Raw 6-Paradol powder (27113-22-0) video
Raw 6-Paradol powder (27113-22-0) Specifications
|Product Name||Raw 6-Paradol powder|
|Chemical Name||Raw 6-Paradol powder;Paradol; 1-(4-Hydroxy-3-methoxyphenyl)decan-3-one;
|Brand Name||No data for available|
|Drug Class||This drug may be formulated in DMSO|
|Molecular Weight||278.392 g/mol|
|Monoisotopic Mass||278.188 g/mol|
|Melting Point||31 – 32 °C|
|Freezing Point||No data for available|
|Biological Half-Life||No data for available|
|Color||White Solid powder|
|Solubility||Soluble in DMSO|
|Storage Temperature||Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Raw 6-Paradol powder Application||Food additives -> Flavoring Agents
Weight loss effect.
Raw 6-Paradol powder (27113-22-0) Description
Paradol, also known as 6-Paradol, is the active flavor constituent of the seeds of Guinea pepper (Aframomum melegueta or grains of paradise). It is also found in ginger. Paradol has been found to have antioxidant and antitumor promoting effects in a mouse model. It is used in flavors as an essential oil to give spiciness.
6-Paradol powder (27113-22-0) Mechanism of Action
Administration of Paradol (6-paradol) (10 mg/kg) clearly reduces the number of Iba1-positive cells 1 and 3 days after the challenge. Moreover, Paradol dramatically reduces the number of Iba1-postive cells in periischemic regions even after 3 days following M/R challenge. Paradol (6-paradol) exhibits the strongest anti-inflammatory effect of several paradol compounds in lipopolysaccharide-stimulated BV2 microglia derived from a mouse brain, including 2-, 4-, 6-, 8-, and 10-paradol. Furthermore, Paradol shows the strongest pungency of all of the known paradol analogues. Paradol also shows the highest contact time at the antiobesity site of action on the basis of the results shown for the absorption of the metabolites in this study.
Paradol (-paradol) induces apoptosis in an oral squamous carcinoma cell line, KB, in a dose-dependent manner. Paradol induces apoptosis through a caspase-3-dependent mechanism.
Benefits of 6-Paradol powder (27113-22-0)
▪ 6-Paradol and antipyretic, prescribed for headache, pain (muscle ache, backache) and fever either alone or combined with other medications.
▪ 6-Paradol is also used with other pain medications to treat low back pain, osteoarthritis, cold, and toothache.
Recommended 6-Paradol powder (27113-22-0) Dosage
TThe oral dose for adults is 325 to 650 mg every 4 to 6 hours. The maximum daily dose is 4 grams.
Child- the recommended dose is 10 to 15 mg/kg every 4 to 6 hours.
It comes as a tablet and liquid to take by mouth, with or without food.
Side effects of 6-Paradol powder (27113-22-0)
6-Paradol is a non-opiate, Paradol and antipyretic, prescribed for headache, pain (muscle ache, backache) and fever. Beside, it may has some side effects as below:
- Stomach pain
- Loss of appetite
- Upper stomach pain
- Dark urine
- Clay colored stool
- Allergic reactions
- Skin rash and kidney impairment
- Liver damage