If you’ve been searching for a peptide with absolutely no severe side effects, you might have heard about AOD 9604. Well, even FDA confirms that it is safe with 100% tolerability on its users. Find out if AOD 9604 works, its benefits, results, and the clinical research that backs up its efficiency.
With all the debate and rumors in the fitness corridors, you must have wondered if AOD 9604 works.
You’ll agree with me that you can’t go a day without meeting an obese or an overweight soul, right?
In a recent statistic, more than 31% of the US population either suffers from obesity or overweight. Well, the data sounds alarming, considering that plumpness is an indisputable gate pass of many diseases such as cancer and diabetes.
If you are obese, a fitness fanatic, or an elite bodybuilder, the chances are that you’re using some peptide blends. This fact will lay our foundation as we connect AOD 9604 with obesity. These supplements are a champ, whether you’re looking to lose weight, burn the abdominal fats, build muscles, or have a shredded physique.
For beginners, the problem is more than just falling for an ideal peptide blend. Sometimes, you will be forced to find a middle ground between a potent supplement and the side effects. Rather than experimenting with dozens of these drugs, you should give AOD 9604 a go.
Do you know why I recommend this treatment? It’s because it has minimal side effects. I have tested and reviewed plenty of anabolic medications, and I can confirm that 90% have adverse negative upshots to the user. Honestly, I would require a full page or more to list them all.
However, the case is different with AOD 9604 side effects. Probably, the reason is that it is less potent than HGH.
So, what’s all the fuss about AOD 9604 with obesity? Find out.
Anti-Obesity Drug-9604 (AOD-9604) is a synthetic analog of the human growth hormone. It is among the rare peptides that have won the FDA approval as a food supplement in the United States.
The molecule is a peptide fragment that has been cut out of the C-terminus, whose amino acid (AA) sequence take after the HGH lipolytic fragment. This region of the hormone derives from AAs 177 to 191 and is in control of burning fats. Does it sound like Chinese arithmetic to you? Well, if it does, don’t kick up a fuss because the detail is just for formalities.
AOD 9604 raw powder is a chemical with CAS number 221231-10-3. It is available in injectable form and as a transdermal cream. An injection is a perfect choice as it increases the absorption rate while maximizing the bioavailability of the drug.
You’re probably questioning whether this drug is a steroid, an anabolic compound, or a prescription drug. Hold your horses because I will be getting to the bottom of this mystery. After all, AOD 9604 benefits have been a bone of contention, especially in the sports regime.
AOD-9604 first came into existence in the late 1990s, courtesy of an Australian Professor, Frank Ng, of Monash University. In 2003, this anti-obesity drug became a patent of Metabolic Pharmaceuticals Limited in Australia. Its primary pharmaceutical function is the treatment of obesity by accelerating weight loss and burning of fats.
Since its production, the drug has undergone rigorous scientific testing. The trials on obese murine models were successful. In mice, the AOD 9604 benefits included efficient metabolism, loss of extra body fat, improved lipolysis, and high plasma glycerol.
From 2001 to 2007, Metabolic Pharmaceuticals actively studied the efficiency of this peptide on humans. Within this period, the research scientists had engaged over 900 subjects in the AOD 9604 clinical research. Since the primary mode of administration was oral, the drug seemed ineffective.
However, in 2010, Metabolic Pharmaceuticals developed a technology to allow the absorption of the drug via the skin. Later on, a groundbreaking discovery saw the company invent an injectable form of the medication. As at now, you can either take AOD 9604 injection or resolve for the transdermal cream.
(2) AOD 9604 Structural Formula
(3) Product Specifications
|Product Name||AOD 9604|
|Amino Acid Sequence||H-Tyr-Leu-Arg-Ile-Val-Gln-Cys(1)-Arg-Ser-Val-Glu-Gly-Ser-Cys(1)-Gly-Phe-OH|
|Synonyms||· HGH fragment 177-191
· Tyr-somatostatin (177-191)
· Sodium chloride
|Appearance||White lyophilized powder|
|Storage Temperature||2°C to 8°C|
AOD 9604 works to enhance the activity of the beta-3 receptors and improve metabolism in the human system. It speeds up the fat-burning process, perks up anabolism, and lessens the catabolic effects. Several studies also confirm the efficacy of this drug in muscle-building.
In lipolysis, AOD 9604 works in two ways. It sparks off the release of extra fat from the fatty tissues and prevents more of it from building up. The target places include the abdomen, buttocks, chin, flabby arms, and around the knees.
So, why should you trust AOD 9604 with obesity, when there are various prescription drugs for overweight patients? I will boldly tell any obese victim to bank on this treatment for two reasons. One, this HGH fragment neither interferes with the rate of food absorption nor your regular diet. Secondly, it will by no means keep a tight rein on your appetite.
If you are no longer proud of walking around with saggy abdomen due to fat deposition, the AOD 9604 benefits will overwhelm you.
The fundamental AOD 9604 work is to regulate metabolism. Although it’s synonymous to the human growth hormone, this treatment neither affects the IGF-1 level nor the blood sugar. What is more, AOD 9604 side effects are mild, such that users rarely feel them.
Just like HGH, this peptide speeds up fat loss. Not only does it suppress lipogenesis but also accelerate lipolysis in the region where there is a high deposition of fats. Thanks to the lipolytic effects, the FDA has approved its use as a food additive. In a nutshell, we can say that AOD 9604 regulates the metabolism of fats in the human body.
The most significant AOD 9604 benefit is that it has a negligible effect on insulin resistance and blood sugar levels. Among the obese population, weighing this treatment against dieting and working out is like comparing apples to oranges. However, I don’t mean that you shouldn’t exercise or check on your diet. Contrary, incorporating these two in your peptide supplementation will not only help you lose excess fat but also burn more calories.
In the fitness industry, AOD 9604 also acts as a muscle-enhancing drug. If you are a bodybuilder, this benefit is a real shot in the arm. After all, it is among the few peptides with no adverse side effects. Countless studies have verified AOD 9604 benefits in the treatment in building muscles and regenerating the cartilages.
Over the years, this anti-obesity peptide has been marketed for the treatment of osteoarthritis. Besides, it can be an excellent anti-depressant, putting in mind that it exhibits some euphoric effects on the user.
Although some scientists are brushing off the efficacy of AOD 9604 in muscle-building, the efficiency of this medication still stands. So, if you’re acting the devil’s advocate, I have one question for you. Why would WADA go to the extent of prohibiting its use in sports if it doesn’t have any effect on performance?
You’ll agree with me that the use of AOD-9604 for other purposes rather than therapeutic application can’t be banned for no apparent reason.
If you want to get the best out of AOD 9604, consult your physician before taking it. However, if you have no time to spare during those lengthy consultations, a comprehensive review like this piece can save you big time.
A few people have been complaining to me about how ineffective the treatment is in weight loss. Do you know how I hit back? I often tell users to check on their current prescriptions, over-the-counter drugs, any supplements, or medical history. For instance, taking AOD 9604 alongside other medications may cause adverse interactions, which may otherwise interfere with its bioavailability.
AOD 9604 is not for you if you’re pregnant or breastfeeding. There’s no data yet to support this contraindication but its better safe than sorry.
(1) AOD 9604 Dosage
A typical AOD 9604 dosage is 300mcg/day. You ought to inject the peptide once a day, preferably before bedtime. However, this recommendation is not final. You can choose to take the shot early in the morning.
There is no specific cycle to follow, but I recommend taking the peptide uninterruptedly for four weeks. Afterward, you can take a one-week off before resuming. Alternatively, you should buy AOD 9604 and take it for five consecutive days before having a two-day break.
The perfect time to inject AOD 9604 is 30 minutes before having breakfast. In so doing, you allow the body to metabolize the drug when the stomach is still empty.
A single dosage of AOD 9604 costs less than what you’ll pay for the same HGH quantity.
(2) How to properly Inject AOD 9604?
There are two options of injecting AOD 9604. It is either you do it yourself or have it done by a doctor. I prefer giving myself a shot.
The ideal place to administer the drug is into the fat tissue around the abdomen. Subcutaneous injection allows AOD 9604 to enter the circulation in less than New York’s time. Unlike other modes of drug delivery like intravenous or intramuscular, this method has a high bioavailability. Therefore, the AOD 9604 results are immediate.
When you buy AOD 9604, the vial is usually in powder form. It’s upon you to make the drug suspension. However, don’t fret because creating this solution is not quantum physics. Allow me to take you through.
Firstly, you need a diluent to mix with AOD 9604 peptide. Take note that the liquid is not your usual tap water. Ensure it is sterile or bacteriostatic. You surely don’t want to mess up and inject yourself with infectious prions, do you?
The amount of diluent will depend on the quantity of the vial. Take, for example, if the bottle holds 2mg of the drug, then 1ml is enough. After pouring water into AOD 9604, allow it to dissolve by rotating the vial between the fingers.
Typically, users will start registering AOD 9604 results at the end of 12 weeks. However, the outcome hinges on some contributing factors. For example, working out regularly and following a strict low-calorie dietary plan will maximize the weight loss process.
If you want to lose a significant amount of body fat, put your best foot forward and steer clear of high carbs or calories. You should also stick to an exercise regime. Of course, I don’t mean that you should do intense compound training or weightlifting. Contrary, you can run some few kilometers in a treadmill, take a walk around the neighborhood, skip, do some crunches, or any other tolerable workout.
Supposing you take AOD 9604 without exercising or following a strict dietary plan, you can lose between six to ten pounds.
What is more, age factor, personal health, and family history may positively or negatively affect the AOD 9604 results. Take, for example, users with biologically active metabolism have indisputable chances of registering excellent results. If your obesity is genetic or familial, the action of this peptide on the body will be sluggish.
Using other medications or supplements will either quicken the fat-burning process or slow down the action of this treatment. One thing I want you to understand is that no two individuals are alike. After all, even our fingerprints are as like as chalk and cheese.
In case you are considering AOD 9604 with obesity, have your pharmacist explain to you all possible requirements.
Is there any drug without a side effect? Well, even taking water has some impacts on the human system.
Allow me to take you through the potential risks involved when you inject AOD 9604. Before I can say anything else, this peptide is not as potent as HGH. Therefore, negative upshots will be less pronounced. The only probability of an adverse complication is when the treatment negatively interacts with other injections, supplements, or prescriptions.
Check out all possible AOD 9604 side effects, which you are most likely to experience;
- Stomach upset
- Reactions such as pain, swelling, or reddening at the injection spot
- Chest tightness
Some substantial AOD 9604 clinical research studies support the use of this treatment in managing obesity. Although the first study was on murine models, Metabolic Pharmaceuticals set out to establish if the drug is efficient to humans as it is to mice.
As I mentioned earlier, AOD 9604 is a lipolytic fragment of the human growth hormone. For this reason, they both exhibit similar characteristics, including the treatment of obesity, weight management, and reduction of excess body fats.
When research scientists tried it out on obese rats, AOD 9604 results were all positive. Unlike HGH, this peptide leaves no severe side effects to the user. However, to win the approval of the Therapeutic Goods Administration (TGA), there was a need for successful human trials.
The objective of this study was to establish if AOD 9604 had similar effects as those exhibited by the recombinant human growth hormone. There was a need to ascertain whether the treatment impacts IGF-1 levels, glucose tolerance, or insulin resistance.
In the AOD 9604 clinical research, 900+ adults participated in six different studies. All these trials were randomized, double-blind, and placebo-controlled. The subjects were healthy but clinically obese patients. Their blood samples were examined to check for antagonistic antibodies. This step was to rule out the possibility of immunogenicity.
The first two trials were administered intravenously with the AOD 9604 dosage ranging between 25 and 400μg/kg. The last four phases of the study used oral doses of 1mg to 54mg.
Unlike in HGH clinical trials, this peptide did not have any impact on IGF-1 levels. When glucose tolerance was tested, there were no adverse effects on the metabolism of carbohydrates. In the antibody assay, no anti-AOD9604 was detected among the patients.
Although the study group registered some side effects, none of them were severe. For instance, the majority of the subjects would experience mild or moderate headaches.
Regardless of the short-term or long-term administration of the drug, the obese patients could safely tolerate it. This AOD 9604 benefit was indistinguishable from the control group. Moreover, no drug-related withdrawals were registered.
AOD 9604 has a high tolerability profile. When the subjects were compared to the placebo, the safety in these two groups was indistinguishable. Even on a 24-week administration, there were still no adverse events as is the case with long-term HGH treatment.
(1) What is the recommended dosage of AOD 9604?
AOD 9604 dosage ranges between 120mcg and 400mcg per day. Although it is a single dose, some people would split it into two or three measures. You should take it shortly before bedtime.
Following the approval of the FDA, you can use it as a food supplement at a maximum daily dose of 1mg.
(2) What is the suggested frequency of use of AOD 9604?
Even on long-term administration, AOD 9604 will neither present withdrawal symptoms nor adverse events.
It is okay to do a four-week cycle. Take the treatment for five days and do a two-day break. Alternatively, continually administer AOD 9604 for four weeks before having a seven-day off.
(3) What Type of water can one mix with AOD 9604?
Remember that this mode of delivery is via injection and not oral administration. Only use sterile water to inject AOD 9604 subcutaneously. This bacteriostatic liquid contains a significant amount of benzyl alcohol, which acts to inhibit the growth of potentially infectious bacteria.
Even when you think you’ve got no option don’t lie to yourself by drawing out water from a dispenser or the tap. You surely don’t want to die young, do you?
(4) How much water do you need to add? How can you mix water and AOD 9604 together?
The amount of diluent you’ll need depends on the vial quantity. Take, for example, you splash out on a 5mg package of AOD 9604. You will need to buy 2ml bacteriostatic water to use as a diluent.
Although it may sound as a Greek puzzle, allow me some time to explain the preparation mode. In international standards, 1ml is equivalent to 200IU. Supposing you are preparing 5mg of the peptide, you will end up with about 5000mcg of AOD 9604 suspension.
Before you can mix these two, ensure they are at room temperature. In our case, I am using 5mg of AOD 9604 finished vials, which I’ll dilute with 200IU of water. Pour the diluent into the vial and allow it to settle for about 10 minutes. Afterward, you can mix the constituents by gently rotating the bottle.
If you were taking a daily dosage of 300mcg, the treatment would last up to three weeks. In this case, I’m considering the fact that you will be injecting AOD 9604 every day but taking a two-day off per week.
(5)Should I take AOD 9604 on an empty stomach or with food?
There are two options for administering AOD 9604 with obesity. You can either do so on an empty stomach in the morning or after the last meal before bedtime.
At dawn, there’s neither food nor liquid in the system. As you take AOD 9604, it will easily flow through the circulation. The rate of absorption will be at the maximum, and therefore, the bioavailability will be high.
Ideally, inject AOD 9604 half an hour before the first meal for the day or 30 minutes after the last meal.
(6)How to store AOD 9604?
An authentic AOD 9604 powder supplier will always ship this product in its lyophilized form. The reason is to protect the powdered peptide from unpredictable short-term temperature changes during shipping. Lyophilizing the drug makes it stable for an extended period as it minimizes degradation.
You should store AOD 9604 under cool temperatures. Once you open the vial, make sure to refrigerate it at 2°C to 8°C. Within this range, the peptide will still be valid for up to two weeks. So, if you buy AOD 9604 in bulk, I would recommend that you only reconstitute what you’ll need for the day. However, you can opt to freeze it at -20°C so that the solution remains stable for long term.
In its lyophilized powder form, you should keep the chemical in a freezer at about -20°C. Since a fair counsel comes with a fair warning, I would advise you to avoid frequent icing up and thawing of AOD 9604.
Another criticl aspect to consider is confirming the expiry date of the drug. This aspect varies depending on the AOD 9604 powder supplier and the manufacturing date.
(7) Where an I buy AOD 9604 online?
If you want to buy AOD 9604, the only sure way of obtaining it is through online stores. At least, it will save you time and money.
Most states, including the U and Australia, have not approved the over-the-counter use, production, or acquisition of AOD 9604. So far, the only legal way of accessing the treatment is on a valid prescription from an authentic doctor.
The ban became critical after the 2013 scandal involving the famous Australian Sporting Code, whose players were allegedly taking this anti-obesity drug. Well, these controversies were mere speculations channeled around like Chinese whispers. However, several anti-doping agencies, including WADA, stood up to condemn AOD 9604 use in the sports arena.
Rummaging for a legitimate AOD 9604 powder supplier is not a walk in the park. Considering the tight law governing its use, you can easily fall for counterfeits from local sellers. It’s even worse when you finally realize that some of these manufacturers have not yet met the quality control standards.
So, how do you hit on a legitimate online AOD 9604 powder supplier when countless websites are claiming to sell the peptide? Allow me to explain. Make sure to check the product’s review. You surely want to find out what the users say, any feedback, experience, and the overall rating.
AOD 9604 costs hinge on the seller, your preferred package, and the location. However, when you buy AOD 9604 in bulk, you can get good price from the peptide supplier.
To an obese, losing 10 pounds is good news than gaining 1 pound. Although some research scientists maintain their ground that AOD 9604 results are negligible, studies confirm that this drug is tolerable to humans.
If youwant to achieve excellent AOD 9604 benefits, you ought to be physically active. Stop cocooning yourself in a comfort zone. You should do some moderate workouts and develop a healthy diet plan. Did I tell you not to crave for sweet nothings, high carb, and caloric meals? Well, now, you know.
Although the peptide is not approved for pharmaceutical applications, you can still use it for research purposes. AOD 9604 costs less if you are buying the powder in bulk.
Chec in with us to make an order from a trusted AOD 9604 powder supplier.
Kamikovski a, R. Renlund b, M.D. Grynpas.”Does the growth hormone-derived peptide AOD9604 have an anabolic effect on bone?” https://doi.org/10.1016/j.bone.2009.03.047
M. Ng; J. Sun; L. Sharma; R. Libinaka; W.J. Jiang; R. Gianello. “Metabolic Studies of a Synthetic Lipolytic Domain (AOD9604) of Human Growth Hormone.” Hormone Research (2000) 53 (6): 274–278.https://doi.org/10.1159/000053183
Mark Heffernan, Roger J. Summers, Anne Thorburn, Esra Ogru, Robert Gianello, Woei-Jia Jiang, Frank M. Ng. “The Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism Following Chronic Treatment in Obese Mice andβ 3-AR Knock-Out Mice” Endocrinology, Volume 142, Issue 12, 1 December 2001, Pages 5182–5189, https://doi.org/10.1210/endo.142.12.8522Published: 01 December 2001
Holly D. Cox, Stacy J. Smeal, Cole M. Hughes, James E. Cox, Daniel Eichner. “Detection and in vitro metabolism of AOD9604” https://doi.org/10.1002/dta.1715
Woei-Jia Jiang, Robert Gianello, Mark Heffernan, Esra Ogru, Roksan Libinaki & Frank Ng. “Development of a Human Growth Hormone Peptide Analogue AOD9604 into an Anti-Obesity Drug”
Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D.”Detection and in vitro metabolism of AOD9604.”Drug Test Anal. 2015 Jan;7(1):31-8. doi: 10.1002/dta.1715. Epub 2014 Sep 10.PMID: 25208511
Kwon DR, Park GY.”Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model.”Ann Clin Lab Sci. 2015 Summer;45(4):426-32.PMID: 26275694
Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM.”The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice.”Endocrinology. 2001 Dec;142(12):5182-9. doi: 10.1210/endo.142.12.8522.PMID: 11713213
Wilding J.”AOD-9604 Metabolic.”Curr Opin Investig Drugs. 2004 Apr;5(4):436-40.PMID: 15134286
Vanhee C, Moens G, Deconinck E, De Beer JO.”Identification and characterization of peptide drugs in unknown pharmaceutical preparations seized by the Belgian authorities: case report on AOD9604.”Drug Test Anal. 2014 Sep;6(9):964-8. doi: 10.1002/dta.1687. Epub 2014 Jun 26.PMID: 24976118
Khan A, Raza S, Khan Y, Aksoy T, Khan M, Weinberger Y, Goldman J.”Current updates in the medical management of obesity.”Recent Pat Endocr Metab Immune Drug Discov. 2012 May;6(2):117-28. doi: 10.2174/187221412800604644.PMID: 22435392
Jensen MD.”Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors.”Obesity (Silver Spring). 2006 Jun;14 Suppl 3:143S-149S. doi: 10.1038/oby.2006.294.PMID: 16931496
Heffernan MA, Thorburn AW, Fam B, Summers R, Conway-Campbell B, Waters MJ, Ng FM.”Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment.”Int J Obes Relat Metab Disord. 2001 Oct;25(10):1442-9. doi: 10.1038/sj.ijo.0801740.PMID: 11673763
Thevis M, Schänzer W.”Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls.”J Pharm Biomed Anal. 2014 Dec;101:66-83. doi: 10.1016/j.jpba.2014.05.020. Epub 2014 May 23.PMID: 24906629
Orlovius AK, Thomas A, Schänzer W, Thevis M.”AOD-9604 does not influence the WADA hGH isoform immunoassay.”Drug Test Anal. 2013 Nov-Dec;5(11-12):850-2. doi: 10.1002/dta.1557. Epub 2013 Sep 30.PMID: 24124033