Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) video
Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9)
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also a parasympathomimetic acetylcholine precursor which may have potential for the treatment of Alzheimer’s disease and other dementias.
Raw Alpha GPC (Choline Alfoscerate) powder rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine. It is a non-prescription drug in most countries.
In Europe alpha-GPC is a prescription medication for the treatment of Alzheimer s disease. In the United States alpha-GPC is only available as a dietary supplement, mostly in products promoted to improve memory.Other uses for alpha-GPC include treatment of various kinds of dementia, stroke, and “mini stroke” (transient ischemic attack, TIA).
Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) Specifications
| Product Name | Raw Alpha GPC (Choline Alfoscerate) powder |
| Chemical Name | Choline Alfoscerate; Alpha GPC; L-Alpha glycerylphosphorylcholine; Choline glycerophosphate |
| Brand Name | No date available |
| Drug Class | parasympathomimetic acetylcholine |
| CAS Number | 28319-77-9 |
| InChIKey | SUHOQUVVVLNYQR-QMMMGPOBSA-N |
| Molecular Formula | C8H20NO6P |
| Molecular Weight | 257.223 g/mol |
| Monoisotopic Mass | 257.103 g/mol |
| Melting Point | 142.5 °C |
| Freezing Point | No date available |
| Biological Half-Life | The Alpha GPC half-life is around 4-6 hours but is said to peak within 1-2 hours of ingestion |
| Color | Solid powder |
| Solubility | Soluble in DMSO |
| Storage Temperature | 0 – 4°C for short term (days to weeks), or -20 °C for long term (months). |
| Application | Choline Alfoscerate is used in the treatment of Alzheimer’s Disease and other dementias. |
Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) Description
alpha GPC is the common name for L-Alpha glycerylphosphorylcholine, a cholinergic nootropic that occurs naturally but can also be taken as a supplement. Alpha GPC powder is best known for quickly and reliably delivering choline to the brain for the creation of the cognition-boosting neurotransmitter acetylcholine.
It has powerful benefits for both brain and body and may enhance the full range of cognitive functions, promote cellular health, and help maintain essential neurochemical balance in the brain.
Alpha-GPC rapidly delivers choline to the brain across the blood–brain barrier and is a biosynthetic precursor of acetylcholine. It is a non-prescription drug in most countries. The FDA determined that intake of no more than 196.2 mg/person/day is considered GRAS. In some European countries, it is regulated as a prescription drug and used for the treatment of Alzheimer’s disease.
Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) Mechanism of Action?
Alpha-GPC supports the whole nervous system by boosting acetylcholine and cholinergic activity. It may also raise the levels of other brain-protective messengers such as:
GABA
Dopamine
Serotonin
Inositol phosphate
Plus, as mentioned, it might boost growth hormone levels as well.
Benefits of Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9)
- Improved Memory and Enhanced Cognition
- Neuroprotectant
- Improves Stroke Recovery
- Boosts Athletic Performance,Increased Strength and Rapid Post-Workout Recovery
- May Improve Eyesight
- May Protect Against Radiation
Recommended Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9) Dosage
Alpha GPC is about 40% choline by weight. So 1,000 mg of Alpha GPC powder provides approximately 400 mg of choline.
Alpha GPC suggested dosage for cognitive benefits is 250–1,200 mg per day. Here’s a breakdown of the dosing regimens:
Alzheimer’s disease and dementia: 400 mg, 3X daily for 6 – 12 months.
Stroke recovery: 1,000 mg daily for 1 month (as injections).
400 mg orally, 3X daily for 5 months afterward
Athletic performance: 250 mg daily for 1 week [11]
600 mg daily for 1 – 6 days.
Eyesight: 400 mg, 2X daily for 2 months.
According to anecdotal evidence, the dose for nootropic effects ranges from 400 to 1,200 mg/day. You might want to start on the lower end and track your response.
Side effects of Raw Alpha GPC (Choline Alfoscerate) powder (28319-77-9)
Alpha-GPC powder was safe in all clinical trials. In a fraction of patients, it caused mild side effects such as:
Heartburn
Nausea
Irritability
Headache
In safety studies on dogs and rats, megadoses (up to 3,000 mg/kg) only slightly reduced the animals’ activity. Researchers concluded that long-term (26 weeks) alpha-GCP consumption of 150 mg/kg (over 10 g daily for adult men) bears no health risks.
Due to the lack of safety data, children and pregnant women may want to avoid alpha-GPC.
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