Raw Flibanserin HCL powder (147359-76-0) video
Raw Flibanserin HCL powder (147359-76-0) Specifications
|Product Name||Flibanserin hydrochloride powder|
|Chemical Name||UNII-96XTC36K1B, 96XTC36K1B|
|Drug Class||Multifunctional serotonin agonist antagonist (MSAA)|
|Monoisotopic Mass||426.143 g/mol|
|Melting Point||>225°C (dec.)|
|Freezing Point||No date available|
|Biological Half-Life||11 hours|
|Solubility||DMSO (Slightly), Methanol (Slightly)|
|Storage Temperature||Room Temperature|
|Application||Developed for the treatment of hypoactive sexual desire disorder in women.|
Raw Flibanserin HCL powder (147359-76-0) Description
Flibanserin hydrochloride is the first drug to be approved for hypoactive sexual desire disorder (HSDD) in premenopausal women by the FDA in August 2015. It was originally developed as an antidepressant medication by Boehringer Ingelheim, but showed lack of efficacy in trials and was further developed as a hypoactive sexual disorder drug by Sprout Pharmaceuticals. Flibanserin’s mechanism of action is attributed to its high affinity for 5-HTA1 and 5-HTA2 receptors, displaying agonist activity on 5-HTA1 and antagonist on 5-HTA2, resulting in lowering of serotonin in the brain as well as an effect on increasing norepinephrine and dopamine neurotransmitters.
Flibanserin hydrochloride powder (147359-76-0) Mechanism of Action
Flibanserin hydrochloride works on three important brain chemicals: dopamine, norepinephrine, and serotonin. These chemicals are neurotransmitters. They are responsible for sending signals between the brain and other parts of the body through the nervous system.
Dopamine and norepinephrine are involved with sexual excitement. However, serotonin contributes to sexual inhibition and may dampen sex drive. It is thought that if these chemicals are out of balance – if dopamine and norepinephrine levels are too low and/or serotonin levels are too high – a woman might feel less sexual desire.
Flibanserin hydrochloride works by raising levels of dopamine and norepinephrine while lowering levels of serotonin. In this way, chemicals that help promote sexual desire are increased and one that can suppress desire is decreased.
Application of Raw Flibanserin HCL powder (147359-76-0)
Flibanserin hydrochloride is a 5-HT1A agonist and 5-HT2A antagonist that is developed for the treatment of hypoactive sexual desire disorder in women (1,2).
Recommended Raw Flibanserin HCL powder (147359-76-0) Dosage
100 mg orally once per day at bedtime
Duration of therapy: This drug should be discontinued after 8 weeks if the patient does not report an improvement in symptoms.
Comments: This drug is not indicated to enhance sexual performance, and is not indicated for treatment in postmenopausal women or in men.
Side effects of Flibanserin hydrochloride powder (147359-76-0)
Adverse events are more common among women taking flibanserin. The majority of adverse events were mild to moderate. The most commonly reported adverse events included dizziness, nausea, feeling tired, sleepiness, and trouble sleeping.
Drinking alcohol while on flibanserin may result in severely low blood pressure (low blood pressure that produced symptoms after 2 glasses of wine occurred in 17%).