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Lorcaserin HCL (846589-98-8)

Lorcaserin hydrochloride is a hydrochloride obtained by reaction of lorcaserin with one equivalent……..


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1380kg/month

Description

Lorcaserin HCL (846589-98-8) video

Lorcaserin HCL (846589-98-8) Description

Lorcaserin hydrochloride is a hydrochloride obtained by reaction of lorcaserin with one equivalent of hydrochloric acid. Used as an anti-obesity drug. Lorcaserin hydrochloride is a 5HT2c receptor agonist indicated for use in adults with a BMI ≥30, or those with a BMI ≥27 and at least one weight-related condition like hypertension, type 2 diabetes or dyslipidemia.Lorcaserin Hydrochloride works by suppressing appetite and induces a feeling of satiety, and is thought to avoid the precipitation of cardiac valvular disease associated with activation of 5-HT2B receptors, the area of the brain known to play a major role in regulating hunger and food intake. By activating these receptors, lorcaserin may decrease food consumption by decreasing appetite and making a person feel full even after eating less food than usual. was approved today by the FDA in a landmark decision after 2 years of scrutiny.

 

Lorcaserin HCL (846589-98-8) Specifications

Product Name Lorcaserin Hydrochloride
Chemical Name Lorcaserin HCL,Lorcaserin
Brand Name BELVIQ
Drug Class 5-HT2C receptor inhibitor
CAS Number 846589-98-8
InChIKey ITIHHRMYZPNGRC-QRPNPIFTSA-N
Molecular Formula C11H15Cl2N
Molecular Weight 232.15
Monoisotopic Mass 231.058154899
Melting Point  No data available
Freezing Point No data available
Biological Half-Life The half-life of lorcaserin is approximately 11 hours.Lorcaserin is eliminated primarily in the urine (92%) and in the feces (2.2%)
Color White powder
Solubility  Water Solubility:0.0709 mg/mL
Storage Temperature  -20°C.
Application Serotonin 2C (HT2C) receptor agonist for weight loss.Decreases food consumption and promotes satiety centrally

 


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References & product citations

FDA Approved Lorcaserin HCL For The Treatment Of Obesity

 

References

  1. Bohula, Erin A., Wiviott, Stephen D., McGuire, Darren K., Inzucchi, Silvio E., et al.: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients, The New England Journal of Medicine, 2018
  2. Food and Drug Administration, Medications Target Long-Term Weight Control, Online, Published 17 July 2012
  3. Ashley Gustafson, Cammile King, Jose A.R., National Centre For Biotechnology Information, PMC Articles, MediMedia, USA Lorcaserin (Belviq), Online, September 2013

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