+86(1812)4514114 info@phcoker.com

Raw Lorcaserin HCL powder (846589-98-8)

(1 customer review)

Raw Lorcaserin hydrochloride powder is a serotonin 2C (5-HT2C) receptor agonist and orally administered medication that promotes….


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1380kg/month

Description

Raw Lorcaserin HCL powder (846589-98-8) video

 

Raw Lorcaserin HCL powder (846589-98-8) Specifications

Product Name Raw Lorcaserin Hydrochloride powder
Chemical Name Raw Lorcaserin HCL powder,Lorcaserin
Brand Name BELVIQ
Drug Class 5-HT2C receptor inhibitor
CAS Number 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Molecular Formula C11H15Cl2N
Molecular Weight 232.15
Monoisotopic Mass 231.058154899
Melting Point  No data available
Freezing Point No data available
Biological Half-Life The half-life of lorcaserin is approximately 11 hours.Lorcaserin powder is eliminated primarily in the urine (92%) and in the feces (2.2%)
Color White powder
Solubility  Water Solubility:0.0709 mg/mL
Storage Temperature  -20°C.
Application Serotonin 2C (HT2C) receptor agonist for weight loss.Decreases food consumption and promotes satiety centrally

 

Raw Lorcaserin Hcl powder (846589-98-8) Description

Raw Lorcaserin hydrochloride powder is a hydrochloride obtained by reaction of lorcaserin powder with one equivalent of hydrochloric acid. Used as an anti-obesity drug. Lorcaserin hydrochloride is a 5HT2c receptor agonist indicated for use in adults with a BMI ≥30, or those with a BMI ≥27 and at least one weight-related condition like hypertension, type 2 diabetes or dyslipidemia.Lorcaserin Hydrochloride powder works by suppressing appetite and induces a feeling of satiety, and is thought to avoid the precipitation of cardiac valvular disease associated with activation of 5-HT2B receptors, the area of the brain known to play a major role in regulating hunger and food intake. By activating these receptors,  Lorcaserin hydrochloride powder may decrease food consumption by decreasing appetite and making a person feel full even after eating less food than usual. was approved today by the FDA in a landmark decision after 2 years of scrutiny.

Lorcaserin hydrochloride powder is specifically indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in clinically obese adults (BMI of 30 kg/m2 or greater) and overweight adults (BMI of 27 kg/m2 or greater) with at least one weight-related comorbid condition.

Lorcaserin hydrochloride powder is used together with diet and exercise to treat obesity. It is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.

Lorcaserin hydrochloride will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure). Keep taking any other medications your doctor has prescribed to treat these conditions.

Lorcaserin Hcl powder (846589-98-8) Mechanism of Action

Although the exact mechanism is unknown, it is believed to involve the selective activation of 5-HT2C receptors in the anorexigenic pro-opiomelanocortin neurons in the arcuate nucleus of the hypothalamus. This results in decreased food intake and satiety by promoting the release of alpha-melanocortin stimulating hormone, which acts on melanocortin-4 receptors.

Lorcaserin hydrochloride powder works by controlling appetite — specifically by activating brain receptors for serotonin, a neurotransmitter that triggers feelings of satiety and satisfaction. Intake of food is controlled by satiety center, located in ventromedial nucleus of hypothalamus and hunger center present in lateral hypothalamus. Various inputs from higher centers and gastrointestinal tracts converge in arcuate nucleus, where two types of neurons controlling food intake is present. Firstly, food intake stimulatory group producing agouti-related protein and neuropeptide Y; and secondly, food intake inhibitory group containing cocaine and amphetamine regulated transcript (CART) and pro-opiomelanocortin (POMC) neurons. POMC contains 5-HT 2C receptors, which when activated releases alpha-melanocyte-stimulating hormone (alfa-MSH).Both inhibitory and stimulatory neurons further projects paraventricular nucleus in the hypothalamus. Paraventricular nucleus contains melanocyte 4 receptors (MC4R) that inhibits appetite in therapeutic doses lorcaserin hydrochloride powder acts as a selective 5-HT 2C agonist on POMC neurons, which in turn causes release of alfa MSH. Further alfa MSH acts on MC4R in paraventricular nucleus in the hypothalamus, leading to decrease in appetite. In supratherapeutic doses, lorcaserin hydrochlorider also acts on 5-HT 2B and 5-HT 2A receptors.

Benefits of Lorcaserin Hcl powder (846589-98-8)

  • Lorcaserin HCL powder is a selective 5-HT2C receptor agonist that is thought to decrease food intake through the central POMC system. Lorcaserin HCL powder benefits:
  • Lorcaserin HCL powder is used together with diet and exercise to treat obesity.
  • Lorcaserin HCL powder is sometimes used to treat obesity that may be related to diabetes, high cholesterol, or high blood pressure.
  • Lorcaserin HCL powder will not treat any underlying health condition (such as heart disease, diabetes, high blood pressure).

Recommended Lorcaserin Hcl powder (846589-98-8) Dosage

Lorcaserin HCL powder comes in tablet form and is taken typically 1-2 times a day, with or without food. Lorcaserin must be used along with a reduced calorie diet and an exercise plan.

The recommended dose of lorcaserin hcl powder is 10 mg administered by mouth twice a day. Lorcaserin may be taken without regard to meals. Lorcaserin hcl should be discontinued in patients who fail to achieve at least a 5% weight loss by week 12 since these patients are not likely to experience meaningful weight loss with continued treatment.

Side effects of Lorcaserin Hcl powder (846589-98-8)

Lorcaserin Hcl powder is used for the treatment of chronic weight management in adults with a body mass index (BMI) of 30 or greater (obese) as an addition to a reduced-calorie diet and exercise. It is also approved for use by adults with a BMI of 27 or greater (overweight) and who have at least one weight-related condition such as high blood pressure (hypertension), or high cholesterol (dyslipidemia). However, it also may have some side effects. As below:

 The most common side effects:

  • -Headache,
  • -Dizziness,
  • -Fatigue,
  • -Nausea,
  • -Dry mouth,
  • -Constipation, and
  • -Hypoglycemia (low blood sugar).

 Other less common but serious side effects associated with lorcaserin include:

  • -Heart valve problems,
  • -Changes in attention or memory,
  • -Mental problems,
  • -Depression or thoughts of suicide,
  • -Painful erections,
  • -Slow heartbeat,
  • -A drop in blood cell count, and
  • -An increase in the hormone, prolactin.

 


=

References & product citations

FDA Approved Lorcaserin HCL For The Treatment Of Obesity

 

References

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., et al.: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients, The New England Journal of Medicine, 2018
  2. Food and Drug Administration, Medications Target Long-Term Weight Control, Online, Published 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose A.R., National Centre For Biotechnology Information, PMC Articles, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

1 review for Raw Lorcaserin HCL powder (846589-98-8)

  1. phcoker

    Got Raw Lorcaserin HCL powder to test, test result show very high quality and purity!

Add a review

Your email address will not be published. Required fields are marked *