4-(Benzyloxy)phenol powder (103-16-2) video
4-(Benzyloxy)phenol powder (103-16-2) Specifications
|Product Name||4-(Benzyloxy)phenol powder|
|Chemical Name||▪ 4-Benzyloxyphenol
▪ Hydroquinone benzyl ether
▪ Hydroquinone monobenzyl ether
|Brand Name||Benoquin (Valeant)|
|Monoisotopic Mass||200.08373 g/mol|
|Melting Point||119-120 °C(lit.)|
|Color||Off-white to beige to brown|
|Water Solubility||slightly soluble|
|Application||▪ treat the loss of skin color (vitiligo)
▪ depigmentation agent
What is 4-benzyloxy phenol (Monobenzone)
4-(Benzyloxy) phenol, also called Monobenzone and monobenzyl ether of hydroquinone (MBEH) is an organic chemical in the phenol family. It has a role as a melanin synthesis inhibitor and a dermatologic drug, and is used as a topical drug for medical depigmentation. It can be used to whiten patchy skin and create and even skin tone that is pale and smooth.
4-(Benzyloxy) phenol has topical depigmentation activity. Although the exact mechanism of action of depigmentation is unknown, the metabolites of 4-(Benzyloxy)phenol appear to have a cytotoxic effect on melanocytes. Furthermore, the depigmentation effect might be mediated through the inhibition of tyrosinase, which is essential in the synthesis of melanin pigments, thereby causing permanent depigmentation of the skin. It works by permanently removing color from normal skin located around skin with vitiligo.
Although 4-(Benzyloxy) phenol can be used to remove skin depigmentation, but it is not for treating freckles, café-au-lait spots, sun damage, melanoma, jaundice, or other pigmentation disorders not caused by vitiligo.
Monobenzone for skin whitening
(1) Monobenzone is a compound used as a topical drug for medical depigmentation.
(2) The topical application of monobenzone in animals decreases the excretion of melanin from melanocytes.
(3) The same action is thought to be responsible for the depigmenting effect of the drug in humans.
(4) Monobenzone may cause destruction of melanocytes and permanent depigmentation.
(5) The histology of the skin after depigmentation with topical monobenzone is the same as that seen in vitiligo.
(6) The epidermis is normal except for the absence of identifiable melanocytes.
- Monobenzone is highly recommended for reducing the appearance of the patches on the skin. During this condition, the melanocytes are attached by the immune system. Melanocytes are responsible for melanin production, a pigment that imparts on the hair or skin color.
- Monobenzone generally works by promoting reduction of the depigmentation on affected body parts thereby contributing towards giving the skin a uniform color.
- Monobenzone is a permanent and perfect Skin Lightener.
- Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water.
- Monobenzone can decompose melanin in the skin, and prevent the formation of melanin in the skin.
Monobenzone side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Stop using monobenzone and call your doctor at once if you have a serious side effect such as:
severe skin irritation;
severe burning; or
redness or swelling of treated skin.
Less serious side effects may include:
dryness or flaking of treated skin; or
mild skin irritation.
- The nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant response promotes melanocyte viability and reduces toxicity of the vitiligo-inducing phenol monobenzone. Arowojolu OA et al. Exp Dermatol. (2017)
- Monobenzone-induced depigmentation: from enzymatic blockade to autoimmunity. van den Boorn JG et al. Pigment Cell Melanoma Res. (2011)
- The nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant response promotes melanocyte viability and reduces toxicity of the vitiligo-inducing phenol monobenzone. Arowojolu OA, Orlow SJ, Elbuluk N, Manga P.
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