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Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7)

Raw Nicotinamide Mononucleotide (NMN) powder suppressed age-associated body weight gain……


Status: In Mass Production
Unit: 25kg/Drum
Capacity: 1370kg/month

Description

Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) video

Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Description

Raw Nicotinamide Mononucleotide powder (“NMN” and “β-NMN”) is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).

Because NADH is a cofactor for processes inside mitochondria, for sirtuins, and for PARP, NMN has been studied in animal models as a potential neuroprotective and anti-aging agent. Dietary supplement companies have aggressively marketed NMN products claiming those benefits, though there is no clinical study on humans published yet.

 

Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Specifications

Product Name Raw Nicotinamide Mononucleotide (NMN) powder
Chemical Name Beta-nicotinamide ribose monophosphate; Raw Nicotinamide Mononucleotide powder; AC1Q6RVF; AC1L23AN; NMN(+); SCHEMBL6858129
Brand Name Mirailabo
Drug Class Dietary supplement
CAS Number 1094-61-7
InChIKey DAYLJWODMCOQEW-TURQNECASA-N
Molecular Formula C11H15N2O8P
Molecular Weight 334.22
Monoisotopic Mass 335.229 g/mol
Melting Point  >96°C
Freezing Point No date available
Biological Half-Life Thus, as illustrated in Fig. 3, nicotinamide disappeared from the blood with a half-life of 5.3 hours, whereas the half-life of nicotinic acid was 1.1 hour.
Color White to off-white powder
Solubility  Methanol (Slightly), Water (Slightly)
Storage Temperature  Hygroscopic, -20˚C Freezer, Under Inert Atmosphere
Application In order to play the role of prolonging life and treating diabetes

 

Raw Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Description

Raw Nicotinamide Mononucleotide powder (“NMN” and “β-NMN”) is a nucleotide derived from ribose and nicotinamide. Like nicotinamide riboside, NMN is a derivative of niacin, and humans have enzymes that can use NMN to generate nicotinamide adenine dinucleotide (NADH).

New research suggests that NMN may restore cellular metabolism, and have profound anti-aging effects. Occurring naturally in the body, NMN (β-Nicotinamide mononucleotide) is critical for the conversion of nutrients into energy. Supplementing NMN as part of your daily regime could offer energy revitalization, protection from the aging process, and decreased risk of cardiovascular complications. NMN is a cofactor in redox reactions, a process critical to metabolic function in the formation of ATP the high-energy supplying molecule. NMN contains a Sirtuin activating compound which promotes metabolic precision and longevity.

Use of Nicotinamide Mononucleotide (NMN) powder (1094-61-7)

  1. Nicotinamide mononucleotide in human cells play an important role in energy generation, it is involved in intracellular NAD (nicotinamide adenine dinucleotide, cell energy conversion important coenzyme) synthesis, used in anti-aging, fall blood sugar and other health care products.
  2. Nicotinamide Mononucleotide is a water-soluble vitamin, The product is white crystalline powder, odorless or nearly odorless, bitter in taste, freely soluble in water or ethanol, dissolvable in glycerin.
  3. Nicotinamide Mononucleotidepowderis easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.

In addition, nicotinamide has prevention and treatment of heart block, sinus node function and anti-fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.

Benefits of Nicotinamide Mononucleotide (NMN) powder (1094-61-7)

  • NMN Boosts Energy Metabolism – NAD+ helps to breakdown food like sugars into energy.
  • Promotes Healthy Brain and Cardiovascular Function.
  • Anti-Aging DNA Repair – NAD+ is used to repair broken DNA strands.
  • SIRTUIN Activator – NAD+ is required for our longevity genes to work.
  • NMN is THE compound used by Harvard Scientists to reverse some signs of aging tissue in mice that started the rush to NAD supplements.
  • NMN treatment protects against cICH-induced acute brain injury
  • NMN Treatment Rescues Cognitive impairments
  • Nicotinamide mononucleotide inhibits JNK activation to reverse Alzheimer disease
  • NMN could restore cognition in AD model rats

Recommended Nicotinamide Mononucleotide (NMN) powder (1094-61-7) Dosage

The generally recommended dosage of Nicotinamide Mononucleotide powder is anywhere between 250 – 1500 mg per day.

NMN is absorbed extremely quickly and has a short half-life, so to keep NAD+ levels high for as much of the day as possible it’s recommended to take one 125 mg capsule on waking and another in the afternoon if taking 250 mg per day.

Side effects of Nicotinamide Mononucleotide (NMN) powder (1094-61-7)

While Nicotinamide mononucleotide (NMN) powder is a fairly new supplement and research is ongoing, studies performed so far have shown it to be very safe and non-toxic.

Side effects are rare, but itchiness, dizziness, sweating, and nausea have been reported in some cases.

 


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References & product citations

2019 Latest Anti-Aging Drugs: Nicotinamide Mononucleotide (NMN)

 

References

  1. Mills, K.F., Yoshino, J., Yoshida, S., et al. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metabolism.
  2. Yoshino, J., Mills, K.F., Imai, S.I., and Yoon, M.J. (2011). Nicotinamide Mononucleotide, a key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice. Cell Metabolism.
  3. Yamamoto, T., Byun, J., Zhai P., Ikeda, Y., Oka, S., and Sadoshima, J. (2014). Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion.
  4. Sinclair, D.A., Uddin, G.M., Youngson, N.A., and Morris, M.J. (2016). Head to Head Comparison of Short-Term Treatment with NAD+ precursor Nicotinamide Mononucleotide (NMN) and six Weeks of Exercise in Obese Female Mice.
  5. Imai, S., Yoshino, J., Mills, K.F., Grozio, A., et al. (2019) Slc12a8 is a Nicotinamide Mononucleotide Transporter. Nature Metabolism.
  6. De Picciotto, N.E., Mills, K.F., Imai, S., Gano, L.B., et al. (2016). Nicotinamide Mononucleotide Reverses Vascular Dysfunction and Oxidative Stress with Aging Mice.
  7. Yao, Z., Gao, Z., Yang, W., and Jia, P. (2017). Nicotinamide Mononucleotide Inhibits JNK Activation to Reverse Alzheimer Disease.
  8. Hou, Y., Wang, Y., Zhang, Y., Lautrup, S., et al. (2018). NAD+ Supplementation Normalizes Key Alzheimer’s Features and DNA Damage Responses in a New AD Mouse Model with Introduced DNA Repair Deficiency.