TB500(Thymosin beta 4)

March 2, 2024
SKU: 77591-33-4

Phcoker is a professional GMP manufacturer of TB 500(Thymosin Beta4) that provide both form of TB500 powder and TB 500 finished lyophilized powder in vial.  The regularly manufacturing specification include TB500 5mg, TB 50010mg, TB500 15mg. Larger dosage and contract manufacturing service is available.

Monthly production capacity: >1,000,000 vials


Other Name:Thymosin Beta 4, tb 500, tb500, tb-500, TMSB4X, Fx Peptide,Timbetasin, PTMB4, Tβ4, TB4X, TMSB4,  X-linked, thymosin beta 4 X-linked

 

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Properties


Sequence:Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser
Molecular Formula:C212H350N56O78S
Molecular Weight:4963g/mol
PubChem CID:16132341
CAS Number:77591-33-4
Synonyms:TB500; Thymosin beta4; Thymosin β4; Thymosin b4; Thymosin beta4 Acetate; Thymosin beta(4); Thymosin Beta 4; Thymosin beta-4; Thymosin beta4 (ox); Thymosin beta4 (human); Timbetasin; Tbeta4;

Description


TB500 peptide, also known as Thymosin beta4, is a precursor protein that has potential benefits for muscle building, recovery, and cognition. It stimulates muscle growth and accelerates the healing process. TB500 has shown promising results in damage repair, cardiac cell effects, and muscle cell effects, making it a subject of research in various medical fields. People who pay attention to TB 500 will find that many people use TB500 and BPC-157 together, many peptide manufacturers provide blend peptide of TB500+BPC 157. So what is the relationship between TB500 and BPC-157? Here is everything you would like to know about TB500 peptide.

What Is TB 500Thymosin beta-4 Peptide?

TB500(Thymosin Beta-4) is a naturally occurring protein encoded by the Thymosin β4 gene in the human body. Its primary function is to promote tissue repair and regeneration. TB500 peptide has been found to enhance muscle tissue growth and repair, reduce inflammation, and prevent fibrosis. Due to these properties, TB500 is a popular supplement among athletes and fitness enthusiasts, particularly during recovery periods when it is believed to accelerate wound healing and alleviate muscle pain.

How Dose TB500Thymosin beta-4 Peptide Work?

TB500 (Thymosin Beta-4) is a synthetic variant of thymosin beta-4. Its mechanism of action in the human body involves the following aspects:

Promote tissue repair and regeneration: TB500 promotes cell migration and tissue repair by binding to actin and affecting the reorganization of the cytoskeleton. This is essential for tissue regeneration and repair.

Promote angiogenesis: TB500 can stimulate the proliferation and angiogenesis of vascular endothelial cells, thereby increasing the blood supply to damaged tissues and promoting wound healing and tissue regeneration.

Anti-inflammatory effect: TB500 has an anti-inflammatory effect that can reduce the inflammatory response and the degree of inflammation caused by tissue damage.

Anti-fibrosis effect: TB500 inhibits the formation of scar tissue and the fibrosis process, reducing the occurrence of adverse fibrotic reactions during tissue repair.

Taken together, TB500 primarily contributes to wound healing, tissue regeneration, and physical recovery by promoting cell migration, tissue repair, and regeneration, increasing angiogenesis, and inhibiting inflammation and fibrosis. Individual buying TB 500 for research use or bodybuilding, will find that there are many different peptide manufacturers supply TB 500 with different forms, the TB 500 powder, TB 500 injection, blend TB500+BPC 157 are the most popular among of them. TB 500 powder is the active ingredient of the injection and blend peptide. If you are an experienced TB 500 user, you can buy TB 500 powder to make it into the forms that you want. If you have no experience about TB 500, TB 500 injection form is a good choice to start. Don’t just focus on comparing prices of TB 500, the quality is the most important.

What Are The Benefits Of TB500 Peptide?

TB500 (Thymosin Beta-4) is primarily used for experimental and research purposes rather than medical use. It is believed to have various benefits. Here are some of the potential benefits of TB500:

Promotes tissue repair and regeneration: TB500 is believed to promote the repair and regeneration process of damaged tissue. It speeds wound healing and helps repair damaged muscles, tendons, ligaments and other tissues.

Anti-inflammatory effect: TB500 has an anti-inflammatory effect that can reduce the inflammatory response and degree of inflammation resulting from tissue damage.

Promote angiogenesis: TB500 stimulates the proliferation and angiogenesis of vascular endothelial cells, increasing blood supply to damaged tissue and promoting wound healing and tissue regeneration.

Reduces Pain and Discomfort: By promoting tissue repair and reducing inflammatory responses, TB500 may help reduce pain and discomfort.

Improves athletic performance:Research indicates that TB500 may enhance athletic performance, endurance, and strength.

Anti-Aging Benefits: Although further research is required to confirm this, some studies indicate that TB500 may have anti-aging effects, aiding in the maintenance of overall body health and function.

It is important to note that the use of TB500 is strictly regulated and limited, and is currently only used for scientific research and laboratory experiments. Before considering the use of TB500, it is advisable to consult a medical professional for further information and advice.

TB500 and anti-aging

TB500 peptide is popular in both medical research and anti-aging fields. It promotes cell growth, repair, and differentiation. Studies have also shown that TB500 peptide affects the maturation and distribution of lymphocytes, which is important in regulating the immune system. Additionally, it increases the production of collagen, a protein critical for skin elasticity. In addition, TB500 may protect cells from damage caused by free radicals and has regenerative properties. TB 500 particularly in various types of heart tissue, promoting overall heart health. TB 500 peptide are increasingly popular as anti-aging treatments.

How to use TB500 peptide?

TB500 peptides are commonly available in various forms such as powder, liquid, tablets, and capsules. Phcoker.com has TB500 raw powder and semi-finished lyophilized powder for sale. The preferred method of administration is through intramuscular or subcutaneous injection due to their quick absorption and effectiveness. In contrast, TB500 tablets and capsules are absorbed into the bloodstream at a slower rate. When reconstituting TB500 lyophilized powder, please note that the powder must be mixed with sterile or bacteriostatic water. TB500 can be injected intramuscularly or subcutaneously anywhere on the body without the need to choose an injured site.

TB500 Peptide Side Effects And Safety

TB500, being a peptide drug, may cause certain side effects. Injection of TB500 may result in local discomfort, such as pain, redness, swelling, and itching at the injection site. Some users have also reported experiencing edema, dizziness, headache, nausea, and fatigue.

Therefore, when considering the use of TB500, it is important to exercise caution to avoid exceeding the recommended dosage and frequency of use in order to reduce potential risks. It is also advisable to seek the advice of a medical professional before use. Additionally, it is crucial to ensure that the TB500 is purchased from a reliable source.

TB500 And BPC157

BPC-157 and TB-500 are two peptides with distinct structures, but they exhibit similar effects in tissue repair and healing processes. Both peptides are believed to possess similar properties in neuroprotection and cardiac regeneration. Although the combination of BPC-157 and TB-500 has not been extensively studied in clinical trials, some users have reported accelerated wound healing by combining the two peptides. TB-500 and BPC-157 can complement each other to provide comprehensive tissue repair and rapid recovery effects, particularly for muscle, tendon, and ligament injuries. It is important to seek advice from a medical professional before use.

 

Manufacturers/Factory


In order to buy high quality TB500 peptide, you need to find a professional peptide factory. Phcoker as the peptide manufacturer, has our own factory and R&D department. All our peptide are pharmaceutical grade.

You can buy the best price TB500 and best quality peptide from this professional peptide manufacturer.

 

Where to buy


Are you planing buy TB500 peptides on online? You have come the right place. As a peptide factory, Phcoker supply high quality TB500 peptide including TB500 raw powder and TB500 lyophilized powder. Before buy TB500 peptide, you may be curious:

What Are The Advantages If Buy TB 500 From Phcoker.com?

  • 【Competitive Factory Price】

Factory direct sales, No middlemen make a difference.

  • 【Customization Service】

Product specifications can be customized to create your own peptide brand.

  • 【Quality Guarantee】

Professional lab reports along with shipment.

  • 【Fast Shipping】

Professional logistics customization solutions, on-time delivery.

  • 【Easy Payment】

Payment methods that are diverse.

  • 【365/24/7 Service】

High quality pre-sales and after-sales service, followed by product and order details consultation.

How To Get The Quick Price Of TB 500 Online?

  • Visit professional TB 500 supplier Phcoker.com, choose the TB 500 you want to buy.
  • Leave your contact and message on Phcoker website, then submit to Phcoker.com.
  • The customer service will reply you in 12 hours once received your message, then talk in details about buy TB 500.

Does Phcoker.com Support The Free Sample Of TB 500 Powder?

It depends, different products with different policy, please check it with our customer service. Most of products can be accepted for sample.

Can I Appoint The TB 500 Colour When Buy TB 500?

YES! Phcoker.com as peptide manufacturer, provide colour customization of TB 500, easy to help you to build your TB 500 peptide brand.

Can I Appoint The Products Standard When Buy TB 500 From Phcoker.com?

YES! As one of the best TB 500 manufacturer, Phcoker not only provide the standard specification of TB 500 in 5mg, 10mg, but support standard customization. Provide the best support to build your own TB 500 brand.

Can I Buy TB 500 In Pure Powder Form From Phcoker.com?

YES! TB 500 powder is the base that use for TB 500 lyophilized powder manufacture. Phcoker provide TB 500 in both of pure powder form and semi-finished vial form.

Can I Buy Discount TB 500 Powder From Phcoker.com?

YES! Our factory produce high quality TB 500 powder in term and keep TB 500 powder in stock. You can buy high quality TB 500 powder in bulk. During promotion sale, you can buy TB 500 peptide by lower price. You can keep touch with our customer manager and they will update the latest bulk TB 500 price for you in time.

 

FAQ


1. What is TB500 used for?

TB500 is a multifunctional and widely distributed peptide that plays a pivotal role in several physiological and pathological processes in the body, namely, increasing angiogenesis and proliferation and inhibiting apoptosis and inflammation.

2. What does TB500 do for athletes?

TB500 can enhance muscle growth, tone, and stamina. Although, this peptide has numerous benefits, which ranges from muscle development, and improvement of connective tissues to improve flexibility. It also prevents the formation of fibrous band formation in body tissues.

3. Is TB 500 the same as Thymosin Beta 4?

TB-500 is a synthetic fraction of the protein thymosin beta-4. The main purpose of this peptide is to promote healing. The effects of TB-500 have drastically improved healing in tendons, ligaments, muscle, skin, and eyes. Thymosin Beta-4 is naturally produced in higher concentration where tissue has been damaged.

4. What is TB500 made of?

TB500 is a naturally occurring peptide made up of 43 amino acid proteins. TB500 has been found to play an important role in protection, regeneration, and remodeling of injured or damaged tissue.

5. TB500 peptide, where to buy?

TB500 peptide is available for sale online at Phcoker.com.

Phcoker is the professional peptide manufacturer and produce all peptides under GMP standard.

6. How to take TB500?

Like most other peptides, TB500 is administered by injection. This includes a variety of injection methods, including subcutaneous, intravenous, and intramuscular injections. TB500 is typically sold as a lyophilized powder and stored in sterile vials that require reconstitution.

7. What caution should be taken when using TB-500?

It is advised to consult a healthcare professional before using TB-500 or any peptide, as excessive use may pose risks and side effects.

 

Referenced Citations


[1]Zhao X, Li N.”Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response”. Invest Ophthalmol Vis Sci. 2023 Aug 1;PMID: 37531112.

[2]Wang X, Zhou Y.”Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation”. 2023 Aug;Epub 2023 May 14.PMID: 37192732.

[3]Effects of thymosin beta 4-derived peptides on migration and invasion of ovarian cancer cells.  |  Yoon, HJ., et al. 2021. Genes Genomics. 43: 987-993. PMID: 34170491.

[4]Effects of Thymosin beta 4 on Myocardial Apoptosis in Burned Rats.  |  Wu, X., et al. 2022. J Healthc Eng. 2022: 2129629. PMID: 35281544.

[5]Moore-Morris T, Lange S, Shen T, Dalton ND, Gu Y, Peterson KL, Evans SM, Chen J (Feb 2012). “Thymosin beta 4 is dispensable for murine cardiac development and function”. Circ Res. 110 (3): 456–64.PMC 3739283. PMID 22158707.Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD (Nov 2012). “Doping control analysis of TB-500, a synthetic version of an active region of thymosin β4, in equine urine and plasma by liquid chromatography-mass spectrometry”. Journal of Chromatography A. 1265: 57–69. PMID 23084823.

[6]Van Troys M, Dewitte D, Goethals M, Carlier MF, Vandekerckhove J, Ampe C (Jan 1996). “The actin binding site of thymosin beta 4 mapped by mutational analysis”. The EMBO Journal. 15 (2): 201–10. PMC 449934. PMID 8617195.

[7]Kleinman HK, Sosne G (2016). “Thymosin β4 Promotes Dermal Healing”. Thymosins. review. Vitamins and Hormones. Vol. 102. pp. 251–75. PMID 27450738.

[8]Safer D, Elzinga M, Nachmias VT (March 1991). “Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable”. J. Biol. Chem. 266 (7): 4029–32.PMID 1999398.

[9]Crockford D, Turjman N, Angel J (April 2010). “Thymosin beta4: structure, function, and biological properties supporting current and future clinical applications”. Annals of the New York Academy of Sciences. 1194 (1): 179–89. Bibcode:2010NYASA1194..179C. PMID 20536467. S2CID 29360082.

[10]Sosne G, Kleinman HK (August 2015). “Primary Mechanisms of Thymosin β4 Repair Activity in Dry Eye Disorders and Other Tissue Injuries”. Investigative Ophthalmology & Visual Science. 56 (9): 5110–7.PMID 26241398.

[11]Hypoxia-inducible transcription factor (HIF)-1 alpha stabilization by actin-sequestering protein, thymosin beta-4 (TB4) in Hela cervical tumor cells. Oh JM, Ryoo IJ, Yang Y, Kim HS, Yang KH, Moon EY. Cancer Lett. 264, 29-35, (2008). PMID: 18272284.

[12]Xing Yuan, Ye Yumeng, Zuo Hongyan, Li Yang. Progress on the Function and Application of Thymosin β4. Frontiers in Endocrinology. VOLUME 12  2021.

[13]Kleinman HK, Sosne G (2016). Thymosin β4 Promotes Dermal Healing. review. Vitamins and Hormones. 102. pp. 251–75.

[14]Goldstein AL, Hannappel E, Sosne G, Kleinman HK. Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications. Expert Opin Biol Ther. 2012 Jan;12(1):37-51. Epub 2011 Nov 10. PMID: 22074294.

[15]Goldstein AL, Kleinman HK. Advances in the basic and clinical applications of thymosin β4. Expert Opin Biol Ther. 2015;15 Suppl 1:S139-45. Epub 2015 Jun 22. PMID: 26096726.

[16]Maar K, Hetenyi R, Maar S, Faskerti G, Hanna D, Lippai B, Takatsy A, Bock-Marquette I. Utilizing Developmentally Essential Secreted Peptides Such as Thymosin Beta-4 to Remind the Adult Organs of Their Embryonic State-New Directions in Anti-Aging Regenerative Therapies. Cells. 2021 May 28; PMCID: PMC8228050.

 

Author of this article:


Dr. Jean Zeng graduated from king’s college london Faculty of Life Sciences & Medicine.

 

Scientific Journal paper Author:


Emmie N.M. Ho

Racing Laboratory, The Hong Kong Jockey Club, Sha Tin Racecourse, Sha Tin, N.T., Hong Kong, China.

Ildiko Bock-Marquette

Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs H-7624, Hungary.

Gabriel Sosne

Department of Ophthalmology, Visual & Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine, 4717 St. Antoine, Detroit, MI 48201, USA.

Othman Othman

School of Life Sciences, Division of Physiology, Pharmacology & Neuroscience, University of Nottingham Medical School, Queens Medical Centre, Nottingham NG7 2UH, United Kingdom.

Sevinç Şahin

Bozok University School of Medicine, Department of Pathology, Adnan Menderes Bulvarı, No: 44, 66200, Yozgat, Turkey.


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