Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7)

Description

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) video

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Description

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7), the short name can be GM1, extracted from pig’s brain and is a member of the ganglio series of gangliosides which contain one sialic acid residue.

GMl can promote the recovery of neurological function after injury of the central nervous system of a variety of causes, promote neuroplasticity. Experiments show GMl vascular brain injury, traumatic brain to restore nerve cells in spinal cord injury has a protective effect and promote the role of cell.

Previous phase II clinical trial showed, it can reduce oxaliplatin-induced neurotoxicity(OIN). But it did not certificated by phase III trial. A phase III trial is needed to investigate the effect and safety of monosialotetrahexosylganglioside Sodium Injection for prevention OIN at gastric cancer.

Monosialotetrahexosylganglioside Sodium (GM1) pig brain (37758-47-7) Specifications

Raw MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  powder (37758-47-7) Description

Monosialotetrahexosylganglioside Sodium (37758-47-7), the short name can be GM1, extracted from pig’s brain and is a member of the ganglio series of gangliosides which contain one sialic acid residue.

GM1 can promote the recovery of neurological function after injury of the central nervous system of a variety of causes, promote neuroplasticity. Experiments show GM1 vascular brain injury, traumatic brain to restore nerve cells in spinal cord injury has a protective effect and promote the role of cell.

Previous phase II clinical trial showed, it can reduce oxaliplatin-induced neurotoxicity(OIN). But it did not certificated by phase III trial. A phase III trial is needed to investigate the effect and safety of monosialotetrahexosylganglioside Sodium Injection for prevention OIN at gastric cancer.

MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Mechanism of actions?

GM1 (monosialotetrahexosylganglioside) the “prototype” ganglioside, is a member of the ganglio series of gangliosides which contain one sialic acid residue. GM1 has important physiological properties and impacts neuronal plasticity and repair mechanisms, and the release of neurotrophins in the brain. Besides its function in the physiology of the brain, GM1 acts as the site of binding for both cholera toxin and E. coli heat-labile enterotoxin (Traveller’s diarrhea).

Benefits of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1)  powder (37758-47-7)

Ganglioside GM1 is a member of the ganglioside family which has been used in many countries and is thought of as a promising alternative treatment for preventing several neurological diseases, including cerebral ischemic injury. The therapeutic effects of GM1 have been proved both in neonates and in adults following ischemic brain damage.

Recommended MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7) Dosage

Drug was administered at the dose of 20-40 mg daily by intravenous or slowly intramuscular injection according to the doctor’s advices. In the acute phase of pathological changes: Drug was used at the dose of 100 mg daily by intravenous injection; After 2-3 weeks, generally maintain the amount of 20-40 mg daily for six weeks, the first dose of 500-1000 mg was administered by intravenous drip for Parkinson’s disease; since the second day, drug was used with the dose of 200 mg daily by subcutaneous, intramuscular injection or intravenous drip for 18 weeks usually. when this drug was administered by Subcutaneous or intravenous injection ,it should be dissolved and diluted in water for injection until the concentration of 10 mg / ml at the;when Intravenous drip, drug was disloved and diluted in 0.9% sodium chloride injection or 5% glucose injection .

Side effects of MONOSIALOTETRAHEXOSYLGANGLIOSIDE SODIUM (GM1) powder (37758-47-7)

The side effect of GM1 powder is mainly rash reaction after use.