Anandamide (AEA) (94421-68-8)

Anandamide (AEA) (94421-68-8) video

Anandamide (AEA) (94421-68-8) Specifications

What is Anandamide (AEA)?

Anandamide, also known as N-arachidonoylethanolamine (AEA), is a fatty acid neurotransmitter derived from the non-oxidative metabolism of eicosatetraenoic acid (arachidonic acid. It has a structure very similar to that of tetrahydrocannabinol, the active constituent of cannabis. It is degraded primarily by the fatty acid amide hydrolase (FAAH) enzyme, which converts anandamide into ethanolamine and arachidonic acid, Finally, Anandamide is synthesized in neuron by a condensation reaction occurs between arachidonic acid and ethanolamine under the regulation of calcium ion and cyclic monophosphate adenosidase. It is a precursor of a group of physiologically active substances (Prostamides) that play a role in many physical activities, including appetite, memory, pain, depression, and fertility. In addition, Anandamide also inhibits humans Proliferation of breast cancer cells.

Anandamide exists in many organisms, such as sea urchin roe, pigs’ brains and mice livers, etc, but its number is small. Also, researchers also found Anandamide and two substances (N-oleoylethanolamine and N-Linoleylethanolamine) in dark chocolate. Anandamide even exists in some Processed grains, (white bread), Alcohol (specifically, chronic use or binge drinking), Refined sugar, Trans fats, Foods fried in vegetable oil and Non-organic foods that contain pesticides etc.

As part of the endocannabinoid system (ECS), Anandamide is classified as a regulator of homeostasis along with another class of cannabis-like chemical 2-AG and endogenous cannabinoid receptors throughout the body. This system exists In all vertebrates. Anandamide plays a role in regulating feeding behavior and neurogenic motivation and pleasure, keeping our body and mind in balance. Studies have found that our emotions, happiness, fear, anxiety, and ability to withstand stress are all regulated by the endocannabinoid system, and various diseases from schizophrenia to depression are accompanied by abnormal anandamide levels.

Anandamide, similar to THC, is a partial agonist of CB1R. It may cause potential enhancements by “full” activation of the brain system. It is worth noting that all these effects of Anandamide seem to be enhanced by pharmacologically inhibiting its metabolic degradation. Anandamide’s discovery may lead to the development of an entirely new family of therapeutic drugs.

Anandamide (AEA) benefits

Anandamide, also known as a “bliss molecule”, is an mood enhancer, neurotransmitter and endocannabinoid, which has multiple health and mental benefits:

Anandamide reduces the rapid formation of cancer cells. In 1998, a group of Italian scientists discovered that anandamide can promote neurogenesis and form new nerve cells, effectively slow the formation/increase the value of breast cancer cells.

Anandamide’s ability to promote neurogenesis (the formation of new neurons) plays a role in controlling feeding behavior and generating motivation and pleasure in mice. This helps alleviate the symptoms of depression and anxiety. A study in 2015 of humans and mice found that high levels of anandamide can promote mood improvement and fear reduction.

In addition, anandamide’s ability to bind to CB1 and CB2 receptors will also profoundly affect many physiological mechanisms, showing good advantages in terms of memory, motivation, cognitive processes, motion control, pain control, appetite stimulation and fertility.

How to increase anandamide(AEA) levels in the human body?

Because anandamide has a role as a neurotransmitter, a vasodilator agent and a human blood serum metabolite, and the health and mental benefits shown, you may want to increase the level of anandamide in your body. Here are some ways to temporarily increase anandamide levels in the human body:

– Exercising

The study found that after only 30 minutes of running, the anandamide(AEA) content of both humans and dogs increased. So if you want to get the most benefit, do some aerobic exercise often.

– Eating dark chocolate

Dark chocolate has a higher proportion of theobromine in healthy chocolate, and theobromine helps increase anandamide production in the brain and temporarily slows its breakdown.

– Eating black truffle

Black truffle (black fungus) naturally contains anandamide. Although the fungus cannot actually use anandamide in any way, researchers believe it is used to attract animals to eat it and reproduce its spores.

– Geting focus

Research shows that when a person is in a state(called “flowing” or “in a region,”) of high concentration, performance, and concentration, not only will you become more productive or create better jobs in your brain It also releases a large number of chemicals, such as serotonin, dopamine, endorphin and anandamide.

Moreover, tea, coriander and celery can also help increase the production of anandamide.

Reference:

• Berger, Alvin; Crozier, Gayle; Bisogno, Tiziana; Cavaliere, Paolo; Innis, Sheila; Di Marzo, Vincenzo (15 May 2001). “Anandamide and diet: Inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets”. Proceedings of the National Academy of Sciences. 98 (11): 6402– Bibcode:2001PNAS…98.6402B. doi:10.1073/pnas.101119098. PMC 33480. PMID 11353819.
• El-Talatini MR, Taylor AH, Konje JC (April 2010). “The relationship between plasma levels of the endocannabinoid, anandamide, sex steroids, and gonadotrophins during the menstrual cycle”. Fertil. Steril. 93 (6): 1989– doi:10.1016/j.fertnstert.2008.12.033. PMID 19200965.
• Habib, Abdella M.; Okorokov, Andrei L.; Hill, Matthew N.; Bras, Jose T.; Lee, Man-Cheung; Li, Shengnan; Gossage, Samuel J.; van Drimmelen, Marie; Morena, Maria (March 2019). “Microdeletion in a pseudogene identified in a patient with high anandamide concentrations and pain insensitivity”. British Journal of Anaesthesia. 123: e249– doi:10.1016/j.bja.2019.02.019. PMID 30929760.
• Mahler SV, Smith KS, Berridge KC (November 2007). “Endocannabinoid hedonic hotspot for sensory pleasure: anandamide in nucleus accumbens shell enhances ‘liking’ of a sweet reward”. Neuropsychopharmacology. 32 (11): 2267– doi:10.1038/sj.npp.1301376. PMID 17406653.
• Mechoulam R, Fride E (1995). “The unpaved road to the endogenous brain cannabinoid ligands, the anandamides”. In Pertwee RG (ed.). Cannabinoid receptors. Boston: Academic Press. pp. 233– ISBN 978-0-12-551460-6.
• Mallet PE, Beninger RJ (1996). “The endogenous cannabinoid receptor agonist anandamide impairs memory in rats”. Behavioural Pharmacology. 7 (3): 276– doi:10.1097/00008877-199605000-00008.