Linaclotide

July 20, 2023

Linaclotide is a synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin peptide family, with secretagogue, analgesic and laxative activities. It is used for treatment of chronic constipation and irritable bowel syndrome. Linaclotide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.


Status:In Mass Production
Unit:5mg,10mg,1g/customized
Capacity: 1kg/month

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Raw Linaclotidepowder (851199-59-2) video

Linaclotide Description

Linaclotide is a synthetic, fourteen amino acid peptide and agonist of intestinal guanylate cyclase type C (GC-C), which is structurally related to the guanylin peptide family, with secretagogue, analgesic and laxative activities. It is used for treatment of chronic constipation and irritable bowel syndrome. Linaclotide has not been linked to serum enzyme elevations during treatment or to episodes of clinically apparent liver injury.

Linaclotide Specifications

Product NameLinaclotide
Chemical NameLinacllotide;Linaelotide Acetate;Linaelotide
Brand NameLinzess
Drug ClassPeptide
CAS Number851199-59-2
InChIKeyKXGCNMMJRFDFNR-WDRJZQOASA-N
Molecular FormulaC59H79N15O21S6
Molecular Weight1526.725
Monoisotopic Mass1525.39 g/mol
Melting Point 231-235° C (dec.)
Biological Half-Lifeapproximately 1.5 hr on day 1 and 7 for both genders
Colorwhite to off-white
Solubility Soluble in DMSO
Storage Temperature −20°C
Applicationused for treatment of chronic constipation and irritable bowel syndrome

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