Zinc Pyrithione powder (13463-41-7) video
Zinc Pyrithione powder (13463-41-7) Specifications
|Product Name||Zinc Pyrithione powder|
|Chemical Name||▪ ZnPT
▪ 2-Mercaptopyridine N-Oxide Zinc Salt
▪ zinc 1-oxidopyridine-2-thione
▪ zinc 1-oxidopyridin-1-ium-2-thiolate
|Brand Name||Zinc Pyrithione|
|Drug Class||Beauty peptide for hair health|
|Melting Point||Approximate 240℃|
|Biological Half-Life||About 14 hours|
|Color||Fine beige powder|
|Solubility||Insoluble (<0.1 g/100 mL at 21 ºC)|
|Application||▪ Used to control seborrheic dermatitis.
▪ Used to treat skin irritation and dandruff.
Zinc Pyrithione powder (13463-41-7) Description
Zinc pyrithione powder is a topical agent used as a topical antifungal and antibacterial. It is often used for the treatment of dandruff and seborrhoeic dermatitis but may also be used to treat other skin conditions including eczema, psoriasis, athletes foot, and ringworm.
Zinc pyrithione powder is the zinc complex of 1-hydroxy-2(1H)-pyridinethione, or more commonly, pyrithione. Pyrithione was first synthesized by E. Shaw and co-workers in 1950. The preparation of the zinc derivative was disclosed by Olin Mathieson in a 1956 British patent, but the compound has been used since the 1930s.
Zinc pyrithione powder was originally used as an antibacterial and antifungal agent. It is still used as an antifungal, primarily as a treatment for dandruff and seborrheic dermatitis. Its current antibacterial uses are treating Streptococcus and Staphylococcus infections and psoriasis, eczema, ringworm, and athlete’s foot. Its primary nonmedical use is as a component in exterior paints to protect against mildew and algae.
Inhibition of fungal growth by pyrithione zinc powder is linked to increased copper uptake and cellular levels of copper, which is demonstrated by decreased CTR1-lacZ expression and slightly increased CUP1-lacZ expression in affected microorganisms 3. The coordination complex of pyrithione zinc dissociates, and pyrithione ligand forms a CuPT complex from available extracellular copper in the target organism. Pyrithione acts as an ionophore, interacting nonspecifically with the plasma membrane to shuttle copper into the cell, and facilitates copper transport across intracellular membranes. Copper may be shuttled into the mitochondria. Copper inactivates iron-sulfur (Fe-S) cluster-containing proteins via a mechanism similar to that described for copper-induced growth inhibition in bacteria. Decreased activity of Fe-S proteins leads to inhibition of fungal metabolism and fungal growth. Pyrithione zinc powder has been shown to slightly increase the levels of zinc.