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Degarelix (214766-78-6)

Degarelix, also known as Degarelix acetate and FE-200486,  a competitive and reversible gonadotropin-releasing………


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1430kg/month

Description

Degarelix (214766-78-6) video

 

Degarelix (214766-78-6) Description

Degarelix, also known as Degarelix acetate and FE-200486,  a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist. It binds reversibly to the pituitary GnRH receptors, thereby reducing the release of gonadotropins and consequently testosterone. Degarelix is specifically indicated for the treatment of advanced prostate cancer.

Degarelix is supplied as a powder to be reconstituted with sterile water for subcutaneous administration in the abdomen. The recommended initial dose of the drug is 240 mg given as two subcutaneous injections of 120 mg at a concentration of 40 mg/mL. The recommended maintenance dose of Degarelix is 80 mg given as one subcutaneous injection at a concentration of 20 mg/mL, every 28 days. Chemically, it is a synthetic linear decapeptide amide with seven unnatural amino acids, five of which are D-amino acids. FDA approved on December 24, 2008.

Degarelix (214766-78-6) Specifications

Product Name Degarelix
Chemical Name Degarelix acetate; FE-200486; UNII-SX0XJI3A11; SX0XJI3A11; CS-5350; Z-3147; CHEMBL415606; Ac-D-Nal-[D-(pCl)Phe]-D-Pal-Ser-[Aph(DHor)]-D-[Aph(Cbm)]-Leu-ILys-Pro-DAla-NH2;
Brand Name Firmagon
Drug Class Antineoplastic Agents
CAS Number 214766-78-6
InChIKey MEUCPCLKGZSHTA-XYAYPHGZSA-N
Molecular Formula C82H103ClN18O16
Molecular Weight 1632.28
Monoisotopic Mass 1630.75 g/mol g·mol−1
Melting Point  N/A
Freezing Point N/A
Biological Half-Life 23~61 days
Color White to off-white solid powder
Solubility  H2O: ≥ 500 mg/mL
Storage Temperature  -20°C
Application Used to treat patients with advanced prostate cancer

 


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Shangke Chemical is a high-tech enterprise specializing in active pharmaceutical intermediates (APIs). To control the quality during production, a large number of experienced professionals, a first-class production equipment and laboratories are the key points.

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