What is lithium orotate?

Lithium Orotate is a compound that consists of orotic acid (a substance produced in the body naturally) and an alkali metal commonly referred to as Lithium. Lithium is an element available in the diet, mostly in vegetables and grains.

We have more lithium orotate sources as we will discuss later in this article. This is why lithium orotate supplement is always known as “nutritional lithium.” Lithium orotate is popular in the supplements market since it is regarded as a natural treatment for a broad range of mental health illnesses.


Why is lithium called a drug?

Lithium is referred to as a drug because lithium compounds, also referred to as lithium salts, are basically used as a psychiatric medication. They are basically used to cure bipolar disorders and manage major depressive illnesses which doesn’t improve after the application of antidepressants. In these diseases, lithium orotate high dose lowers the risk of suicide.


How does lithium orotate work?

Lithium orotate mechanism of action

The orotate ingredient is very crucial since it delivers lithium in its bioactive form enabling your body to absorb it. Lithium orotate mechanism of action shows in several levels, from microscopic to macroscopic levels. Lithium orotate modulates gabaergic neurotransmission and dopaminergic glutamatergic.

Lithium orotate has also demonstrated neuroprotective positive effects in several brain regions. This is evidenced by changes in the volume of grey matter. Lithium orotate supplement provides you with both neuroproliferative and neuroprotective positive effects thanks to its ability to preserve the grey matter.

Lithium orotate also modulates neurotransmitters. It blocks excitatory neurotransmitters including glutamate and dopamine, while promoting GABA-mediated neurotransmission.

Lithium orotate causes downregulation of NMDA receptors which is a subtype of glutamate receptor. Lithium induces the NMDA receptor, raising availability of glutamate in the postsynaptic neuron.

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Current Research in Lithium orotate

Prescription-strength lithium orotate is regarded as a potent neuroprotective agent. It is being widely studied in specific neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease, and ALS (amyotrophic lateral sclerosis). It has been proved to cause disruption of glycogen synthase kinase-3, which is a crucial enzyme that causes the development of neurofibrillary tangles and amyloid plaques that are associated with A.D. (Alzheimer’s disease.) 


What are the benefits of lithium orotate?

Discussed below are some of the lithium orotate benefits in high dose and low dose.


i. Management of Dementia and Alzheimer’s

Lithium orotate high dose of 10 µg per every liter of water gave a lower rate of dementia by a whopping 17 percent. However, lithium orotate dosage of 5 to 10 µg per liter was associated with a 22 percent rise in dementia. This shows that lithium orotate dosage is highly sensitive and the benefits it provides will largely depend on the dosage used. Lithium orotate supplements also provide protective stress responses and neuroprotection.


ii. Low-dose lithium orotate for mood

Very low doses of lithium assist greatly for complex mood challenges. Low lithium orotate dosage is enough to really help in the management of depression. Let us compare the 150 mg, which is the smallest dose made and 900 to 1500 mg per day, which is one of the highest lithium orotate dosage made.

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If you have manic-depressive disease, you need to take lithium orotate high dose to get enough blood levels. Lithium orotate blood levels varies greatly from an individual to another, so a few laboratory tests are usually required to ensure your level is known before taking a dose.

As a usual procedure, when an antidepressant drug for Major Depression has failed to work alone, addition of low-dose lithium is a standard option. This routine is incorporated in the international depression treatment guidelines.


iii. Low-dose lithium orotate prevents suicide

Lithium is always found in the water of various cities around the globe.  Surprisingly, those towns have comparably lower rates of suicide than neighboring cities with no or little lithium in their water. According to the studies conducted, the higher the level of lithium, the lower the rate of suicide.

With lithium orotate supplement, people can possibly add some lithium in their drinking water and this could be beneficial.

Lithium orotate in the management of Neurological conditions

Lithium orotate can be used in the management of various neurological illnesses. These illnesses include dementia, Alzheimer, ADHD, ADD, aggressive and violent behaviors.

Different researchers have found out that administering lithium orotate to dementia patients can assist with biologic and behavioral issues. It can provide positive results to Alzheimer’s-dementia patients too. It has shown to keep neurons alive in humans and animals in several studies. Enhanced focus can assist ADD patients and stabilize those who have ADHD.


iv. Lithium orotate brain positive effects

One of the most important lithium orotate benefits is that it protects the brain through the production of new brain cells and protection against the loss of brain cells. It has also shown to reverse dementia, Parkinson’s, and Alzheimer’s disease.

Animal studies on lithium orotate brain effects showed improvement in strokes and traumatic brain injuries. It can also provide benefits as a protectant against damage of the central nervous system due to Lyme disease. Other lithium orotate brain effects include:

  • Protect the brain against brain shrinkage.
  • Protects brain cells from toxins and infections
  • Boosts growth of new brain cells


v. Lowering Anxiety from PTSD and Management of Bipolar Disorder

People with bipolar disorder may take lithium orotate together with their lithium drug prescription to lower symptoms. The acid content in lithium orotate may boost absorption of prescribed lithium carbonate. Lithium orotate supplement may also assist reduce the prescription version.

Lithium orotate may also help those who are suffering from severe anxiety from PTSD and may assist as a stabilizer after panic attacks.


vi. Lithium orotate and alcohol intake management

Daily treatment with lithium orotate helped alcohol addicts who wanted to quit alcohol intake. Lithium orotate benefits in assisting other addictive behavioral patterns are there as well. Those who suffer from obsessive and OCD disorders may benefit from it. Lithium orotate and alcohol intake control has been a major area of study. Scientists believe lithium orotate can help cope during the process of rehabilitation besides counseling therapy use.

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vii. Low dose lithium orotate can lower inflammation

Lowering inflammation is one of the most crucial lithium orotate benefits to our health. In these days, we have more toxins in our environment and diet than ever before. These toxins raise the level of inflammation causing several diseases. Research has demonstrated that lithium orotate seems to lower inflammatory proteins while increasing anti-inflammatory proteins.

In recent research lithium orotate showed neuroprotective effects against autoimmunity of the nervous system. This study in animals showed that lithium suppressed the production of IFN-γ, which is associated with A.D (Alzheimer’s disease.)


viii. Lithium orotate depression lowering effects

Low-dose lithium is very effective in the treatment of depression. Most studies have found out that low-dose lithium orotate is equally as potent as a high dose with little to no side effects.

Lithium orotate depression lowering effects are associated with its ability to boost 5-HT neurotransmission (“happy” neurotransmitter) receptors. This effect stimulates antidepressant action in the brain, combating depression.


ix. Uses of lithium orotate high dose

For over a century, lithium orotate high dose (typically 300-1200+ mg per day) has been applied in pharmacological doses to cure bipolar disorders and other mood related disorders.  Lithium orotate high dose is also being studied and used to lower the progress of dementia, ALS, and Alzheimer’s disease.


Who might consider lithium orotate?

At least 3 or more groups of people should consider taking lithium orotate. These groups include:


1. People whose parents have Alzheimer’s dementia

You have probably heard of a study that proved lithium might decrease the risk of Alzheimer’s dementia.   If you have a parent with Alzheimer’s, you should be interested in low-risk step which you could take which might lower the chances of getting this condition yourself.

If your parents became ill while young, or you already see in yourself some signs of decline in memory, you may feel that you do not have time to wait for more clinical research.


2.  People who struggled with thoughts regarding suicide

People who struggled with suicide thoughts should consider taking low dose lithium orotate supplements because small amounts of lithium in an area’s water supply have been associated with low suicide rates in those areas.  You may consider lithium orotate if you have ever experienced suicide thoughts and you need some assistance to eliminate the stress.


3. People suffering from anxiety

Lithium orotate is popular for its antipsychotic positive effects in patients with bipolar. Because of this, effects of lithium orotate lower doses are being studied in persons with anxiety. Lithium orotate has been proved in several studies to calm down manic behavior related to (ADHD) attention deficit disorder, anxiety, and bipolar disorder.

Even if most of these investigations involve more extreme cases and always apply lithium carbonate, that is more aggressive form of lithium, many practitioners have reportedly used low-dose lithium orotate for management of anxiety.

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4. People who want to boost their cognitive function

Lithium orotate brain effects are simply amazing. Low dose lithium orotate has been proved to be neuroprotective and to boost cognition.

One of the lithium orotate mechanism of action is to boost BDNF (brain-derived neurotrophic factor), which is crucial to good brain function. Lithium orotate also block glycogen synthase kinase-3 action that is involved in intracellular signaling.

Lithium orotate also lowers calcium-dependent stimulation of pro-apoptotic signaling pathways. This assists to lower the rate of cell death. Lithium orotate longevity benefits are also supported by its ability to lower the rate of cell death.


Where to Find Lithium?

Lithium is a light metal which is highly reactive and naturally found in minute levels throughout the human body. Other lithium orotate sources include:

  • Dietary supplements
  • Drinking water
  • Grains
  • Mustard
  • Pistachios
  • Dairy
  • Kelp
  • Fish
  • Meat
  • Vegetables


How long does lithium orotate take to work?

It normally takes a few weeks for lithium orotate to start working. Your health care professional will ask for blood tests receiving lithium orotate treatment. This is because lithium orotate can influence how well your thyroid or kidney functions because it functions best if the lithium amount in your system is maintained at a constant level.


How to take lithium orotate powder?

How much lithium orotate should I take?

The daily lithium orotate dosage should be between 0.3 to 5 milligrams. This amount of lithium could practically protect your brain.


What is the best time to use lithium orotate supplements?

Lithium orotate tablet supplements should be taken one time per day at night. Lithium liquid supplements are usually taken two times per day. Lithium orotate level in the blood need to be taken not earlier than five to seven days after treatment begins.


How much lithium orotate should I take for depression?

More often than not, the lowest lithium orotate dosage is sufficient to help with depression. Lithium orotate can therefore be used in lower doses such as 5 mg with amazing results and without any lithium orotate side effects. A clinical study involving 150 mg daily lithium orotate dosage given four to five times per week, showed a decrease of depressive and maniac symptoms in patients with depression.


How long will you have to take Lithium Orotate?

Lithium orotate should be taken for at least six months when taking 150mg per day.  An open research involving 42 patients investigated the effects of lithium orotate 150 mg per day administered over 6 months. The study demonstrated that this period was enough for lithium orotate to treat depression, alcoholism, and even migraines.

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Lithium Orotate Side Effects and safety

A majority of lithium orotate side effects may be avoided by taking the correct lithium dosage or through careful monitoring by a health care professional.

The smaller the amount of active lithium orotate contained in a supplement the more likely you’re able to avoid possible lithium orotate dangers.

Some people experienced the following lithium orotate side effects after taking the supplement:

  • Headaches
  • Nausea
  • Tremors (usually in the hands)
  • Vomiting
  • Increased thirst
  • Constipation
  • Dry mouth
  • Increased urination
  • Stomach discomfort
  • Drowsiness
  • Acne
  • Diarrhea
  • Feeling slightly “disconnected.”

It was also reported that lithium orotate cause weight gain when taken in high amounts. Reducing the dosage may alleviate or lower these lithium orotate side effects.

There is very little clinical information concerning lithium orotate interactions with other drugs. More studies in humans will be required to determine lithium orotate interactions with other drugs.


The differences between lithium orotate and lithium

Lithium orotate and lithium differ in that lithium orotate is a supplement or over-the-counter nutraceutical which consists of orotic acid and lithium while lithium is an alkali metal.  Orotic acid which is a component of lithium orotate is produced in the body naturally. Orotic acid is inactive but is used in this compound to act as a carrier for the active component which is lithium. On the other hand, lithium as an alkali metal is normally present in the diet, mainly in vegetables and grains. Lithium element is also present in our drinking water. That’s basically how lithium orotate and lithium differ.


Lithium orotate vs lithium aspartate

Lithium aspartate is another low-dosage lithium route. Whereas lithium orotate is marketed for the special ability of orotate to deliver lithium, aspartate on the other hand is not regarded as special. Aspartate is just another ion that carries lithium, just like the carbonate ion present in the normal prescription lithium.

You can also buy lithium aspartate online. After aspartate leaves lithium aspartate ion is left in the body in small amounts. As with carbonate, aspartate is safe because it is an amino acid which we take in proteins all the time.

Since there’s no enough clinical data to show how effective lithium aspartate is, the safest route for now is to use low-dose lithium orotate.


FAQs of lithium orotate


Take lithium orotate supplement will cause the weight gain?

The claim that lithium orotate cause weight gain is true to some extent. Although there is possibility of weight gain while taking lithium orotate, this side effect doesn’t affect every person who takes the supplement.


How does lithium orotate do the brain?

Lithium Orotate has been proven to support memory and mood while improving cognition and overall brain health. Lithium orotate also protects the brain cells against damage.


– Does lithium orotate help with anxiety?

Yes, lithium orotate powder has been used to lower anxiety for many years. It has also been highly effective in the management of mood swings, attention deficit disorders as well as anger and aggression.


– Does lithium orotate make you sleepy?

Lithium orotate is very useful in the regulation of sleep-wake cycle. However, high doses may cause drowsiness which may make you feel sleepy.


– Can Lithium Orotate help depression?

Yes, Lithium orotate is very useful in lowering depression. Clinical experiments involving lithium orotate 150 mg daily dose administered four to five times per week, showed a remarkable decrease in symptoms associated with depression.


– Does lithium orotate affect thyroid?

Lithium orotate low dosage doesn’t cause much risk to thyroid. But lithium at a slightly higher dose can cause thyroid issues either getting too low which is known as hypothyroid or in rare cases getting too high which is known as hyperthyroid. Ten percent of people may get this problem.


– Is Lithium Orotate (LO) supplementation safe for everyone?

When taken in low doses, Lithium Orotate (LO) supplementation is safe for everyone. All clinical studies carried out shows that lithium orotate dangers are very rare and the supplement is highly effective in neuroprotection functions.


What is lithium orotate half life?

Lithium orotate half life is 24 hours.


– Where to buy lithium orotate powder?

You can buy lithium orotate powder online or from your local foods and supplement store. If you want to place a lithium orotate powder bulk order, feel free to do so from our website. We are a reliable and experienced lithium orotate powder supplier who has the ability to deliver the lithium orotate supplement to your location.


  1. Chiu CT and Chuang DM. Neuroprotective action of lithium in disorders of the central nervous system. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2011;36(6):461-76.
  2. Nunes, M.A., et al., Chronic Microdose Lithium Treatment Prevented Memory Loss and Neurohistopathological Changes in a Transgenic Mouse Model of Alzheimer’s Disease. PLoS One, 2015. 10(11): p.e0142267.
  3. Smith, D. F.; Schou, M. (March 1979). “Kidney function and lithium concentrations of rats given an injection of lithium orotate or lithium carbonate”. The Journal of Pharmacy and Pharmacology. 31 (3): 161–163.
  4. Ina Bach; Otto Kumberger; Hubert Schmidbaur (1990). “Orotate complexes. Synthesis and crystal structure of lithium orotate( – I) monohydrate and magnesium bis[ orotate( – I)] octahydrate”. Chemische Berichte. 123 (12): 2267–2271.
  5. lithium orotate