EUK-134 (81065-76-1)

November 17, 2021

EUK-134 is a strong and effective antioxidant with self-renewing ability, which can reduce skin redness and swelling and prevent UV damage. Also, it can treat the oxidative status of mitochondria and reversed hypertrophy-induced reduction of mitochondrial membrane potential, its identified as a novel approach to attenuate cardiac hypertrophy.


Status:In Mass Production
Capacity: 1100kg/month


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EUK-134 (81065-76-1) Specifications

Product NameEUK-134
Chemical Namechloro[[2,2′-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese
SynonymsEUK 134;


ethylbisiminomethylguaiacol manganese chloride;





CAS Number81065-76-1
Molecular FormulaC18H18ClMnN2O4
Molecular Weight416.7
Monoisotopic Mass416.033553
Melting point >300° C
ColorFaint to very dark brown
Form Powder
Solubility Soluble in water (0.2 mg/ml at 25° C), PBS pH 7.2, ethanol, DMSO, and DMF.
Storage Temperature Store at -20° C
ApplicationEUK-134 has been used as an antioxidant.

EUK-134 has been used to determine the mechanism underlying hypoxia-inducible factor-1α (HIF-1α) stabilization in human aortic endothelial cells (HAECs).

Testing DocumentAvailable


What is EUK-134?

EUK-134 is a mimic of superoxide dismutase and catalase with high antioxidant capacity. It is an extremely rare self-regenerating molecule that can scavenge superoxide free radicals, eliminate hydrogen peroxide and convert reactive oxygen species into water and oxygen.

Although it has been around for many years, few products on the market use this truly outstanding antioxidant. Unlike other antioxidants, EUK 134 can regenerate itself to provide all-weather antioxidant support. That is, after removing free radicals, it will regenerate again to maintain its function and continue to scavenge other free radicals. This can protect us from premature aging of the skin, while reducing the damage to the skin caused by sunlight and ultraviolet rays.

As a powerful antioxidant and a new miracle skin care ingredient, EUK-134 is currently mainly used in skin care products by cosmetic manufacturers to keep the skin young and healthy.

It is worth noting that EUK-134 cannot be used immediately with strong acids (such as ascorbic acid suspension). Strong acid will completely destroy EUK-134 based on manganese.


How does EUK-134 work?

EUK-134 is a molecule that mimics the natural antioxidant enzyme superoxide dismutase. It converts active oxygen superoxide anions into peroxides, and then converts them into water by catalase. Reactive oxygen species is a by-product of cellular respiration, which can cause cell damage and oxidative stress, leading to inflammation, cancer and other age-related diseases. Supplementing EUK-134 may be able to make up for the lack of antioxidant defenses on the skin’s surface and help protect the skin from the accumulation of oxidative damage.


The benefits of EUK-134

(1) It can reduce the damage of ultraviolet rays

EUK 134 can be against ultraviolet radiation, reducing the level of lipid peroxides in the skin after exposure to the sun. Studies have shown that using EUK 134 before exposure to UVB rays reduces the production of p53 protein (a protein that increases when the skin is damaged by UVB rays), thereby reducing oxidative damage.

In addition, unlike other antioxidants (such as alpha tocopherol), EUK 134 can reduce lipid peroxide levels even when used after sun exposure.

By reducing and protecting the skin from ultraviolet rays, it reduces skin redness and reduces pigmentation caused by the sun.


(2) Keep skin youthful

EUK 134 consists of an exceptionally rare self-generating molecule that neutralises free radicals, therefore preventing the production of collagen and elastin from being inhibited, which will  help your skin stay young and healthy.


(3) Reduce myocardial hypertrophy

EUK-134 is a salen-manganese complex with superoxide dismutase and catalase activity. Its treatment improved the oxidative status of mitochondria and reversed hypertrophy-induced reduction of mitochondrial membrane potential. Supplementation with EUK-134 is therefore identified as a novel approach to attenuate cardiac hypertrophy and lends scope for the development of EUK-134 as a therapeutic agent in the management of human cardiovascular disease.

However, EUK-134 should not be used immediately with strong acids, as they will compromise its beneficial effects.


Product conflicts with EUK 134

Some products will conflict with other products when in use, EUK-134 is no exception. When using EUK-134, you should avoid using it with the following products.

– Direct acid

– strong acid

– Vitamin C

– Ferulic acid

Make sure to avoid using these products when using EUK 134. You can use some non-conflicting products because they can bring multiple benefits.


Where is EUK-134 powder sold?

EUK-134 Powder wholesale trades are much more common than retail sales as it is usually purchased in bulk directly from the EUK-134 Powder manufacturer factory. Generally, medications of such private nature are commonly bought online as it provides patients with discretion and privacy that they need.



  1. Sreeja Purushothaman, R Renuka Nair. Mitoprotective antioxidant EUK-134 stimulates fatty acid oxidation and prevents hypertrophy in H9C2 cells. Mol Cell Biochem. 2016 Sep;420(1-2):185-94. doi: 10.1007/s11010-016-2788-9. Epub 2016 Aug 11. PMID: 27514538 DOI: 10.1007/s11010-016-2788-9
  2. L Declercq, I Sente, L Hellemans, H Corstjens, D Maes. Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface. Int J Cosmet Sci. 2004 Oct;26(5):255-63. doi: 10.1111/j.1467-2494.2004.00234.x. PMID: 18492138 DOI: 10.1111/j.1467-2494.2004.00234.

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