Raw 6-Paradol powder (27113-22-0)

December 28, 2018

Paradol, also known as Raw 6-Paradol powder, is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta……..


Status:In Mass Production
Unit:25kg/Drum
Capacity:1560kg/month

 

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Raw 6-Paradol powder (27113-22-0) video

 

Raw 6-Paradol powder (27113-22-0) Specifications

Product NameRaw 6-Paradol powder
Chemical NameRaw 6-Paradol powder;Paradol; 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one;

1-(3-Methoxy-4-hydroxyphenyl)-3-decanone

Brand NameNo data for available
Drug ClassThis drug may be formulated in DMSO
CAS Number27113-22-0
InChIKeyCZNLTCTYLMYLHL-UHFFFAOYSA-N
Molecular FormulaC17H26O3
Molecular Weight278.392 g/mol
Monoisotopic Mass278.188 g/mol
Melting Point 31 – 32 °C
Freezing PointNo data for available
Biological Half-LifeNo data for available
ColorWhite Solid powder
Solubility Soluble in DMSO
Storage Temperature Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).
Raw 6-Paradol powder ApplicationFood additives -> Flavoring Agents
Promote metabolism.
Weight loss effect.
Analgesic effect.

 

Raw 6-Paradol powder (27113-22-0) Description

Paradol, also known as 6-Paradol, is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta or grains of paradise). It is also found in ginger. Paradol has been found to have antioxidant and antitumor promoting effects in a mouse model. It is used in flavors as an essential oil to give spiciness.

6-Paradol powder (27113-22-0) Mechanism of Action

Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.

Paradol ([6]-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.

Benefits of 6-Paradol powder (27113-22-0)

▪ 6-Paradol and antipyretic, prescribed for headache, pain (muscle ache, backache) and fever either alone or combined with other medications.

▪ 6-Paradol is also used with other pain medications to treat low back pain, osteoarthritis, cold, and toothache.

Recommended 6-Paradol powder (27113-22-0) Dosage

TThe oral dose for adults is 325 to 650 mg every 4 to 6 hours. The maximum daily dose is 4 grams.

Child- the recommended dose is 10 to 15 mg/kg every 4 to 6 hours.

It comes as a tablet and liquid to take by mouth, with or without food.

Side effects of 6-Paradol powder (27113-22-0)

6-Paradol is a non-opiate, Paradol and antipyretic, prescribed for headache, pain (muscle ache, backache) and fever. Beside, it may has some side effects as below:

  • Nausea
  • Stomach pain
  • Loss of appetite
  • Upper stomach pain
  • Dark urine
  • Clay colored stool
  • Allergic reactions
  • Skin rash and kidney impairment
  • Liver damage

 

References

How Does 6-Paradol Do as Healthy Fat Burner Supplement?

 

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