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Raw AICAR powder (2627-69-2)

(1 customer review)

AICAR powder, also known as AICA riboside, is a purine precursor with antineoplastic activity and a selective activator of AMP-activated ……..


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1277kg/month

Description

Raw AICAR powder (2627-69-2) video

 

Raw AICAR powder (2627-69-2) Description

Raw AICAR powder also known as ZMP is an analog of AMP that is capable of stimulating AMP-dependent protein kinase activity(AMPK). Raw AICAR powder is an intermediate in the generation of inosine monophosphate. Raw AICAR powder is being clinically used to treat and protect against cardiac ischemic injury, it can enter cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. Raw AICAR powder increases glucose uptake by inducing translocation of GLUT4 and/or by activating the p38 MAPK pathway. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

Raw AICAR powder (2627-69-2) Specifications

Product Name Raw AICAR powder
Chemical Name 1-ribosyl-4-carboxamido-5-aminoimidazole, ARA 100, ARA-100, ARA100, GP 1 110, 5-aminoimidazole-4-carboxamide 1-ribofuranoside, 5-aminoimidazole-4-carboxamide riboside, acadesine, AICA ribofuranoside, AICA riboside, aminoimidazole carboxamide ribonucleoside, arasine, Z-riboside
Brand Name No data for available
Drug Class SARM
CAS Number 2627-69-2
InChIKey RTRQQBHATOEIAF-UUOKFMHZSA-N
Molecular Formula C9H14N4O5
Molecular Weight 258.23
Monoisotopic Mass 258.096 g/mol
Melting Point  214-215 °C
Freezing Point 214 °C
Biological Half-Life Very short
Color tan
Solubility  H2O: >10 mg/mL
Storage Temperature  −20°C
Raw AICAR powder Application AMPK activator

 

Raw AICAR powder (2627-69-2)

Raw AICAR powder also known as ZMP is an analog of AMP,  is Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). It is capable of stimulating AMP-dependent protein kinase activity(AMPK),  augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Raw AICAR powder is an intermediate in the generation of inosine monophosphate. Raw AICAR powder is being clinically used to treat and protect against cardiac ischemic injury, it can enter cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. Raw AICAR powder increases glucose uptake by inducing translocation of GLUT4 and/or by activating the p38 MAPK pathway. Currently, the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

AICAR is a purine precursor with antineoplastic activity. It is important in treatment of metabolic diseases such as type 2 diabetes as well as possible treatment of various cancer types.

AICAR powder (2627-69-2) Mechanism of Action

The nucleoside form of AICAR, acadesine, is an analog of adenosine that enters cardiac cells to inhibit adenosine kinase and adenosine deaminase. It enhances the rate of nucleotide re-synthesis increasing adenosine generation from adenosine monophosphate only during conditions of myocardial ischemia. In cardiac myocytes, acadesine is phosphorylated to AICAR to activate AMPK without changing the levels of the nucleotides. AICAR is able to enter the de novo synthesis pathway for adenosine synthesis to inhibit adenosine deaminase causing an increase in ATP levels and adenosine levels.

Application of AICAR powder (2627-69-2)

▪ Antineoplastic

▪ Performance-enhancing drug

▪ Glucose uptake stimulant

▪ AMPK activator

▪ Metabolic disorders

▪ Acute lymphoblastic leukemia

Recommended AICAR powder (2627-69-2) Dosage

The dosages for AICAR can range from 150 mg every day, if you stack it with GW, to around 500 mg per day when you use it on its own. Every bottle usually comes in 50 mg dosages, so it’s evidently expensive. For this reason, it makes sense to use it in the last four weeks before the day of the competition.

Benefits of AICAR powder (2627-69-2) 

♦ AICAR is a purine precursor with antineoplastic activity. It is important in treatment of metabolic diseases such as type 2 diabetes as well as possible treatment of various cancer types.

♦ AICAR application for treating metabolic disorders.

♦AICAR have therapeutic potential for treating neuroinflammatory diseases where reactive microglia play an etiological role.

♦ AICAR help to improve motor, memory function and brain function

♦ AICAR is best used as an inclusion to an endurance stack. Athletes also use it for performance enhancing in sports where they need endurance.

♦ AICAR is a nucleoside analogue that is able to enter nucleoside pools and is able to significantly increase levels of adenosine during periods of ATP breakdown. Adenosine-regulating agents (ARAs) have been recognized for therapeutic potential in myocardial ischemia.

♦ AICAR is used for the treatment of acute lymphoblastic leukemia and is reported to have cardioprotective effects.

 


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1 review for Raw AICAR powder (2627-69-2)

  1. Phcoker

    Got AICAR powder to test, test result show very high quality and purity!

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