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Tretinoin powder (302-79-4)

Tretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of vitamin A……….


Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month



Tretinoin powder (302-79-4) video


Tretinoin powder (302-79-4) Specifications

Product Name  Tretinoin powder
Chemical Name ▪ ATRA

▪ Retinoic acid

▪ Vitamin A acid

▪ all-trans-Retinoic acid

Brand Name Vesanoid, Avita, Renova, Retin-a
Drug Class Anti-inflammation
CAS Number 302-79-4
Molecular Formula C20H28O2
Molecular Weight 300.44
Monoisotopic Mass 300.20893 g/mol
Melting Point  180-181 °C(lit.)
Freezing Point 180 – 181 °C – lit
Biological Half-Life 0.5-2 hours
Color Yellow powder
Solubility  Practically insoluble in water, soluble in methylene chloride, slightly soluble in ethanol (96 per cent).
Storage Temperature  2-8°C
Application ▪ Mild to moderate acne

▪ Fine wrinkles

▪ Hyperpigmentation


What is tretinoin?

Available as a topical cream, gel or liquid, tretinoin is a retinoid medication that’s widely used to treat acne and reverse many of the visual signs of aging. Tretinoin is also commonly known as ATRA, or all-transretinoic acid.

The most common use of tretinoin is to remove acne. Tretinoin acts quickly and effectively to remove acne from the face by clearing skin pores and preventing pimples from developing as they normally would.

This has made topical tretinoin one of the most widely used and effective acne treatments on the market today.

As well as being used to treat acne, tretinoin is used as an anti-aging product and as an oral treatment for leukemia. It’s a safe, effective medication that’s been approved by the FDA and has hundreds of thousands of users every year.

Tretinoin comes in several different dosage forms. It’s most commonly sold as a cream, but it’s also available as a liquid solution, as gel and as a jelly.

As a first-generation retinoid, Tretinoin is chemically related to vitamin A. By affecting the way in which skin cells develop, tretinoin (and other retinoids) can reduce the development of acne and prevent many of the common aesthetic signs of aging.


The tretinoin benefits?

1.Tretinoin powder used to treat acne vulgaris and keratosis pilaris.

2.It is available as a cream or gel. It is also used to treat acute promyelocytic leukemia.

3.It can stimulate skin growth and keep epidermic normal.

4.It can slow down skin aging process for solarization, remove tiny wrinkles.

5.It can reduce skin roughness, so skin will become ruddy.


Tretinoin Application?

  1. Tretinoin is widely applied in pharmaceutical field, mainly used for the cure of dermatonosus like acne, ichthyosis and psoriasis abnormal, etc..
  2. Tretinoin can be made into tretinoin or retinoic acid cream to cureacne or other unhealthy skin.
  3. Tretinoin is used for skin keratinocytes-resistant drugs and cell-induced differentation drug.
  4. Topical tretinoin use with minoxidil for androgenic alopecia. But It’s important to use this type of medication under the guidance of your doctor. In some circumstances, tretinoin can actually cause hair loss.

Tretinoin for Acne

People that take tretinoin for acne typically use the cream over a period of months before seeing significant changes. In the short term, tretinoin can potentially make acne worse (a period that’s commonly known as “purging”) before the acne improves.

However, over the long term, tretinoin is highly effective at reducing the formation of acne and improving facial skin.

Tretinoin for Anti-Aging

In addition to reducing and preventing acne, tretinoin cream is widely used as a treatment to prevent facial skin aging.

Tretinoin has been widely studied as an anti-aging medication, with several studies looking at the substance’s potential to reverse signs of skin aging such as the development of wrinkles, sun exposure damage and other skin blemishes.


What is the dosage for tretinoin?

Before applying topical tretinoin, the affected area of the skin should be cleansed with soap and dried. Patients should then wait 20 to 30 minutes before applying tretinoin, gently rubbing it into the affected area. The hands should be washed immediately after application. Tretinoin usually is applied once daily, in the evening.


What are the side effects of tretinoin?

Following the application of tretinoin to the skin, there often is local inflammation. This reaction disappears when treatment is stopped. Mild stinging or a sensation of warmth also can occur when applying tretinoin.

(1) The common side effects of tretinoin are:

Excessive dryness




(2) Other side effects of tretinoin include:

Increased sun sensitivity

Darkening or lightening of the skin

Initial acne flare-up



  1. Is tretinoin still a key agent for photoaging management? Ascenso A et al. Mini Rev Med Chem. (2014)
  2. [Tretinoin : One retinoid, many dosage forms]. Melhorn A et al. Hautarzt. (2017)
  3. Novel Tretinoin 0.05% Lotion for the Once-daily Treatment of Moderate-to-severe Acne Vulgaris in a Preadolescent and Adolescent Population. St Surin-Lord S, Schlesinger TE, Guenin E. J Clin Aesthet Dermatol. 2019 Sep;12(9):E57-E61. Epub 2019 Sep 1.
  4. Novel Tretinoin 0.05% Lotion for the Once-Daily Treatment of Moderate-to-Severe Acne Vulgaris in an Asian Population Han G, Armstrong AW, Desai SR, Guenin E. J Drugs Dermatol. 2019 Sep 1;18(9):910-916.



This Material is Sold For Research Use Only. Terms of Sale Apply. Not for Human Consumption, nor Medical, Veterinary, or Household Uses.


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