Lactoperoxidase (9003-99-0)

March 11, 2020

Lactoperoxidase is an enzyme found naturally in milk that is known to have antimicrobial and antioxidant properties………


Status: In Mass Production
Unit: 25kg/Drum


Lactoperoxidase (9003-99-0) video

Lactoperoxidase (9003-99-0) Specifications

Product Name Lactoperoxidase (9003-99-0)
Chemical Name Peroxidase; LPO
Brand Name N/A
Drug Class N/A
CAS Number 9003-99-0
InChIKey N/A
Molecular Formula N/A
Molecular Weight 78 kDa
Monoisotopic Mass N/A
Boiling point  N/A
Freezing Point N/A
Biological Half-Life N/A
Color red-brown
Solubility  H2O: soluble
Storage Temperature  Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C.
Application N/A


Lactoperoxidase (9003-99-0) Overview

Lactoperoxidase is an enzyme found naturally in milk that is known to have antimicrobial and antioxidant properties. According to research published in the Journal of Applied Microbiology, it has antibacterial properties that are helpful for the skin and can eliminate acne-causing bacteria. Lactoperoxidase is also an important component in a combination of ingredients (LPO, glucose, glucose oxidase (GO), iodide and thiocyanate) used to prevent yeasts, fungi, viruses and bacteria from growing in cosmetics and other beauty products (Source).


What is Lactoperoxidase ?

Lactoperoxidase is a glycoprotein with anti-microbial activity, it is used as a stabilizing ingredient to help improve formulation stability and product shelf-life. It is naturally occurring in milk.

Scientific research has revealed that Lactoperoxidase, a naturally existing enzyme in raw milk, catalyses the chemical reaction of thiocyanate, which is also naturally found in milk, in the presence of hydrogen peroxide. The resulting compound has a bacteriostatic effect on most bacteria and even a bactericidal effect on some bacteria, such as Escherichia coli.

The Lactoperoxidase system (LP-s) is one of a growing family of biostatics that can have beneficial effects in the processing of milk by extending the shelf-life and improving the quality of milk collected or preserved.

In 2005 FAO and WHO implemented a technical meeting on the benefits and potential risks of the LP-s of raw milk preservation, in order to provide scientific advice to Codex Alimentarius.

This work also responds to member country concerns regarding the use of LP-s, particularly in light of the current Codex guidance, which limits the application of LP-s of raw milk preservation to milk and dairy products which will not be traded international.‍

Lactoperoxidase side effects

There are no adverse side effects from the use of products containing Lactoperoxidase in normal concentrations.


Lactoperoxidase powder uses and application

Lactoperoxidase is an effective antimicrobial agent. Consequently, applications of lactoperoxidase powder are being found in preserving food, cosmetics, and ophthalmic solutions. Furthermore, lactoperoxidase have found application in dental and wound treatment. Finally lactoperoxidase may find application as anti-tumor and anti viral agents.

Dairy products

Lactoperoxidase is an effective antimicrobial agent and is used as an antibacterial agent in reducing bacterial microflora in milk and milk products. Activation of the lactoperoxidase system by addition of hydrogen peroxide and thiocyanate extends the shelf life of refrigerated raw milk. It is fairly heat resistant and is used as an indicator of overpasteurization of milk.

Oral care

A lactoperoxidase system is claimed to appropriate for the treatment of gingivitis and paradentosis. Lactoperoxidase has been used in toothpaste or a mouthrinse to reduce oral bacteria and consequently the acid produced by those bacteria.


A combination of lactoperoxidase, glucose, glucose oxidase (GOD), iodide and thiocyanate is claimed to be effective in the preservations of cosmetics.

Cancer and viral infections

Antibody conjugates of glucose oxidase and to lactoperoxidase have been found to effective in killing tumor cells in vitro. In addition, macrophages exposed to lactoperoxidase are stimulated to kill cancer cells.

Peroxidase-generated hypothiocyanite inhibits herpes simplex virus and human immunodeficiency virus.



  • The Significance of Lactoperoxidase System in Oral Health: Application and Efficacy in Oral Hygiene Products. Magacz M, Kędziora K, Sapa J, Krzyściak W. Int J Mol Sci. 2019 Mar 21
  • The antibacterial efficacy of a foam mouthwash and its ability to remove biofilms. Jones SB, West NX, Nesmiyanov PP, Krylov SE, Klechkovskaya VV, Arkharova NA, Zakirova SA. BDJ Open. 2018 Sep 27;
  • Clinical efficacy of a bleaching enzyme-based toothpaste. A double-blind controlled clinical trial. Llena C, Oteo C, Oteo J, Amengual J, Forner L. J Dent. 2016 Jan
  • Oral care may reduce pneumonia in the tube-fed elderly: a preliminary study. Maeda K, Akagi J.Dysphagia. 2014 Oct;29