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Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7)

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(1 customer review)

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7), the short name can be GM1,……

Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month



Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) video


Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Description

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7), the short name can be GM1, extracted from pig’s brain and is a member of the ganglio series of gangliosides which contain one sialic acid residue.

GMl can promote the recovery of neurological function after injury of the central nervous system of a variety of causes, promote neuroplasticity. Experiments show GMl vascular brain injury, traumatic brain to restore nerve cells in spinal cord injury has a protective effect and promote the role of cell.

Previous phase II clinical trial showed, it can reduce oxaliplatin-induced neurotoxicity(OIN). But it did not certificated by phase III trial. A phase III trial is needed to investigate the effect and safety of monosialotetrahexosylganglioside Sodium Injection for prevention OIN at gastric cancer.

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Specifications

Product Name Monosialotetrahexosylganglioside Sodium (GM1) pig brain
Chemical Name Monosialotetrahexosylganglioside Sodium (Porcine brain)

Or GM1

Sequence /
Brand Name Shenjie
Drug Class Sphingolipids
CAS Number 37758-47-7
Molecular Formula C73H134N4O31
Molecular Weight 1563.85
Monoisotopic Mass 1563.85
Melting Point  N/A
Biological Half-Life /
Color Off-white lyophilized powder
Solubility  chloroform/methanol (9:1): 10 mg/mL, clear, colorless
Storage Temperature  -20°C
Application Specific receptors for cholera toxin that accumulate in the brain in late infantile lipidosis.
Testing items In house Quality Standards
Character White or white powder; slightly smelly, tasteless; wet. This product is soluble in water, very slightly dissolved in methanol, almost insoluble in anhydrous ethanol.
Color rendering reaction 1 Take the test solution 0.2ml under the content determination, add water 2ml, and then add the Hydroquinone hydrochloric acid solution (hydroquinone 0.2g, add water 10ml dissolved, add hydrochloric acid 90ml, add 0.1mol/L Copper sulfate solution 0.25ml, refrigerator Preservation) 2ml, water bath heating for 15 minutes, solution blue and purple, with N-e alcohol 5ml Vibration extraction, n-e alcohol layer is blue.
Color rendering reaction 2 Take this product about 20mg, add glacial acetic acid 1ml, hot water bath heating fully dissolved, add three ferric chloride test fluid 1 drops, in the hot water bath along the pipe wall slowly add sulfuric acid 1ml, so that the solution into two layers, the two-liquid interface should be brown
Sodium salt The identify reaction of sodium salt in this product (Chinese Pharmacopoeia 2015 edition four 0301).
Liquid chromatography(LC) In the chromatographic graph recorded under the content determination, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the control solution.
Infrared spectroscopy The infrared light absorption map of this product should be consistent with the map of the control product (Chinese Pharmacopoeia 2015 edition four 0402).
PH 5.0~6.5
Clarity and color of solution Should be clarified colorless; if it is cloudy, it shall not be thicker than the standard liquid of turbidity No. 1th; If the color rendering should not be deeper than the Yellow No. 1th colorimetric solution.
High Pressure determination The finished solution should be clear and transparent after high temperature, no milk light, no precipitation
Sensitizing factor (Miscellaneous protein) ≤50000
Total Sialic acid According to the dry product calculation, the saliva containing acid should be 19.0~21.0%
Related substances Sialic acid ≤0.3%;GD3, GD1a, unknown impurities are ≤ 0.5%; impurities and ≤2.0%
Protein ≤1.0%
High molecular weight impurities ≤0.5%
Residual solvents Methanol ≤ 0.1%; acetone ≤ 0.3%; Trichloromethane ≤0.003%
Water ≤4.0%
Burning residue ≤5.0%
Heavy metal ≤20ppm
Abnormal toxicity Comply Regulations
Antihypertensive substances Should be in accordance with the regulations (multiple quantities of administration)
Pyrogen Should be in accordance with the regulations (multiple quantities of administration)
Microbial limits The total number of aerobic bacteria should be <100cfu/g, and the total number of molds and yeasts should be <50cfu/g
Specific ≥98.0%



References & product citations

1 review for Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7)

  1. Rated 5 out of 5


    Got Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) to test, test result show very high quality and purity!

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