Chemical information of 5a-hydroxy laxogenin powder
|Product Name||5a-hydroxy laxogenin powder|
|Synonyms||5alpha-Hydroxy laxogenin; 5-alpha-Hydroxy-laxogenin; 5 alpha hydroxy laxogenin; 5-alpha hydroxy laxogenin; 5-alpha-hydroxy laxogenin; 5a hydroxy laxogenin; 5a-hydroxy Laxogenin|
|Ingredient Purity||>= 99%|
|Drug Class||a spirostanic analogue of brassinosteroid|
|Melting Point||247-250 °C|
|Boiling Point||578.4±50.0 °C(Predicted)|
|Elimination half-life||6-8 hours|
|Solubility||DMF: 15mg/mL; DMSO: 10mg/mL|
|Storage temp||Sealed in dry,Room Temperature|
|Application||Supplement; bodybuilding; gain mussule|
Bodybuilders and athletes are frequently on the lookout for methods to increase lean muscle mass without increasing the fat content in the body. One of the simplest ways to achieve this is to use anabolic steroids, but the long-term use of these steroids has certain side effects that may be off-putting to many.
Recent studies have found a plant derivative that is believed by scientists to have the same effects as anabolic steroids, however, without any adverse side effects of the steroids.
The compound is known as 5a hydroxy laxogenin commonly or by its scientific name, 5-alpha-hydroxy laxogenin. 5a hydroxy laxogenin powder is being sold by most 5a hydroxy laxogenin powder suppliers as a bodybuilding supplement due to the many benefits of the product.
What is 5a-hydroxy laxogenin？
5a-hydroxy laxogenin, is a derivative of laxogenin, a chemical found in nature, in plants. Laxogenin or 3beta-hydroxy-25D,5alpha-spirostan-6-one, is a plant-based anabolic steroid that has become popular amongst athletes and bodybuilders for its muscle mass enhancing properties.
The reason behind the increasing fame of Laxogenins is their role in the plants. They are plant hormones, also known as brassinosteroids which are structurally and functionally, quite similar to the animal and human steroid hormones. Due to this, they are replacing anabolic steroids.
Laxogenins can be obtained from Chinese onions or the underground stems of the Asian plant, Smilax sieboldii. Laxogenins, in most supplements that are produced and sold by the 5a-hydroxy laxogenin powder manufacturer, are actually derived from another plant steroid diosgenin. This plant steorid is also used in the synthesis of many other synthetic hormones such as progesterone, which is used widely in birth control pills.
Most brands that have 5a hydroxy laxogenin powder for sale, as a supplement, contain this derivative of laxogenin, which is derived from diosgenin, instead of having the natural laxogenin. However, this is not of any major concern as 5-alpha-hydroxy-laxogenin benefits are the same as that of laxogenin.
Is 5-alpha-hydroxy laxogenin a prohormone?
Many 5a hydroxy laxogenin manufacturers and 5a hydroxy laxogenin powder suppliers label the compound as a prohormone. A prohormone is an ingredient that once in the body, will undergo changes to become a specific hormone.
An apt example would be androgens, which act as prohormones and once ingested and metabolized, convert to the hormone, testosterone. 5a hydroxy laxogenin powder is not a pre-hormone as it does not convert into a hormone, but rather has similar benefits as the steroid hormone.
Is 5-alpha-hydroxy laxogenin a steroid?
5a hydroxy laxogenin is a plant steroid that shares quite a few similarities with animal steroid hormones. It is the most similar to sex hormones in the human body that are derived from cholesterol. It is important to point out that 5a hydroxy laxogenin powder has a growth-enhancing function in plants but the effects of it on the human body are far more complicated than that.
Rather than passing through the membrane and inducing a change on its own, this compound binds to the receptor and activates a signaling chain, which ends with a significant increase in the muscle-building abilities of the body.
The specific protein that is activated by the 5a hydroxy laxogenin powder is protein kinase B or AKT 1. This protein is well known for its ability to not only increase the production of muscles in the human body but also for the prevention of muscle breakdown.
Muscle proteins are degraded during extensive workouts but it is hypothesized that the various 5-alpha-hydroxy laxogenin benefits include prevention of protein degradation and breakdown during workouts.
Another mechanism through which 5a hydroxy laxogenin powder produces the benefits that appeal to bodybuilders and athletes is by blocking the breakdown of an important enzyme, namely, cAMP.
Increasing the amount of this enzyme in the body by inhibiting its breakdown consequently results in an increased breakdown of fat in the body. At the same time, increasing this enzyme also results in an enhanced fight-or-flight response.
Overall, 5a hydroxy laxogenin powder suppliers are selling a product that increases muscle mass, reduces protein breakdown, and increases fat breakdown, all simultaneously. These effects are believed to occur as these are the effects often seen in different types of 5a hydroxy powder studies that are performed either on animal models or in vitro, in a lab. However, these effects may not be seen in the human body when the supplements sold by different 5a hydroxy laxogenin powder manufacturers are taken.
Is 5a-hydroxy laxogenin the same as Laxogenin: 5a hydroxy laxogenin vs laxogenin
5a-hydroxy laxogenin is derived from the plant hormone, laxogenin. They have the same benefits, according to different pieces of research performed on animal models. However, they are not the same thing.
What does 5-alpha-hydroxy laxogenin do？
5-alpha hydroxy laxogenin is the most similar to sex hormones that are synthesized from cholesterol in the human body. These sex hormones that are found naturally in the human body act on nuclear receptors, whereas the 5a hydroxy laxogenin attaches to a cellular receptor, on the surface of the cell.
Many companies that have 5a hydroxy laxogenin powder for sale often sell this supplement with the advertisement that it has up to 200 percent potency and can improve muscle tone amongst athletes significantly. These claims made by different manufacturers are the result of several studies that have been performed with the purpose of assessing muscle-mass enhancement properties of laxogenins.
A recent Russian research on animal models found that thermogenic compounds derived from the same group of plant hormones as laxogenin, with the same effects as laxogenin. According to this study, these brassinosteroid derivatives were able to increase the protein content of liver, heart, kidney, and leg muscles. Moreover, researchers found that these derivatives did not produce these benefits by replicating or mimicking the effect of sex hormones in the human body.
Another research study that was also performed on animal models and used hormones belonging to the same class of plant hormones as laxogenin was able to replicate the same results as the Russian study. Multiple other pieces of research were conducted to ensure the legitimacy of these results and the results were found to be easily replicated, hence, guaranteeing their potency and efficiency.
It is important to point out that while many users of 5a hydroxy laxogenin powder claim to see the results that the vendors have advertised, finding concrete scientific evidence to support their use has been difficult. Most of the studies are performed on animal models and use compounds that either belong to the brassinosteroid class of hormones or a similar plant hormone, phytoecdysteroids. Laxogenins are similar to these hormones and 5a hydroxy laxogenin is a derivative of laxogenins, but that does not guarantee the same benefits seen with the other hormones.
One study that was performed using natural and synthetic laxogenin in a laboratory setting found that this powder could reduce oxidative stress in the body significantly. Reduction of oxidative stress by laxogenins was performed by reducing free radicals, a type of harmful substance in the body that can participate in different chemical reactions and harm the body markedly. This reduction in free radicals and oxidative stress can explain how 5a hydroxy laxogenin powder is able to improve muscle recovery, post-workout. However, this study has to be performed on both animal models and human subjects before the results of the study are widely believed.
All of the above-mentioned studies were performed with the purpose of finding out if laxogenins would be able to increase muscle mass and tone. However, the only use of 5 alpha-hydroxy laxogenin isn’t bodybuilding and that is what some of the other pieces of research were hoping to prove.
In two separate studies, the use of 5-alpha-hydroxy laxogenin powder in colon cancer patients reduced the size of cancer significantly. Similarly, lung cancer development was found to be reduced with the use of 5a hydroxy laxogenin powder in animal models. While these studies aren’t able to provide the conclusive evidence that is required for any supplement or medication to be included in the treatment protocol, they are a step in the right direction.
When to take 5-alpha-hydroxy laxogenin?
5-alpha-hydroxy laxogenin powder dosage starts from 25 mg, and that is how much one should take at any specific time. However, up to 6, and a minimum of 3, doses can be taken throughout the day, making the dosage of the supplement, 150 mg per day. It is also recommended to take the supplemental powder with food to increase absorption in the stomach.
5a hydroxy laxogenin powder can be taken for up to 3 months to 4 months at a time because that is when the results will become apparent. It can be taken continuously for longer than that if needed or desired. As the natural compound has no effect on the body’s hormone levels, it does not need to be restricted to a short period of time.
5-alpha-hydroxy laxogenin side effects are not well known because most of the studies that are performed to assess the efficiency of the supplement are not performed on human subjects. They are performed on animal models and it is not possible to determine both the benefits and the side effects from these studies. However, the users of the supplements have not reported any toxicities or adverse effects, which has led to the belief that the supplement has no side effects.
Who should consider using it?
Bodybuilders, athletes, and anyone else who would like to increase muscle tone and mass while reducing the fat content of the body should consider using 5a hydroxy laxogenin powder.
Is 5-alpha-hydroxy laxogenin legal?
5a hydroxy laxogenin is considered to be an illegal ingredient that the Food and Drug Association or FDA in the United States has issued multiple warnings about. The ingredient has been monitored by the USADA for quite a long time as they have found it to be in the products or supplements that also contain other performance-enhancing substances. Another cause of concern with 5a hydroxy laxogenin powder is that it is advertised as a natural, plant-based anabolic steroid. Both FDA and USADA have raised questions about the actual source of 5a hydroxy laxogenin as the natural plant source provides laxogenin hormone only. It hasn’t been explained how hydroxy laxogenin is derived from laxogenin.
USADA has performed a detailed analysis of the different 5a hydroxy laxogenin powders for sale and found half of those supplements to be laced with doping substances. In an attempt to save athletes and bodybuilder from accidental doping by using this ‘natural plant steroid’, USADA has asked them to be on the lookout for any supplements that contain laxogenin which may be mentioned in the ingredient list as:
- 25R spirostan-5a-diol-6-one-3-one decanoate
- 25R spirostan-5a-diol-6-one-3-one undecanoate
USADA also suspects that the term laxogenin on an ingredient list could be a hidden clue for those looking for doping supplements, meaning that there isn’t any actual laxogenin or 5a hydroxy laxogenin in the supplement.
FDA, much like USADA, is vary of the laxogenins in dietary supplements as there isn’t enough information regarding its use, safety, and potency. With more research, there is a possibility for the ingredient to be accepted as a potent muscle-boosting supplement.
This possibility exists because, despite the USADA declaring laxogenins and their derivatives as an illegal substance, the World Anti-Doping Authorities have not prohibited their use amongst athletes. 5a hydroxy laxogenin does not meet the criteria for it to be classified as a doping substance.
Moreover, a 5a hydroxy laxogenin drug test would not come positive when checking for doping substances as long as the powder was not tampered with or spiked with other prohibited substances.
5-alpha-hydroxy laxogenin Reviews
Most users of 5-alpha-hydroxy laxogenin powder swear by it and claim to see all the advertised results on themselves. Almost all users praise the supplement’s fast-acting in increasing muscle mass and tone.
There are multiple reviews online claiming to have seen improved muscle tone and increased muscle mass, with a significant fat reduction with only three to four months of using 5a hydroxy laxogenin powder.
Best 5a-hydroxy laxogenin powder buy?
The supplemental powder can be bought through 5a hydroxy laxogenin wholesale suppliers if needed or it can be bought in small amounts. The best powder to buy is the one that has been manufactured, treated, and packaged with strict safety guidelines as this guarantees contamination-free and prohibited substances-free 5a hydroxy laxogenin powder.
- Illegal Ingredient, 5-Alpha-Hydroxy-Laxogenin, Appearing in More Supplements. Education, Spirit of Sport / December 4, 2019
- Bioorg Med Chem. 2012 Apr 15;20(8):2690-700. doi: 10.1016/j.bmc.2012.02.026. Epub 2012 Feb 15.New insights into the structure-cytotoxicity relationship of spirostan saponins and related glycosides. Karell Pérez-Labrada, Ignacio Brouard, Sara Estévez, María Teresa Marrero, Francisco Estévez, Jaime Bermejo, Daniel G Rivera. PMID: 22405922
- Y W Zhang, I Morita, L Zhang, G Shao, X S Yao, S Murota. Screening of anti-hypoxia/reoxygenation agents by an in vitro method. Part 2: Inhibition of tyrosine kinase activation prevented hypoxia/reoxygenation-induced injury in endothelial gap junctional intercellular communication. Planta Med. 2000 Mar;66(2):119-23. doi: 10.1055/s-2000-11126. PMID: 10763583
- Diana M. Cheng, Louis W. Kutzler, Dustin D. Boler, Jenny Drnevich, John Killefer, and Mary Ann Lilaa.Continuous Infusion of 20-Hydroxyecdysone Increased Mass of Triceps Brachii in C57BL/6 Mice. Published online 2012 Apr 12. doi: 10.1002/ptr.4679. PMC3410052
- Debora Esposito, Slavko Komarnytsky, Sue Shapses, and Ilya Raskin.Anabolic effect of plant brassinosteroid. FASEB J. 2011 Oct; 25(10): 3708– doi: 10.1096/fj.11-181271. PMC3177571