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Raw Avanafil powder (330784-47-9)

(1 customer review)

Avanafil powder is used to treat men who have dysfunction (also called sexual impotence). Avanafil belongs to a group of ……..


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1290kg/month

Description

Raw Avanafil powder (330784-47-9) video

 

Raw Avanafil powder (330784-47-9) Description

Raw Avanafil powder is a PDE5 inhibitor approved for dysfunction(ED: impotence; inability to get or keep an erection in men). Raw Avanafil powder acts by inhibiting a specific phosphodiesterase type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis, as well as the retina. It works by increasing blood flow to the penis during sexual stimulation. Other similar drugs are sildenafil, tadalafil and vardenafil. The advantage of Raw Avanafil powder is that it has very fast onset of action compared with other PDE5 inhibitors. It is absorbed quickly, reaching a maximum concentration in about 30–45 minutes.About two-thirds of the participants were able to engage in sexual activity within 15 minutes.

Raw Avanafil powder (330784-47-9) Specifications

Product Name Raw Avanafil powder
Chemical Name 330784-47-9;STENDRA; (s)-4-((3-Chloro-4-methoxybenzyl)amino)-2-(2-(hydroxymethyl)pyrrolidin-1-yl)-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide; TA 1790; TA-1790
Brand Name Stendra and Spedra
Drug Class PDE5 inhibitor
CAS Number 330784-47-9
InChIKey WEAJZXNPAWBCOA-INIZCTEOSA-N
Molecular Formula C23H26ClN7O3
Molecular Weight 483.95
Monoisotopic Mass 483.179 g/mol
Melting Point  150-152°C
Freezing Point No data available
Biological Half-Life Mean elimination half-life = 5.36 – 10.66 hours
Appearance White powder
Solubility  DMSO, Methanol
Storage Temperature  Store at 4° C
Application A phosphodiesterase (PDE5) inhibitor, used to treat dysfunction.

 

Raw Avanafil powder (330784-47-9) Description

Avanafil is used to treat dysfunction (ED: impotence; inability to get or keep an erection in men). Avanafil powder is in a class of medications called phosphodiesterase (PDE) inhibitors. It works by increasing blood flow to the penis during sexual stimulation. This increased blood flow can cause an erection. Avanafil powder does not cure dysfunction or increase sexual desire. Avanafil does not prevent pregnancy or the spread of sexually transmitted diseases such as human immunodeficiency virus (HIV).

Avanafil powder (330784-47-9) Mechanism of Action

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by avanafil enhances function by increasing the amount of cGMP.

Application of Avanafil powder (330784-47-9)

Avanafil powder is used to treat men who have dysfunction (also called sexual impotence).

Recommended Avanafil powder (330784-47-9) Dosage

For most individuals, the recommended starting dose of avanafil powder is 100 mg per day taken about 30 minutes before sexual activity. Depending on the adequacy of the response or side effects, the dose may be increased to 200 mg or decreased to 50 mg a day. Individuals who are taking medications that moderately increase the blood levels of avanafil should not exceed a total dose of 50 mg in 24 hours (See drug interactions).

Benefits of Avanafil powder (330784-47-9)

Stop using avanafil and call your doctor at once if you have:

▪ vision changes, sudden vision loss;

▪ ringing in your ears, or sudden hearing loss;

▪ pain, swelling, warmth, or redness in one or both legs;

▪ shortness of breath, swelling in your hands or feet;

▪ a light-headed feeling, like you might pass out; or

▪ penis erection that is painful or lasts 4 hours or longer.

Common side effects may include:

▪ headache;

▪ flushing (warmth, redness, or tingly feeling);

▪ cold symptoms such as runny or stuffy nose, sore throat; or

▪ back pain.

 


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References & product citations

The 9 questions to ask yourself before taking Avanafil

 

References

  1. Ryan M Burke,  Jeffery D Evans, Avanafil for treatment of dysfunction: review of its potential, Vasc Health Risk Manag. 2012; 8: 517–523.
  2. DeRogatis LR, Burnett AL. The epidemiology of sexual dysfunctions. J Sex Med. 2008;5:289–300.
  3. Zhao C, Kim S, Yan D, et al. Efficacy and safety of avanafil for treating dysfunction: results of a multicentre, randomized, double-blind, placebo-controlled trial. BJU Int. 2012 Mar 27;

1 review for Raw Avanafil powder (330784-47-9)

  1. phcoker

    Got Raw Avanafil powder to test, test result show very high quality and purity!

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