Dihydromyricetin (DHM) (27200-12-0)

March 9, 2020

Dihydromyricetin (or DHM) is an extract from the Japanese Raisin Tree that has been used for centuries as an anti-alcohol…….

 


Status: In Mass Production
Synthesized and Customized Available
Capacity: 1277kg/month

 

Dihydromyricetin (DHM) (27200-12-0) video

Dihydromyricetin Specifications

Product Name Dihydromyricetin (DHM)
Chemical Name Ampelopsin
Ampeloptin
(+)-Dihydromyricetin
Brand Name N/A
Drug Class phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;natural product;Inhibitors;Flavanones;chemical reagent;pharmaceutical intermediate
CAS Number 27200-12-0
InChIKey KJXSIXMJHKAJOD-LSDHHAIUSA-N
Molecular Formula C15H12O8
Molecular Weight 320.25 g/mol
Monoisotopic Mass 320.053217 g/mol
Boiling point  780.7±60.0 °C(Predicted)
Freezing Point N/A
Biological Half-Life N/A
Color white to beige
Solubility  DMSO: ≥5mg/mL (warmed)
Storage Temperature  <+8°C
Application 1. Applied in feed industry, dihydromyricetin powder used as raw materials;
2. Applied in health product, dihydromyricetin powder used as raw materials to enhance body immunity;
3. Applied in pharmaceutical field, dihydromyricetin extract powder used as capsules or pills to treat respiratory tract infection and protect liver.

 

Dihydromyricetin History

Dihydromyricetin (or DHM) is an extract from the Japanese Raisin Tree that has been used for centuries as an anti-alcohol herb and hangover cure in Korean and Chinese traditional medicine. Recent studies suggest that DHM could lower your blood alcohol level and protect your liver from damage and disease.

DHM is a flavonoid most typically extracted from Vine Tea but it also can be extracted from the bark of the Holvenia Dulcis tree. And most importantly, Dihydromyricetin has a long history of being taken specifically for the purposes of treating headaches and hangovers.

What is Dihydromyricetin?

Dihydromyricetin, also know as Ampelopsin, is a flavanonol, a type of flavonoid. It is found in the Ampelopsis species japonica, megalophylla, and grossedentata; Cercidiphyllum japonicum; Hovenia dulcis; Rhododendron cinnabarinum; some Pinus species; and some Cedrus species, as well as in Salix sachalinensis.

Dihydromyricetin extract powder, the main active ingredient is flavonoids. With the functions of scavenging free radicals, antioxidants, antithrombotic, Tumor, anti-inflammatory and other peculiar effects; Dihydromyricetin is a special flavonoid compound. In addition to the general characteristics of flavonoids, it also has the ability to relieve alcohol poisoning, prevent alcoholic liver, fatty liver, and inhibit liver cells. Worsening and reducing the incidence of liver cancer. It is a good product for protecting the liver and hangover.

 

Dihydromyricetin benefits

ANTI-HANGOVER BENEFITS

DHM main benefit is the prevention and reduction of hangovers, to protects your liver and brain. This is achieved by the enhancement of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), which are the main enzymes responsible for breaking down alcohol and acetaldehyde within the body.

Acetaldehyde in particular is a highly toxic chemical and one of the main causes of hangovers. When these enzymes are enhanced, alcohol and acetaldehyde can be broken down faster than normal.

CELLULAR HEALTH

DHM has many cellular health properties that lend themselves to promoting cognitive health. This occurs because DHM promotes heme-oxygenase-1 (HO-1), an enzyme that catalyzes the degradation of heme and confers cellular health properties. Dihydromyricetin can also promote liver health.

The other dihydromyricetin benefits

1)Dihydromyricetin can Clearing the free radical in body and antioxidation

2)Dihydromyricetin can Antibiotic Action

3)Dihydromyricetin can Protecting the Liver: Dihydromyricetin has the strong inhibitory action of the rise of ALT and AST in the blood Serum. It can low the total bilirubin in the blood serum. So it has the strong action of lowing the aminotransferase and jaundice.

4)Dihydromyricetin can Reducing the levels of blood sugar and blood fat: Dihydromyricetin can reduce the blood fat levels in the mouse. It can decrease the damage to liver cells caused by the high blood fat levels and improve the antioxidation ability. At the same time, it can low the levels of high blood sugar.

5)Dihydromyricetin can Anti-inflammation

6)Dihydromyricetin can  Anti-tumor: Dihydromyricetin extract powder has effective restrain to cell proliferation of some tumor cells.

Dihydromyricetin side effects.

Overall there are only a few studies to date looking at DHMs side effect profile and so far no adverse problems have been reported.

A quick search on Amazon will show thousands of reviews. Looking through them, there are some reports of abdominal discomfort, nausea, and diarrhea. However, there aren’t many customers that report these side effects.

 

Dihydromyricetin uses and application

Uses:

  1. Dihydromyricetin powder used to protect liver;
  2. Dihydromyricetin powder used to regulate blood sugar blood fat;
  3. Dihydromyricetin powder has the effect of enhance body immunity;
  4. Dihydromyricetin powder with the function of antioxidant and anti-cancer;
  5. Dihydromyricetin powder used to antibiosis , treat cough, pain and eliminate smoke poison.
  6. The dihydromyricetin has a promising development prospect in the preparation of skin-care products or drugs for preventing and treating optical skin injuries.

Application

  1. Applied in feed industry, dihydromyricetin powder used as raw materials;
  2. Applied in health product, dihydromyricetin powder used as raw materials to enhance body immunity;
  3. Applied in pharmaceutical field, dihydromyricetin extract powder used as capsules or pills to treat respiratory tract infection and protect liver.

Dihydromyricetin research in Anti-Cancer

In fact, there is some pretty compelling research showing that dihydromyricetin has potential to assist with a non-alcohol related condition called Hepatocellular carcinoma (HCC). HCC is a condition which exhibits one of the highest incidences of morbidity and mortality worldwide, and presents the predominant subtype of primary liver cancer. As DHM exhibits a protective ability on the liver (it’s a hepatprotective) the results revealed that it significantly inhibited cell proliferation and induced cell apoptosis in the HCC cell lines, indicating that DHM is a promising candidate for the treatment of HCC.

 

Reference:

Dihydromyricetin alleviates doxorubicin-induced cardiotoxicity by inhibiting NLRP3 inflammasome through activation of SIRT1. Sun Z, Lu W, Lin N, Lin H, Zhang J, Ni T, Meng L, Zhang C, Guo H. Biochem Pharmacol. 2020 Feb 26:113888. doi: 10.1016/j.bcp.2020.113888. [Epub ahead of print]

Metabolomics of the Protective Effect of Ampelopsis grossedentata and Its Major Active Compound Dihydromyricetin on the Liver of High-Fat Diet Hamster. Fan L, Qu X, Yi T, Peng Y, Jiang M, Miao J, Xiao P. Evid Based Complement Alternat Med. 2020 Jan 28;2020:3472578. doi: 10.1155/2020/3472578. eCollection 2020.

Regulation of signaling pathways by Ampelopsin (Dihydromyricetin) in different cancers: exploring the highways and byways less travelled. Fayyaz S, Qureshi MZ, Alhewairini SS, Avnioglu S, Attar R, Sabitaliyevich UY, Buha A, Salahuddin H, Adylova A, Tahir F, Pawlak-Adamska E. Cell Mol Biol (Noisy-le-grand). 2019 Sep 30;65(7):15-20.

Golgi reassembly and stacking protein 65 downregulation is required for the anti-cancer effect of dihydromyricetin on human ovarian cancer cells. Wang F, Chen X, Yuan D, Yi Y, Luo Y.

PLoS One. 2019 Nov 26;14(11):e0225450. doi: 10.1371/journal.pone.0225450. eCollection 2019.