+86(1812)4514114 info@phcoker.com

Raw Synephrine HCL powder (5985-28-4)

(1 customer review)

Synephrine HCL powder is a naturally occurring alkaloid chemical compound found plants and extracted for use as a supplement……..

Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1450kg/month


Raw Synephrine HCL powder (5985-28-4) video


Raw Synephrine HCL powder (5985-28-4) Specifications

Product Name Raw Synephrine HCL powder
Chemical Name Synephrine hydrochloride; 5985-28-4; 4-(1-Hydroxy-2-(methylamino)ethyl)phenol,hydrochloride;
Brand Name Yocon
Drug Class Fat lost
CAS Number 5985-28-4
Molecular Formula C9H14ClNO2
Molecular Weight 203.666 g/mol
Monoisotopic Mass 203.071 g/mol
Melting Point   147-150°C
Boiling Point 341.10 °C. @ 760.00 mm Hg (est)
Biological Half-Life No date available
Color White to off-white powder
Solubility  No date available
Storage Temperature  Refrigerator
Application Arguably the most effective fat burning ingredients


Raw Synephrine hcl powder (5985-28-4) Description

Raw Synephrine HCL powder is a naturally occurring alkaloid chemical compound found plants and extracted for use as a supplement. Synephrine is sometimes referred to as ‘bitter orange’ as it is derived from small oranges. In actual fact, it is naturally found in the rind of the orange, which is why it is known as bitter orange. Bitter orange is currently used for a number similar issues as well as some more modern-day troubles like weight loss and as an aid in the battle against athlete’s foot. it is one of the main compounds in bitter orange and thought to be the foundation of the plant’s healing qualities Raw Synephrine HCL powder , arguably the most effective fat burning ingredients.Synephrine is obtained from the oranges, and once you have it, you can then benefit in a whole host of different ways.

As a dietary supplement ingredient, synephrine HCL powder is likely safe for most grown-ups when used properly. However, there are some mild adverse effects among users who take too many synephrine hcl . Synephrine is a stimulant, so it is important to start at a low dosage to assess tolerance. Excessive synephrine HCL may cause rapid increases in blood pressure, cardiac arrhythmias, flushing of the skin, seating, restlessness, agitation, respiratory problems, dizziness, headaches, tremors, low blood sugar and blood sugar imbalances, stomach pain, nausea, and diarrhea, especially combined with other stimulants.

Synephrine hcl powder (5985-28-4) Mechanism of Action

Cardiovascular effects of ligands are associated with adrenergic receptor binding. In general, when ligands bind to α-adrenergic receptors, vasoconstriction occurs, and when binding to β1-adrenergic receptors, cardiovascular contractility and increased heart rate result. Studies show that synephrine hcl powder binds to β3-adrenergic receptors, resulting in an increase in the body’s ability to break down fats. Binding to β3-adrenergic receptors does not influence heart rate or blood pressure. Again, because synephrine exhibits little or no binding to α1-, α2-, β1-, and β2-adrenergic receptors and does not appear to exert indirect adrenergic effects, cardiovascular effects, such as an increase in heart rate and blood pressure, are not experienced at commonly used doses, unlike a number of other phenylethylamine and phenylpropanolamine derivatives. Small structural changes result in large differences in adrenergic receptor binding and subsequently the ability to produce cardiovascular effects.

Synephrine hcl powder also enhances the body’s utilization of carbohydrates by producing more energy in the form of ATP.49–52 It facilitates cellular uptake of glucose in muscle cells, as well as glycogenolysis, gluconeogenesis, glycolysis, and oxygen uptake. The involvement of both calcium ion and cAMP with adrenergic receptors has been demonstrated to be involved in these biochemical processes, indicating the involvement of multiple mechanisms.

Beside, the use of Synephrine hcl powder will inhibit the activation of NF-kB. This substance is key in causing inflammatory ailments such as asthma. The use of Synephrine powder has also been found to affect the action of the eotaxin-1 hormone largely. This prevents the movement of eosinophil to an area that is inflamed.

Although not well proved through experiments, the use of Synephrine hcl powder has been found to inhibit the action of acetylcholinesterase. This chemical is known to cause Alzheimer’s disease.

Benefits of Synephrine hcl powder (5985-28-4)

  • Synephrine hcl for weight loss
  • Synephrine hcl help appetite loss
  • Synephrine hcl increase better muscular glucose uptake
  • Synephrine hcl improove aids glycogenesis
  • Synephrine hcl help in control diabetes
  • Synephrine hcl improve digestion
  • Synephrine hcl reduce nervousness before surgery
  • Synephrine hcl improve moods and energy levels
  • Synephrine hcl help control of harmful bacteria
  • Synephrine hcl help minimized inflammation

Recommended Synephrine hcl powder (5985-28-4) Dosage

The most commonly used Synephrine hcl dosage is about 100mg per day. This is considered to be enough dosage capable of achieving weight loss. However, the recommended amount that even the conditioned users should not exceed is 200mg per day. Anything above this mark is considered to be toxic and will put the individual at risk of experiencing a raft of the fatal side effects associated with stimulants use. It is advisable, to begin with, 10 to 20mg to ensure that Synephrine hcl powder is seamlessly compatible with your body. After taking this initial dosage, you should take time to assess the body’s response to the supplement. If all is well, the second dosage of about 20mg can be added after two hours. Beside, the safest dosage interval is taking Synephrine hcl powder once every two hours.

Side effects of Synephrine hcl powder (5985-28-4)

The use of Synephrine is also accompanied by side effects just like any other drug. When one dos couple the use of synephrine hcl with together caffeine. also comes with some side effects. The following are some common side effects:

  • High blood pressure.
  • Heart disease.
  • Irregular heartbeat.
  • Fatalities if used in high dosage just before surgery.
  • Hallucinations/psychosis
  • Coronary spasms and thrombosis
  • Heart rhythm disturbances (ventricular fibrillation)
  • A decrease in muscle size (rhabdomyolysis)
  • Kidney failure
  • Blood clots
  • Nerve damage due to increased pressure in muscles (bilateral compartment syndrome)
  • Chest pain (variant angina)
  • Stroke



References & product citations

How Does Synephrine HCL Work On Your Body?



  1. Akhlaghi, M., Shabanian, G., Rafieian-Kopaei, M., Parvin, N., Saadat, M., and Akhlaghi, M. Citrus aurantium blossom and preoperative anxiety. Rev Bras.Anestesiol. 2011;61(6):702-712.
  2. Bent, S., Padula, A., and Neuhaus, J. Safety and efficacy of citrus aurantium for weight loss. Am.J.Cardiol. 11-15-2004;94(10):1359-1361
  3. Campbell-Tofte, J. I., Molgaard, P., Josefsen, K., Abdallah, Z., Hansen, S. H., Cornett, C., Mu, H., Richter, E. A., Petersen, H. W., Norregaard, J. C., and Winther, K. Randomized and double-blinded pilot clinical study of the safety and anti-diabetic efficacy of the Rauvolfia-Citrus tea, as used in Nigerian traditional medicine. J Ethnopharmacol. 1-27-2011;133(2):402-411.
  4. R. Costa, M.B.A. Glória, in Encyclopedia of Food Sciences and Nutrition (Second Edition), 2003
  5. Ghanim H, Sai CL, Upadhyay M. et al. Orange juice neutralizes the proinflammatory effect of a high-fat, high-carbohydrate meal and prevents endotoxin increase and Toll-like receptor expression. Amer J Clin Nutr. 2010;91:940-949
  6. Stohs SJ. Assessment of the adverse event reports associated with Citrus aurantium(bitter orange) from April 2004 to October 2009.
  7. Dragull K, Breksa AP, Cain B. Synephrine content of juice from Satsuma mandarins (Citrus unshiuMarcovitch). J Agric.Food Chem. 2008;56:8874-8878
  8. Roman MC, Betz JM, Hildreth J. Determination of synephrine in bitter orange raw materials, extracts, and dietary supplements by liquid chromatography with ultraviolet detection: single laboratory validation. J Amer Org Anal Chemists Int. 2007;90:68-81
  9. Mercolini L, Mandrioli R, Trere T. et al. Fast CE analysis of adrenergic amines in different parts of Citrus aurantiumfruit and dietary supplements. J Sep Sci. 2010;32:1-8
  10. Haaz S, Fontaine KR, Cutter G, Limdi N. et alCitrus aurantiumand synephrine alkaloids in the treatment of overweight and obesity: an update. Obesity Rev. 2006;7:79-88
  11. Higgins, J. P., Tuttle, T. D., and Higgins, C. L. Energy beverages: content and safety. Mayo Clin Proc. 2010;85(11):1033-1041.
  12. Kaats, G. R., Miller, H., Preuss, H. G., and Stohs, S. J. A 60day double-blind, placebo-controlled safety study involving Citrus aurantium (bitter orange) extract. Food Chem Toxicol. 2013;55:358-362.
  13. Lynch B. Review of the safety of p-synephrine and caffeine. Intertek-Cantox Report, 2013;1-20.
  14. Health assessment of sports and weight loss products containing synephrine and caffeine BfROpinion No. 004/2013, of 16 November 2012

1 review for Raw Synephrine HCL powder (5985-28-4)

  1. phcoker

    Got Raw Synephrine HCL powder to test, test result show very high quality and purity!

Add a review

Your email address will not be published. Required fields are marked *