Chemical information of S-acetylglutathione powder
| Product Name | S-acetylglutathione |
| Synonyms | S-acetyl-L-glutathione;
5-[[3-acetylsulfanyl-1-(carboxymethylamino)-1-oxopropan-2-yl]amino]-2-amino-5-oxopentanoic acid; glutathione-S-acetate; S-Acetylglutamylcysteinylglycine L-γGlu-S-Ac-L-Cys-Gly-OH γGlu-S-Acetyl-L-Cys-Gly-OH s acetyl glutathione s-acetyl glutathione |
| CAS Number | 3054-47-5 |
| Drug Class | NA |
| InChI Key | FVRWSIPJNWXCEO-UHFFFAOYSA-N |
| SMILE | CC(=O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N |
| Molecular Formula | C12H19N3O7S |
| Molecular Weight | 349.36 |
| Monoisotopic Mass | 349.09437113 |
| Melting Point | 199-204°C (dec.) |
| Boiling Point | 770.2±60.0 °C(Predicted) |
| Elimination half-life | NA |
| Appearance | White powder |
| Solubility | Soluble in hot water. Practically insoluble in cold water. |
| Storage temp | Keep in dark place,Inert atmosphere,2-8°C |
| Application | s-acetyl-l-glutathione powderhas widely used in cosmetic products. |
Aging is a natural process that we all go through but, as we age, we become more vulnerable to health problems, particularly chronic diseases. Luckily, there is a powerful antioxidant that has the ability to slow down the process of aging and help prevent cancer, heart disease, dementia and many other illnesses.
Considered as the mother of all antioxidants and an immune system booster, glutathione powder helps our body to stay healthy as demonstrated by several studies. Glutathione not only protects us from certain types of diseases but it also treats cognitive problems, from autism to Alzheimer’s disease, and a wide array of other health problems. In fact, maintaining high levels of glutathione is essential to chronic disease management and recovery.
We don’t absorb glutathione well from foods and, Several oral glutathione supplements are available on the market but there are questions as to their bioavailability. When plain glutathione reaches the stomach, it is almost entirely destroyed by digestive enzymes in the stomach and small intestines. However, binding the acetyl molecule to glutathione produces a chemical that survives well in the digestive tract. A more absorbable and highly stable form of glutathione, S-Acetyl Glutathione powder for sale now.
S-acetylglutathione powder – What is S-Acetyl L-Glutathione ?
S-acetylglutathione powder, also known as s-acetyl glutathione powder, or SALG (S-Acetyl L-Glutathione), S-A-GSH. S-Acetyl Glutathione is an acetylated form of glutathione. It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule. This form is well-absorbed and more stable throughout the digestive tract than any other forms on the market. S-acetylglutathione powder is well-suited for oral ingestion, because this acetyl group protects glutathione from breaking down in the gastrointestinal tract. Once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact. s-acetyl glutathione benefits to support immune function and to optimize glutathione-dependent hepatic detoxifi cation pathways. S-Acetyl Glutathione powder is the best choice when higher doses of glutathione are recommended. But please keep in mind that always buyingbest s-acetyl glutathione powder from a reliable supplier to increase high level of glutathion.
S-acetyl l-glutathione benefits | What is S acetyl glutathione used for?
As we known that glutathione provides detoxification and antioxidant protection, plus it boosts the action and recycling of other antioxidants such as vitamins C and E, alpha-lipoic acid, and CoQ10. One important role it has is to protect the mitochondria power-plants in our cells. It also supports cysteine storage, DNA construction, immune function, production of sperm cells, cell growth and death, cell communication, enzyme function, and other vital activities.
S-Acetyl Glutathione is an acetylated form of glutathione. This form is well-absorbed and more stable throughout the digestive tract than any other forms on the market. S-Acetyl Glutathione powder is 10 times as effective as regular reduced glutathione powder because it does not get destroyed during delivery. It has all the same effects of reduced glutathione excepts its way more efficient.
Benefits of S–Acetyl Glutathione supplementation
Anti-Aging
The less glutathione in your body, the more cellular breakdown and apoptosis (cell death) occurs. This lowers resistance to disease, decreases energy, even contributes to wrinkles and hyperpigmentation in the skin. S-Acetyl glutathione is being used to help slow or reverse these effects. Studies have shown that people who live to over the age of 100 have higher levels of Glutathione in their body.
Boost Energy
When mitochondria are attacked and damaged by oxidative molecules, they slow down and make less adenosine triphosphate (ATP), in turn slowing down the functioning of the entire cell. The patient can feel fatigue, lack of mental focus, brain fog, aches, and pains. This condition is called “mitochondrial dysfunction” and occurs when glutathione levels fall too low. Autoimmune diseases like diabetes, rheumatoid arthritis, multiple sclerosis, Addison’s, and Crohn’s all involve mitochondrial dysfunction that may be improved by raising glutathione levels
Inflammation
Glutathione plays a vital role in reducing inflammation.Chronic inflammation is present in virtually every chronic illness. Research has found that glutathione’s influence on our white cells helps ensure that our inflammatory reaction is strong when needed and subsides when it’s no longer useful. Boosting glutathione levels may bring chronic inflammation under better control. In a disease like chronic obstructive pulmonary disease (COPD), normal glutathione levels could protect lung tissue from inflammation, reduce long-term damage, and maintain healthy lung function.
Improve Cognitive Function
Neurons in our brain become damaged as we age, leaving us with brains that don’t function quite as well as they used to.Glutathione may help enhance brain function, alleviate mental fog and may have a neuro-protective effect. Leaky blood/brain barrier can develop if glutathione levels are depleted. A healthy blood/brain barrier is essential for optimal brain function. Studies have also suggested Glutathione maybe beneficial in helping prevent traumatic Brain injury TBI.
Liver function
Glutathione has been shown to improve enzyme, protein and bilirubin levels in the blood of individuals with alcoholic and nonalcoholic chronic fatty liver disease.
Supports healthy immune function
Multiple studies have shown that glutathione boosts immunity, it may assist the immune system by functioning as an antioxidant within immune cells and enhancing the activity of immune cells.
Improved skin tone and clarity
Studies have shown that Glutathione use significantly improved wrinkles and skin elasticity and attenuated melanin overproduction. It is used for its skin whitening effect on melasma.
Sleep problems
Research has shown that sleep deprivation is linked to low levels of glutathione in specific regions of the brain.
Metabolic Disorders
Studies have indicated that low Glutathione levels are associated with less fat burning and higher rates of fat storage in the body. Older subjects who had Glutathione added to their diet showed improved metabolism and fat burning.
Detox
Balancing glutathione levels is critical in helping to rid the body of toxins. Strengthening the glutathione system improves all three phases of the body’s natural detoxification. Glutathione neutralizes the free radicals produced by Phase I liver metabolism. It is part of the Phase II reactions that make toxins water-soluble so they can be transported and eliminated by the kidneys in Phase III. Glutathione is also critical in transporting mercury, specifically, out of cells and the brain.
Cardiovascular Health
Heart disease starts with plaque buildup in the arteries. Our natural glutathione inactivates the various free radicals and chemicals that lipid oxidize cholesterol particles in the blood and lead to plaque formation. In this way, it may lower the risk of heart attacks.
Improved weight management
When the liver functions properly, it encourages the burning of fat by eliminating low-density lipoproteins and increasing the levels of high-density lipoproteins.
Healthy liver function is also a benefit of glutathione supplementation, allowing it to break down fats in the stomach and turn them into energy rather than deposit it throughout the body.
How do you use s-acetyl glutathione powder to lighten skin?
As we knew that Glutathione is the most important antioxidant produced in the human body and is produced in every cell of the body. Glutathione fights oxidative stress which is an imbalance between free radicals and antioxidants in the body. When free radicals accumulate, they cause cell and tissue damage leading to wrinkles, inflammation, hyperpigmentation, and melasma. S-Acetyl Glutathione is 10 times as effective as regular Glutathione.
S-Acetyl Glutathione powder can help decrease these age-related effects, by combating those nasty effects of free radicals and inflammation. It works activity of the enzyme tyrosinase which is involved in the production of pigmentation. Because of its powerful antioxidant effects and ability to help lighten dark spots and brighten the skin overall, topical s-acetyl-l-glutathione powder is a key ingredient in a number of beauty products.
How many mg of glutathione should I take for skin whitening?
Manufacturers of intravenous glutathione injections recommend a dose of 600–1200 mg for skin lightening, to be injected once to twice weekly.
What is the difference between glutathione and s-acetyl glutathione?
The key difference between l glutathione and s-acetylglutathione is that l-glutathione is the abundant isomer form of glutathione, whereas s-acetyl glutathione is a derivative of glutathione.
Unlike glutathione, s-acetyl-l-glutathione is absorbed well orally. It is not affected by peptidases in the blood, and is absorbed intact into the cell where the acetyl group is cleaved off producing an intact reduced glutathione. Acetyl glutathione has been shown to effectively increase intracellular levels.
What is the difference between S acetyl glutathione and liposomal glutathione?
Liposomal glutathione is an active form of glutathione. It exists encapsulated inside a lipid molecule in order to enhance absorption.
We suggest using s-acetyl-l-glutathione powder over Liposomal Glutathione powder for a few reasons, One is the self-life. Liposomal Glutathione products thought to be only around 24 months. With so many supplements sitting on the shelf for months before they are even sold, it can be a gamble if the Glutathione molecule is still in tact.
Aside from this, Liposomal Glutathione products can have a foul taste and odor. s-acetyl l-glutathione powder has no foul odor or taste because it does not use a phospholipid vessel in order to improve absorption. We have found that most people prefer a capsule or pill to a gel or paste, simply because a glutathione capsule is easier to comply with.
Plus, S-Acetyl Glutathione powder is orally active and stable in the intestines and plasma and is absorbed and delivered directly to the cells for natural de-acetylation intracellularly. While Liposomal glutathione products are delivered to the plasma by precursors and must be broken down by enzymes to the basic amino acid components for absorption into the cell and require more energy expenditure.
Whilst both Liposomal and S-Acetyl-Glutathione are both excellent options for Glutathione supplementation, the Acetylated version has been found to deliver the equivalent amount of Glutathione to the body as IV therapy!
Acetylated glutathione was the innovation in glutathione supplementation those in the know were waiting for. Highly bioavailable and, unlike glutathione foods, able to cross the blood-brain barrier, it lets you reap the benefits of glutathione for a fraction of the price of IV treatment.
S-Acetyl Glutathione VS NAC
There are a few popular forms of acetyl glutathione, one of which is N-Acetyl-Cysteine (NAC) – an orally available precursor to cysteine.
The premise here is that the body needs cysteine for GSH synthesis; however, as many individuals are unable to synthesise Glutathione (GSH) due to heavy metal toxicity and/or magnesium deficiency, the benefit is far from assured.
NAC is also known to have a nasty taste and smell and can, on occasion, induce powerful detox symptoms.
S-Acetyl Glutathione is different. Because an acetyl group is attached to the sulphur atom of cysteine, the molecule is protected from oxidation in the digestive tract, and the objectionable smell and taste of the sulphur atom is absent.
What’s more, the acetyl group detaches while the glutathione molecule activates within the cell to work as needed.
Why we need to take Glutathione supplementation?
AS we age, the body begins to produce less and less Glutathione,our body produces its own glutathione; however, its amount diminishes with poor diet, stress, infection and exposure to toxins, pollution, and radiation. It also starts to deplete at the age of 45. Research shows that healthy young people have high levels of glutathione while unhealthy elderly have low levels of this antioxidant, and it is even lower among sick and hospitalized elderly. With low levels of glutathione in the body, we become more prone to infection and diseases as we lack the ability to effectively detoxify. This also causes damage to the liver which further undermines the detoxification process.
How do you take S-Acetyl L-Glutathione powder| How much s–acetyl glutathione should I take?
S-acetyl glutathione is available in powder form the in the capsules. For S-Acetyl L-Glutathione powder, you can buy online and buy it from the manufacturer in China, Canada, south africa, Australia according your need. For s-acetyl glutathione capsules, you will find so many supplements in the amazon and google, s-acetyl glutathione 500mg, s-acetyl glutathione 200mg and s-acetyl glutathione 1000mg etc. After read s-acetyl glutathione review from the reddit we will know that the s acetyl glutathione best brand will be iherb and Jarrow.
The recommended s-acetyl glutathione dosage is 1-2 100 mg capsule per day. While taking a higher s-acetyl glutathione dosage is unlikely to be dangerous, 100 – 200 mg is plenty to get sufficient levels. Exact amount needed will be directed by your healthcare practitioners.
We would suggest you integrate it with other supplements to truly maximize the absorption, lifespan, recycling, and benefits of S-Acetyl L-Glutathione. A few big name helpers are Coenzyme Q10 (CoQ10), Selenium, Vitamin C, A and E, as well B-complex, B12 (methylcobalamin) and Trans-Resveratrol
Is s-acetyl glutathione safe ? S-acetyl glutathione Side Effects
S-Acetyl L-Glutathione is very well tolerated when taken at the recommended dosage and adverse side effects are very rarely reported. Long term supplementation of glutathione has been shown to lower zinc levels.
While some studies have shown that inhaled glutathione can trigger asthma attacks in people suffering from asthma, there is not currently enough evidence to show that this applies to orally ingested glutathione. Asthma sufferers may want to play it safe and avoid using Glutathione supplements. Please consult with your physician before taking S-Acetyl L-Glutathione powder.
Best S-acetyl glutathione powder manufacturer | Where can we buy s-acetyl glutathione powder?
Online store are the ideal places when looking forS-acetyl glutathione powder for sale as they allow you to compare pricing between different suppliers.
Countless black markets have sprung up but you need to be vigilant and make a good s-acetylglutathione powder buy from reliable manufacturer. The s-acetylglutathione powder factory can offer wholesale price in affordable. We independently produce all our products in quality controlled laboratories. You can save more by buying s-acetyl glutathione powder wholesale. Of course that s-acetyl glutathione powder bulk also available too, if you look for s-acetyl glutathione powder supplier you can be here.
FAQs
How Does S-Acetyl-L-Glutathione Work?
S-Acetyl-L-Glutathione works by lowering the disulfide bonds created within the proteins in the cell cytoplasm to cysteine bonds by standing in as an electron donor. To put it simply, this compound stabilizes the toxins by providing electrons that bind to their active groups. This action has three effects; detoxification, antioxidation and acting as an enzyme co-factor.
Is s acetyl glutathione effective?
S-Acetyl glutathione has been found to increase intracellular glutathione and improve many biomarkers of oxidative stress. Taking S-Acetyl Glutathione powder supplement is a great way to protect ourselves from health problems associated with aging, poor lifestyle and adverse environmental factors.
Is s acetyl glutathione powder better than reduced glutathione powder?
We don’t absorb glutathione well from foods and, taken as an oral supplement, plain glutathione is almost entirely destroyed by digestive enzymes in the stomach and small intestines. However, binding the acetyl molecule to glutathione produces a chemical that survives well in the digestive tract. Taking acetyl-glutathione has been shown to boost levels of glutathione in the body and may help improve and preserve health in a number of ways.
Should S-acetyl glutathione be taken on an empty stomach?
There is a suggested use for S-acetyl glutathione supplement: Take one to two capsules, one to two times daily on an empty stomach or as directed by your healthcare practitioner.
How long does it take for glutathione to work?
On Glutathione injection, the benefits of glutathione are usually seen after at least three weeks of treatment. How quickly you see improvement in your skin will depend on how consistently you come for your treatments, your general health, and your metabolism (slower results with a slow metabolism).
Which form of glutathione is best absorbed?
S-acetyl glutathione is the bioavailable form of glutathione. It is a type of peptide, and it acts mainly as an antioxidant. Moreover, this compound forms in our body endogenously, and it occurs in the food supply as well. This is the most stable form of glutathione.
What is the best way to absorb glutathione?
Intravenous glutathione administration is the most effective delivery system for glutathione, but this is expensive and inconvenient. S-Acetyl-Glutathione powder is an ideal alternative for supporting glutathione status in a simple and effective way.
Should I take glutathione or NAC?
NAC is valued primarily for its role in antioxidant production. Along with two other amino acids — glutamine and glycine — NAC is needed to make and replenish glutathione. Glutathione is one of the body’s most important antioxidants, which helps neutralize free radicals that can damage cells and tissues in your body
References:
[ 1 ] Kidd, PM. “Glutathione: Systemic Protectant Against Oxidative and Free Radical Damage.” Alternative Medicine Review 1997;1:155-176.
[ 2 ] S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Locigno R, Pincemail J, Henno A, Treusch G, Castronovo V. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644
[ 3 ] S-Acetylglutathione normalizes intracellular glutathione content in cultured fibroblasts from patients with glutathione synthetase deficiency. Okun JG, Sauer S, Bähr S, Lenhartz H, Mayatepek E. J Inherit Metab Dis. 2004;27(6):783-6. doi: 10.1023/b:boli.0000045838.65498.ff. PMID: 15617191
[ 4 ] Effects of S-acetylglutathione in cell and animal model of herpes simplex virus type 1 infection.Vogel JU, Cinatl J, Dauletbaev N, Buxbaum S, Treusch G, Cinatl J Jr, Gerein V, Doerr HW.Med Microbiol Immunol. 2005 Jan;194(1-2):55-9. doi: 10.1007/s00430-003-0212-z. Epub 2003 Nov 18.PMID: 14624358
[ 5 ] “Boosting GSH Using the Co-Drug Approach: I-152, a Conjugate of N-acetyl-cysteine and beta-mercaptoethylamine”. Crinelli R, Zara C, Smietana M, Retini M, Magnani M, Fraternale A. Nutrients. 2019 Jun 7;11(6):1291. doi: 10.3390/nu11061291. PMID: 31181621
[ 6 ] “The clinical effect of glutathione on skin color and other related skin conditions: A systematic review”. Dilokthornsakul W, Dhippayom T, Dilokthornsakul P. J Cosmet Dermatol. 2019 Jun;18(3):728-737. doi: 10.1111/jocd.12910. Epub 2019 Mar 20. PMID: 30895708
[ 7 ] “Reduced glutathione and S-acetylglutathione as selective apoptosis-inducing agents in cancer therapy”. Donnerstag B, Ohlenschlager G, Cinatl J, Amrani M, Hofmann D, Flindt S, Treusch G, Träger L. Cancer Lett. 1996 Dec 20;110(1-2):63-70. doi: 10.1016/s0304-3835(96)04461-8. PMID: 9018082
[ 8 ] “Glutathione supplementation improves macrophage functions in HIV”. Morris D, Guerra C, Khurasany M, Guilford F, Saviola B, Huang Y, Venketaraman V. J Interferon Cytokine Res. 2013 May;33(5):270-9. doi: 10.1089/jir.2012.0103. Epub 2013 Feb 14. PMID: 23409922 Clinical Trial.
[ 9 ] “Application of Glutathione as Anti-Oxidative and Anti-Aging Drugs”.Homma T, Fujii J. Curr Drug Metab. 2015;16(7):560-71. doi: 10.2174/1389200216666151015114515. PMID: 26467067 Review.
[ 10 ] “Glutathione and immune function”. Dröge W, Breitkreutz R. Proc Nutr Soc. 2000 Nov;59(4):595-600. doi: 10.1017/s0029665100000847. PMID: 11115795 Review.
[ 11 ] “Analysis of glutathione: implication in redox and detoxification”. Pastore A, Federici G, Bertini E, Piemonte F. Clin Chim Acta. 2003 Jul 1;333(1):19-39. doi: 10.1016/s0009-8981(03)00200-6. PMID: 12809732 Review.
