG2-PEG2- γ-Glu-17-carboxyheptadecanoyl)-Glu-Phe-Ile-Ala-Trp-Leu-Val-Arg-Gly-Arg-Gly
Molecular Formula:C187H291N45O59
Molecular Weight:4113.64 g/mol
PubChem CID:56843331
CAS Number:910463-68-2
Synonyms:Ozempic; Rybelsus; NN9535; Wegovy

Description


Semaglutide History

As a super “weight loss magic drug”, Semaglutide peptide getting more and more popular. When typing “weight loss drug” on the major social platforms, what comes into view is the pursuit of “thinness” and “beauty” by many people. They may share how to buy weight loss drug online or the weight loss drug use effects . One of the most frequently mentioned weight loss drugs is undoubtedly semaglutide.

Semaglutide powder is the active ingredient of famous brand Ozempic; Rybelsus; NN9535; Wegovy. Semaglutide development has gone through a long and complex process, from Semaglutide powder synthesis, Semaglutide finished vials manufacturing, and Semaglutide use, effects, mechanism of action, storage…etc. Here let’s view the history of Semaglutide and its relative products.

【2008】

Semaglutide start its phase II clinical trial studying and achieved good results.

【2012】

As the R&D company of Semaglutide, Novo Nordisk develop Semaglutide as a potential diabetes therapy.

【2016-2017】

Researchers start clinical trials that evaluate semaglutide efficacy in blood sugar control and cardiovascular risk reduction are conducted.

【Oct. 2017】

Semaglutide approved by FAD Advisory Committee for the treatment of diabetes

【Dec. 2017】

Semaglutide marked as brand name of Ozempic, and approved by FDA for diabetes management use in USA

【Jan.2018】

Semaglutide brand Ozempic is approved use in Canada

【Feb.2018】

Ozempic as one of the famous brand of Semaglutide, approved to be used in European Union, and in the same year, Japan approves for medical use.

【Aug. 2019】

Ozempic is approved for medical use by Australian government. In the same year, semaglutide oral brand Rybelsus approved by FDA that use for diabetes treatment in the USA

【Apr.2020】

Rybelsus (brand name of semaglutide oral form) obtain approval for medical use in European Union

【Jun. 2021】

Wegovy, the higher dosage version of Semaglutide, is approved by FDA for long-term weight loss management in adults

【Nov. 2021】

The CHMP of the European Medicines Agency recommends marketing authorization for Wegovy(Semaglutide brand name)

【Jan.2022】

Wegovy is approved for medical use in the European Unioin

【Jan 2023】

The label for Semaglutide oral version Rybelsus is updated to reflect its use as a first-line treatment for adults with type 2 diabetes.

This review of Semaglutide background outlines the significant milestones in the development of semaglutide, from its initial stages of research and clinical trials to its subsequent approvals for the management of diabetes, weight loss, and reduction of cardiovascular risk. These milestones attest to the effectiveness of semaglutide powder as a treatment for weight loss and type 2 diabetes. Ongoing research endeavors focus on elucidating semaglutide’s mechanisms of action, assessing its safety profile, and evaluating its efficacy. These investigations extend to its impact on metabolic health and potential applications beyond diabetes and obesity. Researchers seeking to procure semaglutide powder for their studies will discover that purchasing it online is a cost-efficient option. However, amidst the plethora of semaglutide powder available for sale online, identifying a reputable manufacturer poses a challenge.

What Is Semaglutide Peptide?

Semaglutide is a peptide that belongs to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone, works by increasing insulin release, lowering the amount of glucagon released, delaying gastric emptying and reducing appetite.

Semaglutide is approved as a prescription medicine used for weight loss in specific patients, and to lower blood sugar levels and reduce the risk of major cardiovascular events such as heart attack or stroke in type two diabetes patients.

For your safety, please buy and use Semaglutide with caution.

Semaglutide Brand Name

With different strength versions and for different purposes, Semaglutide is approved under 3 different brand names, including Wegovy, Ozempic, and Rybelsus. Let’s take a look at the differences and similarities between these different Semaglutide brand names.

The similarities of Wegovy, Ozempic, Rybelsus

  1. They all have the same active ingredient of Semaglutide powder;
  2. They all approved by FDA use for different purpose;
  3. They need to buy with prescription;

The difference between Wegovy, Ozempic, Rybelsus

Rybelsus is the oral tablet version of Semaglutide, it is approved use to lower blood sugar levels for type two diabetic patients along with diet and exercise, and is taken as a tablet once a day. The strength has 3mg tablet, 7mg tablet and 14mg tablet. As oral version of Semalgutide, it is more convenient to use than the injection version.

Wegovy is the injection version of Semaglutide, it is approved use for weight management for a specific group of patients and is given as a subcutaneous injection weekly. The strength has 0.25 or 0.5 mg dose pen, 1mg dose pen and 2mg dose pen.

Ozempic is the injection version of Semaglutide, it is approved use for lower blood sugar levels for type two diabetic patients, along with diet and exercise. It is also used for diabetic patients who already have cardiovascular disease, to help lower the risk of major cardiovascular events such as heart attack or stroke. Ozempic is given as a subcutaneous injection weekly.  The strength has 0.25mg dose pen, 0.5mg dose pen, 1mg dose pen, 1.7mg dose pen and 2.4mg dose pen.

Comparison chart

Due to the active ingredient of these 3 version all are Semaglutide powder and can buy with prescription only. If you want to make the medicine or build your own Semaglutide brand, buying Semaglutide powder from Phcoker who is the GMP manufacturer is a good choice and will get a good price.

What Is Semaglutide Working Mechanism?

Semaglutide belongs to a class of compounds called glucagon-like protein-1 (GLP-1) receptor agonists, which have been approved in the United States since 2005 for managing blood sugar levels in type 2 diabetes. Semaglutide is also believed to be a poweful medicine for weight management purpose. Here let’s take a deep look at semaglutide mechanism and how is semaglutide working.

Semaglutide and GLP-1 Receptors

 Semaglutide is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1), modified with a side chain. Glucagon-like peptide-1 (GLP-1) is a physiological hormone that has multiple actions on glucose, mediated by the GLP-1 receptors. It mimics the GLP-1 hormone, released in the gut in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). The method of Semaglutide work for weight loss are:

Boosting Satiety and Controlling Appetite: GLP-1 receptors, abundant in brain regions governing appetite, are activated by Semaglutide. This activation increases the sensation of fullness and decreases hunger, promoting mindful eating and reducing calorie intake, crucial for effective weight management.

Slowing Digestion: Semaglutide not only suppresses appetite but also delays gastric emptying, prolonging the feeling of fullness post-meal. This slows cravings and aids in resisting overeating.

Regulating Pleasure Response: Semaglutide impacts the brain’s reward pathways linked to food enjoyment. By targeting these pathways, Semaglutide diminishes the allure of high-calorie foods, facilitating adherence to dietary goals.

Revving up resting metabolism and burning fat

Semaglutide does not just regulate appetite, but also orchestrates metabolic changes impacting energy expenditure and fat utilization.  Semaglutide has been demonstrated to elevate basal metabolic rate, it supporting weight management even no exercise.  Meantime, another amazing aspect of Semaglutide is its promotion of fat breakdown. By boosting lipolysis, semaglutide facilitates the utilization of storred energy, aiding in weight loss effeorts.

It can be said that Semaglutide is a product that allows you to lose weight while lying down. If you are facing the problem of losing weight, you might as well try to buy semaglutide for a try. Be sure to buy semaglutide from a regular source, buy semaglutide online is not a bad choice, the important is to find a reliable semaglutide manufacturer.

What Benefits Can You Get From Semaglutide?

Semaglutide provide several benefits to people who seeking to lose weight and people with type 2 diabetes. Here are the benefits list relate to the use of semaglutide powder.

Semaglutide for Managing Type 2 Diabetes

 Both Semaglutide brand name of Ozempic and Rybelsus have received FDA approval for treating type 2 diabetes. The active ingredient Semaglutide powder, operates by mimicking the function of the GLP-1 hormone, which aids in regulating blood sugar levels, enhancing insulin secretion, and reducing appetite. Below are several benefits that patients with type 2 diabetes can experience when using semaglutide powder:

Improved Blood Sugar Management: Semaglutide assists in controlling blood sugar levels by increasing insulin secretion and decreasing glucagon production, leading to better blood sugar regulation and a lower risk of hyperglycemia (high blood sugar).

Reduced HbA1c Levels: Studies have demonstrated that use semaglutide can lower HbA1c levels, an indicator of average blood sugar levels over time, thus reducing the risk of diabetes-related complications.

Cardiovascular Advantages: Research suggests that semaglutide use may decrease the likelihood of major adverse cardiovascular events, such as heart attacks, strokes, and cardiovascular-related mortality, in individuals with diabetes and pre-existing cardiovascular conditions.

Weight Management: Many people with type 2 diabetes struggle with weight control. Peptide Semaglutide not only helps regulate blood sugar levels but also promotes weight loss, which is beneficial for overall health and diabetes management.

Semaglutide for Weight Loss

Semaglutide, marketed as Wegovy for weight loss, holds exclusive FDA approval for this purpose. According to a 68-week study, adults experienced an average weight loss of 35 pounds or 15% of their overall body weight while using Semaglutide powder. If you’ve been grappling with obesity or excess weight and have not achieved success with lifestyle changes alone, Semaglutide may offer the additional support you need. Additionally, buying Semaglutide powder in bulk can result in favorable pricing. Here are some benefits of semaglutide for weight loss:

Substantial Weight Reduction: Semaglutide has demonstrated significant and sustained weight loss in individuals with obesity or excess weight, which can positively impact overall health and well-being.

Appetite Control: Use Semaglutide to slow gastric emptying and increases feelings of fullness, aiding in appetite suppression and food intake regulation.

Enhanced Metabolic Health: Weight loss achieved with semaglutide powder can lead to improvements in metabolic markers such as reduced blood pressure, improved cholesterol levels, and enhanced insulin sensitivity.

Reduced Risk of Weight-Related Conditions: Shedding excess weight can decrease the risk of obesity-related conditions, including type 2 diabetes, cardiovascular disease, and certain cancers.

Improved Quality of Life and increased self-confidence : Successful weight loss can lead to enhanced self-esteem, increased mobility, and an overall better quality of life.

It’s important to note that the effects of semaglutide are optimized when combined with a balanced diet, regular physical activity, and ongoing medical supervision. Potential adverse effects and individual responses, as with any medication, should be assessed and discussed with a healthcare professional.”

What Side Effects Of Semaglutide?

Taking Semaglutide is often associated with some side effects, gastrointestinal issues are the most common complaint among people just starting semaglutide. But the side effects of semaglutide powder are typically mild, especially when compared to the complications associated with overweight and obesity.

Here are the primary side effects of people taking semaglutide for weight loss may experience:

Dizziness: taking Semaglutide may cause dizziness, and the degree of dizziness varies from person to person.

Fatigue: may feel tired after taking Semaglutide, which may be relieved by rest.

Gastrointestinal issues:  such as diarrhea, constipation and gassiness

Headache

Stomach issues: including nausea, vomiting, pain or distension (bloat)

Semaglutide Safety

Semaglutide, when prescribed and monitored by healthcare professionals, is generally regarded as safe. While enjoying the many benefits of Semaglutide, how to reduce the side effects of Semaglutide? You may be able to reduce the side effects by beginning on a lower dose and then slowly increasing the amount you take.

Do not share your Semaglutide injection with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.

The shortage and high cost of semaglutide have prompted an increasing number of individuals to buy their Semaglutide powder online that drawing attention from the FDA. The FDA has expressed concerns regarding the safety of different salt forms of semaglutide powder available online. However, despite these warnings, individuals like Carlos Alvarez continue to seek out affordable semaglutide peptide online, often relying on lab test reports and quality guarantees. As this practice gains traction, new online communities have emerged where users exchange experiences on using semaglutide powder and locating reputable peptide suppliers. Before purchasing semaglutide powder, Phcoker stands out as one of the peptide manufacturers you should consider.

Semaglutide Cost, Available Forms In The Market

Semaglutide, a synthetic peptide, was initially developed in 2012 by the global pharmaceutical company Novo Nordisk. Despite its benefits in blood sugar control and weight management, the cost of semaglutide based medications may present economic hurdles for certain individuals and healthcare systems. The ongoing expense of treatment can impact healthcare budgets and patient out-of-pocket expenditures. Moreover, insurance coverage for semaglutide medications varies, with some insurance companies scrutinizing and denying coverage for patients lacking sufficient evidence to support a diabetes diagnosis (citing off-label use for weight loss).

The high semaglutide cost has sparked conversations about accessibility, and the increasing popularity of semaglutide for weight loss and diabetes management has resulted in a surge in demand. Consequently, more qualified peptide manufacturers are producing Semaglutide powder in their independent labs.

Semaglutide is available from Phcoker in both raw powder and lyophilized powder forms.

Semaglutide Raw Powder: Semaglutide powder act as the active ingredient powder found in semaglutide-based medications such as Ozempic, Wegovy, and Rybelsus. It is frequently utilized for research purposes by scientists and researchers. Researchers employ semaglutide powder to develop solutions for laboratory experiments or to formulate various administration methods, including injections or oral tablets.

Semaglutide Injection Form (Semagluitde 5mg,10mg): The most prevalent form of semaglutide available for reconstitution is a lyophilized powder, which is a freeze-dried form of the peptide. This powder is mixed with a suitable diluent, such as bacteriostatic water or sterile water, to create an injectable solution. Reconstitution instructions may vary depending on the specific product and Semaglutide peptide manufacturer, so it is imperative to carefully adhere to the provided guidelines.

Semaglutide Alternatives

Weight management is a long-term investment. With insurance companies no longer covering it, people who use Semaglutide are specifically looking to buy Semaglutide online or find alternatives to Semaglutide. Here are some popular Semaglutide alternatives:

Tirzepatide: Tirzepatide is a novel medication that is FDA approved for the treatment of type 2 diabetes mellitus. Given its potent weight loss properties, tirzepatide be used off-label for obesity treatment. It works as a dual GLP-1 agonist and GIP agonist to maximize similar benefits that are seen with GLP-1 medications such as semaglutide.

Retatrutide: Retatrutide is an investigational treatment for obesity that is a triple hormone receptor agonist from Eli Lilly. Retatrutide is a gastric inhibitory polypeptide (GIP), glucagon-like peptide-1 (GLP-1) and glucagon receptor agonist,works in the treatment of obesity by targeting three different hunger regulating hormones.

Cagrilintide: Cagrilintide is a long-acting amylin analogue for the treatment of obesity. Amylin is co-located with insulin in secretory granules and co-secreted with insulin by pancreatic beta cells in response to food intake.

Where To Buy Semaglutide For Research Purpose

 Continuous research is investigating the effectiveness of semaglutide in comparison to tirzepatide and other semaglutide alternatives, it focus on their impacts on weight loss, blood sugar regulation, and overall metabolic well-being. These studies seek to ascertain which medication yields superior results and exhibits a more favorable safety profile. Semaglutide for research endeavors is commonly obtainable from specialized chemical suppliers, research institutions, or pharmaceutical companies, including peptide powder manufacturers like Phcoker, which provides pharmaceutical-grade peptides.

 

Manufacturers/Factory


As demand for Semaglutide for diabetes and weight loss management continues to increase, demand for Semaglutide on the market exceeds supply. Under such circumstances, many people turn to purchasing Semaglutide powder from the online peptide sources. This Semaglutide powder can be purchased through some laboratories, medical institutions and peptide factories. These Semaglutide powder suppliers must have strict GMP production conditions, conduct strict testing of their products and issue test reports (such as COA, HPLC, etc.). Please be careful before purchasing Semaglutide powder from online Semaglutide powder suppliers. Phcoker is one the best Semaglutide GMP manufacturers worth to check, it not only supply the semaglutide raw powder but also provide the lyophilized powder in vial form.

 

Where to buy


Researchers found that many peptide manufacturers supply semaglutide online, include the raw powder form and lyophilized powder in vial form. If you want to buy the semagluitde peptide online, you have come at the right place!

Phcoker as a peptide GMP manufacturer, is the best place where you can buy semaglutide with compeptitive price, from small to bulk quantity. Click and make a contact, you will get all the details. Before buy semaglutide, you may curious:

What Are The Advantages If Buy Semaglutide From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of Semaglutide Online?

  • Visit professionalSemaglutide supplier Phcoker.com, choose the Semaglutide you want to buy.
  • Leave your contact and message on Phcoker.com website, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy Semaglutide.

Does Phcoker.com Support The Free Sample Of Semaglutide Powder?

It depends, different products with different policy, please check it with the customer service. Most of products can be accepted for sample.

Can I Appoint The Semaglutide Colour When Buy Semaglutide?

YES! Phcoker as peptide GMP manufacturer, provide colour customization of Semaglutide, easy to help you to build your Semaglutide peptide brand.

Can I Appoint The Products Standard When Buy Semaglutide From Phcoker.com?

YES! As one of the best Semaglutide GMP manufacturer, Phcoker not only provide the standard specification of Semaglutide in 5mg, 10mg, but support standard customization. Provide the best support to build your own Semaglutide brand.

Can I Buy Semaglutide In Pure Powder Form From Phcoker.com?

YES! Semaglutide powder is the base that use for Semaglutide lyophilized powder manufacturing. Phcoker provide Semaglutide in both of pure powder form and lyophilized powder in vial form.

Can I Buy Discount Semaglutide Powder From Phcoker.com?

YES! Phcoker produce high quality Semaglutide powder in term and keep Semaglutide powder in stock. You can buy high quality Semaglutide powder in bulk. During promotion sale, you can buy Semaglutide peptide with lower price. You can keep touch with the customer manager and they will update the latest bulk semaglutide price for you in time.

FAQ


Can semaglutide be compounded?

Ozempic and Wegovy are both on the FDA’s Drug Shortages list as of May 2023. When a drug is in low supply, compounders may be able to manufacture a compounded version of that drug if they meet specific requirements.

How much weight can you lose on Semaglutide injection in 3 months?

One study found people who received weekly Semaglutide injections lost an average of about 15 pounds after three months and about 27 pounds after six months, which translates into about a 5-pound weight loss per month.

Does Semaglutide peptide powder get rid of belly fat?

By mimicking the GLP-1 hormone, slowing the digestive process, and stimulating fat oxidation, Semaglutide can help patients lose large amounts of belly fat.

How fast will I lose weight on Semaglutide injection?

According to clinical studies, most people start to see noticeable weight loss after about 4 to 12 weeks of regular Semaglutide use. However, individual results vary based on starting weight, diet, exercise, and adherence to the medication regimen.

Can I lose 20 pounds in a month with Semaglutide peptide?

So with each higher dose, we should continue to see more and more weight loss. Remember that this is the average weight loss. We did have patients who lost a moderate amount but we also had patients losing over 15 pounds and even over 20 pounds in the first month!

Who Cannot take Semaglutide?

Avoid Semaglutide if you have: History of medullary thyroid cancer. History of gallbladder disease. History of pancreatitis. And if you are pregnant or get ready for pregnancy, please do not use Semaglutide.

Why can’t you drink on Semaglutide?

Semaglutide isn’t known to interact with alcohol. However, this medication and alcohol both lower your blood sugar, so drinking alcohol during your Semaglutide weight loss treatment may cause severe hypoglycemia.

How long should I stay on Semaglutide?

Most patients who have been prescribed Semaglutide injections for weight loss will have the prescription for 68 weeks as long as they can continue taking the medication safely without experiencing significant side effects.

What happens when you stop taking Semaglutide?

As you transition off Semaglutide, you’ll slowly and gradually begin to regain your appetite and food cravings. You’ll have time to get used to them while establishing a healthy diet and good exercise routine. This should stop you from regaining weight when you stop semaglutide completely.

Semaglutide Vs Tirzepatide: what are the difference?

Weight loss with semaglutide ranged from 6 to 10 kg (13.2 to 22 lb). With tirzepatide, weight loss ranged from 7 to 13 kg (15.4 to 28.6 lb). Tirzepatide may have a better effect to help lower blood sugar and lead to weight loss in some patients, but may be associated with more stomach side effects at higher doses.

Referenced Citations


[1]Wilding JPH, Batterham RL, Calanna S, Davies M, Van Gaal LF, Lingvay I, McGowan BM, Rosenstock J, Tran MTD, Wadden TA, Wharton S, Yokote K, Zeuthen N, Kushner RF; STEP 1 Study Group.”Once-Weekly Semaglutide in Adults with Overweight or Obesity.”N Engl J Med. 2021 Mar 18;384(11):989-1002. doi: 10.1056/NEJMoa2032183. Epub 2021 Feb 10.PMID: 33567185

[2]Rubino DM, Greenway FL, Khalid U, O’Neil PM, Rosenstock J, Sørrig R, Wadden TA, Wizert A, Garvey WT; STEP 8 Investigators.”Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial.”JAMA. 2022 Jan 11;327(2):138-150. doi: 10.1001/jama.2021.23619.PMID: 35015037

[3]Frías JP, Davies MJ, Rosenstock J, Pérez Manghi FC, Fernández Landó L, Bergman BK, Liu B, Cui X, Brown K; SURPASS-2 Investigators.”Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes.”N Engl J Med. 2021 Aug 5;385(6):503-515. doi: 10.1056/NEJMoa2107519. Epub 2021 Jun 25.PMID: 34170647

[4]Weghuber D, Barrett T, Barrientos-Pérez M, Gies I, Hesse D, Jeppesen OK, Kelly AS, Mastrandrea LD, Sørrig R, Arslanian S; STEP TEENS Investigators.”Once-Weekly Semaglutide in Adolescents with Obesity.”N Engl J Med. 2022 Dec 15;387(24):2245-2257. doi: 10.1056/NEJMoa2208601. Epub 2022 Nov 2.PMID: 36322838

[5]Smits MM, Van Raalte DH.”Safety of Semaglutide.”Front Endocrinol (Lausanne). 2021 Jul 7;12:645563. doi: 10.3389/fendo.2021.645563. eCollection 2021.PMID: 34305810

[6]Rubino D, Abrahamsson N, Davies M, Hesse D, Greenway FL, Jensen C, Lingvay I, Mosenzon O, Rosenstock J, Rubio MA, Rudofsky G, Tadayon S, Wadden TA, Dicker D; STEP 4 Investigators.”Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1414-1425. doi: 10.1001/jama.2021.3224.PMID: 33755728

[7]O’Neil PM, Birkenfeld AL, McGowan B, Mosenzon O, Pedersen SD, Wharton S, Carson CG, Jepsen CH, Kabisch M, Wilding JPH.”Efficacy and safety of semaglutide compared with liraglutide and placebo for weight loss in patients with obesity: a randomised, double-blind, placebo and active controlled, dose-ranging, phase 2 trial.”Lancet. 2018 Aug 25;392(10148):637-649. doi: 10.1016/S0140-6736(18)31773-2. Epub 2018 Aug 16.PMID: 30122305

[8]Chao AM, Tronieri JS, Amaro A, Wadden TA.”Semaglutide for the treatment of obesity.”Trends Cardiovasc Med. 2023 Apr;33(3):159-166. doi: 10.1016/j.tcm.2021.12.008. Epub 2021 Dec 21.PMID: 34942372

[9]Singh G, Krauthamer M, Bjalme-Evans M.”Wegovy (semaglutide): a new weight loss drug for chronic weight management.”J Investig Med. 2022 Jan;70(1):5-13. doi: 10.1136/jim-2021-001952. Epub 2021 Oct 27.PMID: 34706925

[10]Wadden TA, Bailey TS, Billings LK, Davies M, Frias JP, Koroleva A, Lingvay I, O’Neil PM, Rubino DM, Skovgaard D, Wallenstein SOR, Garvey WT; STEP 3 Investigators.”Effect of Subcutaneous Semaglutide vs Placebo as an Adjunct to Intensive Behavioral Therapy on Body Weight in Adults With Overweight or Obesity: The STEP 3 Randomized Clinical Trial.”JAMA. 2021 Apr 13;325(14):1403-1413. doi: 10.1001/jama.2021.1831.PMID: 33625476

[11]Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN.”Semaglutide as a promising antiobesity drug.”Obes Rev. 2019 Jun;20(6):805-815. doi: 10.1111/obr.12839. Epub 2019 Feb 15.PMID: 30768766

[12]Meier JJ.”Efficacy of Semaglutide in a Subcutaneous and an Oral Formulation.”Front Endocrinol (Lausanne). 2021 Jun 25;12:645617. doi: 10.3389/fendo.2021.645617. eCollection 2021.PMID: 34248838

[13]Garvey WT, Batterham RL, Bhatta M, Buscemi S, Christensen LN, Frias JP, Jódar E, Kandler K, Rigas G, Wadden TA, Wharton S; STEP 5 Study Group.”Two-year effects of semaglutide in adults with overweight or obesity: the STEP 5 trial.”Nat Med. 2022 Oct;28(10):2083-2091. doi: 10.1038/s41591-022-02026-4. Epub 2022 Oct 10.PMID: 36216945

[14]Husain M, Birkenfeld AL, Donsmark M, Dungan K, Eliaschewitz FG, Franco DR, Jeppesen OK, Lingvay I, Mosenzon O, Pedersen SD, Tack CJ, Thomsen M, Vilsbøll T, Warren ML, Bain SC; PIONEER 6 Investigators.”Oral Semaglutide and Cardiovascular Outcomes in Patients with Type 2 Diabetes.”N Engl J Med. 2019 Aug 29;381(9):841-851. doi: 10.1056/NEJMoa1901118. Epub 2019 Jun 11.PMID: 31185157

[15]Wilding JPH, Batterham RL, Davies M, Van Gaal LF, Kandler K, Konakli K, Lingvay I, McGowan BM, Oral TK, Rosenstock J, Wadden TA, Wharton S, Yokote K, Kushner RF; STEP 1 Study Group.”Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension.”Diabetes Obes Metab. 2022 Aug;24(8):1553-1564. doi: 10.1111/dom.14725. Epub 2022 May 19.PMID: 35441470

 

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


1.Jesse Richards

Department of Internal Medicine, University of Oklahoma School of Community Medicine, Tulsa, OK, USA

2.Coenraad Withaar MSc

University of Groningen, University Medical Center Groningen, Department of Cardiology, Groningen, the Netherlands

3.Peter Kurtzhals

Novo Nordisk A/S, Vandtaarnsvej 110-114, DK-2860, Søborg, Denmark

4.Satoshi Iwai

Department of Gastroenterology, Nara Medical University, Kashihara, Nara 634-8521, Japan

5.Dimitrios Patoulias

Outpatient Department of Cardiometabolic Medicine, Second Department of Cardiology, Aristotle University of Thessaloniki, General Hospital “Hippokration”, Thessaloniki, Greece


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